Enzyme‐Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen
Source abstract
Abstract
Abstract A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2‐ketoprofendimethylmalate using CAL‐B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug. magnified image
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Polymer Synthesis and Characterization · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (29)
Show source-provided references
1.
2. 10.1016/j.progpolymsci.2007.07.00110.1016/j.progpolymsci.2007.07.001 ↗
3. 10.1016/S0167-7799(02)01962-510.1016/S0167-7799(02)01962-5 ↗
4. 10.1016/j.addr.2006.09.02010.1016/j.addr.2006.09.020 ↗
5. 10.1039/B406727D10.1039/B406727D ↗
6.
7. 10.1002/pola.2222210.1002/pola.22222 ↗
8. 10.1021/ma050489m10.1021/ma050489m ↗
9.
10. 10.1002/pi.231610.1002/pi.2316 ↗
11. 10.1016/j.ijpharm.2008.01.00310.1016/j.ijpharm.2008.01.003 ↗
12. 10.1080/0363904080192907510.1080/03639040801929075 ↗
13. 10.1208/s12249-009-9228-z10.1208/s12249-009-9228-z ↗
14.
15. 10.1021/ma035182710.1021/ma0351827 ↗
16. 10.1021/bm801132d10.1021/bm801132d ↗
17. 10.1021/bm901163410.1021/bm9011634 ↗
18. 10.1016/j.ijpharm.2008.01.00310.1016/j.ijpharm.2008.01.003 ↗
19.
20. 10.1016/j.progpolymsci.2006.09.00410.1016/j.progpolymsci.2006.09.004 ↗
21. 10.1002/ddr.2006310.1002/ddr.20063 ↗
22.
23. 10.1016/j.ijpharm.2008.01.05710.1016/j.ijpharm.2008.01.057 ↗
24. 10.1021/bm049347a10.1021/bm049347a ↗
25. 10.1021/la901092x10.1021/la901092x ↗
26. 10.1039/b907056g10.1039/b907056g ↗
27.
28. Zhang J. X. · J. Biomed. Mater. Res. · 2006
29. 10.1016/j.colsurfb.2010.05.03810.1016/j.colsurfb.2010.05.038 ↗