Supramolecular Combination Chemotherapy: Cucurbit[8]uril Complex Enhanced Platinum Drug Infiltration and Modified Nanomechanical Property of Colorectal Cancer Cells

Hang Zhou; Qingtao Meng; Bin Li; Yikai Liu; Zhaoxiang Li; Xiaobo Li; Zhiwei Sun; Yueyue Chen

doi:10.1021/acs.langmuir.2c02388

journal article·2022-11-22

Supramolecular Combination Chemotherapy: Cucurbit[8]uril Complex Enhanced Platinum Drug Infiltration and Modified Nanomechanical Property of Colorectal Cancer Cells

Hang Zhou, Qingtao Meng, Bin Li, Yikai Liu, Zhaoxiang Li, Xiaobo Li, Zhiwei Sun, Yueyue Chen

Langmuir· Volume 38· Issue 46

Publisher page

Source abstract

Abstract

Combination chemotherapy is recognized as a vital medical treatment for cancer, but it has not achieved clinical ideal effects of combination therapy. Herein, we designed a supramolecular combination chemotherapy strategy based on cucurbit[8]uril (CB[8]), which can be facilely assembled into dual platinum drugs. Interestingly, employing the CB[8] carrier led to a greater than 10-fold intracellular Pt content compared to that of dual drugs at 4 h, and the CB[8] complex (CLE) can enhance the infiltration of platinum drugs in colorectal tumor cells tremendously. The platinum drugs can be released from CLE through consuming more tumor biomarker spermidine. Through analyzing the nanomechanical property of the colorectal tumor cellular surface by bioscope AFM, it was revealed that CLE modified the property by decreasing the adhesion and increasing the stiffness. This study provided a facile and sensitive strategy for improving combination chemotherapy by supramolecular materials.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Supramolecular Chemistry and Complexes · Supramolecular Self-Assembly in Materials · Microtubule and mitosis dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Toxicology and Sanitary Chemistry, School of Public Health, and Beijing Key Laboratory of Environment Toxicology, Capital Medical University, Beijing 100069, P. R. China

Key Laboratory of Environmental Medicine Engineering Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, P. R. China

Funding

Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China

References (62)

Show source-provided references

1. Wild, C. P.; Weiderpass, E.; Stewart, B. W. World Cancer Report: Cancer Research for Cancer Prevention; International Agency for Research on Cancer, 2020.

