Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements
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OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Orthopaedic implants and arthroplasty
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References (100+)
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1. Mendonca G, Mendonca DBS, Aragao FJL, Cooper LF (2008) Advancing dental implant surface technology - From micron- to nanotopography. Biomaterials 29:3822. https://doi.org/10.1016/j.biomaterials.2008.05.01210.1016/j.biomaterials.2008.05.012 ↗
2. Ko W-K, Kim SJ, Heo DN et al (2020) Double layers of gold nanoparticles immobilized titanium implants improve the osseointegration in rabbit models. Nanomedicine-Nanotechnology Biology and Medicine 24:102129. https://doi.org/10.1016/j.nano.2019.10212910.1016/j.nano.2019.102129 ↗
3. Davies JE (2003) Understanding peri-implant endosseous healing. J Dent Educ 67:93210.1002/j.0022-0337.2003.67.8.tb03681.x ↗
4. Albrektsson T, Johansson C (2001) Osteoinduction, osteoconduction and osseointegration. Eur Spine J 10:S96. https://doi.org/10.1007/s00586010028210.1007/s005860100282 ↗
5. Galli C, Guizzardi S, Passeri G et al (2005) Comparison of human mandibular osteoblasts grown on two commercially available titanium implant surfaces. J Periodontol 76:364. https://doi.org/10.1902/jop.2005.76.3.36410.1902/jop.2005.76.3.364 ↗
6. Chrcanovic BR, Kisch J, Albrektsson T, Wennerberg A (2018) A retrospective study on clinical and radiological outcomes of oral implants in patients followed up for a minimum of 20 years. Clin Implant Dent Relat Res 20:199. https://doi.org/10.1111/cid.1257110.1111/cid.12571 ↗
7. Coelho PG, Jimbo R, Tovar N, Bonfante EA (2015) Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales. Dent Mater 31:37. https://doi.org/10.1016/j.dental.2014.10.00710.1016/j.dental.2014.10.007 ↗
8. Dong Q, Zhang M, Zhou X et al (2021) 3D-printed Mg-incorporated PCL-based scaffolds: A promising approach for bone healing. Materials Science & Engineering C-Materials for Biological Applications 129:112372. https://doi.org/10.1016/j.msec.2021.11237210.1016/j.msec.2021.112372 ↗
9. Jin-wen TU, Zhi-hu OU, Yun-feng RUI, Jin-gang H, Hai-jun T, Xiao-ling Z (2009) Biocompatibility, osteoinductivity and biodegradability of bionic zein scaffolds in vitro and in vivo. Chinese Journal of Orthopaedic Trauma 11:1062
10. Goriainov V, Cook R, Latham JM, Dunlop DG, Oreffo ROC (2014) Bone and metal: An orthopaedic perspective on osseointegration of metals. Acta Biomater 10:4043. https://doi.org/10.1016/j.actbio.2014.06.00410.1016/j.actbio.2014.06.004 ↗
11. Xi D, Wong L (2021) Titanium and implantology: a review in dentistry. J Biol Regul Homeost Agents 35:63
12. Sarraf M, Rezvani Ghomi E, Alipour S, Ramakrishna S, Liana Sukiman N (2022) A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications. Bio-Design and Manufacturing 5:371. https://doi.org/10.1007/s42242-021-00170-310.1007/s42242-021-00170-3 ↗
13. Sul YT (2003) The significance of the surface properties of oxidized titanium to the bone response: special emphasis on potential biochemical bonding of oxidized titanium implant. Biomaterials 24:3893. https://doi.org/10.1016/s0142-9612(03)00261-810.1016/s0142-9612(03)00261-8 ↗
14. Wang T, Wang L, Lu Q, Fan Z (2021) Influence of anodized titanium abutments on the esthetics of the peri-implant soft tissue: A clinical study. J Prosthet Dent 125:445. https://doi.org/10.1016/j.prosdent.2019.12.02310.1016/j.prosdent.2019.12.023 ↗
