journal article·2026-03

Cellulose–graphene composite hydrogels (CGHs)

Avik Kumar Dhar, Niloy Chowdhury, Omit Biswas, Adel Mahmood, Nashita Ahmed, Sandesh Poudel, Brishte Paul Lucky, Samia Tahsina Sami, Joyeta Mazumder

Journal of Materials Science· Volume 61· Issue 11
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Abstract

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OpenAlex topics: Advanced Cellulose Research Studies · Hydrogels: synthesis, properties, applications · Graphene and Nanomaterials Applications

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References (100+)

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1. Wei P, Wang L, Xie F et al (2022) Strong and tough cellulose–graphene oxide composite hydrogels by multi-modulus components strategy as photothermal antibacterial platform. Chem Eng J 431 (1). https://doi.org/10.1016/j.cej.2021.13396410.1016/j.cej.2021.133964 ↗
2. Yang K, Chen M, Wang Q et al (2022) Electro-thermo controlled water valve based on 2D graphene-cellulose hydrogels. Adv Funct Mater 32(42):2201904. https://doi.org/10.1002/adfm.20220190410.1002/adfm.202201904 ↗
3. Hussain S, Salman M, Farooq U et al (2024) Fabrication of carboxymethyl cellulose/graphene oxide/ZnO composite hydrogel for efficient removal of fuchsin dye from aqueous media. Int J Biol Macromol 277:134104. https://doi.org/10.1016/j.ijbiomac.2024.13410410.1016/j.ijbiomac.2024.134104 ↗
4. Wang X, Wei W, Guo Z et al (2024) Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine. Biomater Sci 12(5):1079–1114. https://doi.org/10.1039/D3BM01766D10.1039/D3BM01766D ↗
5. Buwalda SJ (2020) Bio-based composite hydrogels for biomedical applications. Multifunct Mater 3(2):022001. https://doi.org/10.1088/2399-7532/ab80d610.1088/2399-7532/ab80d6 ↗
6. Khoo PS, Ilyas RA, Aiman A et al (2024) Revolutionizing wastewater treatment: a review on the role of advanced functional bio-based hydrogels. Int J Biol Macromol 278:135088. https://doi.org/10.1016/j.ijbiomac.2024.13508810.1016/j.ijbiomac.2024.135088 ↗
7. Bhaladhare S, Das D (2022) Cellulose: a fascinating biopolymer for hydrogel synthesis. J Mater Chem B 10(12):1923–1945. https://doi.org/10.1039/D1TB02848K10.1039/D1TB02848K ↗
8. Kawee N, Lam NT, Sukyai P (2018) Homogenous isolation of individualized bacterial nanofibrillated cellulose by high pressure homogenization. Carbohydr Polym 179:394–401. https://doi.org/10.1016/j.carbpol.2017.09.10110.1016/j.carbpol.2017.09.101 ↗
9. Umbreen N, Sohni S, Ahmad I et al (2018) Self-assembled three-dimensional reduced graphene oxide-based hydrogel for highly efficient and facile removal of pharmaceutical compounds from aqueous solution. J Colloid Interface Sci 527:356–367. https://doi.org/10.1016/j.jcis.2018.05.01010.1016/j.jcis.2018.05.010 ↗
10. Chakraborty M, Hashmi MSJ, Ramadan M (2018) Potential of graphene for miniature sensors and conducting devices in biomedical applications, In: Olabi AG (ed) Encyclopedia of smart materials, Elsevier: Oxford. pp 96–108. https://doi.org/10.1016/B978-0-12-803581-8.10320-010.1016/B978-0-12-803581-8.10320-0 ↗