2. 10.1016/j.urolonc.2020.02.02710.1016/j.urolonc.2020.02.027 ↗

3. Zhang P. · Med. Recapit. · 2021 · 27 · 4640

4. Han F. · Acad. J. Chin. PLA. Med. Sch. · 2021 · 42 · 241

5. 10.1038/s41467-021-23232-710.1038/s41467-021-23232-7 ↗

6. 10.1039/D0SC06724E10.1039/D0SC06724E ↗

7. 10.1039/D1CS00187F10.1039/D1CS00187F ↗

8. 10.1016/j.biomaterials.2022.12159510.1016/j.biomaterials.2022.121595 ↗

9. 10.31635/ccschem.021.20210077110.31635/ccschem.021.202100771 ↗

10. 10.31635/ccschem.019.2018001110.31635/ccschem.019.20180011 ↗

11. 10.31635/ccschem.020.20200031210.31635/ccschem.020.202000312 ↗

12. 10.31635/ccschem.021.20210102910.31635/ccschem.021.202101029 ↗

13. 10.1039/C6CS00898D10.1039/C6CS00898D ↗

14. 10.1039/D0CS00011F10.1039/D0CS00011F ↗

15. 10.1002/adma.20210638810.1002/adma.202106388 ↗

16. 10.31635/ccschem.021.20210149010.31635/ccschem.021.202101490 ↗

17. 10.3389/fchem.2019.0061910.3389/fchem.2019.00619 ↗

18. 10.1021/jacs.1c0330310.1021/jacs.1c03303 ↗

19. 10.1021/jacs.0c1073210.1021/jacs.0c10732 ↗

20. 10.1021/acsami.1c0982310.1021/acsami.1c09823 ↗

21. 10.3389/fchem.2019.0061910.3389/fchem.2019.00619 ↗

22. 10.1021/ja407951x10.1021/ja407951x ↗

23. 10.1021/jacs.1c0674110.1021/jacs.1c06741 ↗

24. 10.1021/ja407951x10.1021/ja407951x ↗

25. 10.1039/C9NH00438F10.1039/C9NH00438F ↗

26. 10.1038/nnano.2012.16710.1038/nnano.2012.167 ↗

27. 10.1039/C7NR07023C10.1039/C7NR07023C ↗

28. 10.1039/D1AY00649E10.1039/D1AY00649E ↗

29. 10.1002/jemt.2395710.1002/jemt.23957 ↗

30. 10.1016/j.xpro.2021.10029610.1016/j.xpro.2021.100296 ↗

31. 10.1021/ja303309e10.1021/ja303309e ↗

32. 10.1021/acs.chemrev.5b0058310.1021/acs.chemrev.5b00583 ↗

33. 10.1021/ja031984610.1021/ja0319846 ↗

34. 10.1021/acs.biomac.1c0006110.1021/acs.biomac.1c00061 ↗

35. Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Petersson, G. A.; Nakatsuji, H.; Li, X.; Caricato, M.; Marenich, A. V.; Bloino, J.; Janesko, B. G.; Gomperts, R.; Mennucci, B.; Hratchian, H. P.; Ortiz, J. V.; Izmaylov, A. F.; Sonnenberg, J. L.; Williams-Young, D.; Ding, F.; Lipparini, F.; Egidi, F.; Goings, J.; Peng, B.; Petrone, A.; Henderson, T.; Ranasinghe, D.; Zakrzewski, V. G.; Gao, J.; Rega, N.; Zheng, G.; Liang, W.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Throssell, K.; Montgomery, J. A.; Peralta, J. E.; Ogliaro, F.; Bearpark, M. J.; Heyd, J. J.; Brothers, E. N.; Kudin, K. N.; Staroverov, V. N.; Keith, T. A.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A. P.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Millam, J. M.; Klene, M.; Adamo, C.; Cammi, R.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Farkas, O.; Foresman, J. B.; Fox, D. J. Gaussian 16, Rev. C.01; Gaussian Inc.: Wallingford, CT, 2016.

36. Molecular Operating Environment (MOE); Chemical Computing Group: Montreal, QC, Canada, 2020.

37. Case, D. A.; Darden, T. A.; Cheatham, III, T. E.; Simmerling, C. L.; Wang, J.; Duke, R. E.; Luo, R.; Walker, R. C.; Zhang, W.; Merz, K. M.; Roberts, B.; Hayik, S.; Roitberg, A.; Seabra, G.; Swails, J.; Götz, A. W.; Kolossváry, I.; Wong, K. F.; Paesani, F.; Vanicek, J.; Wolf, R. M.; Liu, J.; Wu, X.; Brozell, S. R.; Steinbrecher, T.; Gohlke, H.; Cai, Q.; Ye, X.; Wang, J.; Hsieh, M. J.; Cui, G.; Roe, D. R.; Mathews, D. H.; Seetin, M. G.; Salomon-Ferrer, R.; Sagui, C.; Babin, V.; Luchko, T.; Gusarov, S.; Kovalenko, A.; Kollman, P. A. AMBER 2018; University of California: San Francisco, 2018.

38. 10.1063/1.44586910.1063/1.445869 ↗

39. 10.1021/ct100525r10.1021/ct100525r ↗

40. 10.1002/jcc.2003510.1002/jcc.20035 ↗

41. 10.1016/0021-9991(77)90098-510.1016/0021-9991(77)90098-5 ↗

42. 10.1080/0026897880010188110.1080/00268978800101881 ↗

43. 10.1039/b9pp00041k10.1039/b9pp00041k ↗

44. 10.1016/j.jinorgbio.2008.06.00510.1016/j.jinorgbio.2008.06.005 ↗

45. 10.1021/acs.langmuir.0c0360310.1021/acs.langmuir.0c03603 ↗

46. 10.1007/s00726-004-0076-610.1007/s00726-004-0076-6 ↗

47. Linsalata M. · Anticancer Res. · 2002 · 22 · 2465

48. 10.1021/acsami.7b0115710.1021/acsami.7b01157 ↗

49. 10.1021/acs.langmuir.1c0142210.1021/acs.langmuir.1c01422 ↗

50. 10.1021/acsami.1c1969810.1021/acsami.1c19698 ↗

51. 10.1038/s41419-020-03174-610.1038/s41419-020-03174-6 ↗

52. 10.1016/j.ejmech.2021.11358610.1016/j.ejmech.2021.113586 ↗

53. 10.1039/C3IB40246K10.1039/C3IB40246K ↗

54. 10.3389/fcell.2021.71883410.3389/fcell.2021.718834 ↗

55. 10.1038/s41563-021-01085-110.1038/s41563-021-01085-1 ↗

56. 10.1016/j.ccell.2020.05.00510.1016/j.ccell.2020.05.005 ↗

57. 10.1016/j.canlet.2021.10.03010.1016/j.canlet.2021.10.030 ↗

58. 10.1021/acsami.6b0769810.1021/acsami.6b07698 ↗

59. 10.1021/acsnano.1c0089710.1021/acsnano.1c00897 ↗

60. 10.1002/advs.20210082510.1002/advs.202100825 ↗

61. 10.1039/D1NR03900H10.1039/D1NR03900H ↗

62. 10.1021/acs.nanolett.1c0000310.1021/acs.nanolett.1c00003 ↗