Self-Assembly of Integrin Ligands on the Apical Membrane Inhibits the Migration of Glioma Cells
Source abstract
Abstract
Malignant brain cancer remains challenging in treatment due to the highly invasive quality of gliomas. Inspired by the upregulated expression of integrin β1 subunits in tumors, we designed and synthesized an integrin-targeting self-assembling ligand based on a laminin-derived peptide that selectively forms nanofibrous microdomains on the apical membrane of glioma cells, inhibiting their migration and invasion.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Cell Adhesion Molecules Research · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Bioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna son, Okinawa 904-0495, Japan
Funding
Takeda Science Foundation · Okinawa Institute of Science and Technology Graduate University
References (31)
Show source-provided references
1. 10.1056/nejmoa130857310.1056/nejmoa1308573 ↗
2. 10.1038/s41571-019-0177-510.1038/s41571-019-0177-5 ↗
3. 10.4155/tde.13.3810.4155/tde.13.38 ↗
4. 10.1002/adma.20130176210.1002/adma.201301762 ↗
5. 10.1021/acs.langmuir.8b0345210.1021/acs.langmuir.8b03452 ↗
6. 10.1021/acs.langmuir.8b0251010.1021/acs.langmuir.8b02510 ↗
7. 10.1002/jbm.b.3272810.1002/jbm.b.32728 ↗
8. 10.1016/j.biomaterials.2010.07.01410.1016/j.biomaterials.2010.07.014 ↗
9. 10.1016/j.biomaterials.2018.04.02110.1016/j.biomaterials.2018.04.021 ↗
10. 10.1016/j.tcb.2014.12.00610.1016/j.tcb.2014.12.006 ↗
11. 10.1038/ncb271710.1038/ncb2717 ↗
12. Yamamura K. · Cancer Res. · 1993 · 53 · 423
13. 10.1016/s0142-9612(01)00133-810.1016/s0142-9612(01)00133-8 ↗
14. 10.1016/s0142-9612(00)00338-010.1016/s0142-9612(00)00338-0 ↗
15. Nomizu M. · Cancer Res. · 1993 · 53 · 3459
16. 10.1021/acs.chemrev.5b0029910.1021/acs.chemrev.5b00299 ↗
17. 10.1093/beheco/arm09010.1093/beheco/arm090 ↗
18. 10.1021/la102032410.1021/la1020324 ↗
19. 10.1242/jcs.01855610.1242/jcs.018556 ↗
20. 10.1242/jcs.01856410.1242/jcs.018564 ↗
21. 10.1007/s11060-009-9875-710.1007/s11060-009-9875-7 ↗
22. 10.1039/b712971h10.1039/b712971h ↗
23. 10.1007/bf0018689410.1007/bf00186894 ↗
24. 10.1158/1078-0432.ccr-11-064210.1158/1078-0432.ccr-11-0642 ↗
25. 10.1093/oxfordjournals.jbchem.a12431510.1093/oxfordjournals.jbchem.a124315 ↗
26. 10.1083/jcb.134.1.25510.1083/jcb.134.1.255 ↗
27. 10.1006/excr.2000.504310.1006/excr.2000.5043 ↗
28. 10.1242/jcs.00023210.1242/jcs.000232 ↗
29. 10.1091/mbc.e08-01-007610.1091/mbc.e08-01-0076 ↗
30. 10.1038/3501051710.1038/35010517 ↗
31. 10.1128/mcb.25.21.9700-9712.200510.1128/mcb.25.21.9700-9712.2005 ↗