journal article·2025-10

pNIPAM/Alginate ferrogels as soft actuators for the thermoresponsive release of organic probes under high-frequency alternating magnetic fields

Denisse Jara, Roxana Coppola, Pedro Mendoza-Zélis, Gabriel Omar Ybarra, Pablo Tancredi

Journal of Materials Science· Volume 60· Issue 37
Publisher page

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Materials and Mechanics · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (41)

Show source-provided references
1. Frazar EM, Shah RA, Dziubla TD, Hilt JZ (2020) Multifunctional temperature-responsive polymers as advanced biomaterials and beyond. J Appl Polym Sci 137:1−14. https://doi.org/10.1002/app.4877010.1002/app.48770 ↗
2. Xu X, Liu Y, Fu W et al (2020) Poly(N-isopropylacrylamide)-based thermoresponsive composite hydrogels for biomedical applications. Polymers 12:1−22. https://doi.org/10.3390/polym1203058010.3390/polym12030580 ↗
3. Jalili NA, Muscarello M, Gaharwar AK (2016) Nanoengineered thermoresponsive magnetic hydrogels for biomedical applications. Bioeng Transl Med 1:297–305. https://doi.org/10.1002/btm2.1003410.1002/btm2.10034 ↗
4. Zhang J, Huang Q, Du J (2016) Recent advances in magnetic hydrogels. Polym Int 65:1365–1372. https://doi.org/10.1002/pi.517010.1002/pi.5170 ↗
5. Wang H, Luo W, Chen J (2012) Fabrication and characterization of thermoresponsive Fe3O4@PNIPAM hybrid nanomaterials by surface-initiated RAFT polymerization. J Mater Sci 47:5918–5925. https://doi.org/10.1007/s10853-012-6493-010.1007/s10853-012-6493-0 ↗
6. Backes S, Witt MU, Roeben E et al (2015) Loading of PNIPAM based microgels with CoFe2O4 nanoparticles and their magnetic response in bulk and at surfaces. J Phys Chem B 119:12129–12137. https://doi.org/10.1021/acs.jpcb.5b0377810.1021/acs.jpcb.5b03778 ↗
7. Campbell S, Preciado Rivera N, Said S et al (2023) Injectable on-demand pulsatile drug delivery hydrogels using alternating magnetic field-triggered polymer glass transitions. ACS Appl Mater Interfaces 15:48892–48902. https://doi.org/10.1021/acsami.3c0929910.1021/acsami.3c09299 ↗
8. Pernia Leal M, Torti A, Riedinger A et al (2012) Controlled release of doxorubicin loaded within magnetic thermo-responsive nanocarriers under magnetic and thermal actuation in a microfluidic channel. ACS Nano 6:10535–10545. https://doi.org/10.1021/nn302842510.1021/nn3028425 ↗
9. Kang Z, Peng Y, Zhou L et al (2018) Thermo-responsive phase-transition polymer grafted magnetic FePt nanoparticles with tunable critical temperature for controlled drug release. Mater Chem Front 2:1609–1617. https://doi.org/10.1039/C8QM00154E10.1039/C8QM00154E ↗
10. Shekhar S, Mukherjee M, Sen AK (2021) Effect of Fe2O3 on the swelling, mechanical and thermal behaviour of NIPAM-based terpolymer. Polym Bull 78:5029–5054. https://doi.org/10.1007/s00289-020-03336-810.1007/s00289-020-03336-8 ↗
11. Ang KL, Venkatraman S, Ramanujan RV (2007) Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy. Mater Sci Eng C Mater Biol Appl 27:347–351. https://doi.org/10.1016/j.msec.2006.05.02710.1016/j.msec.2006.05.027 ↗
12. Hernández R, Sacristán J, Asín L et al (2010) Magnetic hydrogels derived from polysaccharides with improved specific power absorption: potential devices for remotely triggered drug delivery. J Phys Chem B 114:12002–12007. https://doi.org/10.1021/jp105556e10.1021/jp105556e ↗
