journal article·2022

Monitoring cardiovascular disease severity using near-infrared mechanoluminescent materials as a built-in indicator

Xiangyu Liu, Puxian Xiong, Lejing Li, Mei Yang, Mingying Yang, Chuanbin Mao

Materials Horizons· Volume 9· Issue 6
Publisher page

Abstract

Artificial vascular grafts (AVGs) are widely used to treat cardiovascular diseases (CVDs). But none of the reported AVGs can also monitor the CVD severity. Because CVDs affect the blood pressure, we proposed to employ a force-sensing material that emits near-infrared (NIR) light upon force loading, a NIR mechanoluminescent (ML) material (CaZnOS:Nd3+), as an indicator in AVGs to tackle this challenge. Specifically, we used a polydimethylsiloxane AVG modified with this ML material, termed ML-AVG, to achieve the rapid and convenient monitoring of two CVD models (vascular occlusion and hypertension) in real time. The NIR ML material showed good blood and tissue compatibility without causing an inflammatory response. By implanting the ML-AVGs into the common carotid artery (CCA) of rats, we observed the NIR ML signals emitted from the AVGs by a thermal camera, a NIR spectrometer, and a NIR camera. The NIR ML signal was linearly correlated with the degree of vascular opening (in the vascular occlusion model) or the degree of hypertension (in the hypertension model). Our work suggests that NIR ML materials can monitor the severity of diseases with force or pressure as biomarkers.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China

The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, P. R. China

The China-Germany Research Center for Photonic Materials and Devices, The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Technology, South China University of Technology, Guangzhou 510640, P. R. China

Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang 310058, P. R. China

Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA

Funding

National Natural Science Foundation of China · University of Oklahoma

References (32)

Show source-provided references
1. Wu · Adv. Funct. Mater. · 2018 · 28 · 180316810.1002/adfm.201803168 ↗
2. Li · ACS Appl. Mater. Interfaces · 2018 · 10 · 1450910.1021/acsami.8b02530 ↗
3. Xiong · J. Am. Ceram. Soc. · 2019 · 102 · 589910.1111/jace.16444 ↗
4. Xiong · Adv. Funct. Mater. · 2021 · 31 · 201068510.1002/adfm.202010685 ↗
5. Guo · Mater. Horiz. · 2019 · 6 · 99610.1039/C8MH01624K ↗
6. Guo · Composites, Part B · 2021 · 227 · 10943410.1016/j.compositesb.2021.109434 ↗
7. Kenry · Adv. Mater. · 2018 · 30 · 180239410.1002/adma.201802394 ↗
8. Vasilis · Eur. Radiol. · 2003 · 13 · 19510.1007/s00330-002-1524-x ↗
9. Xiong · iScience · 2021 · 24 · 10194410.1016/j.isci.2020.101944 ↗
10. Li · Nano Energy · 2020 · 69 · 9
11. Leitao · Macromol. Biosci. · 2016 · 16 · 13910.1002/mabi.201500251 ↗
12. Shepherd · N. Engl. J. Med. · 1999 · 1 · 1349
13. Foley · Nephron. Clin. Pract. · 1998 · 101 · c47
14. Xie · J. Mech. Behav. Biomed. Mater. · 2016 · 61 · 41010.1016/j.jmbbm.2016.04.011 ↗
15. Ferrari · Int. J. Polym. Mater. Polym. Biomater. · 2017 · 66 · 63510.1080/00914037.2016.1252361 ↗
16. Shi · Exp. Ther. Med. · 2018 · 15 · 3899
17. Loneker · J. Biomed. Mater. Res., Part B · 2018 · 106 · 65910.1002/jbm.b.33874 ↗
18. Dellegrottaglie · Nat. Clin. Pract. Cardiovasc. Med. · 2007 · 4 · 67710.1038/ncpcardio1035 ↗
19. Schuleri · Nat. Rev. Cardiol. · 2009 · 6 · 69910.1038/nrcardio.2009.172 ↗
20. Yannuzzi · Ophthalmology · 1986 · 93 · 61110.1016/S0161-6420(86)33697-2 ↗
21. Byrne · Nat. Rev. Cardiol. · 2013 · 10 · 2710.1038/nrcardio.2012.160 ↗
22. Culp · J. Vasc. Interv. Radiol. · 2007 · 18 · 18710.1016/j.jvir.2006.12.720 ↗
23. Toshiharu · J. Synchrotron Radiat. · 2014 · 21 · 132710.1107/S1600577514017500 ↗
24. Chen · Adv. Sci. · 2018 · 5 · 170056010.1002/advs.201700560 ↗
25. Sambrook · Inorg. Chem. · 2010 · 38 · 2571
26. Towner · Tissue Eng., Part A · 2010 · 16 · 35710.1089/ten.tea.2009.0233 ↗
27. Hong · J. Clin. Ultrasound · 2011 · 39 · 8310.1002/jcu.20759 ↗
28. He · Nano Energy · 2021 · 86 · 10605810.1016/j.nanoen.2021.106058 ↗
29. Sohn · ACS Appl. Mater. Interfaces · 2016 · 8 · 3477710.1021/acsami.6b12931 ↗
30. Zhou · Biomaterials · 1999 · 20 · 209310.1016/S0142-9612(99)00080-0 ↗
31. Shih · Int. J. Pharm. · 2006 · 327 · 11710.1016/j.ijpharm.2006.07.043 ↗
32. Liu · Mater. Sci. Eng., C · 2017 · 71 · 28910.1016/j.msec.2016.10.019 ↗