The degradation behavior of nanoscale HA/PLGA and α-TCP/PLGA composites
Source abstract
Abstract
The aim of this work was to prepare and analyze the degradation properties of pure PLGA, homogeneous α-tricalcium phosphate (α-TCP)/PLGA and hydroxyapatite (HA)/PLGA composites for potential bone replacement applications. α-TCP and HA powders were prepared in-house and 25 nominal wt% of calcium phosphate (CaP) powder was incorporated into commercially available PLGA pellets by twin screw extrusion. The degradation studies showed that pure PLGA had the fastest degradation rate followed by HA/PLGA and α-TCP/PLGA. Overall, it was found that α-TCP acted as a better buffering agent than HA, resulting in reduced acid group autocatalysis and hence a slower degradation rate.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Metallurgy, Cambridge Centre for Medical Materials, University of Cambridge, New Museums Site, Cambridge, UK
Professor, Department of Materials Science and Metallurgy, Cambridge Centre for Medical Materials, University of Cambridge, New Museums Site, Cambridge, UK
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