3D printing of PCL-based composite scaffolds coated with mesoporous bioactive glass nanoparticles (MBGNs) incorporating boron and molybdenum for ion-assisted bone tissue engineering
Source abstract
Abstract
Abstract A new family of composite scaffolds based on polycaprolactone (PCL) and mesoporous bioactive glass nanoparticles (MBGNs) were 3D-printed. These printed scaffolds were further coated by boron and molybdenum doped MBGNs. The scaffolds were characterized in terms of microstructure, hydrophilicity, bioactivity and cytocompatibility. The scaffolds exhibited well-defined pore geometries characterized by layer-by-layer microscale struts. MBGNs coatings increased the hydrophilicity of the PCL scaffolds. A burst release of silicon within the first 48 h (100 ppm cumulative) was observed, indicating the fast dissolution/degradation of MBGNs. In contrast, the release of other ions such as calcium, boron and molybdenum was found to be lower, which is associated with their lower doping levels in the MBGNs silica matrix. In vitro experiments showed that MBGNs (doped and non-doped) enhanced the adhesion and proliferation of MC3T3-E1 cells; these positive biological outcomes were correlated with the release and biological activity of inorganic ions. The results thus demonstrate the potential of the composite scaffolds as suitable candidates for bone tissue engineering.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Dental Implant Techniques and Outcomes
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References (54)
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