Influence of the Lipid Backbone on Electrochemical Phase Behavior

Philip N. Jemmett; David C. Milan; Richard J. Nichols; Thomas Howitt; Alexandra L. Martin; Thomas Arnold; Jonathan L. Rawle; Christopher L. Nicklin; Timothy R. Dafforn; Liam R. Cox; Sarah L. Horswell

doi:10.1021/acs.langmuir.2c02370

journal article·2022-11-22Open access

Influence of the Lipid Backbone on Electrochemical Phase Behavior

Philip N. Jemmett, David C. Milan, Richard J. Nichols, Thomas Howitt, Alexandra L. Martin, Thomas Arnold, Jonathan L. Rawle, Christopher L. Nicklin, Timothy R. Dafforn, Liam R. Cox, Sarah L. Horswell

Langmuir· Volume 38· Issue 46

Publisher page Open full text

Source abstract

Abstract

-Palmitoyl sphingomyelin forms bilayers of similar coverage and thickness to its close analogue di-palmitoyl phosphatidylcholine. Grazing incidence diffraction data show slightly closer packing and a smaller chain tilt angle from the surface normal. Electrochemical IR results at low charge density show that the difference in tilt angle is retained on deposition to form bilayers. The bilayers respond differently to increasing electric field strength: chain tilt angles increase for both molecules, but sphingomyelin chains remain tilted as field strength is further increased. This behavior is correlated with disruption of the hydrogen-bonding network of small groups of sphingomyelin molecules, which may have significance for the behavior of molecules in lipid rafts in the presence of strong fields induced by ion gradients or asymmetric distribution of charged lipids.

Source: openalex_inverted_index · Quality: baseline

Research context

Materials processing

OpenAlex topics: Lipid Membrane Structure and Behavior · Nanopore and Nanochannel Transport Studies · Sphingolipid Metabolism and Signaling

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry, University of Birmingham, Edgbaston, BirminghamB15 2TT, UK

Department of Chemistry, University of Liverpool, Crown Street, LiverpoolL69 7ZD, UK

Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot, OxfordshireOX11 0DE, UK

European Spallation Source ERICPO Box 176, LundSE-221 00, Sweden

ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, OxfordshireOX11 0QX, UK

Department of Chemistry, University of Bath, Claverton Down, BathBA2 7AY, UK

School of Biosciences, University of Birmingham, Edgbaston, BirminghamB15 2TT, UK

Funding

University of Birmingham · Biotechnology and Biological Sciences Research Council

References (89)

Show source-provided references

1. Alberts B. · 2002

2. 10.1242/jcs.07123310.1242/jcs.071233 ↗

3. 10.1038/nrm233010.1038/nrm2330 ↗

4. 10.1038/nrm.2017.13810.1038/nrm.2017.138 ↗

5. 10.1073/pnas.131336411110.1073/pnas.1313364111 ↗

6. Cheever M. · 2004

7. 10.1101/cshperspect.a00470510.1101/cshperspect.a004705 ↗

8. 10.1038/nature1074210.1038/nature10742 ↗

9. 10.1016/S0955-0674(02)00351-410.1016/S0955-0674(02)00351-4 ↗

10. 10.1021/cr010044610.1021/cr0100446 ↗

11. 10.1126/science.117462110.1126/science.1174621 ↗

12. 10.1073/pnas.111828810910.1073/pnas.1118288109 ↗

13. 10.1007/PL0000083610.1007/PL00000836 ↗

14. 10.1038/4240810.1038/42408 ↗

15. 10.1039/C1SM06703F10.1039/C1SM06703F ↗

16. 10.1016/j.plipres.2013.05.00110.1016/j.plipres.2013.05.001 ↗

17. 10.1038/nrm.2017.10710.1038/nrm.2017.107 ↗

18. 10.1016/j.chemphyslip.2018.09.01010.1016/j.chemphyslip.2018.09.010 ↗

19. 10.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-310.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-3 ↗

