Development of a resveratrol–zein–dopamine–lecithin delivery system with enhanced stability and mucus permeation
Source abstract
Abstract
The development of multi-functional nanoparticles is important in overcoming the poor stability and low mucus permeation of traditional drug delivery systems. Hence, the encapsulation of a model drug, resveratrol (RES), into zein–polydopamine–lecithin (ZPLs) nanoparticles was investigated through a delicately controlled phase separation process. The surface of the nanoparticles obtained was successfully modified with lecithin, which endowed them with neutral and hydrophilic properties. Due to the strong charge repulsion of the particles, the fabricated ZPLs showed high stability under the conditions of a saline solution, various pH, long-term storage and high-speed centrifugation. In vitro study suggested that the RES exhibited remarkably sustained release performance after loading into ZPLs. The quantificational experiment of the Transwell system suggested that most of the ZPLs could pass through mucus and exhibited high mucus permeation. This study provides a new opportunity to prepare RES-ZPLs nanospheres as a smart drug nanocarrier, with enhanced stability and mucus permeation.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Botulinum Toxin and Related Neurological Disorders · Advancements in Transdermal Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Sosnik A, das Neves J, Sarmento B (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci 39:2030–207510.1016/j.progpolymsci.2014.07.010 ↗
2. Date AA, Hanes J, Ensign LM (2016) Nanoparticles for oral delivery: design, evaluation and state-of-the-art. J Control Release 240:504–52610.1016/j.jconrel.2016.06.016 ↗
3. Huang J, Shu Q, Wang L, Wu H, Wang AY, Mao H (2015) Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine. Biomaterials 39:105–11310.1016/j.biomaterials.2014.10.059 ↗
4. Shan W, Zhu X, Liu M, Li L, Zhong J, Sun W, Zhang Z, Huang Y (2015) Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin. ACS Nano 9:2345–235610.1021/acsnano.5b00028 ↗
5. Ensign LM, Cone R, Hanes J (2012) Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev 64:557–57010.1016/j.addr.2011.12.009 ↗
6. Chen MC, Wong HS, Lin KJ, Chen HL, Wey SP, Sonaje K, Lin YH, Chu CY et al (2009) The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 30:6629–663710.1016/j.biomaterials.2009.08.030 ↗
7. Dong Y, Feng SS (2005) Poly(d, l-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs. Biomaterials 26:6068–607610.1016/j.biomaterials.2005.03.021 ↗
8. Lopes M, Shrestha N, Correia A, Shahbazi MA, Sarmento B, Hirvonen J, Veiga F, Seica R, Ribeiro A, Santos HA (2016) Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin. J Control Release 232:29–4110.1016/j.jconrel.2016.04.012 ↗
9. Huyghebaert N, De Beer J, Vervaet C, Remon JP (2007) Compounding of vitamin A, D3, E and K3 supplements for cystic fibrosis patients: formulation and stability study. J Clin Pharm Ther 32:489–49610.1111/j.1365-2710.2007.00855.x ↗
10. Yao K, Chen W, Song F, McClements DJ, Hu K (2018) Tailoring zein nanoparticle functionality using biopolymer coatings: impact on curcumin bioaccessibility and antioxidant capacity under simulated gastrointestinal conditions. Food Hydrocolloid 79:262–27210.1016/j.foodhyd.2017.12.029 ↗
11. Wang W, Zhang L, Le Y, Chen JF, Wang J, Yun J (2015) Synergistic effect of PEGylated resveratrol on delivery of anticancer drugs. Int J Pharm 498:134–14110.1016/j.ijpharm.2015.12.016 ↗
12. Penalva R, Esparza I, Larraneta E, Gonzalez-Navarro CJ, Gamazo C, Irache JM (2015) Zein-based nanoparticles improve the oral bioavailability of resveratrol and its anti-inflammatory effects in a mouse model of endotoxic shock. J Agric Food Chem 63:5603–561110.1021/jf505694e ↗
13. Cho AR, Chun YG, Kim BK, Park DJ (2014) Preparation of alginate–CaCl2 microspheres as resveratrol carriers. J Mater Sci 49:4612–4619. https://doi.org/10.1007/s10853-014-8163-x10.1007/s10853-014-8163-x ↗
14. Zhang Y, Cui L, Li F, Shi N, Li C, Yu X, Chen Y, Kong W (2016) Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems. Int J Pharm 513:191–21010.1016/j.ijpharm.2016.09.023 ↗
15. Dai L, Sun C, Li R, Mao L, Liu F, Gao Y (2017) Structural characterization, formation mechanism and stability of curcumin in zein–lecithin composite nanoparticles fabricated by antisolvent co-precipitation. Food Chem 237:1163–117110.1016/j.foodchem.2017.05.134 ↗
16. Fan Y, Liu Y, Gao L, Zhang Y, Yi J (2018) Improved chemical stability and cellular antioxidant activity of resveratrol in zein nanoparticle with bovine serum albumin-caffeic acid conjugate. Food Chem 261:283–29110.1016/j.foodchem.2018.04.055 ↗
17. Haham M, Ish-Shalom S, Nodelman M, Duek I, Segal E, Kustanovich M, Livney YD (2012) Stability and bioavailability of vitamin D nanoencapsulated in casein micelles. Food Funct 3:737–74410.1039/c2fo10249h ↗
