Enhanced dielectric constant and structural transformation in Fe-doped hydroxyapatite synthesized by wet chemical method
Source abstract
Abstract
We report the synthesis of single-phase Fe-doped hydroxyapatite (HAp) [Ca10−xFe x (PO4)6(OH)2 (0.0 ≤ x ≤ 0.3)] and enhanced dielectric constant of HAp with Fe doping. Rietveld analysis shows the change in x-axis-oriented lattice constant a in Fe-doped x = 0.1 and 0.3 compositions in comparison with parent HAp, while z-axis-oriented lattice constant c does not show any considerable change. Analysis of absorbance data shows two new symmetric stretching peaks for Fe-doped x = 0.1 and x = 0.3 compositions, which are not present in parent HAp. Magnetic measurements show paramagnetic behaviour of all Fe-doped samples at 300 K. Fe-doped Ca9.9Fe0.1(PO4)6(OH)2 composition shows increase in impedance in the presence of 500 Oersted (Oe) applied magnetic field in comparison with impedance in the absence of magnetic field. Ca9.9Fe0.1(PO4)6(OH)2 composition shows increase in dielectric constant in comparison with parent HAp in frequency range 5–35 MHz. Fe-doped Ca9.9Fe0.1(PO4)6(OH)2 composition shows ~ 970% colossal magnetoimpedance at 100 Hz and ~ 200% at 20 MHz frequency.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Multiferroics and related materials · Crystal Structures and Properties · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (43)
Show source-provided references
1. Kay M, Young R, Posner A (1964) Crystal structure of hydroxyapatite. Nature 204:1050–105210.1038/2041050a0 ↗
2. Han GG, Lee S, Kim DW, Kim DH, Noh JH, Park JH, Roy S, Ahn TK, Jung HS (2013) A simple method to control morphology of hydroxyapatite nano- and microcrystals by altering phase transition route. Cryst Growth Des 13:3414–341810.1021/cg400308a ↗
3. Inoue K, Sassa K, Yokogawa Y, Sakka Y, Okido M, Asai S (2003) Control of crystal orientation of hydroxyapatite by imposition of a high magnetic field. Mater Trans 44:1133–113710.2320/matertrans.44.1133 ↗
4. Mahabole M, Aiyer R, Ramakrishan C, Sreedhar B, Khaimar R (2005) Synthesis, characterization and gas sensing property of hydroxyapatite ceramic. Bull Mater Sci 28:535–54510.1007/BF02706339 ↗
5. Jevtic M, Mitric M, Skapin S, Jancar B, Ignjatovic N, Uskokovic D (2008) Crystal structure of hydroxyapatite nanorods synthesized by sonochemical homogeneous precipitation. Cryst Growth Des 8:2217–222210.1021/cg7007304 ↗
6. Singh B, Dubey AK, Kumar S, Saha N, Basu B, Gupta R (2011) In vitro biocompatibility and antimicrobial activity of wet chemically prepared Ca10−xAgx(PO4)6(OH)2 (0.0 ≤ x ≤ 0.5) hydroxyapatites. Mater Sci Eng, C 31:1320–132910.1016/j.msec.2011.04.015 ↗
7. Boanini E, Gazzano M, Bigi A (2010) Ionic substitutions in calcium phosphates synthesized at low temperature. Acta Biomater 6:1882–189410.1016/j.actbio.2009.12.041 ↗
8. Ning CQ, Zhou Y (2002) In vitro bioactivity of a biocomposite fabricated from HA and Ti powders by powder metallurgy method. Biomaterials 23:2909–291510.1016/S0142-9612(01)00419-7 ↗
9. Goodwin CB, Brighton CT, Guyer RD, Johnson JR, Light KI, Yuan HA (1999) A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions. Spine 24:1349–135610.1097/00007632-199907010-00013 ↗
