DataVXLangmuirPaper
journal article·2023-01-10

Water Content in Nanoparticles Determined by Small-Angle Neutron Scattering and Light Scattering

Behrad Kangarlou, Donyeil Hoy, Haden L. Scott, Sai Venkatesh Pingali, Nora Khalil, Benjamin Chung, John Katsaras, Mu-Ping Nieh

Langmuir· Volume 39· Issue 1
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Source abstract

Abstract

The amount of water in therapeutic nanoparticles (NPs) is of great importance to the pharmaceutical industry, as water content reflects the volume occupied by the solid components. For example, certain biomolecules, such as mRNA, can undergo conformational change or degradation when exposed to water. Using static light scattering (SLS) and dynamic light scattering (DLS), we estimated the water content of NPs, including extruded liposomes of two different sizes and polystyrene (PS) Latex NPs. In addition, we used small-angle neutron scattering (SANS) to independently access the water content of the samples. The water content of NPs estimated by SLS/DLS was systematically higher than that from SANS. The discrepancy is most likely attributed to the larger radius determined by DLS, in contrast to the SANS-derived radius observed by SANS. However, because of low accessibility to the neutron facilities, we validate the combined SLS/DLS to be a reasonable alternative to SANS for determining the water (or solvent) content of NPs.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Electrostatics and Colloid Interactions · Nuclear Physics and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Materials Science Program, Institute of Materials Science, University of Connecticut, Storrs, Connecticut06269, United States

Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut06269, United States

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee37831, United States

Shull Wollan Center, Oak Ridge National Laboratory, Oak Ridge, Tennessee37831, United States

Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut06269, United States

Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut06269, United States

Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, Connecticut06269, United States

Funding

Basic Energy Sciences

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