Effect of processing Mg–6Zn–0.2Ce through high-pressure torsion on its use as a biomaterial
Source abstract
Abstract
Here, we investigate the effect of high-pressure torsion (HPT), a severe plastic deformation process, on the mechanical properties, corrosion, and cytotoxicity of Mg–6Zn–0.2Ce alloy, a candidate material for bioresorbable bone implants. This alloy was processed by quasi-constrained HPT by applying a pressure of 6 GPa at room temperature for 1, 2, and 5 turns. Samples processed to two turns of HPT showed the smallest grain size, the highest strength that was approximately five times higher than the as-received coarse-grained sample and a reduction in the ductility. Electrochemical impedance spectroscopy and potentiodynamic polarization demonstrated the highest corrosion resistance for the Mg-alloy processed for two turns of HPT; however, accelerated degradation due to pitting corrosion was observed after immersion in simulated body fluid for 3 days. Nevertheless, all HPT-processed samples showed lower corrosion rates in all corrosion tests compared to their annealed counterparts. Finally, cell culture revealed good cytocompatibility without any noticeable changes in cytotoxicity following HPT processing. Overall, HPT for two turns showed enhanced strength and reduced corrosion rates without loss in cytocompatibility for the Mg–6Zn–0.2Ce alloy, making it a promising strategy to enhance the performance of the alloy as a bioresorbable orthopedic biomaterial. This work highlights the potential of HPT as a viable technique to improve the biomedical performance of Mg alloys for engineering next-generation biomedical implants.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Aluminum Alloys Composites Properties · MXene and MAX Phase Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (62)
Show source-provided references
1. Pietrzak WS, Sarver D, Verstynen M (1996) Bioresorbable implants-practical considerationS. Bone 19:109–11910.1016/S8756-3282(96)00139-1 ↗
2. Williams DF (2003) Biomaterials and tissue engineering in reconstructive surgery. Sadhana 28:563–57410.1007/BF02706447 ↗
3. Tsakiris V, Tardei C, Clicinschi FM (2021) Biodegradable Mg alloys for orthopedic implants—a review-NC-ND License (http://Creativecommons.Org/Licenses/by-Nc-Nd/4.0/) Peer Review under Responsibility of Chongqing University. J Magn Alloys 9:1884–1905, https://doi.org/10.1016/j.jma.2021.06.02410.1016/j.jma.2021.06.024 ↗
4. Prakasam M, Locs J, Salma-Ancane K, Loca D, Largeteau A, Berzina-Cimdina L (2017) Biodegradable materials and metallic implants—a review. J Funct Biomater 8:44. https://doi.org/10.3390/jfb804004410.3390/jfb8040044 ↗
5. Kluin OS, Van der Mei HC, Busscher HJ, Neut D (2013) Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin Drug Deliv 10:341–35110.1517/17425247.2013.751371 ↗
6. Amini AR, Wallace JS, Nukavarapu SP (2011) Short-term and long-term effects of orthopedic biodegradable implants. J Long Term Eff Med Implants 21:93–12210.1615/JLongTermEffMedImplants.v21.i2.10 ↗
7. Bergman C, Gray-Scott D, Chen J-J, Meacham S (2009) What is next for the dietary reference intakes for bone metabolism related nutrients beyond calcium: phosphorus, magnesium, vitamin D, and fluoride? Crit Rev Food Sci Nutr 49:136–14410.1080/10408390701764468 ↗