11. Banerjee AN (2018) Graphene and its derivatives as biomedical materials: future prospects and challenges. Interface Focus 8(3):20170056. https://doi.org/10.1098/rsfs.2017.005610.1098/rsfs.2017.0056 ↗
12. Dai H, Zhang Y, Ma L et al (2019) Synthesis and response of pineapple peel carboxymethyl cellulose-g-poly (acrylic acid-co-acrylamide)/graphene oxide hydrogels. Carbohydr Polym 215:366–376. https://doi.org/10.1016/j.carbpol.2019.03.09010.1016/j.carbpol.2019.03.090 ↗
13. Lu H, Zhang S, Guo L et al (2017) Applications of graphene-based composite hydrogels: a review. RSC Adv 7(80):51008–51020. https://doi.org/10.1039/C7RA09634H10.1039/C7RA09634H ↗
14. Chen X, Zhou S, Zhang L et al (2016) Adsorption of heavy metals by graphene oxide/cellulose hydrogel prepared from NaOH/urea aqueous solution. Materials 9(7):582. https://doi.org/10.3390/ma907058210.3390/ma9070582 ↗
15. Xu M, Huang Q, Wang X et al (2015) Highly tough cellulose/graphene composite hydrogels prepared from ionic liquids. Ind Crops Prod 70:56–63. https://doi.org/10.1016/j.indcrop.2015.03.00410.1016/j.indcrop.2015.03.004 ↗
16. Wang H, Li J, Ding N et al (2020) Eco-friendly polymer nanocomposite hydrogel enhanced by cellulose nanocrystal and graphitic-like carbon nitride nanosheet. Chem Eng J 386. https://doi.org/10.1016/j.cej.2020.12402110.1016/j.cej.2020.124021 ↗
17. Li JC, Zheng LF, Sha XH et al (2020) Microstructural and mechanical characteristics of graphene oxide-fly ash cenosphere hybrid reinforced epoxy resin composites. J Appl Polym Sci 137(2):47173. https://doi.org/10.1002/app.4717310.1002/app.47173 ↗
18. Qu X, Xu N, Zhao L et al (2025) High-performance flexible zinc–air batteries enabled by carboxymethyl cellulose/graphene oxide composite hydrogel electrolytes. New J Chem 49(18):7376–7383. https://doi.org/10.1039/D5NJ00929D10.1039/D5NJ00929D ↗
19. Ray T, Das D, Pramanik G et al (2024) Fluorescent hydrogels of Zn2+ cross-linked cellulose-graphene-Brij composite for ultra-trace sensing of serum uric acid with high interfering triglyceride. Inorg Chim Acta 566:122010. https://doi.org/10.1016/j.ica.2024.12201010.1016/j.ica.2024.122010 ↗
20. Goenka S, Sant V, Sant S (2014) Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release 173:75–88. https://doi.org/10.1016/j.jconrel.2013.10.01710.1016/j.jconrel.2013.10.017 ↗
21. Yu H, Feng W (2024) Carbon-based multifunctional nanomaterials. Nanomaterials 14(19):1600. https://doi.org/10.3390/nano1419160010.3390/nano14191600 ↗
22. Geim AK, Novoselov KS (2007) The rise of graphene. Nat Mater 6(3):183–191. https://doi.org/10.1038/nmat184910.1038/nmat1849 ↗
23. Sarath PS, Reghunath R, Thomas S et al (2023) 8 - Tribology of graphene-based polymeric systems. In: George SC et al. (eds.) Tribology of polymers, polymer composites, and polymer nanocomposites, Elsevier. pp 215–233. https://doi.org/10.1016/B978-0-323-90748-4.00009-110.1016/B978-0-323-90748-4.00009-1 ↗
24. Zhu Y, Kong G, Pan Y et al (2022) An improved hummers method to synthesize graphene oxide using much less concentrated sulfuric acid. Chin Chem Lett 33(10):4541–4544. https://doi.org/10.1016/j.cclet.2022.01.06010.1016/j.cclet.2022.01.060 ↗
25. Yadav S, Raman APS, Meena H et al (2022) An update on graphene oxide: applications and toxicity. ACS Omega 7(40):35387–35445. https://doi.org/10.1021/acsomega.2c0317110.1021/acsomega.2c03171 ↗
