Biomolecules induce the synthesis of hollow hierarchical mesoporous structured hydroxyapatite microflowers: application in macromolecule drug delivery
Source abstract
Abstract
A novel hollow HAp microflower with hierarchical mesoporous structure was designed through biomolecules induction and explored as macromolecular drug carrier. It is found that biomolecules play a vital role in the formation of hollow morphology and the construction of hierarchical mesoporous structure, which could remarkably improve the specific surface area of microflowers. Moreover, the microflowers display a higher drug loading capacity (263 ± 7.2 mg/g), sustained release behavior and exhibit a better biocompatibility in the cytotoxicity test, suggesting the microflowers can be regarded as a promising candidate in macromolecular drug delivery fields. In addition, it is proved that the excellent drug delivery property is attributed not only to the interaction among carrier, drug and medium environment but also to the pore structure and morphology of carrier. Over all, the work represents a versatile, new route toward the preparation of hollow HAp-based macromolecular drug carrier with hierarchical mesoporous structural features and provides new insight into the optimization of macromolecular drug delivery performance.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Hydrogels: synthesis, properties, applications · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
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1. Hajebi S, Rabiee N, Bagherzadeh M, Ahmadi S, Rabiee M, Roghani-Mamaqani H, Tahriri M, Tayebi L, Hamblin MR (2019) Stimulus-responsive polymeric nanogels as smart drug delivery systems. Acta Biomater 92:1–18. https://doi.org/10.1016/j.actbio.2019.05.01810.1016/j.actbio.2019.05.018 ↗
2. Fu L-H, Hu Y-R, Qi C, He T, Jiang S, Jiang C, He J, Qu J, Lin J, Huang P (2019) Biodegradable manganese-doped calcium phosphate nanotheranostics for traceable cascade reaction-enhanced anti-tumor therapy. ACS Nano. https://doi.org/10.1021/acsnano.9b0583610.1021/acsnano.9b05836 ↗
3. Chen S, Shi Y, Luo Y, Ma J (2019) Layer-by-layer coated porous 3D printed hydroxyapatite composite scaffolds for controlled drug delivery. Colloid Surf B Biointerfaces 179:121–127. https://doi.org/10.1016/j.colsurfb.2019.03.06310.1016/j.colsurfb.2019.03.063 ↗
4. Shao D, Li M, Wang Z, Zheng X, Lao Y-H, Chang Z, Zhang F, Lu M, Yue J, Hu H, Yan H, Chen L, Dong W-f, Leong KW (2018) Bioinspired diselenide-bridged mesoporous silica nanoparticles for dual-responsive protein delivery. Adv Mater 30:1801198. https://doi.org/10.1002/adma.20180119810.1002/adma.201801198 ↗
5. Liu W, Zhang X, Zhou L, Shang L, Su Z (2019) Reduced graphene oxide (rGO) hybridized hydrogel as a near-infrared (NIR)/pH dual-responsive platform for combined chemo-photothermal therapy. J Colloid Interface Sci 536:160–170. https://doi.org/10.1016/j.jcis.2018.10.05010.1016/j.jcis.2018.10.050 ↗
6. Kim WJ, Kim BS, Cho YD, Yoon WJ, Baek JH, Woo KM, Ryoo HM (2017) Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery. Biomaterials 122:154–162. https://doi.org/10.1016/j.biomaterials.2017.01.01910.1016/j.biomaterials.2017.01.019 ↗
7. Bose S, Tarafder S (2012) Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review. Acta Biomater 8:1401–1421. https://doi.org/10.1016/j.actbio.2011.11.01710.1016/j.actbio.2011.11.017 ↗
8. Mondal S, Dorozhkin SV, Pal U (2018) Recent progress on fabrication and drug delivery applications of nanostructured hydroxyapatite. Wiley Interdiscip Rev Nanomed Nanobiotechnol. https://doi.org/10.1002/wnan.150410.1002/wnan.1504 ↗
9. He ZH, Sun SL, Deng CL (2020) Effect of hydroxyapatite coating surface morphology on adsorption behavior of differently charged proteins. J Bionic Eng 17:345–356. https://doi.org/10.1007/s42235-020-0028-110.1007/s42235-020-0028-1 ↗
