Effect of Cationic Brush-Type Copolymers on the Colloidal Stability of GdPO₄ Particles with Different Morphologies in Biological Aqueous Media

In this study, we present the synthesis of cationic brush-type polyelectrolytes and their use in the stabilization of GdPO4 particles in aqueous media. Polymers of various compositions were synthesized via the RAFT polymerization route. SEC equipped with triple detection (RI, DP, RALS, and LALS) was used to determine the molecular parameters (Mn, Mw, Mw/Mn). The exact composition of synthesized polymers was determined using NMR spectroscopy. Cationic brush-type polymers were used to improve the stability of aqueous GdPO4 particle dispersions. First, the IEPs of GdPO4 particles with different morphologies (nanorods, hexagonal nanoprisms, and submicrospheres) were determined by measuring the zeta potential of bare particle dispersions at various pH values. Afterward, cationic brush-type polyelectrolytes with different compositions were used for the surface modification of GdPO4 particles (negatively charged in alkaline media under a pH value of ∼10.6). The concentration and composition effects of used polymers on the change in particle surface potential and stability (DLS measurements) in dispersions were investigated and presented in this work. The most remarkable result of this study is redispersible GdPO4 nanoparticle colloids with increased biocompatibility and stability as well as new insights into possible cationic brush-type polyelectrolyte applicability in both scientific and commercial fields.