26. Gholampour A, Kiamahalleh MV, Tran DNH et al (2017) From graphene oxide to reduced graphene oxide: impact on the physiochemical and mechanical properties of graphene–cement composites. ACS Appl Mater Interfaces 9(49):43275–43286. https://doi.org/10.1021/acsami.7b1673610.1021/acsami.7b16736 ↗
27. Liu Z, Navik R, Tan H et al (2022) Graphene-based materials prepared by supercritical fluid technology and its application in energy storage. J Supercrit Fluids 188:105672. https://doi.org/10.1016/j.supflu.2022.10567210.1016/j.supflu.2022.105672 ↗
28. Valappil MO, Pillai VK, Alwarappan S (2017) Spotlighting graphene quantum dots and beyond: synthesis, properties and sensing applications. Appl Mater Today 9:350–371. https://doi.org/10.1016/j.apmt.2017.09.00210.1016/j.apmt.2017.09.002 ↗
29. Zainal SH, Mohd NH, Suhaili N et al (2021) Preparation of cellulose-based hydrogel: a review. J Mater Res Technol 10:935–952. https://doi.org/10.1016/j.jmrt.2020.12.01210.1016/j.jmrt.2020.12.012 ↗
30. Luo X, Zhang L (2013) New solvents and functional materials prepared from cellulose solutions in alkali/urea aqueous system. Food Res Int 52(1):387–400. https://doi.org/10.1016/j.foodres.2010.05.01610.1016/j.foodres.2010.05.016 ↗
31. Song EH, Shang J, Ratner DM (2012) 9.08 - polysaccharides, in polymer science: a comprehensive reference, Matyjaszewski K, Möller M, Editors. 2012, Elsevier: Amsterdam. pp 137–15510.1016/B978-0-444-53349-4.00246-6 ↗
32. Tang Y, Fang Z, Lee HJ (2024) Exploring applications and preparation techniques for cellulose hydrogels: a comprehensive review. Gels 10(6):365. https://doi.org/10.3390/gels1006036510.3390/gels10060365 ↗
33. Fu LH, Qi C, Ma MG et al (2019) Multifunctional cellulose-based hydrogels for biomedical applications. J Mater Chem B 7(10):1541–1562. https://doi.org/10.1039/C8TB02331J10.1039/C8TB02331J ↗
34. Mazega A, Lehrhofer AF, Aguado RJ et al (2025) Key insights into TEMPO-mediated oxidation of cellulose: influence of starting material. Cellulose 32(9):5227–5246. https://doi.org/10.1007/s10570-025-06477-z10.1007/s10570-025-06477-z ↗
35. Erfanian E, Moaref R, Ajdary R et al (2023) Electrochemically synthesized graphene/TEMPO-oxidized cellulose nanofibrils hydrogels: highly conductive green inks for 3D printing of robust structured EMI shielding aerogels. Carbon. https://doi.org/10.1016/j.carbon.2023.11803710.1016/j.carbon.2023.118037 ↗
36. Rakhshaei R, Namazi H, Hamishehkar H et al (2020) Graphene quantum dot cross-linked carboxymethyl cellulose nanocomposite hydrogel for pH-sensitive oral anticancer drug delivery with potential bioimaging properties. Int J Biol Macromol 150:1121–1129. https://doi.org/10.1016/j.ijbiomac.2019.10.11810.1016/j.ijbiomac.2019.10.118 ↗
37. Hennink WE, van Nostrum CF (2012) Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 64:223–236. https://doi.org/10.1016/j.addr.2012.09.00910.1016/j.addr.2012.09.009 ↗
38. Shu R, Xu L, Guan Y (2024) Preparation of cellulose derived carbon/reduced graphene oxide composite aerogels for broadband and efficient microwave dissipation. J Colloid Interface Sci 675:401–410. https://doi.org/10.1016/j.jcis.2024.07.02610.1016/j.jcis.2024.07.026 ↗
