Miscibility Transitions and Lateral Compressibility in Liquid Phases of Lipid Monolayers
Source abstract
Abstract
Lateral compressibility and miscibility phase behavior of monolayers of phospholipids and cholesterol were investigated using a Langmuir film balance and epifluorescence microscopy. Three lipid mixtures were used: dihydrocholesterol and either DMPC [di(14:0)PC], DLPC [di(12:0)PC], or 1/1 DMPC/DPPC [1/1 di(14:0)PC/di(16:0)PC]. The mixtures were chosen to produce liquid phases and a variety of miscibility phase diagrams. No general correlation was found between changes in lateral compressibility and miscibility phase transitions, even at miscibility critical points. A previously reported correlation for a monolayer system of cholesterol and DMPC seems to be coincidental. These results strongly argue against using only pressure−area isotherms to determine miscibility phase transitions in liquid monolayers.
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Research context
OpenAlex topics: Lipid Membrane Structure and Behavior · Spectroscopy and Quantum Chemical Studies · Force Microscopy Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, University of Washington, Seattle, Washington 98195-1700
References (34)
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