DataVXJournal of Materials SciencePaper
journal article·2024-05

Research advances in hydrogel-based wound dressings for diabetic foot ulcer treatment: a review

Jie Zhao, Jie Liu, Yuxin Hu, Wanxuan Hu, Juan Wei, Haisheng Qian, Yexiang Sun

Journal of Materials Science· Volume 59· Issue 19
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Polymers

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Pressure Ulcer Prevention and Management

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References (100+)

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1. American Diabetes A (2020) 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care 43(Suppl 1):S14–S31. https://doi.org/10.2337/dc20-S00210.2337/dc20-S002 ↗
2. Sun H, Saeedi P, Karuranga S et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119. https://doi.org/10.1016/j.diabres.2021.10911910.1016/j.diabres.2021.109119 ↗
3. Armstrong DG, Swerdlow MA, Armstrong AA et al (2020) Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res 13(1):16. https://doi.org/10.1186/s13047-020-00383-210.1186/s13047-020-00383-2 ↗
4. Armstrong DG, Boulton AJM, Bus SA (2017) Diabetic foot ulcers and their recurrence. N Engl J Med 376(24):2367–2375. https://doi.org/10.1056/NEJMra161543910.1056/NEJMra1615439 ↗
5. Reardon R, Simring D, Kim B et al (2020) The diabetic foot ulcer. Aust J Gen Pract 49(5):250–255. https://doi.org/10.31128/AJGP-11-19-516110.31128/AJGP-11-19-5161 ↗
6. Huang ZH, Li SQ, Kou Y et al (2019) Risk factors for the recurrence of diabetic foot ulcers among diabetic patients: a meta-analysis. Int Wound J 16(6):1373–1382. https://doi.org/10.1111/iwj.1320010.1111/iwj.13200 ↗
7. Chamberlain RC, Fleetwood K, Wild SH et al (2022) Foot ulcer and risk of lower limb amputation or death in people with diabetes: a national population-based retrospective cohort study. Diabetes Care 45(1):83–91. https://doi.org/10.2337/dc21-159610.2337/dc21-1596 ↗
8. Bandyk DF (2018) The diabetic foot: pathophysiology, evaluation, and treatment. Semin Vasc Surg 31(2–4):43–48. https://doi.org/10.1053/j.semvascsurg.2019.02.00110.1053/j.semvascsurg.2019.02.001 ↗
9. Francia P, Gualdani E, Policardo L et al (2022) Mortality risk associated with diabetic foot complications in people with or without history of diabetic foot hospitalizations. J Clin Med 11(9):2454. https://doi.org/10.3390/jcm1109245410.3390/jcm11092454 ↗
10. Dogruel H, Aydemir M, Balci MK (2022) Management of diabetic foot ulcers and the challenging points: an endocrine view. World J Diabetes 13(1):27–36. https://doi.org/10.4239/wjd.v13.i1.2710.4239/wjd.v13.i1.27 ↗
11. Schaper NC, van Netten JJ, Apelqvist J et al (2020) Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev 36(Suppl 1):e3266. https://doi.org/10.1002/dmrr.326610.1002/dmrr.3266 ↗
12. Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366(9498):1736–1743. https://doi.org/10.1016/S0140-6736(05)67700-810.1016/S0140-6736(05)67700-8 ↗
13. Ryall C, Duarah S, Chen S et al (2022) Advancements in skin delivery of natural bioactive products for wound management: a brief review of two decades. Pharmaceutics 14(5):1072. https://doi.org/10.3390/pharmaceutics1405107210.3390/pharmaceutics14051072 ↗
