Ibrutinib conjugated surface-functionalized multiwalled carbon nanotubes and its biopolymer composites for targeting prostate carcinoma
Source abstract
Abstract
In this report, nanocomposites are composed of surface-functionalized multi-walled carbon nanotubes (f-MWCNTs) and polymers (polyethylene glycol, chitosan) or silver nanoparticles (AgNPs) were successfully synthesized and used as nanocarriers for drug delivery. The drug (Ibrutinib, Ibr) encapsulated with different nanocomposites was used for effective prostate cancer treatment. The as-prepared bioconjugates were confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, and Raman spectroscopy. The drug loading efficiency of 95.5% was achieved for f-MWCNTs/AgNPs composite. The drug release profile showed that the f-MWCNTs/AgNPs composite released 79% in 84 h at pH 5.5 indicating the sustainable drug release. Further, these Ibr-loaded nanocomposites were conjugated with T30 oligonucleotides (T30 ODN) for targeting over-expressed prostate-specific membrane antigen in the prostate gland. The prostate anti-cancer activity was evaluated using PC-3 and MDA-MB-231 cancer cells and the results indicated that the Ibr- loaded nanocomposites conjugated with T30 ODN exhibited higher cell killing efficiency compared to the free Ibr. Therefore, these conjugated nanocomposites are effective drug delivery systems for prostate cancer disease targeted therapy.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · HER2/EGFR in Cancer Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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