20. 10.1002/ejlt.20070004610.1002/ejlt.200700046 ↗

21. 10.1016/j.bpj.2014.05.03410.1016/j.bpj.2014.05.034 ↗

22. 10.1016/S0006-3495(03)74963-710.1016/S0006-3495(03)74963-7 ↗

23. 10.1016/j.chemphyslip.2018.03.00310.1016/j.chemphyslip.2018.03.003 ↗

24. 10.1016/j.cis.2014.03.00810.1016/j.cis.2014.03.008 ↗

25. 10.1039/C5CP04131G10.1039/C5CP04131G ↗

26. 10.1016/j.bpj.2016.07.03510.1016/j.bpj.2016.07.035 ↗

27. 10.1016/j.bbamem.2007.12.01210.1016/j.bbamem.2007.12.012 ↗

28. 10.1146/annurev.ph.50.030188.00142110.1146/annurev.ph.50.030188.001421 ↗

29. 10.1021/la063190l10.1021/la063190l ↗

30. 10.1016/S0006-3495(04)74244-710.1016/S0006-3495(04)74244-7 ↗

31. 10.1016/0022-0728(86)90123-310.1016/0022-0728(86)90123-3 ↗

32. 10.1021/la980314o10.1021/la980314o ↗

33. 10.1016/0022-0728(90)85123-M10.1016/0022-0728(90)85123-M ↗

34. 10.1016/S0022-0728(01)00382-510.1016/S0022-0728(01)00382-5 ↗

35. 10.1016/S0006-3495(98)77947-010.1016/S0006-3495(98)77947-0 ↗

36. 10.1016/S0022-0728(98)00276-910.1016/S0022-0728(98)00276-9 ↗

37. 10.1016/j.jelechem.2010.01.01110.1016/j.jelechem.2010.01.011 ↗

38. 10.1016/j.jelechem.2003.11.00210.1016/j.jelechem.2003.11.002 ↗

39. 10.1016/j.jelechem.2007.11.02710.1016/j.jelechem.2007.11.027 ↗

40. 10.1039/b923895f10.1039/b923895f ↗

41. 10.1021/nn403726710.1021/nn4037267 ↗

42. 10.1039/c0cp00658k10.1039/c0cp00658k ↗

43. 10.1021/la800800m10.1021/la800800m ↗

44. 10.1021/ja711020q10.1021/ja711020q ↗

45. 10.3390/membranes1101001110.3390/membranes11010011 ↗

46. 10.1039/B911246B10.1039/B911246B ↗

47. 10.1021/ja808180m10.1021/ja808180m ↗

48. 10.1016/j.electacta.2018.02.05710.1016/j.electacta.2018.02.057 ↗

49. 10.1021/acs.langmuir.8b0092810.1021/acs.langmuir.8b00928 ↗

50. 10.1021/acs.langmuir.8b0226510.1021/acs.langmuir.8b02265 ↗

51. 10.1016/j.bioelechem.2018.06.00610.1016/j.bioelechem.2018.06.006 ↗

52. 10.1021/la304455d10.1021/la304455d ↗

53. 10.1016/j.electacta.2014.01.03510.1016/j.electacta.2014.01.035 ↗

54. 10.1021/acs.langmuir.5b0276510.1021/acs.langmuir.5b02765 ↗

55. 10.1016/j.bioelechem.2019.10744310.1016/j.bioelechem.2019.107443 ↗

56. 10.1021/acs.langmuir.1c0197510.1021/acs.langmuir.1c01975 ↗

57. 10.1016/S0006-3495(00)76740-310.1016/S0006-3495(00)76740-3 ↗

58. 10.1107/S160057751600987510.1107/S1600577516009875 ↗

59. 10.1107/S090904951200927210.1107/S0909049512009272 ↗

60. 10.1140/epjst/e2009-00949-010.1140/epjst/e2009-00949-0 ↗

61. Hughes, A. V. RasCAL_2019.https://github.com/arwelHughes/RasCAL_2019

62. 10.1149/1.210850510.1149/1.2108505 ↗

63. 10.1063/1.46096710.1063/1.460967 ↗

64. Nečas D. · Cent. Eur. J. Phys. · 2012 · 10 · 181

65. Zamlynny V. · 2006

66. Optical constants and Fresnel 1 software written by V. Zamlynny. Email: vlad.zamlynny@acadiau.ca

67. 10.1016/j.electacta.2007.11.05110.1016/j.electacta.2007.11.051 ↗

68. 10.1103/PhysRevLett.102.23810110.1103/PhysRevLett.102.238101 ↗

69. 10.1016/0370-1573(94)90046-910.1016/0370-1573(94)90046-9 ↗

70. 10.1016/0921-4526(94)90137-610.1016/0921-4526(94)90137-6 ↗

71. 10.1063/1.140650110.1063/1.1406501 ↗

72. 10.1529/biophysj.106.08513410.1529/biophysj.106.085134 ↗

73. 10.1038/s41598-020-74781-810.1038/s41598-020-74781-8 ↗

74. 10.1016/j.jcis.2018.07.02210.1016/j.jcis.2018.07.022 ↗

75. 10.1209/0295-5075/4/6/01010.1209/0295-5075/4/6/010 ↗

76. 10.1016/j.electacta.2018.05.14110.1016/j.electacta.2018.05.141 ↗

77. Damaskin B. B. · 1968

78. 10.1039/D1RA01920A10.1039/D1RA01920A ↗

79. 10.1016/0005-2736(83)90153-010.1016/0005-2736(83)90153-0 ↗

80. 10.1016/0304-4157(84)90017-010.1016/0304-4157(84)90017-0 ↗

81. 10.1021/bi00557a00510.1021/bi00557a005 ↗

82. 10.1016/0009-3084(91)90077-O10.1016/0009-3084(91)90077-O ↗

83. 10.1016/S0006-3495(96)79512-710.1016/S0006-3495(96)79512-7 ↗

84. 10.1016/0022-2860(91)85001-J10.1016/0022-2860(91)85001-J ↗

85. 10.1016/0584-8539(78)80167-610.1016/0584-8539(78)80167-6 ↗

86. 10.1021/j100364a00910.1021/j100364a009 ↗

87. 10.1016/S0006-3495(81)84844-810.1016/S0006-3495(81)84844-8 ↗

88. 10.1016/0005-2736(93)90336-X10.1016/0005-2736(93)90336-X ↗

89. 10.1021/bi001980310.1021/bi0019803 ↗