13. Hoare T, Timko BP, Santamaria J et al (2011) Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. Nano Lett 11:1395–1400. https://doi.org/10.1021/nl200494t10.1021/nl200494t ↗
14. Satarkar NS, Zach Hilt J (2008) Hydrogel nanocomposites as remote-controlled biomaterials. Acta Biomater 4:11–16. https://doi.org/10.1016/j.actbio.2007.07.00910.1016/j.actbio.2007.07.009 ↗
15. Zhou L, He B, Zhang F (2012) Facile one-pot synthesis of iron oxide nanoparticles cross-linked magnetic poly(vinyl alcohol) gel beads for drug delivery. ACS Appl Mater Interfaces 4:192–199. https://doi.org/10.1021/am201649b10.1021/am201649b ↗
16. Ma M, Ma Y, Zhang B et al (2015) Fabrication and characterization of 1 D Fe3O4/P(NIPAM–MAA–MBA) nanochains with thermo- and pH-responsive shell for controlled release for phenolphthalein. J Mater Sci 50:3083–3090. https://doi.org/10.1007/s10853-015-8868-510.1007/s10853-015-8868-5 ↗
17. Purushotham S, Ramanujan RV (2010) Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy. Acta Biomater 6:502–510. https://doi.org/10.1016/j.actbio.2009.07.00410.1016/j.actbio.2009.07.004 ↗
18. Monfared AH, Zamanian A, Sharifi I, Mozafari M (2019) Reversible multistimuli-responsive manganese–zinc ferrite/P(NIPAAM-AAc-AAm) core-shell nanoparticles: a programmed ferrogel system. Mater Chem Phys 226:44–50. https://doi.org/10.1016/j.matchemphys.2019.01.01610.1016/j.matchemphys.2019.01.016 ↗
19. Bruvera IJ, Hernández R, Mijangos C, Goya GF (2015) An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing. J Magn Magn Mater 377:446–451. https://doi.org/10.1016/j.jmmm.2014.10.14910.1016/j.jmmm.2014.10.149 ↗
20. Satarkar N, Hilt J (2008) Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release. J Control Release 130:246–251. https://doi.org/10.1016/j.jconrel.2008.06.00810.1016/j.jconrel.2008.06.008 ↗
21. Park TG, Hoffman AS (1994) Deswelling characteristics of poly(N-isopropylacrylamide) hydrogel. J Appl Polym Sci 52:85–89. https://doi.org/10.1002/app.1994.07052011010.1002/app.1994.070520110 ↗
22. Campbell SB, Patenaude M, Hoare T (2013) Injectable superparamagnets: highly elastic and degradable poly(N-isopropylacrylamide)–superparamagnetic iron oxide nanoparticle (SPION) composite hydrogels. Biomacromol 14:644–653. https://doi.org/10.1021/bm301703x10.1021/bm301703x ↗
23. Garcia-Pinel B, Ortega-Rodríguez A, Porras-Alcalá C et al (2020) Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery. Artif Cells Nanomed Biotechnol 48:1022–1035. https://doi.org/10.1080/21691401.2020.177348810.1080/21691401.2020.1773488 ↗
24. Jara D, Ávila NH, Medina GAM et al (2023) Influence of different magnetic nanoheaters on the thermoresponsive deswelling of pNIPAM/alginate ferrogels for remotely activated release devices. ACS Appl Nano Mater 6:16475–16485. https://doi.org/10.1021/acsanm.3c0270110.1021/acsanm.3c02701 ↗
25. Tancredi P, Veiga LS, Garate O, Ybarra G (2019) Magnetophoretic mobility of iron oxide nanoparticles stabilized by small carboxylate ligands. Colloids Surf A Physicochem Eng Asp 579:1−6. https://doi.org/10.1016/j.colsurfa.2019.12366410.1016/j.colsurfa.2019.123664 ↗
26. Dumitriu RP, Mitchell GR, Vasile C (2011) Multi-responsive hydrogels based on N-isopropylacrylamide and sodium alginate. Polym Int 60:222–23310.1002/pi.2929 ↗