14. Ongarora BG (2022) Recent technological advances in the management of chronic wounds: a literature review. Health Sci Rep 5(3):e641. https://doi.org/10.1002/hsr2.64110.1002/hsr2.641 ↗
15. Hunt TK, Hopf HW (1997) Wound healing and wound infection. What surgeons and anesthesiologists can do. Surg Clin North Am 77(3):587–606. https://doi.org/10.1016/s0039-6109(05)70570-310.1016/s0039-6109(05)70570-3 ↗
16. Stadelmann WK, Digenis AG, Tobin GR (1998) Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176(2A Suppl):26S-38S. https://doi.org/10.1016/s0002-9610(98)00183-410.1016/s0002-9610(98)00183-4 ↗
17. Undas A, Wiek I, Stepien E et al (2008) Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome. Diabetes Care 31(8):1590–1595. https://doi.org/10.2337/dc08-028210.2337/dc08-0282 ↗
18. Al SH (2022) Macrophage phenotypes in normal and diabetic wound healing and therapeutic interventions. Cells 11(15):2430. https://doi.org/10.3390/cells1115243010.3390/cells11152430 ↗
19. Peng Y, Xiong RP, Zhang ZH et al (2021) Ski promotes proliferation and inhibits apoptosis in fibroblasts under high-glucose conditions via the FoxO1 pathway. Cell Prolif 54(2):e12971. https://doi.org/10.1111/cpr.1297110.1111/cpr.12971 ↗
20. Hu SC, Lan CE (2016) High-glucose environment disturbs the physiologic functions of keratinocytes: focusing on diabetic wound healing. J Dermatol Sci 84(2):121–127. https://doi.org/10.1016/j.jdermsci.2016.07.00810.1016/j.jdermsci.2016.07.008 ↗
21. Wei F, Wang A, Wang Q et al (2020) Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. Aging (Albany NY) 12(12):12002–12018. https://doi.org/10.18632/aging.10336610.18632/aging.103366 ↗
22. Nie X, Zhang H, Shi X et al (2020) Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt/beta-catenin signaling pathway. Int Immunopharmacol 79:106109. https://doi.org/10.1016/j.intimp.2019.10610910.1016/j.intimp.2019.106109 ↗
23. Geng K, Ma X, Jiang Z et al (2023) WDR74 facilitates TGF-beta/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice. Cell Biol Toxicol 39(4):1577–1591. https://doi.org/10.1007/s10565-022-09748-810.1007/s10565-022-09748-8 ↗
24. Yang Y, Zhang B, Yang Y et al (2022) FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog signaling. Diabetes Res Clin Pract 184:109121. https://doi.org/10.1016/j.diabres.2021.10912110.1016/j.diabres.2021.109121 ↗
25. Luanraksa S, Jindatanmanusan P, Boonsiri T et al (2018) An MMP/TIMP ratio scoring system as a potential predictive marker of diabetic foot ulcer healing. J Wound Care 27(12):849–855. https://doi.org/10.12968/jowc.2018.27.12.84910.12968/jowc.2018.27.12.849 ↗
26. Zubair M, Ahmad J (2019) Role of growth factors and cytokines in diabetic foot ulcer healing: a detailed review. Rev Endocr Metab Disord 20(2):207–217. https://doi.org/10.1007/s11154-019-09492-110.1007/s11154-019-09492-1 ↗
27. Yang H-L, Tsai Y-C, Korivi M et al (2017) Lucidone promotes the cutaneous wound healing process via activation of the PI3K/AKT. Wnt/β-catenin and NF-κB signaling pathways 1864(1):151–168
28. Zhao Y, Liu M, Zhang Y et al (2015) Expression changes of Wnt/β-catenin signaling pathway in diabetic ulcer. Chin J Pathophysiol 31(11):2033–2038. https://doi.org/10.3969/j.issn.1000-4718.2015.11.01810.3969/j.issn.1000-4718.2015.11.018 ↗
29. Lee EG, Luckett-Chastain LR, Calhoun KN et al (2019) Interleukin 6 function in the skin and isolated keratinocytes is modulated by hyperglycemia. J Immunol Res 3:5087847. https://doi.org/10.1155/2019/508784710.1155/2019/5087847 ↗