15. Webber LP, Chan H-L, Wang H-L (2021) Will Zirconia Implants Replace Titanium Implants? Applied Sciences-Basel 11:6776. https://doi.org/10.3390/app1115677610.3390/app11156776 ↗
16. Kunrath MF, Gupta S, Lorusso F, Scarano A, Noumbissi S (2021) Oral Tissue Interactions and Cellular Response to Zirconia Implant-Prosthetic Components: A Critical Review. Materials 14:2825. https://doi.org/10.3390/ma1411282510.3390/ma14112825 ↗
17. Linares A, Grize L, Munoz F et al (2016) Histological assessment of hard and soft tissues surrounding a novel ceramic implant: a pilot study in the minipig. J Clin Periodontol 43:538. https://doi.org/10.1111/jcpe.1254310.1111/jcpe.12543 ↗
18. Furuya K, Takemoto S, Yamashita S, Sekine H, Yajima Y, Yoshinari M (2020) Low-temperature degradation of high-strength Y-TZP (yttria-stabilized tetragonal zirconia polycrystal). Dent Mater J 39:577. https://doi.org/10.4012/dmj.2019-09010.4012/dmj.2019-090 ↗
19. Lughi V, Sergo V (2010) Low temperature degradation -aging- of zirconia: A critical review of the relevant aspects in dentistry. Dent Mater 26:807. https://doi.org/10.1016/j.dental.2010.04.00610.1016/j.dental.2010.04.006 ↗
20. Rezaei NM, Hasegawa M, Ishijima M et al (2018) Biological and osseointegration capabilities of hierarchically (meso-/micro-/nano-scale) roughened zirconia. Int J Nanomed 13:3381. https://doi.org/10.2147/Ijn.S15995510.2147/Ijn.S159955 ↗
21. Elnayef B, Lazaro A, del Amo FSL et al (2017) Zirconia Implants as an Alternative to Titanium: A Systematic Review and Meta-Analysis. Int J Oral Max Impl 32:E125. https://doi.org/10.11607/jomi.522310.11607/jomi.5223 ↗
22. Diefenbeck M, Mueckley T, Schrader C et al (2011) The effect of plasma chemical oxidation of titanium alloy on bone-implant contact in rats. Biomaterials 32:8041. https://doi.org/10.1016/j.biomaterials.2011.07.04610.1016/j.biomaterials.2011.07.046 ↗
23. Kong L, Sun Y, Hu K et al (2008) Selections of the cylinder implant neck taper and implant end fillet for optimal biomechanical properties: A three-dimensional finite element analysis. J Biomech 41:1124. https://doi.org/10.1016/j.jbiomech.2007.12.01310.1016/j.jbiomech.2007.12.013 ↗
24. Maksimkin AV, Senatov FS, Niaza K, Dayyoub T, Kaloshkin SD (2020) Ultra-High Molecular Weight Polyethylene/Titanium-Hybrid Implant for Bone-Defect Replacement. Materials 13:3010. https://doi.org/10.3390/ma1313301010.3390/ma13133010 ↗
25. Thome G, Sandgren R, Bernardes S et al (2021) Osseointegration of a novel injection molded 2-piece ceramic dental implant: a study in minipigs. Clin Oral Invest 25:603. https://doi.org/10.1007/s00784-020-03513-z10.1007/s00784-020-03513-z ↗
26. Brezavscek M, Fawzy A, Baechle M, Tuna T, Fischer J, Att W (2016) The Effect of UV Treatment on the Osteoconductive Capacity of Zirconia-Based Materials. Materials 9:958. https://doi.org/10.3390/ma912095810.3390/ma9120958 ↗
27. Wang L-j, X-h Ni F, Zhang, et al (2021) Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration. Nanoscale Res Lett 16:1–15. https://doi.org/10.1186/s11671-021-03602-210.1186/s11671-021-03602-2 ↗
28. Sun L, Guo J, Chen H et al (2021) Tailoring Materials with Specific Wettability in Biomedical Engineering. Advanced Science 8:2100126. https://doi.org/10.1002/advs.20210012610.1002/advs.202100126 ↗
29. Bevilacqua L, Faccioni F, Porrelli D et al (2021) Blood Wettability of Different Dental Implant Surfaces after Different Pre-Treatments: Ultrasonic Instrumentation, Platelet-Rich Fibrin Coating, and Acid Etching. An In Vitro Study. Applied Sciences-Basel 11:1433. https://doi.org/10.3390/app1104143310.3390/app11041433 ↗
