Toward the Electrostatic Catalysis of Nucleophilic Substitutions: A Surface Chemistry Study of the Menshutkin Reaction

The catalysis of nonredox reactions by external electric fields is one of the most rapidly expanding areas of chemistry. The Menshutkin reaction, a classic example of bimolecular nucleophilic substitution (S N 2), involves the conversion of a tertiary amine to a quaternary ammonium salt by coupling it with an alkyl halide. The reaction barrier of the Menshutkin reaction is theoretically predicted to be highly sensitive to the magnitude and direction of an external electric field experienced by the transition state. In this study, we investigate how near-surface electric fields can drive this prototypical nucleophilic substitution by examining the coupling of a diffusive redox-tagged tertiary amine with an electrode-tethered alkyl bromide under a variable external bias. Our findings reveal a competition between electrostatically assisted reactions, solvent effects, and electrochemically triggered side reactions involving radical intermediates. We estimate that only about 5% of the coupling events are attributable to the external field, while the majority of the reaction products originate from electrochemically generated radical intermediates.