Highly porous electrospun 3D polycaprolactone/β-TCP biocomposites for tissue regeneration

Abstract Micro/nanofibres can provide outstanding biological activity in tissue regeneration. However, their use as a biomedical scaffold has been limited due to difficulty of three-dimensional (3D) shapability, small pore size, and weak mechanical properties. In this study, we suggest a facile method of fabricating mechanically enhanced 3D polycaprolactone (PCL)/β-TCP micro/nanofibres with homogeneous micro-pores using modified wet-electrospinning supplemented with a femtosecond laser. The fabricated scaffolds demonstrated improved mechanical properties and relatively high cellular activities compared to rapid-prototyped 3D PCL/β-TCP scaffolds.