39. Sun P, Wang M, Wu T et al (2023) Covalent crosslinking cellulose/graphene aerogels with high elasticity and adsorbability for heavy metal ions adsorption. Polymers 15(11):2434. https://doi.org/10.3390/polym1511243410.3390/polym15112434 ↗
40. Saputra AH, Hapsari M, Pitaloka AB et al (2015) Synthesis and characterization of hydrogel from cellulose derivatives of water hyacinth (Eichhornia crassipes) through chemical cross-linking method by using citric acid. J Eng Sci Technol 10:75–86
41. Kayra N, Aytekin AÖ (2019) Synthesis of cellulose-based hydrogels: preparation, formation, mixture, and modification. In: Cellulose-based superabsorbent hydrogels pp 407–43410.1007/978-3-319-77830-3_16 ↗
42. Bashir S, Hina M, Iqbal J et al (2020) Fundamental concepts of hydrogels: synthesis, properties, and their applications. Polymers 12(11):2702. https://doi.org/10.3390/polym1211270210.3390/polym12112702 ↗
43. Estevam BR, Perez ID, Moraes ÂM et al (2023) A review of the strategies used to produce different networks in cellulose-based hydrogels. Mater Today Chem 34:101803. https://doi.org/10.1016/j.mtchem.2023.10180310.1016/j.mtchem.2023.101803 ↗
44. Cheng H, Li Y, Wang B et al (2018) Chemical crosslinking reinforced flexible cellulose nanofiber-supported cryogel. Cellulose 25:573–582. https://doi.org/10.1007/s10570-017-1548-710.1007/s10570-017-1548-7 ↗
45. Nasution H, Harahap H, Dalimunthe NF et al (2022) Hydrogel and effects of crosslinking agent on cellulose-based hydrogels: a review. Gels 8(9):568. https://doi.org/10.3390/gels809056810.3390/gels8090568 ↗
46. Luo H, Dong J, Xu X et al (2018) Exploring excellent dispersion of graphene nanosheets in three-dimensional bacterial cellulose for ultra-strong nanocomposite hydrogels. Compos Part A Appl Sci Manuf 109:290–297. https://doi.org/10.1016/j.compositesa.2018.03.00710.1016/j.compositesa.2018.03.007 ↗
47. Yang S, Fu S, Liu H et al (2011) Hydrogel beads based on carboxymethyl cellulose for removal heavy metal ions. J Appl Polym Sci 119(2):1204–1210. https://doi.org/10.1002/app.3282210.1002/app.32822 ↗
48. Huber T, Feast S, Dimartino S et al (2019) Analysis of the effect of processing conditions on physical properties of thermally set cellulose hydrogels. Materials (Basel) 12(7):1066–1066. https://doi.org/10.3390/ma1207106610.3390/ma12071066 ↗
49. Wang H, Wu J, Qiu J et al (2019) In situ formation of a renewable cellulose hydrogel electrolyte for high-performance flexible all-solid-state asymmetric supercapacitors. Sustain Energy Fuels 3(11):3109–3115. https://doi.org/10.1039/c9se00339h10.1039/c9se00339h ↗
50. Gao Mh, Xie X, Huang T et al (2022) Glutaraldehyde-assisted crosslinking in regenerated cellulose films toward high dielectric and mechanical properties. Cellulose 29(15):8177–8194. https://doi.org/10.1007/s10570-022-04785-210.1007/s10570-022-04785-2 ↗
51. Treesuppharat W, Rojanapanthu P, Siangsanoh C et al (2017) Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems. Biotechnol Rep (Amst) 15:84–91. https://doi.org/10.1016/j.btre.2017.07.00210.1016/j.btre.2017.07.002 ↗
