Arginine–malate-based dual-emission carbon dots for uric acid determination in human serum with a miniaturized device
Source abstract
Abstract
Determination of uric acid is very important for the clinical diagnosis of several diseases correlated with their variations in human serum. In this work, dual-emission arginine carbon dots (Arg-CDs) were synthesized for the determination of uric acid (UA). After optimization, the obtained Arg-CD was excited at 360 nm, which exhibited dual-emission fluorescence peaks at 445 nm and 514 nm, respectively. Because of the electrostatic interaction between the secondary amine group in UA and the carboxyl group on the Arg-CD, the formation of hydrogen bonds between the ketone/hydroxyl group in the UA molecule and the amino group on the surface of Arg-CD, the mixture could cause the fluorescent signal to be activated. Particularly, Arg-CD showed a good line relationship to UA between 330 and 630 µM (the concentration of uric acid in the serum for healthy people is 240–520 μM), and the lower detection limits are 7.14 µM. With the high selectivity and sensitivity to uric acid, Arg-CD could be applied in the UA determination of the human serum samples, whose accuracy rate was in the range of 98.5–101.5% and relative standard deviation (RSD) value was lower than 4%. And we also designed a miniaturized device for UA determination conveniently.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Electrochemical sensors and biosensors · Analytical chemistry methods development
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Zhao L, Blackburn J, Brosseau CL (2015) Quantitative detection of uric acid by electrochemical-surface enhanced raman spectroscopy using a multilayered Au/Ag substrate. Anal Chem 87:441–44710.1021/ac503967s ↗
2. Xiong Q, Liu V, Xu YC (2019) Effects of uric acid on diabetes mellitus and its chronic complications. Int J Endocrinol 2019:1–810.1155/2019/9691345 ↗
3. Watanabe S, Kawano T, Horino T, Matsumoto T, Nagata K, Hatakeyama Y, Locatelli FM, Yokoyama M, Terada Y, Okuhara Y (2019) Influence of hyperuricemia treatment on postoperative acute kidney injury among hyperuricemia patients: a single-center retrospective database analysis. BMC Res Notes 12:1–510.1186/s13104-019-4783-1 ↗
4. Simonato M, Agoston DV, Brooks KA, Dulla C, Fureman B, Henshall DC, Pitkänen A, Theodore WH, Twyman RE, Kobeissy FH, Wang KK, Whittemore V, Wilcox KS (2021) Identification of clinically relevant biomarkers of epileptogenesis: a strategic roadmap. Nat Rev Neurol 17:231–24210.1038/s41582-021-00461-4 ↗
5. Zhu J, Chu HY, Shen JW, Wang CZ, Wei YM (2021) Nitrogen and fluorine co-doped green fluorescence carbon dots as a label-free probe for determination of cytochrome c in serum and temperature sensing. J Coll Interface Sci 586:683–69110.1016/j.jcis.2020.10.138 ↗
6. Sha R, Vishnu N, Badhulika S (2019) MoS2 based ultra-low-cost, flexible, non-enzymatic and non-invasive electrochemical sensor for highly selective detection of uric acid in human urine samples. Sens Actuators B Chem 279:53–6010.1016/j.snb.2018.09.106 ↗
7. Hinterberger V, Damm C, Haines P, Guldi DM, Peukert W (2019) Purification and structural elucidation of carbon dots by column chromatography. Nanoscale 11:8464–847410.1039/C9NR01029G ↗
8. Maleki S, Madrakian T, Afkhami A (2018) Application of polyacrylonitrile nanofibers decorated with magnetic carbon dots as a resonance light scattering sensor to determine famotidine. Talanta 181:286–29510.1016/j.talanta.2018.01.021 ↗
9. Xie X, Wang DP, Guo CX, Liu YH, Rao QH, Lou FM, Li QN, Dong YQ, Li QF, Yang HB, Hu FX (2021) Single-atom ruthenium biomimetic enzyme for simultaneous electrochemical detection of dopamine and uric acid. Anal Chem 93:4916–492310.1021/acs.analchem.0c05191 ↗