10. Kojima S, Nakamura H, Lee S, Nagata F, Kato K (2019) Hydroxyapatite formation on self-assembling peptides with differing secondary structures and their selective adsorption for proteins. Int J Mole Sci 20:4650. https://doi.org/10.3390/ijms2018465010.3390/ijms20184650 ↗
11. Ibrahim M, Labaki M, Giraudon J-M, Lamonier J-F (2020) Hydroxyapatite, a multifunctional material for air, water and soil pollution control: a review. J Hazard Mater 383:121139. https://doi.org/10.1016/j.jhazmat.2019.12113910.1016/j.jhazmat.2019.121139 ↗
12. Yang MS, Tian C, Han CR, Zhao GZ (2018) Hierarchical self-assembled hollow hydroxyapatite flower microspheres containing terpene functional groups for efficient drug loading and pH-responsive drug release. Ceram Int 44:20913–20920. https://doi.org/10.1016/j.ceramint.2018.05.26410.1016/j.ceramint.2018.05.264 ↗
13. Xu Y, An L, Chen L, Cao L, Zeng D, Wang G (2018) A facile chemical route to synthesize Zn doped hydroxyapatite nanorods for protein drug delivery. Mater Chem Phys 214:359–363. https://doi.org/10.1016/j.matchemphys.2018.04.11710.1016/j.matchemphys.2018.04.117 ↗
14. Kim J-J, Lee J-Y, Kim H-W (2016) Hydroxyapatite mineral tubes developed for the loading and release of biological proteins. Mater Lett 167:170–174. https://doi.org/10.1016/j.matlet.2015.12.12810.1016/j.matlet.2015.12.128 ↗
15. Lai W, Chen C, Ren X, Lee IS, Jiang G, Kong X (2016) Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system. Mater Sci Eng C Mater Biol Appl 62:166–172. https://doi.org/10.1016/j.msec.2016.01.05510.1016/j.msec.2016.01.055 ↗
16. Xiao Q, Zhou K, Chen C, Jiang M, Zhang Y, Luo H, Zhang D (2016) Hollow and porous hydroxyapatite microspheres prepared with an O/W emulsion by spray freezing method. Mater Sci Eng C Mater Biol Appl 69:1068–1074. https://doi.org/10.1016/j.msec.2016.07.08210.1016/j.msec.2016.07.082 ↗
17. Mondal S, Hoang G, Manivasagan P, Kim H, Oh J (2019) Nanostructured hollow hydroxyapatite fabrication by carbon templating for enhanced drug delivery and biomedical applications. Ceram Int 45:17081–17093. https://doi.org/10.1016/j.ceramint.2019.05.26010.1016/j.ceramint.2019.05.260 ↗
18. Li R, Chen K, Li G, Han G, Yu S, Yao J, Cai Y (2016) Structure design and fabrication of porous hydroxyapatite microspheres for cell delivery. J Mol Struct 1120:34–41. https://doi.org/10.1016/j.molstruc.2016.05.01710.1016/j.molstruc.2016.05.017 ↗
19. Kang Y, Sun W, Li S, Li M, Fan J, Du J, Liang X-J, Peng X (2019) Oligo hyaluronan-coated silica/hydroxyapatite degradable nanoparticles for targeted cancer treatment. Adv Sci. https://doi.org/10.1002/advs.20190071610.1002/advs.201900716 ↗
20. Wei J, Zhou D, Sun Z, Deng Y, Xia Y, Zhao D (2013) A controllable synthesis of rich nitrogen-doped ordered mesoporous carbon for CO2 capture and supercapacitors. Adv Funct Mater 23:2322–2328. https://doi.org/10.1002/adfm.20120276410.1002/adfm.201202764 ↗
21. Cao X, Wang G, Wang K, Guo L, Cao Y, Cao X, Yang Y (2020) Organic phosphorous and calcium source induce the synthesis of yolk-shell structured microspheres of calcium phosphate with high-specific surface area: application in HEL adsorption. Nanoscale Res Lett 15:69. https://doi.org/10.1186/s11671-020-03298-w10.1186/s11671-020-03298-w ↗
22. Peng H-L, Zhang J-B, Zhang J-Y, Zhong F-Y, Wu P-K, Huang K, Fan J-P, Liu F (2019) Chitosan-derived mesoporous carbon with ultrahigh pore volume for amine impregnation and highly efficient CO2 capture. Chem Eng J 359:1159–1165. https://doi.org/10.1016/j.cej.2018.11.06410.1016/j.cej.2018.11.064 ↗
23. Zhao J, Xie P, Ye C, Wu C, Han W, Huang M, Wang S, Chen H (2018) Outside-in synthesis of mesoporous silica/molybdenum disulfide nanoparticles for antitumor application. Chem Eng J 351:157–168. https://doi.org/10.1016/j.cej.2018.06.10110.1016/j.cej.2018.06.101 ↗
24. Li Y, Shi J (2014) Hollow-structured mesoporous materials: chemical synthesis, functionalization and applications. Adv Mater 26:3176–3205. https://doi.org/10.1002/adma.20130531910.1002/adma.201305319 ↗