30. Amin KN, Umapathy D, Anandharaj A et al (2020) miR-23c regulates wound healing by targeting stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) among patients with diabetic foot ulcer. Microvasc Res 127:103924. https://doi.org/10.1016/j.mvr.2019.10392410.1016/j.mvr.2019.103924 ↗
31. Liu L, Chen R, Jia Z et al (2022) Downregulation of hsa-miR-203 in peripheral blood and wound margin tissue by negative pressure wound therapy contributes to wound healing of diabetic foot ulcers. Microvasc Res 139:104275. https://doi.org/10.1016/j.mvr.2021.10427510.1016/j.mvr.2021.104275 ↗
32. Pichu S, Sathiyamoorthy J, Vimalraj S et al (2017) Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers. Int J Biol Macromol 103:242–247. https://doi.org/10.1016/j.ijbiomac.2017.05.05010.1016/j.ijbiomac.2017.05.050 ↗
33. Xu Y, Chen H, Fang Y et al (2022) Hydrogel combined with phototherapy in wound healing. Adv Healthc Mater 11(16):e2200494. https://doi.org/10.1002/adhm.20220049410.1002/adhm.202200494 ↗
34. Stan D, Tanase C, Avram M et al (2021) Wound healing applications of creams and “smart” hydrogels. Exp Dermatol 30(9):1218–1232. https://doi.org/10.1111/exd.1439610.1111/exd.14396 ↗
35. Gjorevski N, Sachs N, Manfrin A et al (2016) Designer matrices for intestinal stem cell and organoid culture. Nature 539(7630):560–564. https://doi.org/10.1038/nature2016810.1038/nature20168 ↗
36. Zhang W, Zhang Y, Zhang Y et al (2021) Adhesive and tough hydrogels: from structural design to applications. J Mater Chem B 9(30):5954–5966. https://doi.org/10.1039/d1tb01166a10.1039/d1tb01166a ↗
37. Fuchs S, Shariati K, Ma M (2020) Specialty Tough Hydrogels and Their Biomedical Applications. Adv Healthc Mater 9(2):e1901396. https://doi.org/10.1002/adhm.20190139610.1002/adhm.201901396 ↗
38. Vasile C, Pamfil D, Stoleru E et al (2020) New developments in medical applications of hybrid hydrogels containing natural polymers. Molecules 25(7):1539. https://doi.org/10.3390/molecules2507153910.3390/molecules25071539 ↗
39. Hotz N, Wilcke L, Weber W (2013) Design, synthesis, and application of stimulus-sensing biohybrid hydrogels. Macromol Rapid Commun 34(20):1594–1610. https://doi.org/10.1002/marc.20130046810.1002/marc.201300468 ↗
40. Malone-Povolny MJ, Maloney SE, Schoenfisch MH (2019) Nitric Oxide Therapy for Diabetic Wound Healing. Adv Healthc Mater 8(12):e1801210. https://doi.org/10.1002/adhm.20180121010.1002/adhm.201801210 ↗
41. Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dent Res 89(3):219–229. https://doi.org/10.1177/002203450935912510.1177/0022034509359125 ↗
42. Bjarnsholt T, Kirketerp-Moller K, Jensen PO et al (2008) Why chronic wounds will not heal: a novel hypothesis. Wound Repair Regen 16(1):2–10. https://doi.org/10.1111/j.1524-475X.2007.00283.x10.1111/j.1524-475X.2007.00283.x ↗
43. Satitsri S, Muanprasat C (2020) Chitin and chitosan derivatives as biomaterial resources for biological and biomedical applications. Molecules 25(24):5961. https://doi.org/10.3390/molecules2524596110.3390/molecules25245961 ↗
44. Webber MJ, Pashuck ET (2021) (Macro)molecular self-assembly for hydrogel drug delivery. Adv Drug Deliv Rev 172:275–295. https://doi.org/10.1016/j.addr.2021.01.00610.1016/j.addr.2021.01.006 ↗