52. Pal K, Paulson AT, Rousseau D (2009) Biopolymers in controlled-release delivery systems. Elsevier. p 329–363. https://doi.org/10.1016/B978-0-12-374195-0.00016-110.1016/B978-0-12-374195-0.00016-1 ↗
53. Raucci MG, Alvarez-Perez MA, Demitri C et al (2014) Effect of citric acid crosslinking cellulose-based hydrogels on osteogenic differentiation. J Biomed Mater Res A 103(6):2045–2056. https://doi.org/10.1002/jbm.a.3534310.1002/jbm.a.35343 ↗
54. Morais MAP, Silva M, Barros M et al (2024) Impact of citric acid on guar gum carboxymethylcellulose crosslinked blend films. J Appl Polym Sci. https://doi.org/10.1002/app.5616210.1002/app.56162 ↗
55. Xu L, Li Y, Fu J et al (2024) Advances in functional cellulose hydrogels as electrolytes for flexible Zinc-Ion batteries. Nanomaterials (Basel) 14(20):1645–1645. https://doi.org/10.3390/nano1420164510.3390/nano14201645 ↗
56. Geng H (2018) A one-step approach to make cellulose-based hydrogels of various transparency and swelling degrees. Carbohydr Polym 186:208–216. https://doi.org/10.1016/j.carbpol.2018.01.03110.1016/j.carbpol.2018.01.031 ↗
57. Qian L (2018) Cellulose-based composite hydrogels: preparation, structures, and applications p. 1–50. In: Mondal M (eds.) Cellulose-based superabsorbent hydrogels. polymers and polymeric composites: a reference series. Springer, Cham. https://doi.org/10.1007/978-3-319-76573-0_23-110.1007/978-3-319-76573-0_23-1 ↗
58. Lin R, Xu R, Chen H et al (2023) Dual cross-linked starch hydrogel for eugenol encapsulation and the formation of hydrogen bonds on textural hydrogel. Carbohyd Polym 316:121044–121044. https://doi.org/10.1016/j.carbpol.2023.12104410.1016/j.carbpol.2023.121044 ↗
59. Sannino A, Pappadà S, Madaghiele M et al (2005) Crosslinking of cellulose derivatives and hyaluronic acid with water-soluble carbodiimide. Polymer 46(25):11206–11212. https://doi.org/10.1016/j.polymer.2005.10.04810.1016/j.polymer.2005.10.048 ↗
60. Patiño-Ruiz D (2020) Fabricación de hidrogeles entrecruzados de carboximetil celulosa-SiO2: Composición y estabilidad térmica hacia aplicaciones biomédicas. IPSA Sci Rev Científ Multidiscip 5(1):60–71. https://doi.org/10.25214/27114406.93510.25214/27114406.935 ↗
61. Rumon MMH (2025) Advances in cellulose-based hydrogels: tunable swelling dynamics and their versatile real-time applications. RSC Adv 15(15):11688–11729. https://doi.org/10.1039/D5RA00521C10.1039/D5RA00521C ↗
62. Nair SS, Zhu JY, Deng Y et al (2014) Hydrogels prepared from cross-linked nanofibrillated cellulose. ACS Sustain Chem Eng 2(4):772–780. https://doi.org/10.1021/sc400445t10.1021/sc400445t ↗
63. Khan MUA, Stojanović GM, Rehman RA et al (2023) Graphene oxide-functionalized bacterial cellulose–gelatin hydrogel with curcumin release and kinetics: in vitro biological evaluation. ACS Omega 8(43):40024–40035. https://doi.org/10.1021/acsomega.2c0682510.1021/acsomega.2c06825 ↗
64. Rehman N, Dilshad MR, Islam A et al (2021) Novel graphene oxide loaded sodium alginate hydrogels cross-linked with tetraethyl orthosilicate for cephradine release analysis. J Drug Deliv Sci Technol 66:102784–102784. https://doi.org/10.1016/j.jddst.2021.10278410.1016/j.jddst.2021.102784 ↗