27. Hernández R, Sacristán J, Nogales A et al (2009) Structural organization of iron oxide nanoparticles synthesized inside hybrid polymer gels derived from alginate studied with small-angle X-ray scattering. Langmuir 25:13212–13218. https://doi.org/10.1021/la902441s10.1021/la902441s ↗
28. Ma X, Li Y, Wang W et al (2013) Temperature-sensitive poly(N-isopropylacrylamide)/graphene oxide nanocomposite hydrogels by in situ polymerization with improved swelling capability and mechanical behavior. Eur Polym J 49:389–396. https://doi.org/10.1016/j.eurpolymj.2012.10.03410.1016/j.eurpolymj.2012.10.034 ↗
29. Peppas NA, Barr-Howell BD (2019) Characterization of the cross-linked structure of hydrogels. In: Peppas NA, Peppas NA (eds) Hydrogels in medicine and pharmacy. CRC Press, Boca Raton, pp 27–5610.1201/9780429285097-2 ↗
30. Jeon YS, Lei J, Kim J-H (2008) Dye adsorption characteristics of alginate/polyaspartate hydrogels. J Ind Eng Chem 14:726–731. https://doi.org/10.1016/j.jiec.2008.07.00710.1016/j.jiec.2008.07.007 ↗
31. Hu N, Chen C, Tan J et al (2020) Enhanced adsorption of methylene blue triggered by the phase transition of thermoresponsive polymers in hybrid interpenetrating polymer network hydrogels. ACS Appl Polym Mater 2:3674–3684. https://doi.org/10.1021/acsapm.0c0066110.1021/acsapm.0c00661 ↗
32. Zhang M, Li Y, Yang Q et al (2018) Adsorption of methyl violet using pH- and temperature-sensitive cellulose filament/poly(NIPAM-co-AAc) hybrid hydrogels. J Mater Sci 53:11837–11854. https://doi.org/10.1007/s10853-018-2342-010.1007/s10853-018-2342-0 ↗
33. Gan T, Guan Y, Zhang Y (2010) Thermogelable PNIPAM microgel dispersion as 3D cell scaffold: effect of syneresis. J Mater Chem 20:5937–5944. https://doi.org/10.1039/C0JM00338G10.1039/C0JM00338G ↗
34. Li Z, Shen J, Ma H et al (2012) Preparation and characterization of sodium alginate/poly(N-isopropylacrylamide)/clay semi-IPN magnetic hydrogels. Polym Bull 68:1153–1169. https://doi.org/10.1007/s00289-011-0671-010.1007/s00289-011-0671-0 ↗
35. Halperin A, Kröger M, Winnik FM (2015) Poly(N-isopropylacrylamide) phase diagrams: fifty years of research. Angew Chem Int Ed 54:15342–1536710.1002/anie.201506663 ↗
36. Arana M, Bercoff PG, Jacobo SE et al (2016) Mechanochemical synthesis of MnZn ferrite nanoparticles suitable for biocompatible ferrofluids. Ceram Int 42:1545–1551. https://doi.org/10.1016/j.ceramint.2015.09.10310.1016/j.ceramint.2015.09.103 ↗
37. Nemati Z, Alonso J, Rodrigo I et al (2018) Improving the heating efficiency of iron oxide nanoparticles by tuning their shape and size. J Phys Chem C 122:2367–2381. https://doi.org/10.1021/acs.jpcc.7b1052810.1021/acs.jpcc.7b10528 ↗
38. Li G, Song S, Guo L, Ma S (2008) Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery. J Polym Sci A Polym Chem 46:5028–5035. https://doi.org/10.1002/pola.2283110.1002/pola.22831 ↗
39. Li Y, Maciel D, Tomás H et al (2011) pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism. Soft Matter 7:6238. https://doi.org/10.1039/c1sm05345k10.1039/c1sm05345k ↗
40. Mohammadzadeh F, Golshan M, Haddadi-Asl V, Salami-Kalajahi M (2023) Adsorption kinetics of methylene blue from wastewater using pH-sensitive starch-based hydrogels. Sci Rep 13:1−13. https://doi.org/10.1038/s41598-023-39241-z10.1038/s41598-023-39241-z ↗
41. Atkinson WJ, Brezovich IA, Chakraborty DP (1984) Usable frequencies in hyperthermia with thermal seeds. IEEE Trans Biomed Eng BME-31:70–75. https://doi.org/10.1109/TBME.1984.32537210.1109/TBME.1984.325372 ↗