45. Waters DJ, Engberg K, Parke-Houben R et al (2010) Morphology of photopolymerized end-linked poly(ethylene glycol) hydrogels by small angle X-ray Scattering. Macromolecules 43(16):6861–6870. https://doi.org/10.1021/ma101070s10.1021/ma101070s ↗
46. Ferreira PG, Ferreira VF, da Silva FC et al (2022) Chitosans and nanochitosans: recent advances in skin protection, regeneration, and repair. Pharmaceutics 14(6):1307. https://doi.org/10.3390/pharmaceutics1406130710.3390/pharmaceutics14061307 ↗
47. Ganan M, Carrascosa AV, Martinez-Rodriguez AJ (2009) Antimicrobial activity of chitosan against Campylobacter spp. and other microorganisms and its mechanism of action. J Food Prot 72(8):1735–1738. https://doi.org/10.4315/0362-028x-72.8.173510.4315/0362-028x-72.8.1735 ↗
48. Matica MA, Aachmann FL, Tondervik A et al (2019) Chitosan as a wound dressing starting material: antimicrobial properties and mode of action. Int J Mol Sci 20(23):5889. https://doi.org/10.3390/ijms2023588910.3390/ijms20235889 ↗
49. Raafat D, von Bargen K, Haas A et al (2008) Insights into the mode of action of chitosan as an antibacterial compound. Appl Environ Microbiol 74(12):3764–3773. https://doi.org/10.1128/AEM.00453-0810.1128/AEM.00453-08 ↗
50. Lopez-Moya F, Suarez-Fernandez M, Lopez-Llorca LV (2019) Molecular mechanisms of chitosan interactions with fungi and plants. Int J Mol Sci 20(2):332. https://doi.org/10.3390/ijms2002033210.3390/ijms20020332 ↗
51. Tan H, Ma R, Lin C et al (2013) Quaternized chitosan as an antimicrobial agent: antimicrobial activity, mechanism of action and biomedical applications in orthopedics. Int J Mol Sci 14(1):1854–1869. https://doi.org/10.3390/ijms1401185410.3390/ijms14011854 ↗
52. Vishu Kumar AB, Varadaraj MC, Gowda LR et al (2005) Characterization of chito-oligosaccharides prepared by chitosanolysis with the aid of papain and Pronase, and their bactericidal action against Bacillus cereus and Escherichia coli. Biochem J 391(Pt 2):167–175. https://doi.org/10.1042/BJ2005009310.1042/BJ20050093 ↗
53. Hu C, Long L, Cao J et al (2021) Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release. Chem Eng J 411:12856410.1016/j.cej.2021.128564 ↗
54. He J, Li Z, Wang J et al (2023) Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing. Compos Part B Eng 266:11098510.1016/j.compositesb.2023.110985 ↗
55. Kasparova P, Zmuda M, Vankova E et al (2021) Low-molecular weight chitosan enhances antibacterial effect of antibiotics and permeabilizes cytoplasmic membrane of Staphylococcus epidermidis biofilm cells. Folia Microbiol (Praha) 66(6):983–996. https://doi.org/10.1007/s12223-021-00898-610.1007/s12223-021-00898-6 ↗
56. Jing YJ, Hao YJ, Qu H et al (2007) Studies on the antibacterial activities and mechanisms of chitosan obtained from cuticles of housefly larvae. Acta Biol Hung 58(1):75–86. https://doi.org/10.1556/ABiol.57.2007.1.710.1556/ABiol.57.2007.1.7 ↗
57. Younes I, Sellimi S, Rinaudo M et al (2014) Influence of acetylation degree and molecular weight of homogeneous chitosans on antibacterial and antifungal activities. Int J Food Microbiol 185:57–63. https://doi.org/10.1016/j.ijfoodmicro.2014.04.02910.1016/j.ijfoodmicro.2014.04.029 ↗