10. Scott G, King JB (1994) A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J Bone Joint Surg Am 76:820–82610.2106/00004623-199406000-00005 ↗
11. Yamashita K (2003) Enhanced bioactivity of electrically poled hydroxyapatite ceramics and coatings. Mater Sci Forum 426:3237–324210.4028/www.scientific.net/MSF.426-432.3237 ↗
12. Otter MW, McLeod KJ, Rubin CT (1998) Effects of electromagnetic fields in experimental fracture repair. Clin Orthop Relat Res 335:S90–S11210.1097/00003086-199810001-00011 ↗
13. Xue W, Moore JL, Hosick HL, Bose S, Bandyopadhyay A, Lu W, Cheung KM, Luk KD (2006) Osteoprecursor cell response to strontium-containing hydroxyapatite ceramics. J Biomed Mater Res A 79:80410.1002/jbm.a.30815 ↗
14. Singh B, Kumar S, Basu B, Gupta R (2013) Enhanced ionic conduction in hydroxyapatites. Mater Lett 95:100–10210.1016/j.matlet.2012.12.074 ↗
15. Singh B, Kumar S, Basu B, Gupta R (2015) Conductivity studies of silver-, potassium-, and magnesium-doped hydroxyapatite. Int J Appl Ceram Technol 12:319–32810.1111/ijac.12167 ↗
16. Singh B, Kumar S, Saha N, Basu B, Gupta R (2015) Phase stability of silver particles embedded calcium phosphate bioceramics. Bull Mater Sci 38:525–52910.1007/s12034-014-0839-y ↗
17. Kim TN, Feng QL, Kim JO, Wu J, Wang H, Chen GC, Cui FZ (1998) Antimicrobial effects of metal ions (Ag+, Cu2+, Zn2+) in hydroxyapatite. J Mater Sci Mater Med 9:129–13410.1023/A:1008811501734 ↗
18. Bose S, Fielding G, Tarfer S, Bandypadhyay A (2013) Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics. Trends Biotechnol 31:594–60510.1016/j.tibtech.2013.06.005 ↗
19. Williams R (1968) Role of transition metal ions (1/26) in biological processes. R Inst Chem Rev 1:13–3810.1039/rr9680100013 ↗
20. Xu H, Aguilar ZP, Yang LKM, Duan HXY, Wei H, Wang A (2011) Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood. Biomaterials 32:9758–976510.1016/j.biomaterials.2011.08.076 ↗
21. Na HB, Song IC, Hyeon T (2009) Inorganic nanoparticles for MRI contrast agents. Adv Mater 21(2009):2133–214810.1002/adma.200802366 ↗
22. Pankhurst QA, Conolly J, Jones S, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 36:R16710.1088/0022-3727/36/13/201 ↗
23. Veiseh O, Gunn JW, Zhang M (2010) Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 62:284–30410.1016/j.addr.2009.11.002 ↗
24. Soenen SJ, Himmelreich U, Nuytten N, Cuyper MD (2011) Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials 32:195–20510.1016/j.biomaterials.2010.08.075 ↗
25. Singh B (2015) Structural, transport, magnetic and magnetoelectric properties of CaMn1−xFe x O3−δ (0.0 ≤ x ≤ 0.4). RSC Adv 5:39938–3994510.1039/C5RA03565A ↗
26. Singh B (2015) Room temperature large positive and negative magnetocapacitance in CaMn0.95Fe0.05O3−δ. Mater Lett 156:76–7810.1016/j.matlet.2015.04.150 ↗
27. Singh B (2016) Ru4+ induced colossal magnetoimpedance in Ru doped perovskite manganite at room temperature. Phys Chem Chem Phys 18:12947–1295110.1039/C6CP01224H ↗
28. Chandra VS, Baskar G, Suganthi RV, Elayaraja K, Joshy MIA, Beaula WS, Mythili R, Venkatraman G, Kalkura SN (2012) Blood compatibility of iron-doped nanosize hydroxyapatite and its drug release. ACS Appl Mater Interfaces 4:1200–121010.1021/am300140q ↗