8. Quamme GA, de Rouffignac C (2000) Epithelial magnesium transport and regulation by the kidney. Front Biosci 5:694–711. https://doi.org/10.2741/quamme10.2741/quamme ↗
9. Xu L, Liu X, Sun K, Fu R, Wang G (2022) Corrosion behavior in magnesium-based alloys for biomedical applications. Materials 15:2613. https://doi.org/10.3390/ma1507261310.3390/ma15072613 ↗
10. Xu Y, Wang L, Huang M, Gensch F, Kainer KU, Hort N (2018) The effect of solid solute and precipitate phase on young’s modulus of binary Mg–RE alloys. Adv Eng Mater 20:1800271. https://doi.org/10.1002/adem.20180027110.1002/adem.201800271 ↗
11. Zhang S, Zhang X, Zhao C, Li J, Song Y, Xie C, Tao H, Zhang Y, He Y, Jiang Y (2010) Research on an Mg–Zn alloy as a degradable biomaterial. Acta Biomater 6:626–64010.1016/j.actbio.2009.06.028 ↗
12. Song YL, Liu YH, Wang SH, Yu SR, Zhu XY (2007) Effect of cerium addition on microstructure and corrosion resistance of die cast AZ91 magnesium alloy. Mater Corros 58:189–19210.1002/maco.200603988 ↗
13. Xie F, Shen J, Song H, Xie X (2018) Effects of cerium and SiC mixed particles on nanoparticle strengthening activated TIG-welded AZ31 Alloy joints. J Mater Res 33:4340–434810.1557/jmr.2018.404 ↗
14. Zhou H, Zeng X, Liu L, Zhang Y, Zhu Y, Ding W (2004) Effect of cerium on microstructures and mechanical properties of AZ61 wrought magnesium alloy. J Mater Sci 39:7061–7066. https://doi.org/10.1023/B:JMSC.0000047551.04037.fe10.1023/B:JMSC.0000047551.04037.fe ↗
15. Sabat RK, Brahme AP, Mishra RK, Inal K, Suwas S (2018) Ductility enhancement in Mg-0.2% Ce alloys. Acta Mater 161:246–25710.1016/j.actamat.2018.09.023 ↗
16. Behera M, Rajput M, Acharya S, Nadammal N, Suwas S, Chatterjee K (2021) Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials. Biomed Mater 16:044109. https://doi.org/10.1088/1748-605X/ac045310.1088/1748-605X/ac0453 ↗
17. Galiyev A, Sitdikov O, Kaibyshev R (2003) Deformation behavior and controlling mechanisms for plastic flow of magnesium and magnesium alloy. Mater Trans 44:426–43510.2320/matertrans.44.426 ↗
18. Silva CLP, Soares RB, Pereira PHR, Figueiredo RB, Lins VFC, Langdon TG (2019) The effect of high-pressure torsion on microstructure, hardness and corrosion behavior for pure magnesium and different magnesium alloys. Adv Eng Mater 21:1801081. https://doi.org/10.1002/adem.20180108110.1002/adem.201801081 ↗
19. Li W, Liu X, Zheng Y, Wang W, Qiao W, Yeung KWK, Cheung KMC, Guan S, Kulyasova OB, Valiev RZ (2020) In vitro and in vivo studies on ultrafine-grained biodegradable pure Mg, Mg–Ca alloy and Mg–Sr alloy processed by high-pressure torsion. Biomater Sci 8:5071–5087. https://doi.org/10.1039/d0bm00805b10.1039/d0bm00805b ↗
20. Udio C, Silva LP, Oliveira AC, Costa CGF, Figueiredo RB, De Fátima Leite M, Pereira MM, Lins VFC, Langdon TG (2017) Effect of severe plastic deformation on the biocompatibility and corrosion rate of pure magnesium. J Mater Sci 52:5992–6003. https://doi.org/10.1007/s10853-017-0835-x10.1007/s10853-017-0835-x ↗
21. Medeiros MP, Carvalho AP, Isaac A, Afonso CRM, Janeček M, Minárik P, Celis MM, Figueiredo RB (2023) Using high pressure torsion to process magnesium alloys for biological applications. J Market Res 22:3075–3084. https://doi.org/10.1016/j.jmrt.2022.12.12710.1016/j.jmrt.2022.12.127 ↗
