Temperature-triggered gelation and controlled drug release via NIPAAm/NVP-based hydrogels
Source abstract
Abstract
Novel physically crosslinked hydrogels based on N-isopropylacrylamide and 1-vinyl-2-pyrrolidinone were synthesised using photopolymerisation. The gelation behaviour of the copolymers was investigated using modulated differential scanning calorimetry, oscillatory rheological analysis and the test tube inversion method. A number of the samples gelled spontaneously under physiological conditions and importantly did not undergo syneresis within the desired temperature window. Two active pharmaceutical ingredients (APIs), diclofenac sodium and procaine hydrochloride, were entrapped within the thermogelling materials by increasing external test temperature. The temperature-triggered gelation of the copolymer gels was used as a means of controlling the release of the APIs, and was found to retard the dissolution rate significantly.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research · Advancements in Transdermal Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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