58. Mellegard H, Strand SP, Christensen BE et al (2011) Antibacterial activity of chemically defined chitosans: influence of molecular weight, degree of acetylation and test organism. Int J Food Microbiol 148(1):48–54. https://doi.org/10.1016/j.ijfoodmicro.2011.04.02310.1016/j.ijfoodmicro.2011.04.023 ↗
59. Younes I, Rinaudo M (2015) Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs 13(3):1133–1174. https://doi.org/10.3390/md1303113310.3390/md13031133 ↗
60. Cele ZED, Somboro AM, Amoako DG et al (2020) Fluorinated Quaternary Chitosan Derivatives: Synthesis, Characterization, Antibacterial Activity, and Killing Kinetics. ACS Omega 5(46):29657–29666. https://doi.org/10.1021/acsomega.0c0135510.1021/acsomega.0c01355 ↗
61. Hoque J, Adhikary U, Yadav V et al (2016) Chitosan derivatives active against multidrug-resistant bacteria and pathogenic fungi: in vivo evaluation as topical antimicrobials. Mol Pharm 13(10):3578–3589. https://doi.org/10.1021/acs.molpharmaceut.6b0076410.1021/acs.molpharmaceut.6b00764 ↗
62. Wahid F, Hu XH, Chu LQ et al (2019) Development of bacterial cellulose/chitosan based semi-interpenetrating hydrogels with improved mechanical and antibacterial properties. Int J Biol Macromol 122:380–387. https://doi.org/10.1016/j.ijbiomac.2018.10.10510.1016/j.ijbiomac.2018.10.105 ↗
63. Omidi S, Kakanejadifard A (2019) Modification of chitosan and chitosan nanoparticle by long chain pyridinium compounds: Synthesis, characterization, antibacterial, and antioxidant activities. Carbohydr Polym 208:477–485. https://doi.org/10.1016/j.carbpol.2018.12.09710.1016/j.carbpol.2018.12.097 ↗
64. Zhao X, Wu H, Guo B et al (2017) Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials 122:34–47. https://doi.org/10.1016/j.biomaterials.2017.01.01110.1016/j.biomaterials.2017.01.011 ↗
65. Wang M, Yue L, Niazi S et al (2022) Synthesis and characterization of cinnamic acid conjugated N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride derivatives: A hybrid flocculant with antibacterial activity. Int J Biol Macromol 206:886–895. https://doi.org/10.1016/j.ijbiomac.2022.03.07510.1016/j.ijbiomac.2022.03.075 ↗
66. Sivanesan I, Muthu M, Gopal J et al (2021) Nanochitosan: commemorating the metamorphosis of an exoskeletal waste to a versatile nutraceutical. Nanomater (Basel) 11(3):821. https://doi.org/10.3390/nano1103082110.3390/nano11030821 ↗
67. Duan S, Wang R (2013) Bimetallic nanostructures with magnetic and noble metals and their physicochemical applications. Prog Nat Sci Mater Int 23(2):113–126. https://doi.org/10.1016/j.pnsc.2013.02.00110.1016/j.pnsc.2013.02.001 ↗
68. Guo Z, Chen Y, Wang Y et al (2020) Advances and challenges in metallic nanomaterial synthesis and antibacterial applications. J Mater Chem B 8(22):4764–4777. https://doi.org/10.1039/d0tb00099j10.1039/d0tb00099j ↗
69. Hamdan S, Pastar I, Drakulich S et al (2017) Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS Cent Sci 3(3):163–175. https://doi.org/10.1021/acscentsci.6b0037110.1021/acscentsci.6b00371 ↗
70. Kedziora A, Speruda M, Krzyzewska E et al (2018) Similarities and differences between silver ions and silver in nanoforms as antibacterial agents. Int J Mol Sci 19(2):444. https://doi.org/10.3390/ijms1902044410.3390/ijms19020444 ↗
71. Choudhury H, Pandey M, Lim YQ et al (2020) Silver nanoparticles: Advanced and promising technology in diabetic wound therapy. Mater Sci Eng C Mater Biol Appl 112:110925. https://doi.org/10.1016/j.msec.2020.11092510.1016/j.msec.2020.110925 ↗