22. Ahmadkhaniha D, Huang Y, Jaskari M, Järvenpää A, Sohi MH, Zanella C, Karjalainen LP, Langdon TG (2018) Effect of high-pressure torsion on microstructure, mechanical properties and corrosion resistance of cast pure Mg. J Mater Sci 53:16585–16597. https://doi.org/10.1007/s10853-018-2779-110.1007/s10853-018-2779-1 ↗
23. Lee H-J, Ahn B, Kawasaki M, Langdon TG (2015) Evolution in hardness and microstructure of ZK60A magnesium alloy processed by high-pressure torsion. J Mater Res Technol 4(1):18–25. https://doi.org/10.1016/j.jmrt.2014.10.01510.1016/j.jmrt.2014.10.015 ↗
24. Song D, Ma A, Jiang J, Lin P, Yang D, Fan J (2010) Corrosion behavior of equal-channel-angular-pressed pure magnesium in NaCl aqueous solution. Corros Sci 52:481–49010.1016/j.corsci.2009.10.004 ↗
25. Zhang CZ, Zhu SJ, Wang LG, Guo RM, Yue GC, Guan SK (2016) Microstructures and degradation mechanism in simulated body fluid of biomedical Mg-Zn–Ca alloy processed by high pressure torsion. Mater Des 96:54–62. https://doi.org/10.1016/j.matdes.2016.01.07210.1016/j.matdes.2016.01.072 ↗
26. Kim S-M, Jo J-H, Lee S-M, Kang M-H, Kim H-E, Estrin Y, Lee J-H, Lee J-W, Koh Y-H, S-m K et al (2013) Hydroxyapatite-coated magnesium implants with improved in vitro and in vivo biocorrosion, biocompatibility, and bone response. J Biomed Mater Res Part A 102:429–441. https://doi.org/10.1002/jbm.a.3471810.1002/jbm.a.34718 ↗
27. King AD, Birbilis N, Scully JR (2014) Accurate electrochemical measurement of magnesium corrosion rates; a combined impedance, mass-loss and hydrogen collection study. Electrochim Acta 121:394–406. https://doi.org/10.1016/j.electacta.2013.12.12410.1016/j.electacta.2013.12.124 ↗
28. Światowska J, Volovitch P, Ogle K (2010) The anodic dissolution of Mg in NaCl and Na2SO4 electrolytes by atomic emission spectroelectrochemistry. Corros Sci 52:2372–237810.1016/j.corsci.2010.02.038 ↗
29. Williams G, Birbilis N, McMurray HN (2013) The source of hydrogen evolved from a magnesium anode. Electrochem commun 36:1–510.1016/j.elecom.2013.08.023 ↗
30. Frankel GS, Samaniego A, Birbilis N (2013) Evolution of hydrogen at dissolving magnesium surfaces. Corros Sci 70:104–11110.1016/j.corsci.2013.01.017 ↗
31. Lopes DR, Silva CLP, Soares RB, Pereira HR, Oliveira AC, Figueiredo RB, Langdon TG, Lins VFC (2019) Cytotoxicity and corrosion behavior of magnesium and magnesium alloys in Hank’s solution after processing by high-pressure torsion. Adv Eng Mater 21(8):1900391. https://doi.org/10.1002/adem.20190039110.1002/adem.201900391 ↗
32. Zhilyaev AP, Langdon TG (2008) Using high-pressure torsion for metal processing: fundamentals and applications. Prog Mater Sci 53:893–979. https://doi.org/10.1016/j.pmatsci.2008.03.00210.1016/j.pmatsci.2008.03.002 ↗
33. Acharya S, Panicker AG, Laxmi DV, Suwas S, Chatterjee K (2019) Study of the influence of Zr on the mechanical properties and functional response of Ti–Nb–Ta–Zr–O Alloy for orthopedic applications. Mater Des 164:107555. https://doi.org/10.1016/J.MATDES.2018.10755510.1016/J.MATDES.2018.107555 ↗
34. Kirkland NT, Birbilis N (2014) Magnesium biomaterials: design, testing, and best practice. Springer, Berlin/Heidelberg, Germany. https://doi.org/10.1007/978-3-319-02123-210.1007/978-3-319-02123-2 ↗
