Modulation of Colloidal Particle Stiffness for the Exploration of Bio–Nano Interactions
Source abstract
Abstract
Tuning the physicochemical parameters (e.g., size, shape, and surface chemistry) of colloidal particles (CPs) for the engineering of drug carriers has proven to be a promising approach to improve drug delivery efficacy. Recently, the stiffness of CPs has attracted widespread attention for modulating bio-nano interactions. In this perspective, we outline the strategies for the modulation and characterization of CP stiffness and highlight the importance of CP stiffness in the control over biological interactions. Challenges and opportunities of current and future developments in the modulation of CP stiffness for the exploration of bio-nano interactions in therapeutic delivery are also discussed. This perspective is expected to help thoroughly understand the role of CP stiffness in bio-nano interactions and facilitate the design of CPs as carriers for improved drug and vaccine delivery.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoparticles: synthesis and applications · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China
Funding
National Natural Science Foundation of China · Innovation Project of Jinan Science and Technology Bureau
References (40)
Show source-provided references
1. 10.1016/j.jconrel.2021.12.03010.1016/j.jconrel.2021.12.030 ↗
2. 10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗
3. 10.1002/anie.20140303610.1002/anie.201403036 ↗
4. 10.1021/acsnano.9b0392410.1021/acsnano.9b03924 ↗
5. 10.1016/j.addr.2016.01.00710.1016/j.addr.2016.01.007 ↗
6. 10.1016/j.pmatsci.2017.12.00310.1016/j.pmatsci.2017.12.003 ↗
7. 10.1002/adma.20140275310.1002/adma.201402753 ↗
8. 10.1016/j.jconrel.2016.12.01310.1016/j.jconrel.2016.12.013 ↗
9. 10.1038/s41467-017-02588-910.1038/s41467-017-02588-9 ↗
10. 10.1016/j.biomaterials.2020.12032310.1016/j.biomaterials.2020.120323 ↗
11. 10.1021/jacs.7b1069410.1021/jacs.7b10694 ↗
12. 10.1016/j.jcis.2021.08.14810.1016/j.jcis.2021.08.148 ↗
13. 10.1021/acsnano.5b0014710.1021/acsnano.5b00147 ↗
14. 10.1016/j.jconrel.2021.11.02610.1016/j.jconrel.2021.11.026 ↗
15. 10.1021/acsnano.9b0478910.1021/acsnano.9b04789 ↗
16. 10.1021/acsnano.9b0118110.1021/acsnano.9b01181 ↗
17. 10.1002/adma.20210010610.1002/adma.202100106 ↗
18. 10.1002/adma.20140478810.1002/adma.201404788 ↗
19. 10.1039/C9CS00575G10.1039/C9CS00575G ↗
20. 10.1021/la402146t10.1021/la402146t ↗
21. 10.1002/anie.20140969310.1002/anie.201409693 ↗
22. 10.1021/acsnano.8b0024210.1021/acsnano.8b00242 ↗
23. 10.1021/nn301159a10.1021/nn301159a ↗
24. 10.1002/adfm.20191060610.1002/adfm.201910606 ↗
25. Wang L. · 2018 · 39310.1016/B978-0-12-813339-2.00013-X ↗
26. 10.1016/S0167-5729(99)00003-510.1016/S0167-5729(99)00003-5 ↗
27. 10.1111/jmi.1203610.1111/jmi.12036 ↗
28. 10.1002/adma.20160662810.1002/adma.201606628 ↗
29. 10.1021/acsnano.7b0779710.1021/acsnano.7b07797 ↗
30. 10.1073/pnas.101001310810.1073/pnas.1010013108 ↗
31. 10.1038/s41551-019-0405-410.1038/s41551-019-0405-4 ↗
32. 10.1039/C8CC00398J10.1039/C8CC00398J ↗
33. 10.1021/acs.langmuir.1c0160710.1021/acs.langmuir.1c01607 ↗
34. 10.1021/acsnano.2c0140710.1021/acsnano.2c01407 ↗
35. 10.1038/s41578-021-00372-210.1038/s41578-021-00372-2 ↗
36. 10.1021/acs.accounts.0c0026010.1021/acs.accounts.0c00260 ↗
37. 10.1016/j.jconrel.2012.03.01610.1016/j.jconrel.2012.03.016 ↗
38. 10.1021/acsinfecdis.9b0018910.1021/acsinfecdis.9b00189 ↗
39. 10.1073/pnas.181892411610.1073/pnas.1818924116 ↗
40. 10.1038/s41467-018-05061-310.1038/s41467-018-05061-3 ↗