30. GdS De Lucca A, Daleffe GSS et al (2021) Investigation of Wettability Using Contact Angle Measurements and Geometric Discrepancy Analysis of Heat-Treated Pure Titanium Grade 2. Materials Research-Ibero-American Journal of Materials 24:e20210102. https://doi.org/10.1590/1980-5373-mr-2021-010210.1590/1980-5373-mr-2021-0102 ↗
31. Parisi L, Ghezzi B, Bianchi MG et al (2020) Titanium dental implants hydrophilicity promotes preferential serum fibronectin over albumin competitive adsorption modulating early cell response. Materials Science and Engineering C-Materials for Biological Applications 117:111307. https://doi.org/10.1016/j.msec.2020.11130710.1016/j.msec.2020.111307 ↗
32. Kumar SS, Hiremath SS (2019) Effect of surface roughness and surface topography on wettability of machined biomaterials using flexible viscoelastic polymer abrasive. Surface Topography-Metrology and Properties 7:015004. https://doi.org/10.1088/2051-672X/aaf6f610.1088/2051-672X/aaf6f6 ↗
33. Cui H, Wang W, Shi L, Song W, Wang S (2020) Superwettable Surface Engineering in Controlling Cell Adhesion for Emerging Bioapplications. Small Methods 4:202000573. https://doi.org/10.1002/smtd.20200057310.1002/smtd.202000573 ↗
34. Toffoli A, Parisi L, Bianchi MG, Lumetti S, Bussolati O, Macaluso GM (2020) Thermal treatment to increase titanium wettability induces selective proteins adsorption from blood serum thus affecting osteoblasts adhesion. Materials Science & Engineering C-Materials for Biological Applications 107:110250. https://doi.org/10.1016/j.msec.2019.11025010.1016/j.msec.2019.110250 ↗
35. Matsumoto T, Tashiro Y, Komasa S, Miyake A, Komasa Y, Okazaki J (2021) Effects of Surface Modification on Adsorption Behavior of Cell and Protein on Titanium Surface by Using Quartz Crystal Microbalance System. Materials 14:97. https://doi.org/10.3390/ma1401009710.3390/ma14010097 ↗
36. Albrektsson T, Wennerberg A (2004) Oral implant surfaces: Part 2 - Review focusing on clinical knowledge of different surfaces. Int J Prosthodont 17:544
37. Liu H, Li K, Yi D, Ding Y, Gao Y, Zheng X (2024) Deferoxamine-Loaded Chitosan-Based Hydrogel on Bone Implants Showing Enhanced Bond Strength and Pro-Angiogenic Effects. Journal of Functional Biomaterials 15:112. https://doi.org/10.3390/jfb1504011210.3390/jfb15040112 ↗
38. Rupp F, Gittens RA, Scheideler L et al (2014) A review on the wettability of dental implant surfaces I: Theoretical and experimental aspects. Acta Biomater 10:2894. https://doi.org/10.1016/j.actbio.2014.02.04010.1016/j.actbio.2014.02.040 ↗
39. Wang C, Wang X, Lu R, Cao X, Yuan D, Chen S (2023) Influence of surface nanotopography and wettability on early phases of peri-implant soft tissue healing: an in-vivo study in dogs. BMC Oral Health 23:651. https://doi.org/10.1186/s12903-023-03347-710.1186/s12903-023-03347-7 ↗
40. Jing X, Pu Z, Zheng S, Wang F, Qi H (2020) Nanosecond laser induced microstructure features and effects thereof on the wettability in zirconia. Ceram Int 46:24173. https://doi.org/10.1016/j.ceramint.2020.06.19710.1016/j.ceramint.2020.06.197 ↗
41. H Zou, L Shi, C Lin, Y Zhang, L Liu (2020) Optimization parameter of the graphene dispersion and the wettability of graphene/${\rm{Zr}}{{\rm{O}}_2}$ ceramic composites. Journal of Shanghai University. Natural Science Edition 26: 102
42. Matos GRM (2021) Surface Roughness of Dental Implant and Osseointegration. Journal of maxillofacial and oral surgery 20:1. https://doi.org/10.1007/s12663-020-01437-510.1007/s12663-020-01437-5 ↗
43. (2012) Fabrication and in vivo evaluation of Ti6Al4V implants with controlled porous structure and complex shape. Frontiers of Mechanical Engineering 7: 66.10.1007/s11465-012-0302-y ↗