25. Poostforooshan J, Belbekhouche S, Shaban M, Alphonse V, Habert D, Bousserrhine N, Courty J, Weber AP (2020) Aerosol-assisted synthesis of tailor-made hollow mesoporous silica microspheres for controlled release of antibacterial and anticancer agents. ACS Appl Mater Interfaces 12:6885–6898. https://doi.org/10.1021/acsami.9b2051010.1021/acsami.9b20510 ↗
26. Huang X, Meng X, Tang F, Li L, Chen D, Liu H, Zhang Y, Ren J (2008) Mesoporous magnetic hollow nanoparticles-protein carriers for lysosome escaping and cytosolic delivery. Nanotechnology 19:445101. https://doi.org/10.1088/0957-4484/19/44/44510110.1088/0957-4484/19/44/445101 ↗
27. Gu X, Liu Y, Chen G, Wang H, Shao C, Chen Z, Lu P, Zhao Y (2018) Mesoporous colloidal photonic crystal particles for intelligent drug delivery. ACS Appl Mater Interfaces 10:33936–33944. https://doi.org/10.1021/acsami.8b1117510.1021/acsami.8b11175 ↗
28. Wang Y, Kong A, Chen X, Lin Q, Feng P (2015) Efficient oxygen electroreduction: hierarchical porous fe–n-doped hollow carbon nanoshells. ACS Catal 5:3887–3893. https://doi.org/10.1021/acscatal.5b0053010.1021/acscatal.5b00530 ↗
29. Li Y, Li N, Pan W, Yu Z, Yang L, Tang B (2017) Hollow mesoporous silica nanoparticles with tunable structures for controlled drug delivery. ACS Appl Mater Interfaces 9:2123–2129. https://doi.org/10.1021/acsami.6b1387610.1021/acsami.6b13876 ↗
30. Hadipour Moghaddam SP, Yazdimamaghani M, Ghandehari H (2018) Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery. J Control Release 282:62–75. https://doi.org/10.1016/j.jconrel.2018.04.03210.1016/j.jconrel.2018.04.032 ↗
31. Zhang M, Zhang L, Chen Y, Li L, Su Z, Wang C (2017) Precise synthesis of unique polydopamine/mesoporous calcium phosphate hollow Janus nanoparticles for imaging-guided chemo-photothermal synergistic therapy. Chem Sci 8:8067–8077. https://doi.org/10.1039/c7sc03521g10.1039/c7sc03521g ↗
32. Qi C, Musetti S, Fu L-H, Zhu Y-J, Huang L (2019) Biomolecule-assisted green synthesis of nanostructured calcium phosphates and their biomedical applications. Chem Soc Rev 48:2698–2737. https://doi.org/10.1039/c8cs00489g10.1039/c8cs00489g ↗
33. Ren X, Sun Z, Ma X, Wang Y, Cui X, Yi Z, Sun X, Guo B, Li X (2018) Alginate-mediated mineralization for ultrafine hydroxyapatite hybrid nanoparticles. Langmuir 34:6797–6805. https://doi.org/10.1021/acs.langmuir.8b0015110.1021/acs.langmuir.8b00151 ↗
34. Park SY, Kim K-I, Park SP, Lee JH, Jung HS (2016) Aspartic acid-assisted synthesis of multifunctional strontium-substituted hydroxyapatite microspheres. Cryst Growth Des 16:4318–4326. https://doi.org/10.1021/acs.cgd.6b0042010.1021/acs.cgd.6b00420 ↗
35. Khalifehzadeh R, Arami H (2019) DNA-templated strontium-doped calcium phosphate nanoparticles for gene delivery in bone cells. ACS Biomater Sci Eng 5:3201–3211. https://doi.org/10.1021/acsbiomaterials.8b0158710.1021/acsbiomaterials.8b01587 ↗
36. Zhou H, Yang Y, Yang M, Wang W, Bi Y (2018) Synthesis of mesoporous hydroxyapatite via a vitamin C templating hydrothermal route. Mater Lett 218:52–55. https://doi.org/10.1016/j.matlet.2018.01.15410.1016/j.matlet.2018.01.154 ↗
37. Das P, Jana NR (2016) Length-controlled synthesis of calcium phosphate nanorod and nanowire and application in intracellular protein delivery. ACS Appl Mater Interfaces 8:8710–8720. https://doi.org/10.1021/acsami.6b0166710.1021/acsami.6b01667 ↗
38. Yu Y-D, Zhu Y-J, Qi C, Wu J (2017) Solvothermal synthesis of hydroxyapatite with various morphologies using trimethyl phosphate as organic phosphorus source. Mater Lett 193:165–168. https://doi.org/10.1016/j.matlet.2017.01.12410.1016/j.matlet.2017.01.124 ↗
39. Yu W, Sun T-W, Qi C, Ding Z, Zhao H, Chen F, Chen D, Zhu Y-J, Shi Z, He Y (2017) Strontium-doped amorphous calcium phosphate porous microspheres synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration. ACS Appl Mater Interfaces 9:3306–3317. https://doi.org/10.1021/acsami.6b1232510.1021/acsami.6b12325 ↗