65. Singh NK, Pramoda K, Gopalakrishnan K et al (2018) Synthesis, characterization, surface properties and energy device characterstics of 2D borocarbonitrides, (BN) x C 1–x, covalently cross-linked with sheets of other 2D materials. RSC Adv 8(31):17237–17253. https://doi.org/10.1039/C8RA01885E10.1039/C8RA01885E ↗
66. Gupta AS, Mukherjee K, Giri TK (2025) Borax cross-linked polysaccharide-based self-healing hydrogels for drug delivery and regenerative medicine. J Drug Deliv Sci Technol 105:106592–106592. https://doi.org/10.1016/j.jddst.2024.10659210.1016/j.jddst.2024.106592 ↗
67. Tanpichai S, Phoothong F, Boonmahitthisud A (2022) Superabsorbent cellulose-based hydrogels cross-liked with borax. Sci Rep 12(1):8920–8920. https://doi.org/10.1038/s41598-022-12688-210.1038/s41598-022-12688-2 ↗
68. Dolfing J, Eekert Mv, Seech A et al (2007) In situ chemical reduction (ISCR) technologies: significance of low Eh reactions. Soil Sediment Contam 17(1):63–74. https://doi.org/10.1080/1532038070174143810.1080/15320380701741438 ↗
69. Chen Y, Pötschke P, Pionteck J et al (2018) Smart cellulose/graphene composites fabricated by in situ chemical reduction of graphene oxide for multiple sensing applications. J Mater Chem A 6(17):7777–7785. https://doi.org/10.1039/C8TA00618K10.1039/C8TA00618K ↗
70. Adhikari B, Biswas A, Banerjee A (2012) Graphene oxide-based hydrogels to make metal nanoparticle-containing reduced graphene oxide-based functional hybrid hydrogels. ACS Appl Mater Interfaces 4(10):5472–5482. https://doi.org/10.1021/am301373n10.1021/am301373n ↗
71. Peng H, Meng L, Niu L et al (2012) Simultaneous reduction and surface functionalization of graphene oxide by natural cellulose with the assistance of the ionic liquid. J Phys Chem C 116(30):16294–16299. https://doi.org/10.1021/jp304388910.1021/jp3043889 ↗
72. Urbina L, Eceiza A, Gabilondo N et al (2020) Tailoring the in situ conformation of bacterial cellulose-graphene oxide spherical nanocarriers. Int J Biol Macromol 163:1249–1260. https://doi.org/10.1016/j.ijbiomac.2020.07.07710.1016/j.ijbiomac.2020.07.077 ↗
73. Wang X, Wan K, Xie P et al (2021) Ultralight, high capacitance, mechanically strong graphene-cellulose aerogels. Molecules 26(16):4891. https://doi.org/10.3390/molecules2616489110.3390/molecules26164891 ↗
74. Zheng H, Zuo B (2021) Functional silk fibroin hydrogels: preparation, properties and applications. J Mater Chem B 9(5):1238–1258. https://doi.org/10.1039/D0TB02099K10.1039/D0TB02099K ↗
75. Babaluei M, Mojarab Y, Mottaghitalab F et al (2023) Injectable hydrogel based on silk fibroin/carboxymethyl cellulose/agarose containing polydopamine functionalized graphene oxide with conductivity, hemostasis, antibacterial, and anti-oxidant properties for full-thickness burn healing. Int J Biol Macromol 249:126051. https://doi.org/10.1016/j.ijbiomac.2023.12605110.1016/j.ijbiomac.2023.126051 ↗
76. Haque SN, Bhuyan MM, Jeong JH (2024) Radiation-induced hydrogel for water treatment. Gels 10(6):375. https://doi.org/10.3390/gels1006037510.3390/gels10060375 ↗
77. Lu R, Dongliang L, Yuan Z et al (2021) Radiation preparation and mechanical properties of a high-strength graphene oxide/ highly substituted hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel. J Radiat Res Radiat Process 39(6):29–38. https://doi.org/10.11889/j.1000-3436.2021.rrj.39.06120410.11889/j.1000-3436.2021.rrj.39.061204 ↗