44. Levin M, Spiro RC, Jain H, Falk MM (2022) Effects of Titanium Implant Surface Topology on Bone Cell Attachment and Proliferation in vitro. Medical devices (Auckland, N.Z.) 15:103–119. https://doi.org/10.2147/mder.S36029710.2147/mder.S360297 ↗
45. Kim JJ, Lee JK (2020) Influence of substrate surface-grinding on surface roughness of zirconia coatings fabricated by room temperature spray processing. J Ceram Process Res 21:S68. https://doi.org/10.36410/jcpr.2020.21.S1.s6810.36410/jcpr.2020.21.S1.s68 ↗
46. Imade S, Mori R, Uchio Y, Furuya S (2009) Effect of implant surface roughness on bone fixation: the differences between bone and metal pegs. J Orthop Sci 14:652. https://doi.org/10.1007/s00776-009-1369-010.1007/s00776-009-1369-0 ↗
47. Bartold PM, Kuliwaba JS, Lee V, Shah S, Marino V, Fazzalari NL (2011) Influence of surface roughness and shape on microdamage of the osseous surface adjacent to titanium dental implants. Clin Oral Implant Res 22:613. https://doi.org/10.1111/j.1600-0501.2010.02024.x10.1111/j.1600-0501.2010.02024.x ↗
48. Sealy MP, Guo YB (2011) Fabrication and characterization of surface texture for bone ingrowth by sequential laser peening biodegradable orthopedic magnesium-calcium implants. Journal of Medical Devices-Transactions of the Asme 5:011003. https://doi.org/10.1115/1.400311710.1115/1.4003117 ↗
49. Rodriguez A, Trueba P, Manuel Amado J et al (2020) Surface modification of porous titanium discs using femtosecond laser structuring. Metals 10:748. https://doi.org/10.3390/met1006074810.3390/met10060748 ↗
50. Hariharan A, Goldberg P, Schell F et al (2024) single- and multiscale laser patterning of 3d printed biomedical titanium alloy: toward an enhanced adhesion and early differentiation of human bone marrow stromal cells. Adv Func Mater 34:2310607. https://doi.org/10.1002/adfm.20231060710.1002/adfm.202310607 ↗
51. Lackington WA, Bellon B, Guimond S et al (2024) Bio-Inspired Micro- and Nano-Scale Surface Features Produced by Femtosecond Laser-Texturing Enhance TiZr-Implant Osseointegration. Adv Healthc Mater. https://doi.org/10.1002/adhm.20240081010.1002/adhm.202400810 ↗
52. Balshe AA, Assad DA, Eckert SE, Koka S, Weaver AL (2009) A Retrospective Study of the Survival of Smooth- and Rough-Surface Dental Implants. Int J Oral Maxillofac Implants 24:1113
53. Robles-Ruiz JJ, Arana-Chavez VE, Ciamponi AL, Abrao J, Kanashiro LK (2015) Effects of sandblasting before orthophosphoric acid etching on lingual enamel: In-vitro roughness assessment. Am J Orthod Dentofac Orthop 147:S76. https://doi.org/10.1016/j.ajodo.2014.11.02310.1016/j.ajodo.2014.11.023 ↗
54. Vu VT, Oh G-J, Lim H-P, Yun K-D, Kim J-W, Park S-W (2018) Evaluation of Acid Etching on Surface Characteristics, Strength and Biological Response of Glass-Infiltrated Zirconia. J Nanosci Nanotechnol 18:2223. https://doi.org/10.1166/jnn.2018.1497310.1166/jnn.2018.14973 ↗
55. Lagonegro P, Trevisi G, Nasi L et al (2018) Osteoblasts preferentially adhere to peaks on micro-structured titanium. Dent Mater J 37:278. https://doi.org/10.4012/dmj.2017-00810.4012/dmj.2017-008 ↗
56. Ma P, Yu Y, Yie KHR et al (2021) Effects of titanium with different micro/nano structures on the ability of osteoblasts to resist oxidative stress. Mater Sci Eng C Mater Biol Appl 123:111969. https://doi.org/10.1016/j.msec.2021.11196910.1016/j.msec.2021.111969 ↗
57. Lotz EM, Berger MB, Schwartz Z, Boyan BD (2018) Regulation of osteoclasts by osteoblast lineage cells depends on titanium implant surface properties. Acta Biomater 68:296. https://doi.org/10.1016/j.actbio.2017.12.03910.1016/j.actbio.2017.12.039 ↗
