Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy
Source abstract
Abstract
A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Cancer Research and Treatments · Nanoplatforms for cancer theranostics · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical and Biomolecular Engineering
National University of Singapore
Engineering Drive 4
Singapore
Department of Hepatobiliary and Pancreatic Surgery
First Affiliated Hospital
Zhejiang University
School of Medicine
Hangzhou 310003
Department of Chemistry
Hangzhou 310028
China
Joint School of National University of Singapore and Tianjin University
Funding
National Research Foundation Singapore · National Natural Science Foundation of China · National University of Singapore
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