Molecular Lipid Films on Microengineering Materials

Silver Jõemetsa; Karolina Spustova; Kiryl Kustanovich; Alar Ainla; Severin Schindler; Siegfried Eigler; Tatsiana Lobovkina; Samuel Lara-Avila; Aldo Jesorka; Irep Gözen

doi:10.1021/acs.langmuir.9b01120

journal article·2019-08-13Open access

Molecular Lipid Films on Microengineering Materials

Silver Jõemetsa, Karolina Spustova, Kiryl Kustanovich, Alar Ainla, Severin Schindler, Siegfried Eigler, Tatsiana Lobovkina, Samuel Lara-Avila, Aldo Jesorka, Irep Gözen

Langmuir· Volume 35· Issue 32

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Source abstract

Abstract

In this study, we have systematically investigated the formation of molecular phospholipid films on a variety of solid substrates fabricated from typical surface engineering materials and the fluidic properties of the lipid membranes formed on these substrates. The surface materials comprise of borosilicate glass, mica, SiO2, Al (native oxide), Al2O3, TiO2, ITO, SiC, Au, Teflon AF, SU-8, and graphene. We deposited the lipid films from small unilamellar vesicles (SUVs) by means of an open-space microfluidic device, observed the formation and development of the films by laser scanning confocal microscopy, and evaluated the mode and degree of coverage, fluidity, and integrity. In addition to previously established mechanisms of lipid membrane–surface interaction upon bulk addition of SUVs on solid supports, we observed nontrivial lipid adhesion phenomena, including reverse rolling of spreading bilayers, spontaneous nucleation and growth of multilamellar vesicles, and the formation of intact circular patches of double lipid bilayer membranes. Our findings allow for accurate prediction of membrane–surface interactions in microfabricated devices and experimental environments where model membranes are used as functional biomimetic coatings.

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Research context

Ceramics & glasses Nanomaterials

OpenAlex topics: Nanofabrication and Lithography Techniques · Microfluidic and Capillary Electrophoresis Applications · Electrowetting and Microfluidic Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, Chalmers University of Technology, Fysikgränd 3, 412 96 Gothenburg, Sweden

Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway

Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, 412 96 Gothenburg, Sweden

International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal

Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany

Department of Microtechnology and Nanoscience, Chalmers University of Technology, Kemivägen 9, 412 96, Gothenburg, Sweden

National Physical Laboratory, Hampton Road, TW11 0LW Teddington, U.K.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Oslo, Sem Sælands vei 26, 0371 Oslo, Norway

Funding

Vetenskapsr?det · Norges Forskningsr?d · Universitetet i Oslo · Stiftelsen f?r?Strategisk Forskning · H2020 European Research Council

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