Novel multifunctional bioactive glass incorporated alginate/poly(amidoamine) hydrogels with controlled drug release for cartilage tissue regeneration
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Osteoarthritis Treatment and Mechanisms · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (90)
Show source-provided references
1. Tran HDN, Park KD, Ching YC et al (2020) A comprehensive review on polymeric hydrogel and its composite: matrices of choice for bone and cartilage tissue engineering. J Ind Eng Chem 89:58–82. https://doi.org/10.1016/j.jiec.2020.06.01710.1016/j.jiec.2020.06.017 ↗
2. Gao X, Gao L, Groth T et al (2019) Fabrication and properties of an injectable sodium alginate/PRP composite hydrogel as a potential cell carrier for cartilage repair. J Biomed Mater Res Part A 107:2076–2087. https://doi.org/10.1002/jbm.a.3672010.1002/jbm.a.36720 ↗
3. Zhang Z-Z, Jiang D, Ding J-X et al (2016) Role of scaffold mean pore size in meniscus regeneration. Acta Biomater 43:314–326. https://doi.org/10.1016/j.actbio.2016.07.05010.1016/j.actbio.2016.07.050 ↗
4. Lima AC, Ferreira H, Reis RL, Neves NM (2019) Biodegradable polymers: an update on drug delivery in bone and cartilage diseases. Expert Opin Drug Deliv 16:795–813. https://doi.org/10.1080/17425247.2019.163511710.1080/17425247.2019.1635117 ↗
5. Cutcliffe HC, DeFrate LE (2020) Comparison of cartilage mechanical properties measured during creep and recovery. Sci Rep 10:1547. https://doi.org/10.1038/s41598-020-58220-210.1038/s41598-020-58220-2 ↗
6. Bilgen B, Jayasuriya CT, Owens BD (2018) Current concepts in meniscus tissue engineering and repair. Adv Healthc Mater 7:1701407. https://doi.org/10.1002/adhm.20170140710.1002/adhm.201701407 ↗
7. Ma X, Yang R, Wang P et al (2022) Bioinspired dual dynamic network hydrogels promote cartilage regeneration through regulating BMSC chondrogenic differentiation. Mater Today Chem 23:100648. https://doi.org/10.1016/j.mtchem.2021.10064810.1016/j.mtchem.2021.100648 ↗
8. Asadi N, Alizadeh E, Salehi R et al (2018) Nanocomposite hydrogels for cartilage tissue engineering: a review. Artif Cells Nanomed Biotechnol 46:465–471. https://doi.org/10.1080/21691401.2017.134592410.1080/21691401.2017.1345924 ↗
9. Chuang E-Y, Chiang C-W, Wong P-C, Chen C-H (2018) Hydrogels for the application of articular cartilage tissue engineering: a review of hydrogels. Adv Mater Sci Eng 2018:1–13. https://doi.org/10.1155/2018/436891010.1155/2018/4368910 ↗
10. Yang F, Zhao J, Koshut WJ et al (2020) A synthetic hydrogel composite with the mechanical behavior and durability of cartilage. Adv Funct Mater 30:2003451. https://doi.org/10.1002/adfm.20200345110.1002/adfm.202003451 ↗
11. Bertuola M, Aráoz B, Gilabert U et al (2021) Gelatin–alginate–hyaluronic acid inks for 3D printing: effects of bioglass addition on printability, rheology and scaffold tensile modulus. J Mater Sci 56:15327–15343. https://doi.org/10.1007/s10853-021-06250-010.1007/s10853-021-06250-0 ↗
12. Zhang M, Zhao X (2020) Alginate hydrogel dressings for advanced wound management. Int J Biol Macromol 162:1414–1428. https://doi.org/10.1016/j.ijbiomac.2020.07.31110.1016/j.ijbiomac.2020.07.311 ↗
13. García-García P, Reyes R, Pérez-Herrero E et al (2020) Alginate-hydrogel versus alginate-solid system efficacy in bone regeneration in osteoporosis. Mater Sci Eng C 115:111009. https://doi.org/10.1016/j.msec.2020.11100910.1016/j.msec.2020.111009 ↗
14. Chen Z, Lv Y (2022) Gelatin/sodium alginate composite hydrogel with dynamic matrix stiffening ability for bone regeneration. Compos Part B Eng 243:110162. https://doi.org/10.1016/j.compositesb.2022.11016210.1016/j.compositesb.2022.110162 ↗
15. Liu W, Madry H, Cucchiarini M (2022) Application of alginate hydrogels for next-generation articular cartilage regeneration. Int J Mol Sci 23:1147. https://doi.org/10.3390/ijms2303114710.3390/ijms23031147 ↗
16. Gorroñogoitia I, Urtaza U, Zubiarrain-Laserna A et al (2022) A study of the printability of alginate-based bioinks by 3D bioprinting for articular cartilage tissue engineering. Polymers 14:354. https://doi.org/10.3390/polym1402035410.3390/polym14020354 ↗
