Anti-acute thrombogenic surface using coaxial electrospraying coating for vascular graft application

Abstract Improvement of thrombo-resistant properties is vital for vascular substitutes. Heparin, an effective natural anticoagulant, attracted concerns about its incorporate way, releasing profile, and the biological function when applied onto vascular substitutes. Coaxial electrospraying technology was used to develop and form PCL-PEG encapsulated heparin microspheres in this study. Heparin can maintain its activity and sustained release in 15 days with the package and protection of shell layer. When the microspheres were sprayed onto the PCL porous membrane, the materials showed sufficient property in avoiding the platelet adhesion and blood coagulation.