10. Shi B, Su YB, Duan Y, Chen SY, Zuo WY (2019) A nanocomposite prepared from copper(II) and nitrogen-doped graphene quantum dots with peroxidase mimicking properties for chemiluminescent determination of uric acid. Microchim Acta 186:1–1010.1007/s00604-019-3491-9 ↗
11. Wang Q, Wen X, Kong JM (2019) Recent progress on uric acid detection: a review. Crit Rev Anal Chem 50:359–37510.1080/10408347.2019.1637711 ↗
12. Guo R, Li L, Wang BW, Xiang YE, Zou GQ, Zhu YR, Hou HS, Ji XB (2021) Functionalized carbon dots for advanced batteries. Energy Storage Mater 37:8–3910.1016/j.ensm.2021.01.020 ↗
13. Zhang HQ, Wang H, Wang Y, Xin BF (2020) Controlled synthesis and photocatalytic performance of biocompatible uniform carbon quantum dots with microwave absorption capacity. Appl Surf Sci 512:14575110.1016/j.apsusc.2020.145751 ↗
14. Miao S, Liang K, Zhu JJ, Yang B, Zhao DY, Kong B (2020) Hetero-atom-doped carbon dots: doping strategies, properties and applications. Nano Today 33:10087910.1016/j.nantod.2020.100879 ↗
15. Hoang V, Dave K, Gomes VG (2019) Carbon quantum dot-based composites for energy storage and electrocatalysis: mechanism, applications and future prospects. Nano Energy 66:10409310.1016/j.nanoen.2019.104093 ↗
16. Kalaiyarasan G, Veerapandian M, JebaMercy G, Balamurugan K, Joseph J (2019) Amygdalin-functionalized carbon quantum dots for probing β-glucosidase activity for cancer diagnosis and therapeutics. ACS Biomater Sci Eng 5:3089–309910.1021/acsbiomaterials.9b00394 ↗
17. Pardo J, Peng ZL, Leblanc RM (2018) Cancer targeting and drug delivery using carbon-based quantum dots and nanotubes. Molecules 23:37810.3390/molecules23020378 ↗
18. Wu P, Xu YX, Zhan JY, Li Y, Xue HG, Pang H (2018) The research development of quantum dots in electrochemical energy storage. Small 14:180147910.1002/smll.201801479 ↗
19. Han Y, Yang WX, Luo XL, He X, Yu Y, Li CH, Tang WZ, Yue TL, Li ZH (2019) Cu2+-triggered carbon dots with synchronous response of dual emission for ultrasensitive ratiometric fluorescence determination of thiophanate-methyl residues. J Agric Food Chem 67:12576–1258310.1021/acs.jafc.9b04720 ↗
20. Hou J, Li H, Tang YQ, Sun JY, Fu H, Qu X, Zheng S (2018) Supported N-doped carbon quantum dots as the highly effective peroxydisulfate catalysts for bisphenol F degradation. Appl Catal B 238:225–23510.1016/j.apcatb.2018.07.032 ↗
21. Fu C, Qian K, Fu AL (2017) Arginine-modified carbon dots probe for live cell imaging and sensing by increasing cellular uptake efficiency. Mater Sci Eng C 76:350–35510.1016/j.msec.2017.03.084 ↗
22. Zhao D, Ma WT, Xiao XC (2018) The recognition of sweat latent fingerprints with green-emitting carbon dots. Nanomaterials 8:61210.3390/nano8080612 ↗
23. Pang S, Zhang Y, Wu CK, Feng SL (2016) Fluorescent carbon dots sensor for highly sensitive detection of guanine. Sens Actuators B Chem 222:857–86310.1016/j.snb.2015.09.037 ↗
24. Atchudan R, Edison T, Sethuraman MG, Lee YR (2016) Efficient synthesis of highly fluorescent nitrogen-doped carbon dots for cell imaging using unripe fruit extract of prunus mume. Appl Surf Sci 384:432–44110.1016/j.apsusc.2016.05.054 ↗
25. Mohan R, Drbohlavova J, Hubalek J (2018) Dual band emission in carbon dots. Chem Phys Lett 692:196–20110.1016/j.cplett.2017.12.029 ↗
26. Liu R, Yang R, Qu CJ, Mao HC, Hu Y, Li JJ, Qu LB (2017) Synthesis of glycine-functionalized graphene quantum dots as highly sensitive and selective fluorescent sensor of ascorbic acid in human serum. Sens Actuators B Chem 241:644–65110.1016/j.snb.2016.10.096 ↗