58. Ding Q, Zhang L, Bao R, Zheng G, Sun Y, Xie Q (2018) Effects of different surface treatments on the cyclic fatigue strength of one-piece CAD/CAM zirconia implants. J Mech Behav Biomed Mater 84:249. https://doi.org/10.1016/j.jmbbm.2018.05.00210.1016/j.jmbbm.2018.05.002 ↗
59. Thu MK, Kang YS, Kwak JM, Jo Y-H, Han J-S, Yeo I-SL (2023) Comparison between bone-implant interfaces of microtopographically modified zirconia and titanium implants. Sci Rep-Uk 13:11142. https://doi.org/10.1038/s41598-023-38432-y10.1038/s41598-023-38432-y ↗
60. Gaggl A, Schultes G, Muller WD, Karcher H (2000) Scanning electron microscopical analysis of laser-treated titanium implant surfaces - a comparative study. Biomaterials 21:1067. https://doi.org/10.1016/s0142-9612(00)00002-810.1016/s0142-9612(00)00002-8 ↗
61. Allegrini S Jr, Yoshimoto M, Salles MB, de Almeida Bressiani AH (2014) Biologic Response to Titanium Implants with Laser-Treated Surfaces. Int J Oral Maxillofac Implants 29:63. https://doi.org/10.11607/jomi.321310.11607/jomi.3213 ↗
62. Luo F, Wang L, Xiao Z et al (2021) Application of femtosecond laser microfabrication in the preparation of advanced bioactive titanium surfaces. Journal of Materials Chemistry B 9:3912. https://doi.org/10.1039/d1tb00231g10.1039/d1tb00231g ↗
63. Cunha A, Serro AP, Oliveira V, Almeida A, Vilar R, Durrieu M-C (2013) Wetting behaviour of femtosecond laser textured Ti-6Al-4V surfaces. Appl Surf Sci 265:688. https://doi.org/10.1016/j.apsusc.2012.11.08510.1016/j.apsusc.2012.11.085 ↗
64. Ferraris S, Cochis A, Scalia AC, Tori A, Rimondini L, Spriano S (2024) Laser surface texturing of Ti-cp and Ti6Al4V alloy for the improvement of fibroblast adhesion and alignment and the reduction of bacterial adhesion. Journal of Materials Research and Technology-Jmr&T 29:5464. https://doi.org/10.1016/j.jmrt.2024.03.03310.1016/j.jmrt.2024.03.033 ↗
65. Shan H, Zhou H, Sun N, Ren L, Chen L, Li X (2008) Study on adhesion resistance behavior of sample with striated non-smooth surface by laser processing technique. J Mater Process Technol 199:221. https://doi.org/10.1016/j.jmatprotec.2007.07.03310.1016/j.jmatprotec.2007.07.033 ↗
66. Mirzadeh H, Dadsetan M (2003) Influence of laser surface modifying of polyethylene terephthalate on fibroblast cell adhesion. Radiat Phys Chem 67:381. https://doi.org/10.1016/s0969-806x(03)00071-910.1016/s0969-806x(03)00071-9 ↗
67. Tzanakakis E, Kontonasaki E, Voyiatzis G, Andrikopoulos K, Tzoutzas L (2020) Surface characterization of monolithic zirconia submitted to different surface treatments applying optical interferometry and raman spectrometry. Dent Mater J 39:111. https://doi.org/10.4012/dmj.2018-35810.4012/dmj.2018-358 ↗
68. Inglam S, Chantarapanich N, Suebnukarn S, Vatanapatimaku N, Sucharitpwatskul S, Sitthiseripratip K (2013) Biomechanical Evaluation of a Novel Porous-Structure Implant: Finite Element Study. Int J Oral Max Impl 28:E48. https://doi.org/10.11607/jomi.166610.11607/jomi.1666 ↗
69. Huo W, Zhang X, Chen Y et al (2018) Novel mullite ceramic foams with high porosity and strength using only fly ash hollow spheres as raw material. J Eur Ceram Soc 38:2035. https://doi.org/10.1016/j.jeurceramsoc.2017.11.00210.1016/j.jeurceramsoc.2017.11.002 ↗
70. Chen A-N, Li M, Wu J-M et al (2019) Enhancement mechanism of mechanical performance of highly porous mullite ceramics with bimodal pore structures prepared by selective laser sintering. J Alloy Compd 776:486. https://doi.org/10.1016/j.jallcom.2018.10.33710.1016/j.jallcom.2018.10.337 ↗
71. Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH (1970) Potential of ceramic materials as permanently implantable skeletal prostheses. J Biomed Mater Res 4:433. https://doi.org/10.1002/jbm.82004030910.1002/jbm.820040309 ↗
72. van den Meerakker J, Elfrink RJG, Weeda WM, Roozeboom F (2003) Anodic silicon etching; the formation of uniform arrays of macropores or nanowires. Physica Status Solidi a-Applied Research 197:57. https://doi.org/10.1002/pssa.20030646810.1002/pssa.200306468 ↗
73. Tadic D, Beckmann F, Donath T, Epple M (2004) Comparison of different methods for the preparation of porous bone substitution materials and structural investigations by synchrotron μ-computer tomography. Materialwiss Werkstofftech 35:240. https://doi.org/10.1002/mawe.20040073010.1002/mawe.200400730 ↗
74. Frosch KH, Barvencik F, Lohmann CH et al (2002) Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants. Cells Tissues Organs 170:214. https://doi.org/10.1159/00004792510.1159/000047925 ↗
75. M de Wild, S Zimmermann, J Ruegg, et al. 2016 Influence of Microarchitecture on Osteoconduction and Mechanics of Porous Titanium Scaffolds Generated by Selective Laser Melting. 3d Printing and Additive Manufacturing 3 142-151 https://doi.org/10.1089/3dp.2016.000410.1089/3dp.2016.0004 ↗
76. Mappa TA, Chu S-F, Hung K-S et al (2024) An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential. Mater Design 238:112692. https://doi.org/10.1016/j.matdes.2024.11269210.1016/j.matdes.2024.112692 ↗
77. Guenther F, Pilz S, Hirsch F et al (2023) Shape optimization of additively manufactured lattices based on triply periodic minimal surfaces. Addit Manuf 73:103659. https://doi.org/10.1016/j.addma.2023.10365910.1016/j.addma.2023.103659 ↗
78. Xiao F, Ye J-H, Huang C-X et al (2024) Gradient gyroid Ti6Al4V scaffolds with TiO2 surface modification: Promising approach for large bone defect repair. Biomaterials advances 161:213899. https://doi.org/10.1016/j.bioadv.2024.21389910.1016/j.bioadv.2024.213899 ↗
79. He X, Zhang Z, Wang S, Su F (2023) Microstructure and properties of hierarchical porous ZrO2/Al2O3 ceramics prepared by gel-foaming method. J Aust Ceram Soc 59:905. https://doi.org/10.1007/s41779-023-00883-x10.1007/s41779-023-00883-x ↗
80. van Ruijven LJ, Giesen EBW, Farella M, van Eijden T (2003) Prediction of mechanical properties of the cancellous bone of the mandibular condyle. J Dent Res 82:819. https://doi.org/10.1177/15440591030820101110.1177/154405910308201011 ↗
81. Henys P, Kuchar M, Hajek P, Hammer N (2021) Mechanical metric for skeletal biomechanics derived from spectral analysis of stiffness matrix. Sci Rep-Uk 11:15690. https://doi.org/10.1038/s41598-021-94998-510.1038/s41598-021-94998-5 ↗
82. Ganesh VK, Ramakrishna K, Ghista DN (2005) Biomechanics of bone-fracture fixation by stiffness-graded plates in comparison with stainless-steel plates. Biomed Eng Online 4:1–15. https://doi.org/10.1186/1475-925x-4-4610.1186/1475-925x-4-46 ↗
83. Xing X, Liu B (2002) The influence of osseointegration patterns on implant-bone interfacial stresses. Xi’an Yike Daxue Xuebao 23:152
84. Silva-Henao JD, Schober S, Pahr DH, Reisinger AG (2024) Critical loss of primary implant stability in osteosynthesis locking screws under cyclic overloading. Med Eng Phys 126:104143. https://doi.org/10.1016/j.medengphy.2024.10414310.1016/j.medengphy.2024.104143 ↗
85. Benli S, Aksoy S, Havitcioglu H, Kucuk M (2008) Evaluation of bone plate with low-stiffness material in terms of stress distribution. J Biomech 41:3229. https://doi.org/10.1016/j.jbiomech.2008.08.00310.1016/j.jbiomech.2008.08.003 ↗
