Polysaccharide-Hair Cationic Polypeptide Nanogels: Self-Assembly and Enzymatic Polymerization of Amylose Primer-Modified Cholesteryl Poly(l-lysine)
Source abstract
Abstract
In this study, we prepared a new associating polymer, ChMaPLL, by the substitution of the poly(L-lysine) moiety with oligosaccharide amylose primer and cholesterol. ChMaPLL formed positively charged polypeptide nanogels (~50 nm) via self-assembly in water. The nanogels showed a secondary structural transition to an α-helix structure induced by poly(L-lysine) in response to an increase in pH. Oligosaccharides of the nanogels reacted with the phosphorylase a enzyme. Amylose-conjugated nanogels were obtained by enzymatic polymerization. The elongation of the saccharide chain shielded the positive charge of the nanogels. The multiresponsive polysaccharide-polypeptide hybrid nanogels might prove to be useful in the areas of biotechnology and biomedicine.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Glycosylation and Glycoproteins Research · Carbohydrate Chemistry and Synthesis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Processing, Graduate School of Engineering, Tohoku University, 6-6-02 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
ERATO Bio-nanotransporter Project, Japan Science and Technology Agency (JST), North Building, Kyodai Katsura Venture Plaza, 1-36, Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan
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