27. Yang S, Wang K, Wang X, Sun XH (2020) Organic acid participation strategy for the synthesis of highly fluorescent carbon dots and their application in dual-mode determination of copper ions. Appl Surf Sci 505:14456710.1016/j.apsusc.2019.144567 ↗
28. Sudolská M, Otyepka M (2017) Exact roles of individual chemical forms of nitrogen in the photoluminescent properties of nitrogen-doped carbon dots. Appl Mater Today 7:190–20010.1016/j.apmt.2017.03.004 ↗
29. Kumar N, Gupta SK, Jagadeesh D, Kanny K, Bux F (2015) Development of poly (aspartic acid-co-malic acid) composites for calcium carbonate and sulphate scale inhibition. Environ Technol 36:1281–129010.1080/09593330.2014.984773 ↗
30. Durán G, Benavidez TE, Contento AM, Ríos A, García CD (2017) Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor. J Pharm Anal 7:324–33110.1016/j.jpha.2017.07.002 ↗
31. Lu W, Gao YF, Jiao Y, Shuang SM, Li CZ, Dong C (2017) Carbon nano-dots as a fluorescent and colorimetric dual-readout probe for the detection of arginine and Cu(2+) and its logic gate operation. Nanoscale 9:11545–1155210.1039/C7NR02336G ↗
32. Yang P, Zhu ZQ, Zhang T, Zhang W, Chen WM, Cao YZ, Chen MZ, Zhou XY (2019) Orange-emissive carbon quantum dots: toward application in wound pH monitoring based on colorimetric and fluorescent changing. Small 15:190282310.1002/smll.201902823 ↗
33. Zhang T, Sun XY, Liu B (2011) Synthesis of positively charged CdTe quantum dots and detection for uric acid. Spectrochim Acta Part A 79:1566–157210.1016/j.saa.2011.05.014 ↗
34. Sahoo N, Jana GC, Aktara MN, Das S, Nayim S, Patra A, Bhattacharjee P, Bhadra K, Hossain M (2020) Carbon dots derived from lychee waste: Application for Fe(3+) ions sensing in real water and multicolor cell imaging of skin melanoma cells. Mater Sci Eng C Mater Biol Appl 108:11042910.1016/j.msec.2019.110429 ↗
35. Zhou Y, Liyanage PY, Geleroff DL, Peng ZL, Mintz KJ, Hettiarachchi SD, Pandey RR, Chusuei CC, Blackwelder PL, Leblanc RM (2018) Photoluminescent carbon dots: a mixture of heterogeneous fractions. ChemPhysChem 19:2589–259710.1002/cphc.201800248 ↗
36. Huang S, Yang E, Yao J, Chu X, Liu Y, Zhang Y, Xiao Q (2019) Nitrogen, cobalt co-doped fluorescent magnetic carbon dots as ratiometric fluorescent probes for cholesterol and uric acid in human blood serum. ACS Omega 4:9333–934210.1021/acsomega.9b00874 ↗
37. Li C, Zheng YK, Ding HW, Jiang H, Wang XM (2009) Chromium (III)-doped carbon dots: fluorometric detection of p-nitrophenol via inner filter effect quenching. Microchim Acta 186:1–8
38. Liu H, Xu CY, Bai YL, Liu L, Liao DM, Liang JG, Liu LZ, Han HY (2017) Interaction between fluorescein isothiocyanate and carbon dots: Inner filter effect and fluorescence resonance energy transfer. Spectrochim Acta Part A 171:311–31610.1016/j.saa.2016.08.018 ↗
39. Chen Q, Zhu PP, Xiong J, Gao LX, Tan KJ (2019) A sensitive and selective triple-channel optical assay based on red-emissive carbon dots for the determination of PFOS. Microchem J 145:388–39610.1016/j.microc.2018.11.003 ↗
40. Yang Y, Huo DQ, Wu HX, Wang XF, Yang JS, Bian MH, Ma Y, Hou CJ (2018) N, P-doped carbon quantum dots as a fluorescent sensing platform for carbendazim detection based on fluorescence resonance energy transfer. Sens Actuators, B Chem 274:296–30310.1016/j.snb.2018.07.130 ↗
41. Zhao C, Jiao Y, Hu F, Yang YL (2018) Green synthesis of carbon dots from pork and application as nanosensors for uric acid detection. Spectrochim Acta Part A 190:360–36710.1016/j.saa.2017.09.037 ↗
42. Liang T, Yang PW, Wu TH, Shi MH, Xu XY, Qiang TT, Sun XL (2020) A general strategy to quantify analytes through fluorescence chromaticity and luminosity. Chin Chem Lett 31:2975–297910.1016/j.cclet.2020.07.012 ↗