Moisture-triggered release of self-produced ClO2 gas from microcapsule antibacterial film system
Source abstract
Abstract
In this study, a novel chlorine dioxide (ClO2) microcapsule with a performance of moisture-triggered release was fabricated followed by the mixing with polylactic acid (PLA) for the preparation of an antibacterial packaging film. ClO2 microcapsules were first prepared by encapsulating stable ClO2 solution (NaClO2 as the main component) in a PLA shell, and the resulting microcapsules together with tartaric acid were applied as antibacterial components for antimicrobial PLA film using solvent casting method. The impact of ClO2 microcapsules on the antimicrobial effectiveness, oxygen and water vapor barrier properties, mechanical behavior, and thermal stability of PLA films was investigated. The results showed that the addition of ClO2 microcapsules at a concentration of 20% imparted PLA films excellent antimicrobial properties with a growth inhibition of Escherichia coli and Staphylococcus aureus by 4.95 log CFU/mL and the antibacterial rate was 99%. Furthermore, the tensile strength of the films with ClO2 microcapsules at a concentration of 20% was 21.20 MPa, which was 19% higher than that of the PLA film without microcapsules. The oxygen and water vapor transmission rates reached 2800 cm3 m−2 24 h−1 and 20.00 g m−2 24 h−1, respectively, and the barrier properties were improved by 20 and 36.14%. Thermogravimetric analysis showed that the generated film was stable before 193 °C. Scanning electron microscopy analysis confirmed a good compatibility between the ClO2 microcapsules and the PLA matrix, and the emerged voids indicated the generation of ClO2 and its release from the antimicrobial film. An obvious sustained release of ClO2 from the antimicrobial film completed until 240 h. The release behavior fitted the logistic model, and the release mechanism followed the S model. This study may provide a feasible approach for the development of food packaging materials with efficient antibacterial activity and sustained-release performance.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanocomposite Films for Food Packaging · Antimicrobial agents and applications · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (34)
Show source-provided references
1. Dutta PK, Tripathi S, Mehrotra GK, Dutta J (2009) Perspectives for chitosan based antimicrobial films in food applications. Food Chem 114(4):1173–1182. https://doi.org/10.1016/j.foodchem.2008.11.04710.1016/j.foodchem.2008.11.047 ↗
2. Nobile MAD, Conte A (2013) Bio-based packaging materials for controlled release of active compounds
3. Lavoine N, Desloges I, Sillard C, Bras J (2014) Controlled release and long-term antibacterial activity of chlorhexidine digluconate through the nanoporous network of microfibrillated cellulose. Cellulose 21(6):4429–4442. https://doi.org/10.1007/s10570-014-0392-210.1007/s10570-014-0392-2 ↗
4. Bora A, Mishra P (2016) Characterization of casein and casein-silver conjugated nanoparticle containing multifunctional (pectin-sodium alginate/casein) bilayer film. J Food Sci Technol Mysore 53(10):3704–3714. https://doi.org/10.1007/s13197-016-2343-410.1007/s13197-016-2343-4 ↗
5. Shankar S, Rhim J-W (2016) Tocopherol-mediated synthesis of silver nanoparticles and preparation of antimicrobial PBAT/silver nanoparticles composite films. LWT Food Sci Technol 72:149–156. https://doi.org/10.1016/j.lwt.2016.04.05410.1016/j.lwt.2016.04.054 ↗
6. Bodaghi H, Mostofi Y, Oromiehie A, Ghanbarzadeh B, Hagh ZG (2015) Synthesis of clay-TiO2 nanocomposite thin films with barrier and photocatalytic properties for food packaging application. J Appl Polym Sci. https://doi.org/10.1002/app.4176410.1002/app.41764 ↗