35. American Society for Testing and Materials (Filadelfia, P. ASTM) (2004) G31–72: standard practice for laboratory immersion corrosion testing of metals. ASTM
36. Materials, AS for T. and ASTM G1–03 (2011) Standard practice for preparing, cleaning, and evaluating corrosion test specimens 2011
37. Figueiredo RB, Poggiali FSJ, Silva CLP, Cetlin PR, Langdon TG (2016) The influence of grain size and strain rate on the mechanical behavior of pure magnesium. J Mater Sci 51:3013–3024. https://doi.org/10.1007/S10853-015-9612-X/FIGURES/1210.1007/S10853-015-9612-X/FIGURES/12 ↗
38. Bonarski BJ, Schafler E, Mingler B, Skrotzki W, Mikulowski B, Zehetbauer MJ (2008) Texture evolution of Mg during high-pressure torsion. J Mater Sci 43:7513–7518. https://doi.org/10.1007/s10853-008-2794-810.1007/s10853-008-2794-8 ↗
39. Edalati K, Yamamoto A, Horita Z, Ishihara T (2011) High-pressure torsion of pure magnesium: evolution of mechanical properties, microstructures and hydrogen storage capacity with equivalent strain. Scr Mater 64:880–883. https://doi.org/10.1016/j.scriptamat.2011.01.02310.1016/j.scriptamat.2011.01.023 ↗
40. Rijal A, Singh SP, Han JK, Kawasaki M, Kumar P (2020) Effect of high-pressure torsion on hardness and electrical resistivity of commercially pure Cu. Adv Eng Mater 22:1900547. https://doi.org/10.1002/ADEM.20190054710.1002/ADEM.201900547 ↗
41. Mungole T, Nadammal N, Dawra K, Kumar P, Kawasaki M, Langdon TG (2013) Evolution of microhardness and microstructure in a cast Al-7% Si alloy during high-pressure torsion. J Mater Sci 48:4671–4680. https://doi.org/10.1007/s10853-012-7061-310.1007/s10853-012-7061-3 ↗
42. Bazarnik P, Huang Y, Lewandowska M, Langdon TG (2015) Structural impact on the Hall–Petch relationship in an Al–5Mg alloy processed by high-pressure torsion. Mater Sci Eng A 626:9–15. https://doi.org/10.1016/J.MSEA.2014.12.02710.1016/J.MSEA.2014.12.027 ↗
43. Heczel A, Kawasaki M, Lábár JL, Jang J-I, Langdon TG, Gubicza J (2017) Defect structure and hardness in nanocrystalline CoCrFeMnNi high-entropy alloy processed by high-pressure torsion. J Alloys CompD 711:143–154. https://doi.org/10.1016/j.jallcom.2017.03.35210.1016/j.jallcom.2017.03.352 ↗
44. Kumar P, Kawasaki M, Langdon TG (2016) Review: overcoming the paradox of strength and ductility in ultrafine-grained materials at low temperatures. J Mater Sci 51:7–18. https://doi.org/10.1007/s10853-015-9143-510.1007/s10853-015-9143-5 ↗
45. Horky J, Ghaffar A, Werbach K, Mingler B, Pogatscher S, Schäublin R, Setman D, Uggowitzer PJ, Löffler JF, Zehetbauer MJ (2019) Exceptional strengthening of biodegradable Mg–Zn–Ca alloys through high pressure torsion and subsequent heat treatment. Materials 12:2460. https://doi.org/10.3390/ma1215246010.3390/ma12152460 ↗
46. Zhao C, Li Z, Shi J, Chen X, Tu T, Luo Z, Cheng R, Atrens A, Pan F (2019) Strain hardening behavior of Mg–Y alloys after extrusion process. J Magn Alloys 7:672–680. https://doi.org/10.1016/j.jma.2019.09.00410.1016/j.jma.2019.09.004 ↗
47. Xiong H, Liang Z, Wang Z, Qin C, Zhao W, Yu H (2018) Mechanical properties and degradation behavior of Mg(100–7x)Zn6xYx(x = 0.2, 0.4, 0.6, 0.8) alloys. Metals (Basel) 8:261. https://doi.org/10.3390/met804026110.3390/met8040261 ↗