72. Burdusel AC, Gherasim O, Grumezescu AM et al (2018) Biomedical applications of silver nanoparticles: an up-to-date overview. Nanomater (Basel) 8(9):681. https://doi.org/10.3390/nano809068110.3390/nano8090681 ↗
73. Das S, Baker AB (2016) Biomaterials and nanotherapeutics for enhancing skin wound healing. Front Bioeng Biotechnol 4:82. https://doi.org/10.3389/fbioe.2016.0008210.3389/fbioe.2016.00082 ↗
74. Bruna T, Maldonado-Bravo F, Jara P et al (2021) Silver nanoparticles and their antibacterial applications. Int J Mol Sci 22(13):7202. https://doi.org/10.3390/ijms2213720210.3390/ijms22137202 ↗
75. Zhao Y, Li Z, Song S et al (2019) Skin-Inspired Antibacterial Conductive Hydrogels for Epidermal Sensors and Diabetic Foot Wound Dressings. Adv Funct Mater 29(31):1901474. https://doi.org/10.1002/adfm.20190147410.1002/adfm.201901474 ↗
76. Wang P, Jiang S, Li Y et al (2021) Virus-like mesoporous silica-coated plasmonic Ag nanocube with strong bacteria adhesion for diabetic wound ulcer healing. Nanomedicine 34:102381. https://doi.org/10.1016/j.nano.2021.10238110.1016/j.nano.2021.102381 ↗
77. Pham TN, Jiang YS, Su CF et al (2020) In situ formation of silver nanoparticles-contained gelatin-PEG-dopamine hydrogels via enzymatic cross-linking reaction for improved antibacterial activities. Int J Biol Macromol 146:1050–1059. https://doi.org/10.1016/j.ijbiomac.2019.09.23010.1016/j.ijbiomac.2019.09.230 ↗
78. Laurenti M, Cauda V (2017) ZnO nanostructures for tissue engineering applications. Nanomater (Basel) 7(11):374. https://doi.org/10.3390/nano711037410.3390/nano7110374 ↗
79. Jamnongkan T, Sukumaran SK, Sugimoto M et al (2015) Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly (vinyl alcohol) hybrids. J Polym Eng 35(6):575–58610.1515/polyeng-2014-0319 ↗
80. Ottone C, Rivera VF, Fontana M et al (2014) Ultralong and mesoporous ZnO and γ-Al2O3 oriented nanowires obtained by template-assisted hydrothermal approach. J Mater Sci Technol 30(12):1167–117310.1016/j.jmst.2014.11.005 ↗
81. Dumontel B, Canta M, Engelke H et al (2017) Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer. J Mater Chem B 5(44):8799–8813. https://doi.org/10.1039/c7tb02229h10.1039/c7tb02229h ↗
82. Ahmed S, Chaudhry SA et al (2017) A review on biogenic synthesis of ZnO nanoparticles using plant extracts and microbes: a prospect towards green chemistry. J Photochem Photobiol B 166:272–284. https://doi.org/10.1016/j.jphotobiol.2016.12.01110.1016/j.jphotobiol.2016.12.011 ↗
83. Hajipour MJ, Fromm KM, Ashkarran AA et al (2012) Antibacterial properties of nanoparticles. Trends Biotechnol 30(10):499–511. https://doi.org/10.1016/j.tibtech.2012.06.00410.1016/j.tibtech.2012.06.004 ↗
84. Chupani L, Zuskova E, Niksirat H et al (2017) Effects of chronic dietary exposure of zinc oxide nanoparticles on the serum protein profile of juvenile common carp (Cyprinus carpio L.). Sci Total Environ 579:1504–1511. https://doi.org/10.1016/j.scitotenv.2016.11.15410.1016/j.scitotenv.2016.11.154 ↗
85. Blecher K, Nasir A, Friedman A (2011) The growing role of nanotechnology in combating infectious disease. Virulence 2(5):395–401. https://doi.org/10.4161/viru.2.5.1703510.4161/viru.2.5.17035 ↗