7. Matsukizono H, Endo T (2016) Ring-opening polymerization of six-membered cyclic carbonates initiated by ethanol amine derivatives and their application to protonated or quaternary ammonium salt-functionalized polycarbonate films. J Polym Sci Part A Polym Chem 54(4):487–497. https://doi.org/10.1002/pola.2792210.1002/pola.27922 ↗
8. Nowzari F, Shabanpour B, Ojagh SM (2013) Comparison of chitosan-gelatin composite and bilayer coating and film effect on the quality of refrigerated rainbow trout. Food Chem 141(3):1667–1672. https://doi.org/10.1016/j.foodchem.2013.03.02210.1016/j.foodchem.2013.03.022 ↗
9. Torabi S, Mahdavian AR, Sanei M, Abdollahi A (2016) Chitosan and functionalized acrylic nanoparticles as the precursor of new generation of bio-based antibacterial films. Mater Sci Eng C Mater Biol Appl 59:1–9. https://doi.org/10.1016/j.msec.2015.09.09610.1016/j.msec.2015.09.096 ↗
10. Peng Y, Li Y (2014) Combined effects of two kinds of essential oils on physical, mechanical and structural properties of chitosan films. Food Hydrocoll 36:287–293. https://doi.org/10.1016/j.foodhyd.2013.10.01310.1016/j.foodhyd.2013.10.013 ↗
11. Perdones A, Vargas M, Atares L, Chiralt A (2014) Physical, antioxidant and antimicrobial properties of chitosan-cinnamon leaf oil films as affected by oleic acid. Food Hydrocoll 36:256–264. https://doi.org/10.1016/j.foodhyd.2013.10.00310.1016/j.foodhyd.2013.10.003 ↗
12. Gião MS, Pereira CI, Pintado ME, Malcata FX (2013) Effect of technological processing upon the antioxidant capacity of aromatic and medicinal plant infusions: from harvest to packaging. Lebenson Wiss Technol 50(1):320–325. https://doi.org/10.1016/j.lwt.2012.05.00710.1016/j.lwt.2012.05.007 ↗
13. Du J, Han Y, Linton RH (2003) Efficacy of chlorine dioxide gas in reducing Escherichia coli O157:H7 on apple surfaces. Food Microbiol 20(5):583–591. https://doi.org/10.1016/s0740-0020(02)00129-610.1016/S0740-0020(02)00129-6 ↗
14. Al-Otoum F, Al-Ghouti M, Ahmed T, Abu-dieyeh M, Ali M (2016) Disinfection by-products of chlorine dioxide (chlorite, chlorate, and trihalomethanes): occurrence in drinking water in Qatar. Chemosphere 164:649–656. https://doi.org/10.1016/j.chemosphere.2016.09.00810.1016/j.chemosphere.2016.09.008 ↗
15. Haute S, Tryland I, Escudero C, Vanneste M, Sampers I (2016) Chlorine dioxide as water disinfectant during fresh-cut iceberg lettuce washing: disinfectant demand, disinfection efficiency, and chlorite formation. LWT Food Sci Technol. https://doi.org/10.1016/j.lwt.2016.09.00210.1016/j.lwt.2016.09.002 ↗
16. Zhou S, Hu C, Zhao G, Liu L, Sheen S, Yam KL (2018) A novel gaseous chlorine dioxide generating method utilizing carbon dioxide and moisture respired from tomato for Salmonella inactivation. Food Control 89:54–61. https://doi.org/10.1016/j.foodcont.2018.01.00910.1016/j.foodcont.2018.01.009 ↗
17. Ci Y, Wang L, Guo Y, Sun R, Wang X, Li J (2015) Study on encapsulation of chlorine dioxide in gelatin microsphere for reducing release rate. Int J Clin Exp Med 8(8):12404–12410
18. Li Y, Leung WK, Yeung KL, Lau PS, Kwan JKC (2009) A multilevel antimicrobial coating based on polymer-encapsulated ClO2. Langmuir 25(23):13472–13480. https://doi.org/10.1021/la901974d10.1021/la901974d ↗
19. Ray S, Jin T, Fan X, Liu L, Yam KL (2013) Development of chlorine dioxide releasing film and its application in decontaminating fresh produce. J Food Sci 78(2):M276–M284. https://doi.org/10.1111/1750-3841.1201010.1111/1750-3841.12010 ↗
20. Bai Z, Cristancho DE, Rachford AA, Reder AL, Williamson A, Grzesiak AL (2016) Controlled release of antimicrobial ClO2 gas from a two-layer polymeric film system. J Agric Food Chem 64(45):8647–8652. https://doi.org/10.1021/acs.jafc.6b0387510.1021/acs.jafc.6b03875 ↗