18. Liu GJ, Li SM, Huang Y, Wang HD, Jiang YB (2016) Incorporation of 10-hydroxycamptothecin nanocrystals into zein microspheres. Chem Eng Sci 155:405–41410.1016/j.ces.2016.08.029 ↗
19. Liu CM, Chen Y, Wang XM, Huang J, Chang PR, Anderson DP (2010) Improvement in physical properties and cytocompatibility of zein by incorporation of pea protein isolate. J Mater Sci 45:6775–6785. https://doi.org/10.1007/s10853-010-4774-z10.1007/s10853-010-4774-z ↗
20. Rouf TB, Schmidt G, Kokini JL (2018) Zein–Laponite nanocomposites with improved mechanical, thermal and barrier properties. J Mater Sci 53:7387–7402. https://doi.org/10.1007/s10853-018-2600-110.1007/s10853-018-2061-6 ↗
21. Wang HD, Zhu W, Huang YN, Li ZX, Jiang YB, Xie Q (2017) Facile encapsulation of hydroxycamptothecin nanocrystals into zein-based nanocomplexes for active targeting in drug delivery and cell imaging. Acta Biomater 61:88–10010.1016/j.actbio.2017.04.017 ↗
22. Li S, Li Z, Pang J, Chen J, Wang H, Xie Q, Jiang Y (2018) Polydopamine-mediated carrier with stabilizing and self-antioxidative properties for polyphenol delivery systems. Ind Eng Chem Res 57:590–59910.1021/acs.iecr.7b04070 ↗
23. Pang JF, Li ZX, Li SM, Lin SY, Wang HD, Xie QL, Jiang YB (2018) Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib. J Mater Sci 53:14907–14921. https://doi.org/10.1007/s10853-018-2684-710.1007/s10853-018-2684-7 ↗
24. Wu L, Shan W, Zhang Z, Huang Y (2018) Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties. Adv Drug Deliv Rev 124:150–16310.1016/j.addr.2017.10.001 ↗
25. Cone RA (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61:75–8510.1016/j.addr.2008.09.008 ↗
26. Garcia-Diaz M, Birch D, Wan F, Nielsen HM (2018) The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. Adv Drug Deliv Rev 124:107–12410.1016/j.addr.2017.11.002 ↗
27. Huckaby JT, Lai SK (2018) PEGylation for enhancing nanoparticle diffusion in mucus. Adv Drug Deliv Rev 124:125–13910.1016/j.addr.2017.08.010 ↗
28. Wang YY, Lai SK, Suk JS, Pace A, Cone R, Hanes J (2008) Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that “slip” through the human mucus barrier. Angew Chem Int Ed 47:9726–972910.1002/anie.200803526 ↗
29. Shan W, Zhu X, Tao W, Cui Y, Liu M, Wu L, Li L, Zheng Y, Huang Y (2016) Enhanced oral delivery of protein drugs using zwitterion-functionalized nanoparticles to overcome both the diffusion and absorption barriers. ACS Appl Mater Interfaces 8:25444–2545310.1021/acsami.6b08183 ↗
30. Yang Q, Jacobs TM, McCallen JD, Moore DT, Huckaby JT, Edelstein JN, Lai SK (2016) Analysis of pre-existing IgG and IgM antibodies against polyethylene Glycol (PEG) in the general population. Anal Chem 88:11804–1181210.1021/acs.analchem.6b03437 ↗
31. Pozzi D, Colapicchioni V, Caracciolo G, Piovesana S, Capriotti AL, Palchetti S, De Grossi S, Riccioli A et al (2014) Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells. Nanoscale 6:2782–279210.1039/c3nr05559k ↗
32. Liang H, Huang Q, Zhou B, He L, Lin L, An Y, Li Y, Liu S et al (2015) Self-assembled zein–sodium carboxymethyl cellulose nanoparticles as an effective drug carrier and transporter. J Mater Chem B 3:3242–325310.1039/C4TB01920B ↗
33. Jose S, Anju SS, Cinu TA, Aleykutty NA, Thomas S, Souto EB (2014) In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery. Int J Pharm 474:6–1310.1016/j.ijpharm.2014.08.003 ↗
34. Davidov-Pardo G, Joye IJ, Mcclements DJ (2015) Encapsulation of resveratrol in biopolymer particles produced using liquid antisolvent precipitation. Food Hydrocolloid 45:309–31610.1016/j.foodhyd.2014.11.023 ↗
35. Wang X, Chen Y, Dahmani FZ, Yin L, Zhou J, Yao J (2014) Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Biomaterials 35:7654–766510.1016/j.biomaterials.2014.05.053 ↗
36. Wang Y, Padua GW (2012) Nanoscale characterization of zein self-assembly. Langmuir 28:2429–243510.1021/la204204j ↗
37. Kahlweit M (1975) Ostwald ripening of precipitates. Adv Colloid Interface Sci 5:1–3510.1016/0001-8686(75)85001-9 ↗
38. Venuti V, Cannavà C, Cristiano MC, Fresta M, Majolino D, Paolino D, Stancanelli R, Tommasini S et al (2014) A characterization study of resveratrol/sulfobutyl ether-β-cyclodextrin inclusion complex and in vitro anticancer activity. Colloids Surf B 115:22–2810.1016/j.colsurfb.2013.11.025 ↗
39. Patel A, Hu Y, Tiwari JK, Velikov KP (2010) Synthesis and characterisation of zein–curcumin colloidal particles. Soft Matter 6:6192–619910.1039/c0sm00800a ↗
40. Dreyer DR, Miller DJ, Freeman BD, Paul DR, Bielawski CW (2012) Elucidating the structure of poly(dopamine). Langmuir 28:6428–643510.1021/la204831b ↗
41. Shukla R, Cheryan M (2001) Zein: the industrial protein from corn. Ind Crops Prod 13:171–19210.1016/S0926-6690(00)00064-9 ↗
42. Lau ET, Giddings SJ, Mohammed SG, Dubois P, Johnson SK, Stanley RA, Halley PJ, Steadman KJ (2013) Encapsulation of hydrocortisone and mesalazine in zein microparticles. Pharmaceutics 5:277–29310.3390/pharmaceutics5020277 ↗