86. Huh AJ, Kwon YJ (2011) “Nanoantibiotics”: a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. J Control Release 156(2):128–145. https://doi.org/10.1016/j.jconrel.2011.07.00210.1016/j.jconrel.2011.07.002 ↗
87. Steffy K, Shanthi G, Maroky AS et al (2018) Enhanced antibacterial effects of green synthesized ZnO NPs using Aristolochia indica against multi-drug resistant bacterial pathogens from Diabetic Foot Ulcer. J Infect Public Health 11(4):463–471. https://doi.org/10.1016/j.jiph.2017.10.00610.1016/j.jiph.2017.10.006 ↗
88. Vinotha V, Iswarya A, Thaya R et al (2019) Synthesis of ZnO nanoparticles using insulin-rich leaf extract: anti-diabetic, antibiofilm and anti-oxidant properties. J Photochem Photobiol B 197:111541. https://doi.org/10.1016/j.jphotobiol.2019.11154110.1016/j.jphotobiol.2019.111541 ↗
89. Tavakoli S, Mokhtari H, Kharaziha M et al (2020) A multifunctional nanocomposite spray dressing of Kappa-carrageenan-polydopamine modified ZnO/L-glutamic acid for diabetic wounds. Mater Sci Eng C Mater Biol Appl 111:110837. https://doi.org/10.1016/j.msec.2020.11083710.1016/j.msec.2020.110837 ↗
90. Soenen SJ, Parak WJ, Rejman J et al (2015) (Intra)cellular stability of inorganic nanoparticles: effects on cytotoxicity, particle functionality, and biomedical applications. Chem Rev 115(5):2109–2135. https://doi.org/10.1021/cr400714j10.1021/cr400714j ↗
91. Wynn TA, Barron L (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30(3):245–257. https://doi.org/10.1055/s-0030-125535410.1055/s-0030-1255354 ↗
92. Bratton DL, Henson PM (2011) Neutrophil clearance: when the party is over, clean-up begins. Trends Immunol 32(8):350–357. https://doi.org/10.1016/j.it.2011.04.00910.1016/j.it.2011.04.009 ↗
93. Krzyszczyk P, Schloss R, Palmer A et al (2018) The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol 9:419. https://doi.org/10.3389/fphys.2018.0041910.3389/fphys.2018.00419 ↗
94. Shen T, Dai K, Yu Y et al (2020) Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice. Acta Biomater 117:192–203. https://doi.org/10.1016/j.actbio.2020.09.03510.1016/j.actbio.2020.09.035 ↗
95. Yang H, Song L, Sun B et al (2021) Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing. Mater Today Bio 12:100139. https://doi.org/10.1016/j.mtbio.2021.10013910.1016/j.mtbio.2021.100139 ↗
96. Xia H, Dong Z, Tang Q et al (2023) Glycopeptide-based multifunctional hydrogels promote diabetic wound healing through ph regulation of microenvironment. Adv Funct Mater. https://doi.org/10.1002/adfm.20221511610.1002/adfm.202215116 ↗
97. Wong SL, Demers M, Martinod K et al (2015) Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med 21(7):815–819. https://doi.org/10.1038/nm.388710.1038/nm.3887 ↗
98. Yuan Y, Fan D, Shen S et al (2022) An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation for regulating chronic inflammation and impaired angiogenesis of diabetic wounds. Chem Eng J 433:13385910.1016/j.cej.2021.133859 ↗
99. Soehnlein O, Steffens S, Hidalgo A et al (2017) Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol 17(4):248–261. https://doi.org/10.1038/nri.2017.1010.1038/nri.2017.10 ↗
100. Karima M, Kantarci A, Ohira T et al (2005) Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol 78(4):862–870. https://doi.org/10.1189/jlb.100458310.1189/jlb.1004583 ↗