High-Throughput Cardiomyocytes Biosensing: From Single-Parameter Detection to Integrated Mechano-Electrophysiological Platforms
Source abstract
Abstract
Developing the in vitro cardiac sensing platform is promising to study cardiac physiology, disease mechanisms, drug development, and personalized medicine. Changes in the electrophysiological activity and contractile strength of cardiomyocytes are particularly important for generating accurate in vitro cardiac platforms. Existing platforms generally have in situ sensing capabilities to capture changes in the electrophysiological or mechanical behavior of cardiomyocytes. However, sensing platforms still face challenges in high-throughput detection and simultaneous mechano-electrophysiological detection. This review covers the latest progress and shortcomings from high-throughput single physiological parameter detection platforms to mechano-electrophysiological simultaneous detection sensing platforms. Finally, we discuss the future prospects of mechano-electrophysiological sensing platforms in cardiomyocyte detection in order to achieve a more accurate and efficient in vitro cardiac sensing platform to facilitate heart disease research and drug screening.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Force Microscopy Techniques and Applications · Analytical Chemistry and Sensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
Shandong Institute of Mechanical Design and Research, Jinan 250353, China
State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China
Funding
Department of Education of Shandong Province · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province · Jinan Science and Technology Bureau · Shandong Academy of Sciences · Key Technology Research and Development Program of Shandong Province · Research Leader Studio in Colleges and Universities of Jinan · Talent research project of the pilot project of science, education and industry integration
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