86. Lian H, Ding X, Jiao G, Duan P (2022) stiffness and stress distribution of internal fixation system for long bone fractures. Journal of Medical Biomechanics 37:604
87. Dehaghani AE, Javanbakht Z, Barzan M, Lloyd DG, Feih S (2024) Multifunctional Design of Triply Periodic Minimal Surface Structures for Temporary Pediatric Fixation Devices. Adv Eng Mater. https://doi.org/10.1002/adem.20240051810.1002/adem.202400518 ↗
88. Chen W-M, Xie YM, Imbalzano G et al (2016) Lattice Ti Structures with Low Rigidity But Compatible Mechanical Strength: Design of Implant Materials for Trabecular Bone. Int J Precis Eng Manuf 17:793. https://doi.org/10.1007/s12541-016-0097-610.1007/s12541-016-0097-6 ↗
89. Kobayashi N, Fujii T, Shimamura Y (2024) Unidirectional titanium fiber-reinforced porous titanium with mechanical properties suitable for load-bearing biomaterials. J Mech Behav Biomed 151:106388. https://doi.org/10.1016/j.jmbbm.2024.10638810.1016/j.jmbbm.2024.106388 ↗
90. Facchinello Y, Brailovski V, Petit Y, Brummund M, Tremblay J, Mac-Thiong J-M (2015) In-vitro assessment of the stabilization capacity of monolithic spinal rods with variable flexural stiffness: Methodology and examples. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. https://doi.org/10.1109/embc.2015.731924910.1109/embc.2015.7319249 ↗
91. Jin M, Sun N, Weng W et al (2023) The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications. Int J Biol Macromol 242:124820. https://doi.org/10.1016/j.ijbiomac.2023.12482010.1016/j.ijbiomac.2023.124820 ↗
92. Kohal RJ, Baechle M, Att W et al (2013) Osteoblast and bone tissue response to surface modified zirconia and titanium implant materials. Dent Mater 29:763. https://doi.org/10.1016/j.dental.2013.04.00310.1016/j.dental.2013.04.003 ↗
93. Wennerberg A, Albrektsson T (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implant Res 20:172. https://doi.org/10.1111/j.1600-0501.2009.01775.x10.1111/j.1600-0501.2009.01775.x ↗
94. Awad K, Young S, Aswath P, Varanasi V (2022) Interfacial adhesion and surface bioactivity of anodized titanium modified with SiON and SiONP surface coatings. Surfaces and Interfaces 28:101645. https://doi.org/10.1016/j.surfin.2021.10164510.1016/j.surfin.2021.101645 ↗
95. Liao C, He D, Yin K et al (2024) Effect of the Sr-Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats. Journal of Materials Chemistry B 12:1592. https://doi.org/10.1039/d3tb02410e10.1039/d3tb02410e ↗
96. Xu H, Su J, Sun J, Ren T (2012) Preparation and characterization of new nano-composite scaffolds loaded with vascular stents. Int J Mol Sci 13:3366. https://doi.org/10.3390/ijms1303336610.3390/ijms13033366 ↗
97. Munting E (1996) The contributions and limitations of hydroxyapatite coatings to implant fixation: A histomorphometric study of load bearing implants in dogs. Int Orthop 20:1. https://doi.org/10.1007/pl0000669110.1007/pl00006691 ↗
98. Badr NA, El Hadary AA (2007) Hydroxyapatite-electroplated cp-titanium implant and its bone integration potentiality: An in vivo study. Implant Dent 16:297. https://doi.org/10.1097/ID.0b013e31805d7dc410.1097/ID.0b013e31805d7dc4 ↗
99. Bai L, Du Z, Du J et al (2018) A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegratioxn. Biomaterials 162:154. https://doi.org/10.1016/j.biomaterials.2018.02.01010.1016/j.biomaterials.2018.02.010 ↗
100. Topuz M, Dikici B, Gavgali M, Kaseem M (2021) Processing of Ti/(HA+ZrO2) biocomposite and 50% porous hybrid scaffolds with low Young’s modulus by powder metallurgy: Comparing of structural, mechanical, and corrosion properties. Materials Today Communications 29:102813. https://doi.org/10.1016/j.mtcomm.2021.10281310.1016/j.mtcomm.2021.102813 ↗