48. Singh IB, Singh M, Das S (2015) A comparative corrosion behavior of Mg, AZ31 and AZ91 alloys in 3.5% NaCl solution. J Magn Alloys 3(2):142–148. https://doi.org/10.1016/j.jma.2015.02.00410.1016/j.jma.2015.02.004 ↗
49. Makar GL, Kruger J (1993) Corrosion of magnesium. Int Mater Rev 38:138–153. https://doi.org/10.1179/imr.1993.38.3.13810.1179/imr.1993.38.3.138 ↗
50. Srinivasan A, Kwang A, Shin S, Rajendran N (2014) Dynamic electrochemical impedance spectroscopy (DEIS) studies of AZ31 magnesium alloy in simulated body fluid solution. RSC Adv Commun 4(53):27791–27795. https://doi.org/10.1039/c4ra02432j10.1039/c4ra02432j ↗
51. Kirkland NT, Birbilis N, Staiger MP (2012) Assessing the corrosion of biodegradable magnesium implants: a critical review of current methodologies and their limitations. Acta Biomater 8(3):925–936. https://doi.org/10.1016/j.actbio.2011.11.01410.1016/j.actbio.2011.11.014 ↗
52. Gerashi E, Alizadeh R, Langdon TG (2022) Effect of crystallographic texture and twinning on the corrosion behavior of Mg alloys: a review. J Magn Alloys 10:313–325. https://doi.org/10.1016/j.jma.2021.09.00910.1016/j.jma.2021.09.009 ↗
53. Liu J, Han E, Song Y, Shan D (2018) Effect of twins on the corrosion behavior of Mg–5Y–7Gd–0.5Zr Mg alloy. J Alloys Compd 757:356–363. https://doi.org/10.1016/j.jallcom.2018.05.10510.1016/j.jallcom.2018.05.105 ↗
54. Iso E(1999) Biological evaluation of medical devices-Part 5: tests for cytotoxicity: in vitro methods. German version EN ISO, pp 10993–10995
55. Gonzalez J, Hou RQ, Nidadavolu EPS, Willumeit-Römer R, Feyerabend F (2018) Magnesium degradation under physiological conditions-best practice. Bioact Mater 3:174–185
56. Mackenzie LWF, Pekguleryuz MO (2008) The recrystallization and texture of magnesium–zinc–cerium alloys. Scr Mater 59:665–66810.1016/j.scriptamat.2008.05.021 ↗
57. Song G-L, Mishra R, Xu Z (2010) Crystallographic orientation and electrochemical activity of AZ31 Mg alloy. Electrochem Commun 12(8):1009–1012. https://doi.org/10.1016/j.elecom.2010.05.01110.1016/j.elecom.2010.05.011 ↗
58. Xin R, Li B, Li L, Liu Q (2011) Influence of texture on corrosion rate of AZ31 Mg alloy in 3.5 wt% NaCl. Mater Des 32:4548–4552. https://doi.org/10.1016/j.matdes.2011.04.03110.1016/j.matdes.2011.04.031 ↗
59. Argade GR, Panigrahi SK, Mishra RS (2012) Effects of grain size on the corrosion resistance of wrought magnesium alloys containing neodymium. Corros Sci 58:145–151. https://doi.org/10.1016/j.corsci.2012.01.02110.1016/j.corsci.2012.01.021 ↗
60. Patel V, Li W, Andersson J, Li N (2022) Enhancing grain refinement and corrosion behavior in AZ31B magnesium alloy via stationary shoulder friction stir processing. J Mater Res Technol 17:3150–3156. https://doi.org/10.1016/j.jmrt.2022.02.05910.1016/j.jmrt.2022.02.059 ↗
61. Pei Y, Gui Y, Huang T, Chen F, Guo J, Zhong S, Song Z (2020) Microstructure and corrosion behaviors of AZ63 magnesium alloy fabricated by accumulative roll bonding process. Mater Res Express 7:66525. https://doi.org/10.1088/2053-1591/ab9c6110.1088/2053-1591/ab9c61 ↗
62. Torbati-Sarraf H, Torbati-Sarraf SA, Poursaee A, Langdon TG (2019) Electrochemical behavior of a magnesium ZK60 alloy processed by high-pressure torsion. Corros Sci 154:90–100. https://doi.org/10.1016/j.corsci.2019.04.00610.1016/j.corsci.2019.04.006 ↗