Polydopamine/keratin complexes as gatekeepers of mesoporous silica nanoparticles for pH and GSH dual responsive drug delivery
Source abstract
Abstract
Abstract Mesoporous silica nanoparticles (MSNs) have attracted considerable attention for drug delivery due to their tunable pore sizes and morphologies, excellent biocompatibility, and ideal sites to bind other chemical groups. In this study, MSNs were first coated with polydopamine (PDA) by mussel-inspired polymerization and then conjugated with keratin via iron(III)-mediated coordination chemistry. The doxorubicin (DOX)-loaded MSNs(MSNs-DOX@PDA@keratin) exhibited pH and glutathione (GSH) dual-responsive drug release behavior as well as higher toxicity against tumor cells with lower toxicity on normal cells. These drug carriers could be uptaken by the tumor cells through endocytosis, having great potential in drug delivery applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Dyeing and Modifying Textile Fibers · Photonic Crystals and Applications · Nonlinear Optical Materials Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (16)
Show source-provided references
1. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers10.1016/j.addr.2008.03.012 ↗
2. Functionalized mesoporous silica materials for controlled drug delivery10.1039/c2cs15308d ↗
3. Electrophoretic deposition of core-shell Ag@MSN incorporated-chitosan coatings with biocompatible and antibacterial activities10.1016/j.matlet.2018.12.042 ↗
4. Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release10.1016/j.ijpharm.2013.12.045 ↗
5. Formulation and development of smart pH responsive mesoporous silica nanoparticles for breast cancer targeted delivery of anastrozole: in vitro and in vivo characterizations10.1016/j.micromeso.2018.12.026 ↗
6. J. Wen, K, Yang, FY. Liu, H.J. Li, Y.Q. Xu, S.G. Sun. Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems. Chem. Soc. Rev. 46(2017) 6024-6045.10.1039/C7CS00219J ↗
7. Mesoporous Silica Nanoparticles for Drug Delivery10.1002/adfm.201902634 ↗
8. A Review of Keratin-Based Biomaterials for Biomedical Applications10.3390/ma3020999 ↗
9. Preparation and characterization of DOX loaded keratin nanoparticles for pH/GSH dual responsive release10.1016/j.msec.2016.12.067 ↗
10. Human hair keratin and its-based biomaterials for biomedical applications10.1007/s13770-014-0029-4 ↗
11. One-step fabricated keratin nanoparticles as pH and redox-responsive drug nanocarriers10.1080/09205063.2018.1519987 ↗
12. Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy10.1016/j.jcis.2015.11.001 ↗
13. Triple stimuli-responsive keratin nanoparticles as carriers for drug and potential nitric oxide release10.1016/j.msec.2018.05.073 ↗
14. Coordination bonding-based polydopamine-modified mesoporous silica for sustained avermectin release10.1016/j.msec.2019.110073 ↗
15. Z. Du, K.L. Y, Y. Cao, Y. Li, Y.Q. Yao, G. Yang, Regenerated keratin-encapsulated gold nanorods for chemo-photothermal synergistic therapy, Mater. Sci. Eng. C. 117 (2020) 111340.10.1016/j.msec.2020.111340 ↗
16. Folate-conjugated dually responsive micelles for targeted anticancer drug delivery10.1039/C6RA01885H ↗