78. Passornraprasit N, Siripongpreda T, Ninlapruk S et al (2022) γ-irradiation crosslinking of graphene oxide/cellulose nanofiber/poly (acrylic acid) hydrogel as a urea sensing patch. Int J Biol Macromol 213:1037–1046. https://doi.org/10.1016/j.ijbiomac.2022.06.05310.1016/j.ijbiomac.2022.06.053 ↗
79. Kolhe A, Chauhan A, Dongre A (2022) A review on various methods for the cross-linking of polymers. Res J Pharmaceut Dosage Forms Technol 14(2):183–188. https://doi.org/10.52711/0975-4377.2022.0002910.52711/0975-4377.2022.00029 ↗
80. Batta-Mpouma J, Kandhola G, Sakon J et al (2022) Covalent crosslinking of colloidal cellulose nanocrystals for multifunctional nanostructured hydrogels with tunable physicochemical properties. Biomacromol 23(10):4085–4096. https://doi.org/10.1021/acs.biomac.2c0041710.1021/acs.biomac.2c00417 ↗
81. De France KJ, Chan KJW, Cranston ED et al (2016) Enhanced mechanical properties in cellulose nanocrystal–poly (oligoethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linking. Biomacromol 17(2):649–660. https://doi.org/10.1021/acs.biomac.5b0159810.1021/acs.biomac.5b01598 ↗
82. Zhang T, Zuo T, Hu D et al (2017) Dual physically cross-linked nanocomposite hydrogels reinforced by tunicate cellulose nanocrystals with high toughness and good self-recoverability. ACS Appl Mater Interfaces 9(28):24230–24237. https://doi.org/10.1021/acsami.7b0621910.1021/acsami.7b06219 ↗
83. Jamshaid U, Anton N, Elhassan M et al (2024) Novel hydrogels based on the nano-emulsion formulation process: development, rheological characterization, and study as a drug delivery system. Pharmaceutics 16(6):812. https://doi.org/10.3390/pharmaceutics1606081210.3390/pharmaceutics16060812 ↗
84. Işıklan N, Aytekin H, Sonkaya Ö et al (2025) Multi-stimuli-responsive carboxymethyl cellulose/κ-carrageenan nanogels integrated with magnetic graphene oxide for colon-specific delivery of sunitinib. Cellulose 32(11):6727–6751. https://doi.org/10.1007/s10570-025-06635-310.1007/s10570-025-06635-3 ↗
85. Waresindo WX, Luthfianti HR, Priyanto A et al (2023) Freeze–thaw hydrogel fabrication method: basic principles, synthesis parameters, properties, and biomedical applications. Mater Res Express 10(2):024003. https://doi.org/10.1088/2053-1591/acb98e10.1088/2053-1591/acb98e ↗
86. Bernal-Chávez SA et al (2023) Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach. J Biol Eng 17(1):3510.1186/s13036-023-00353-9 ↗
87. Rui-Hong X, Romero-Montero A, Hernández-Parra H et al (2016) Preparation and properties of graphene oxide-regenerated cellulose/polyvinyl alcohol hydrogel with pH-sensitive behavior. Carbohyd Polym 138:222–228. https://doi.org/10.1186/s13036-023-00353-910.1186/s13036-023-00353-9 ↗
88. Odziomek K, Drabczyk AK, Kościelniak P et al (2024) The role of freeze-drying as a multifunctional process in improving the properties of hydrogels for medical use. Pharmaceuticals 17(11):1512. https://doi.org/10.3390/ph1711151210.3390/ph17111512 ↗
89. Liu H, Pan B, Wang Q et al (2021) Crucial roles of graphene oxide in preparing alginate/nanofibrillated cellulose double network composites hydrogels. Chemosphere 263:128240. https://doi.org/10.1016/j.chemosphere.2020.12824010.1016/j.chemosphere.2020.128240 ↗