40. Qi C, Zhu YJ, Lu BQ, Zhao XY, Zhao J, Chen F, Wu J (2013) Hydroxyapatite hierarchically nanostructured porous hollow microspheres: rapid, sustainable microwave-hydrothermal synthesis by using creatine phosphate as an organic phosphorus source and application in drug delivery and protein adsorption. Chem Eur J 19:5332–5341. https://doi.org/10.1002/chem.20120388610.1002/chem.201203886 ↗
41. Olsen T, Cui G, Goll R, Husebekk A, Florholmen J (2009) Infliximab therapy decreases the levels of TNF- and IFN-mRNA in colonic mucosa of ulcerative colitis. Scand J Gastroenterol 44:727–735. https://doi.org/10.1080/0036552090280350710.1080/00365520902803507 ↗
42. Fuhrmann K, Fuhrmann G (2017) Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation. Curr Opin Colloid Interface Sci 31:67–74. https://doi.org/10.1016/j.cocis.2017.07.00210.1016/j.cocis.2017.07.002 ↗
43. Tang QL, Zhu YJ, Wu J, Chen F, Cao SW (2011) Calcium phosphate drug nanocarriers with ultrahigh and adjustable drug-loading capacity: one-step synthesis, in situ drug loading and prolonged drug release. Nanomed Nanotechnol Biol Med 7:428–434. https://doi.org/10.1016/j.nano.2010.12.00510.1016/j.nano.2010.12.005 ↗
44. Tian B, Liu S, Wu S, Lu W, Wang D, Jin L, Hu B, Li K, Wang Z, Quan Z (2017) pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin. Colloid Surf B Biointerfaces 154:287–296. https://doi.org/10.1016/j.colsurfb.2017.03.02410.1016/j.colsurfb.2017.03.024 ↗
45. Wang M, Wang S, Li B, Tian Y, Zhang H, Bai L, Ba X (2020) Synthesis of linear polyglucoside and inhibition on the amyloid fibril formation of hen egg white lysozyme. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2020.10.23410.1016/j.ijbiomac.2020.10.234 ↗
46. Rani RS, Saharay M (2019) Molecular dynamics simulation of protein-mediated biomineralization of amorphous calcium carbonate. RSC Adv 9:1653–1663. https://doi.org/10.1039/C8RA08459A10.1039/C8RA08459A ↗
47. Yu W, Sun T-W, Ding Z, Qi C, Zhao H, Chen F, Shi Z, Zhu Y-J, Chen D, He Y (2017) Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration. J Mat Chem B 5:1039–1052. https://doi.org/10.1039/c6tb02747d10.1039/c6tb02747d ↗
48. Li T, Geng T, Md A, Banerjee P, Wang B (2019) Novel scheme for rapid synthesis of hollow mesoporous silica nanoparticles (HMSNs) and their application as an efficient delivery carrier for oral bioavailability improvement of poorly water-soluble BCS type II drugs. Colloid Surf B Biointerfaces 176:185–193. https://doi.org/10.1016/j.colsurfb.2019.01.00410.1016/j.colsurfb.2019.01.004 ↗
49. Zhu Y, Shi J, Shen W, Dong X, Feng J, Ruan M, Li Y (2005) Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core–shell structure. Angew Chem Int Edit 44:5083–5087. https://doi.org/10.1002/anie.20050150010.1002/anie.200501500 ↗
50. Combes C, Rey C (2010) Amorphous calcium phosphates: synthesis, properties and uses in biomaterials. Acta Biomater 6:3362–3378. https://doi.org/10.1016/j.actbio.2010.02.01710.1016/j.actbio.2010.02.017 ↗
51. Qi C, Zhu YJ, Chen F (2014) Microwave hydrothermal transformation of amorphous calcium carbonate nanospheres and application in protein adsorption. ACS Appl Mater Interfaces. https://doi.org/10.1021/am406064510.1021/am4060645 ↗
52. Yu Y-D, Zhu Y-J, Qi C, Wu J (2017) Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4 and their application in protein/drug delivery. Ceram Int 43:6511–6518. https://doi.org/10.1016/j.ceramint.2017.02.07310.1016/j.ceramint.2017.02.073 ↗
53. Yu Y-D, Zhu Y-J, Qi C, Jiang Y-Y, Li H, Wu J (2017) Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers. J Colloid Interface Sci 496:416–424. https://doi.org/10.1016/j.jcis.2017.02.04110.1016/j.jcis.2017.02.041 ↗
54. Louka DA, Holwell N, Thomas BH, Chen F, Amsden BG (2018) Highly bioactive SDF-1α delivery from low-melting-point, biodegradable polymer microspheres. ACS Biomater Sci Eng 4:3747–3758. https://doi.org/10.1021/acsbiomaterials.7b0040310.1021/acsbiomaterials.7b00403 ↗