Plant-derived oxidized nanofibrillar cellulose-chitosan composite as an absorbable hemostat
Source abstract
Abstract
Abstract In this study, a new absorbable hemostat was developed with two most abundantly found natural polymers. Oxidized nanofibrillar cellulose (ONFC)-chitosan (Ch) sponge was prepared by lyophilization at a volume ratio of 50:50. Cytotoxicity and cell proliferation studies revealed that the sponge was non-cytotoxic and the cell proliferated continuously on the sponge. ONFC-Ch sponge showed better hemostatic effect on hepatic trauma than ONFC sponge. Both sponges were implanted on hepatic trauma for 1 and 3 weeks. ONFC-Ch sponge showed greater degree biodegradability and biocompatibility. Thus, ONFC-Ch sponge can be considered as a potential hemostatic material.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Cellulose Research Studies · Electrospun Nanofibers in Biomedical Applications · Nanocomposite Films for Food Packaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (28)
Show source-provided references
1. AC5 Surgical Hemostat™ as an effective hemostatic agent in an anticoagulated rat liver punch biopsy model10.1016/j.nano.2015.01.001 ↗
2. Comparative evaluation of absorbable hemostats: advantages of fibrin-based sheets10.1016/j.biomaterials.2004.01.013 ↗
3. Oxidized regenerated cellulose-based hemostat with microscopically gradient structure10.1016/j.carbpol.2012.01.058 ↗
4. Effects of fibrin pad hemostat on the wound healing process invivo and invitro10.1016/j.biomaterials.2011.09.019 ↗
5. Nanocellulose properties and applications in colloids and interfaces10.1016/j.cocis.2014.10.003 ↗
6. Cellulose-based bio- and nanocomposites: a review10.1155/2011/837875 ↗
7. Cellulose nanofibers prepared by TEMPO-mediated oxidation of native cellulose10.1021/bm0703970 ↗
8. TEMPO-oxidized cellulose nanofibers10.1039/C0NR00583E ↗
9. The use of periosteum and Surgicel® for bone restoration in congenital clefts of the maxilla: a clinical report and experimental investigation
10. Evaluation of Surgicel Nu-knit, Merocel and Vasolene gauze nasal packs: a randomized trial
11. Enzymatic hydrolysis combined with mechanical shearing and high-pressure homogenization for nanoscale cellulose fibrils and strong gels10.1021/bm061215p ↗
12. Preparation and in vitro release performance of sustained-release captopril/Chitosan-gelatin net-polymer microspheres10.1007/s11802-007-0249-5 ↗
13. Preparations, characterizations and applications of chitosan-based nanoparticles10.1007/s11802-007-0237-9 ↗
14. Roberts · 1992
15. The evaluation on biological properties of carboxymethyl-chitosan and carboxymethyl-chitin10.1007/s11802-008-0404-7 ↗
16. Hemostatic agents derived from chitin and chitosan10.1080/15321790500304122 ↗
17. Biodegradation, biodistribution and toxicity of chitosan10.1016/j.addr.2009.09.004 ↗
18. Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis10.1016/j.biomaterials.2005.01.023 ↗
19. The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins10.1016/j.biomaterials.2011.05.062 ↗
20. Development and assessment of hemostasis chitosan dressings10.1016/j.carbpol.2011.03.015 ↗
21. Nanocomposite films based on TEMPO-mediated oxidized bacterial cellulose and chitosan10.1007/s10570-014-0330-3 ↗
22. Mesenchymal stem cells: isolation and therapeutics10.1089/scd.2004.13.436 ↗
23. 15. Oxidized Cellulose: Chemistry, Processing and Medical Applications
24. Use of chitosan as a biomaterial: studies on its safety and hemostatic potential10.1002/(SICI)1097-4636(199701)34:1<21::AID-JBM4>3.0.CO;2-P ↗
25. The effect of chitosan (poly-N-acetyl glucosamine) on lingual hemostasis in heparinized rabbits10.1016/S0278-2391(99)90632-8 ↗
26. Chitosan enhances platelet adhesion and aggregation10.1016/S0006-291X(03)00173-6 ↗
27. Biodegradation and distribution of water-soluble chitosan in mice10.1016/S0142-9612(98)00159-8 ↗
28. Novel derivatives of chitosan and their antifungal activities in vitro10.1016/j.carres.2005.11.002 ↗