90. Sohni S, Abdullah BEM et al (2025) Evaluating catalytic and antibacterial properties of composite hydrogel based on biomimetically synthesized CeO(2) nanoparticles anchored onto microcrystalline cellulose/reduced graphene oxide. Int J Biol Macromol 306(Pt 4):141749. https://doi.org/10.1016/j.ijbiomac.2025.14174910.1016/j.ijbiomac.2025.141749 ↗
91. Luo H, Dong J, Yao F et al (2018) Layer-by-layer assembled bacterial cellulose/graphene oxide hydrogels with extremely enhanced mechanical properties. Nano-Micro Lett 10(3):42. https://doi.org/10.1007/s40820-018-0195-310.1007/s40820-018-0195-3 ↗
92. Zhao D, Huang J, Zhong Y et al (2016) High-strength and high-toughness double-cross-linked cellulose hydrogels: a new strategy using sequential chemical and physical cross-linking. Adv Funct Mater 26(34):6279–6287. https://doi.org/10.1002/adfm.20160164510.1002/adfm.201601645 ↗
93. Zhang H, Gan X, Yan Y et al (2024) A sustainable dual cross-linked cellulose hydrogel electrolyte for high-performance zinc-metal batteries. Nano-Micro Lett 16(1):106. https://doi.org/10.1007/s40820-024-01329-010.1007/s40820-024-01329-0 ↗
94. Shen Y, Zhang X, Su J et al (2023) Significantly enhancing mechanical and thermal properties of cellulose-based composites by adding small amounts of lysozyme-modified graphene nanoplatelets via forming strong double-cross-linked interface interactions. ACS Appl Mater Interfaces 15(36):43159–43168. https://doi.org/10.1021/acsami.3c0819510.1021/acsami.3c08195 ↗
95. Khabibullin A, Alizadehgiashi M, Khuu N et al (2017) Injectable shear-thinning fluorescent hydrogel formed by cellulose nanocrystals and graphene quantum dots. Langmuir 33(43):12344–12350. https://doi.org/10.1021/acs.langmuir.7b0290610.1021/acs.langmuir.7b02906 ↗
96. Zheng ALT, Sabidi S, Ohno T et al (2022) Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications. Chemosphere 286:131731. https://doi.org/10.1016/j.chemosphere.2021.13173110.1016/j.chemosphere.2021.131731 ↗
97. Youssef AM, Hasanin MS, El-Aziz MEA et al (2021) Conducting chitosan/hydroxylethyl cellulose/polyaniline bionanocomposites hydrogel based on graphene oxide doped with Ag-NPs. Int J Biol Macromol 167:1435–1444. https://doi.org/10.1016/j.ijbiomac.2020.11.09710.1016/j.ijbiomac.2020.11.097 ↗
98. Chen Z, Pan Y, Cai P (2022) Sugarcane cellulose-based composite hydrogel enhanced by g-C(3)N(4) nanosheet for selective removal of organic dyes from water. Int J Biol Macromol 205:37–48. https://doi.org/10.1016/j.ijbiomac.2022.02.03510.1016/j.ijbiomac.2022.02.035 ↗
99. Parvaneh S, Pourmadadi M, Abdouss M et al (2023) Carboxymethyl cellulose/starch/reduced graphene oxide composite as a pH-sensitive nanocarrier for curcumin drug delivery. Int J Biol Macromol 241:124566. https://doi.org/10.1016/j.ijbiomac.2023.12456610.1016/j.ijbiomac.2023.124566 ↗
100. Ostovar S, Pourmadadi M, Zaker MA (2023) Co-biopolymer of chitosan/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment. Int J Biol Macromol 253(4):127091. https://doi.org/10.1016/j.ijbiomac.2023.12709110.1016/j.ijbiomac.2023.127091 ↗