21. Jain R, Abbasi R, Nelson K, Busche D, Lynn DM, Abbott NL (2017) Generation of gaseous ClO2 from thin films of solid NaClO2 by sequential exposure to ultraviolet light and moisture. ACS Appl Mater Interfaces 9(19):16594–1660310.1021/acsami.6b16570 ↗
22. Zavrazhnov SA, Fomin VA, Beloded LN, Lobaeva TS (2012) Effect of polymerization conditions on the polylactic acid properties. Russ J Appl Chem 85(8):1264–1268. https://doi.org/10.1134/S107042721208021610.1134/S1070427212080216 ↗
23. Arrieta MP, Samper MD, López J, Jiménez A (2014) Combined effect of poly(hydroxybutyrate) and plasticizers on polylactic acid properties for film intended for food packaging. J Polym Environ 22(4):460–470. https://doi.org/10.1007/s10924-014-0654-y10.1007/s10924-014-0654-y ↗
24. Rogalsky S, Bardeau JF, Wu H, Lyoshina L, Bulko O, Tarasyuk O, Makhno S, Cherniavska T, Kyselov Y, Koo JH (2016) Structural, thermal and antibacterial properties of polyamide 11/polymeric biocide polyhexamethylene guanidine dodecylbenzenesulfonate composites. J Mater Sci 51(19):1–15. https://doi.org/10.1007/s10853-016-0054-x10.1007/s10853-016-0163-6 ↗
25. Abulateefeh SR, Alkilany AM (2016) Synthesis and characterization of PLGA shell microcapsules containing aqueous cores prepared by internal phase separation. AAPS PharmSciTech 17(4):891–897. https://doi.org/10.1208/s12249-015-0413-y10.1208/s12249-015-0413-y ↗
26. Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, K-i Aoki, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, R-i Inoue, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, Hiramatsu K (2001) Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 357(9264):1225–1240. https://doi.org/10.1016/S0140-6736(00)04403-210.1016/S0140-6736(00)04403-2 ↗
27. Rivadeneira J, Di Virgilio AL, Audisio MC, Boccaccini AR, Gorustovich AA (2017) 45S5 Bioglass® concentrations modulate the release of vancomycin hydrochloride from gelatin–starch films: evaluation of antibacterial and cytotoxic effects. J Mater Sci 52(15):9091–9102. https://doi.org/10.1007/s10853-016-0512-510.1007/s10853-016-0512-5 ↗
28. Ogata N (2007) Denaturation of protein by chlorine dioxide: oxidative modification of tryptophan and tyrosine residues. Biochemistry 46(16):4898–4911. https://doi.org/10.1021/bi061827u10.1021/bi061827u ↗
29. Silhavy TJ, Kahne D, Walker S (2010) The bacterial cell envelope. Cold Spring Harb Perspect Biol 2(5):a000414. https://doi.org/10.1101/cshperspect.a00041410.1101/cshperspect.a000414 ↗
30. Rhim J-W, Hong S-I, Ha C-S (2009) Tensile, water vapor barrier and antimicrobial properties of PLA/nanoclay composite films. LWT Food Sci Technol 42(2):612–617. https://doi.org/10.1016/j.lwt.2008.02.01510.1016/j.lwt.2008.02.015 ↗
31. Gorrasi G, Tammaro L, Vittoria V, Paul MA, Alexandre M, Dubois P (2004) Transport properties of water vapor in polylactide/montmorillonite nanocomposites. J Macromol Sci Part B 43(3):565–575. https://doi.org/10.1081/MB-12003000610.1081/MB-120030006 ↗
32. Sankalia JM, Sankalia MG, Mashru RC (2008) Drug release and swelling kinetics of directly compressed glipizide sustained-release matrices: establishment of level A IVIVC. J Control Release 129(1):49–58. https://doi.org/10.1016/j.jconrel.2008.03.01610.1016/j.jconrel.2008.03.016 ↗
33. Adibkia K, Ghanbarzadeh S, Mohammadi G, Khiavi HZ, Sabzevari A, Barzegar-Jalali M (2014) Drug release kinetic analysis and prediction of release data via polymer molecular weight in sustained release diltiazem matrices. Drug Res (Stuttg) 64(3):118–123. https://doi.org/10.1055/s-0033-135318610.1055/s-0033-1353186 ↗
34. Polli JE, Rekhi GS, Augsburger LL, Shah VP (1997) Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets†. J Pharm Sci 86(6):690–700. https://doi.org/10.1021/js960473x10.1021/js960473x ↗