Supramolecular Shear-Thinning Glycopeptide Hydrogels for Injectable Enzyme Prodrug Therapy Applications
Source abstract
Abstract
Transplantable catalytic reactors have attracted considerable attention as therapeutic biomedical materials. However, existing transplantable reactors such as biocatalytic films are limited by their invasiveness. Here, we report the fabrication of biocatalytic supramolecular hydrogels via self-assembly of amphiphilic glycopeptides. We show that the hydrogels have shear-thinning properties, demonstrating their potential to be administered using a syringe. Enzymes can be loaded into the hydrogels by simply adding enzyme solution, and the enzyme-loaded hydrogels can transform a prodrug into an anticancer drug that inhibits tumor cell growth. This study demonstrates the potential of these biocatalytic hydrogels as injectable therapeutic reactors for enzyme prodrug therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Polydiacetylene-based materials and applications · Glycosylation and Glycoproteins Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, 3-15-1, Tokida, Ueda, Nagano 386-8567, Japan
Department of Chemistry and Biochemistry, University of Kitakyushu, 1-1 Hibikino, Kitakyushu, Fukuoka 808-0135, Japan
Funding
Asahi Glass Foundation · MEXT Promotion of Distinctive Joint Research Center Program · the MEXT Leading Initiative for Excellent Young Researchers · the Ube foundation · the JSPS in the form of grants-in-aid for scientific research · JST FOREST Program
References (62)
Show source-provided references
1. 10.1038/nnano.2006.18010.1038/nnano.2006.180 ↗
2. 10.1002/chem.20180115910.1002/chem.201801159 ↗
3. 10.1002/advs.20180080110.1002/advs.201800801 ↗
4. 10.1002/anie.20211146110.1002/anie.202111461 ↗
5. 10.1016/j.addr.2021.11389310.1016/j.addr.2021.113893 ↗
6. 10.1016/j.bmc.2021.11631010.1016/j.bmc.2021.116310 ↗
7. 10.1002/anie.20150833910.1002/anie.201508339 ↗
8. 10.1021/acs.nanolett.7b0353110.1021/acs.nanolett.7b03531 ↗
9. 10.1002/adma.20170240610.1002/adma.201702406 ↗
10. 10.1021/acsnano.8b0908210.1021/acsnano.8b09082 ↗
11. 10.1038/s41929-019-0333-410.1038/s41929-019-0333-4 ↗
12. 10.1016/j.jconrel.2021.10.01510.1016/j.jconrel.2021.10.015 ↗
13. 10.1038/nchem.228410.1038/nchem.2284 ↗
14. 10.1038/ncomms1590610.1038/ncomms15906 ↗
15. 10.1021/acsnano.0c0062910.1021/acsnano.0c00629 ↗
16. 10.1016/j.chempr.2020.06.00210.1016/j.chempr.2020.06.002 ↗
17. 10.1021/acsami.1c2018810.1021/acsami.1c20188 ↗
18. 10.1038/nnano.2012.26410.1038/nnano.2012.264 ↗
19. 10.1002/anie.20161027310.1002/anie.201610273 ↗
20. 10.1038/s41929-019-0317-410.1038/s41929-019-0317-4 ↗
21. 10.1126/sciadv.abg403810.1126/sciadv.abg4038 ↗
22. 10.1021/nn100634r10.1021/nn100634r ↗
23. 10.1039/c3nr05999e10.1039/c3nr05999e ↗
24. 10.1002/smll.20130310110.1002/smll.201303101 ↗
25. 10.1021/acsami.8b0165810.1021/acsami.8b01658 ↗
26. 10.1016/j.jconrel.2018.08.02510.1016/j.jconrel.2018.08.025 ↗
27. 10.1021/acsabm.0c0117410.1021/acsabm.0c01174 ↗
28. 10.1038/s41565-021-00910-710.1038/s41565-021-00910-7 ↗
29. 10.1039/B200242F10.1039/B200242F ↗
30. 10.1021/cr030204910.1021/cr0302049 ↗
31. 10.1002/asia.20130169310.1002/asia.201301693 ↗
32. 10.1021/acs.chemrev.5b0029910.1021/acs.chemrev.5b00299 ↗
33. 10.1038/nmat103410.1038/nmat1034 ↗
34. 10.1002/anie.20070040410.1002/anie.200700404 ↗
35. 10.1021/la804271d10.1021/la804271d ↗
36. 10.1038/nchem.193710.1038/nchem.1937 ↗
37. 10.1039/C9SC01754B10.1039/C9SC01754B ↗
38. 10.1039/C1SM06513K10.1039/C1SM06513K ↗
39. 10.1002/adma.20160114710.1002/adma.201601147 ↗
40. 10.1021/acs.langmuir.7b0290610.1021/acs.langmuir.7b02906 ↗
41. 10.1002/app.4866810.1002/app.48668 ↗
42. 10.1021/acs.biomac.1c0077810.1021/acs.biomac.1c00778 ↗
43. 10.1002/psc.337710.1002/psc.3377 ↗
44. 10.3389/fchem.2021.77010210.3389/fchem.2021.770102 ↗
45. 10.1021/la301371q10.1021/la301371q ↗
46. 10.1021/ja404215g10.1021/ja404215g ↗
47. 10.1021/acs.langmuir.9b0183710.1021/acs.langmuir.9b01837 ↗
48. 10.1039/C9CC09947F10.1039/C9CC09947F ↗
49. 10.1021/acsnano.0c0604110.1021/acsnano.0c06041 ↗
50. 10.1126/science.108238710.1126/science.1082387 ↗
51. 10.1002/adma.20050176510.1002/adma.200501765 ↗
52. 10.1021/acsmacrolett.5b0004910.1021/acsmacrolett.5b00049 ↗
53. 10.1007/BF0297763410.1007/BF02977634 ↗
54. 10.1039/B611255B10.1039/B611255B ↗
55. 10.1016/j.biomaterials.2009.01.01010.1016/j.biomaterials.2009.01.010 ↗
56. 10.1021/la302583a10.1021/la302583a ↗
57. 10.1039/D0SM01068E10.1039/D0SM01068E ↗
58. 10.1021/la034675210.1021/la0346752 ↗
59. Krimm S. · 1986 · 38 · 181
60. 10.1021/jp904251j10.1021/jp904251j ↗
61. 10.1016/j.actbio.2009.01.00610.1016/j.actbio.2009.01.006 ↗
62. 10.1021/acs.langmuir.8b0337810.1021/acs.langmuir.8b03378 ↗