journal article·2024

Injectable hydrogels for bone regeneration with tunable degradability via peptide chirality modification

Weikai Chen, Shihao Sheng, Kai Tan, Sicheng Wang, Xiang Wu, Jiayi Yang, Yan Hu, Liehu Cao, Ke Xu, Fengjin Zhou, Jiacan Su, Qin Zhang, Lei Yang

Materials Horizons· Volume 11· Issue 18
Publisher page

Abstract

The degradability of hydrogels plays a pivotal role in bone regeneration, yet its precise effects on the bone repair process remain poorly understood. Traditional studies have been limited by the use of hydrogels with insufficient variation in degradation properties for thorough comparative analysis. Addressing this gap, our study introduces the development of matrix metalloproteinase (MMP)-responsive hydrogels engineered with a tunable degradation rate, specifically designed for bone regeneration applications. These innovative hydrogels are synthesized by integrating MMP-sensitive peptides, which exhibit chirality-transferred amino acids, with norbornene (NB)-modified 8-arm polyethylene glycol (PEG) macromers to form the hydrogel network. The degradation behavior of these hydrogels is manipulated through the chirality of the incorporated peptides, resulting in the classification into L, LD, and D hydrogels. Remarkably, the L hydrogel variant shows a significantly enhanced degradation rate, both in vitro and in vivo, which in turn fosters bone regeneration by promoting cell migration and upregulating osteogenic gene expression. This research highlights the fundamental role of hydrogel degradability in bone repair and lays the groundwork for the advancement of degradable hydrogel technologies for bone regeneration, offering new insights and potential for future biomaterials development.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Supramolecular Self-Assembly in Materials · Connective tissue disorders research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Translational Medicine, Shanghai University, Shanghai 200444, P. R. China

Organoid Research Center, Shanghai University, Shanghai 200444, P. R. China

National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, P. R. China

Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P. R. China

Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang 325035, P. R. China

Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China

Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai 200941, P. R. China

Department of Gynaecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P. R. China

Department of Orthopedics, Shanghai Luodian Hospital, Shanghai 201908, P. R. China

Honghui Hospital, Xi'an Jiao Tong University, Xi'an 710000, P. R. China

Funding

Natural Science Foundation of Zhejiang Province · National Natural Science Foundation of China · Natural Science Foundation of Shanghai Municipality · Science and Technology Plan Project of Wenzhou Municipality

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