29. Kramer E, Staruch M, Morey-Oppenheim A, Jain M, Budnick J, Suib S, Wei M (2013) synthesis and characterization of iron substituted hydroxyapatite via a simple ion-exchange procedure. J Mater Sci 48:665–673. https://doi.org/10.1007/s10853-012-6779-210.1007/s10853-012-6779-2 ↗
30. Panseri S, Cunha C, D’Alessandro T, Sandri M, Giavaresi G, Marcacci M, Hung CT, Tampieri A (2012) Intrinsically superparamagnetic Fe-hydroxyapatite nanoparticles positively influence osteoblast-like cell behaviour. J Nanobiotechnol 10:3210.1186/1477-3155-10-32 ↗
31. Zilm ME, Staruch M, Jain M, Wei M (2014) An intrinsically magnetic biomaterial with tunable magnetic properties. J Mater Chem B 2:7176–718510.1039/C4TB00925H ↗
32. Arends J, Christoffersen J, Christoffersen MR, Eckert H, Fowler BO, Heughebaert JC, Nancollas GH, Yesinowski JP, Zawacki SJ (1987) A calcium hydroxyapatite precipitated from an aqueous solution: an international multimethod analysis. J Cryst Growth 84:515–53210.1016/0022-0248(87)90284-3 ↗
33. Chaudhry AA, Haque S, Kellici S, Boldrin P, Rehman I, Khalid FA, Darr JA (2006) Instant nano-hydroxyapatite: a continuous and rapid hydrothermal synthesis. Chem Commun 0:2286–228810.1039/b518102j ↗
34. Kaygilia O, Dorozhkin SV, Ates T, Al-Ghamdi AA, Yakuphanoglua F (2014) Dielectric properties of Fe doped hydroxyapatite prepared by sol–gel method. Ceram Int 40:9395–940210.1016/j.ceramint.2014.02.009 ↗
35. Tampieri A, D’Alessandro T, Sandri M, Sprio S, Landi E, Bertinetti L, Panseri S, Pepponi G, Goettlicher J, Bañobre-López M, Rivas J (2012) Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite. Acta Biomater 8:843–85110.1016/j.actbio.2011.09.032 ↗
36. Li Y, Widodo J, Lim S, Ooi CP (2012) Synthesis and cytocompatibility of manganese(II) and iron(III) substituted hydroxyapatite nanoparticles. J Mater Sci 47:754–763. https://doi.org/10.1007/s10853-011-5851-710.1007/s10853-011-5851-7 ↗
37. Mene RU, Mahabole MP, Mohite KC, Khairnar RS (2014) Improved gas sensing and dielectric properties of Fe doped hydroxyapatite thick films: effect of molar concentrations. Mater Res Bull 50:227–23410.1016/j.materresbull.2013.10.040 ↗
38. Antonakos A, Liarokapis E, Leventouri T (2007) Micro-Raman and FTIR studies of synthetic and natural apatites. Biomaterials 28:3043–305410.1016/j.biomaterials.2007.02.028 ↗
39. Fowler BO (1974) Infrared studies of apatites. I. Vibrational assignments for calcium, strontium, and barium hydroxyapatites utilizing isotopic substitution. Inorg Chem 13:194–20410.1021/ic50131a039 ↗
40. Geng Z, Cui Z, Li Z, Zhu S, Liang Y, Lu WW, Yang X (2015) Synthesis, characterization and the formation mechanism of magnesium- and strontium-substituted hydroxyapatite. J Mater Chem B 3:3738–374610.1039/C4TB02148G ↗
41. Aza PND, Guitian F, Santos C, Aza SD, Cusco R, Artus L (1997) Vibrational properties of calcium phosphate compounds. 2. Comparison between hydroxyapatite and β-tricalcium phosphate. Chem Mater 9:916–92210.1021/cm9604266 ↗
42. Phan M, Peng H (2008) Giant magnetoimedance materials: fundamentals and applications. Prog Mater Sci 53:323–42010.1016/j.pmatsci.2007.05.003 ↗
43. Ipatov M, Zhukova V, Zhukov A, Gonzalez J (2016) Current controlled switching of impedance in magnetic conductor with tilted anisotropy easy axis and its applications. Sci Rep 6(1–8):3618010.1038/srep36180 ↗