17. Farokhi M, Jonidi Shariatzadeh F, Solouk A, Mirzadeh H (2020) Alginate based scaffolds for cartilage tissue engineering: a review. Int J Polym Mater Polym Biomater 69:230–247. https://doi.org/10.1080/00914037.2018.156292410.1080/00914037.2018.1562924 ↗
18. Calori IR, Braga G, de Jesus P, da CC, et al (2020) Polymer scaffolds as drug delivery systems. Eur Polym J 129:109621. https://doi.org/10.1016/j.eurpolymj.2020.10962110.1016/j.eurpolymj.2020.109621 ↗
19. Moshaverinia A, Xu X, Chen C et al (2013) Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration. Acta Biomater 9:9343–9350. https://doi.org/10.1016/j.actbio.2013.07.02310.1016/j.actbio.2013.07.023 ↗
20. El-Houssiny AS, Ward AA, Mostafa DM et al (2016) Drug–polymer interaction between glucosamine sulfate and alginate nanoparticles: FTIR, DSC and dielectric spectroscopy studies. Adv Nat Sci Nanosci Nanotechnol 7:025014. https://doi.org/10.1088/2043-6262/7/2/02501410.1088/2043-6262/7/2/025014 ↗
21. Mathew M, Rad MA, Mata JP et al (2022) Hyperbranched polymers tune the physicochemical, mechanical, and biomedical properties of alginate hydrogels. Mater Today Chem 23:100656. https://doi.org/10.1016/j.mtchem.2021.10065610.1016/j.mtchem.2021.100656 ↗
22. Malik N, Wiwattanapatapee R, Klopsch R et al (2000) Dendrimers. J Control Release 65:133–148. https://doi.org/10.1016/S0168-3659(99)00246-110.1016/S0168-3659(99)00246-1 ↗
23. Matai I, Gopinath P (2016) Chemically cross-linked hybrid nanogels of alginate and PAMAM dendrimers as efficient anticancer drug delivery vehicles. ACS Biomater Sci Eng 2:213–223. https://doi.org/10.1021/acsbiomaterials.5b0039210.1021/acsbiomaterials.5b00392 ↗
24. Staehlke S, Lehnfeld J, Schneider A et al (2019) Terminal chemical functions of polyamidoamine dendrimer surfaces and its impact on bone cell growth. Mater Sci Eng C 101:190–203. https://doi.org/10.1016/j.msec.2019.03.07310.1016/j.msec.2019.03.073 ↗
25. Patil S, Nune K, Misra R (2018) Alginate/poly(amidoamine) injectable hybrid hydrogel for cell delivery. J Biomater Appl 33:295–314. https://doi.org/10.1177/088532821879021110.1177/0885328218790211 ↗
26. Rahaman MN, Day DE, Sonny Bal B et al (2011) Bioactive glass in tissue engineering. Acta Biomater 7:2355–2373. https://doi.org/10.1016/j.actbio.2011.03.01610.1016/j.actbio.2011.03.016 ↗
27. Chevalier J, Gremillard L (2009) Ceramics for medical applications: a picture for the next 20 years. J Eur Ceram Soc 29:1245–1255. https://doi.org/10.1016/j.jeurceramsoc.2008.08.02510.1016/j.jeurceramsoc.2008.08.025 ↗
28. Utech S, Boccaccini AR (2016) A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers. J Mater Sci 51:271–310. https://doi.org/10.1007/s10853-015-9382-510.1007/s10853-015-9382-5 ↗
29. Kargozar S, Hamzehlou S, Baino F (2019) Can bioactive glasses be useful to accelerate the healing of epithelial tissues? Mater Sci Eng C 97:1009–1020. https://doi.org/10.1016/j.msec.2019.01.02810.1016/j.msec.2019.01.028 ↗
30. Sonatkar J, Kandasubramanian B (2021) Bioactive glass with biocompatible polymers for bone applications. Eur Polym J 160:110801. https://doi.org/10.1016/j.eurpolymj.2021.11080110.1016/j.eurpolymj.2021.110801 ↗
31. Miguez-Pacheco V, de Ligny D, Schmidt J et al (2018) Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications. J Eur Ceram Soc 38:871–876. https://doi.org/10.1016/j.jeurceramsoc.2017.07.02810.1016/j.jeurceramsoc.2017.07.028 ↗
32. Balasubramanian P, Büttner T, Miguez Pacheco V, Boccaccini AR (2018) Boron-containing bioactive glasses in bone and soft tissue engineering. J Eur Ceram Soc 38:855–869. https://doi.org/10.1016/j.jeurceramsoc.2017.11.00110.1016/j.jeurceramsoc.2017.11.001 ↗
33. Shahrbabak MSN, Sharifianjazi F, Rahban D, Salimi A (2019) A comparative investigation on bioactivity and antibacterial properties of sol-gel derived 58S bioactive glass substituted by Ag and Zn. Silicon 11:2741–2751. https://doi.org/10.1007/s12633-018-0063-210.1007/s12633-018-0063-2 ↗
34. Sepulveda P, Jones JR, Hench LL (2002) In vitro dissolution of melt-derived 45S5 and sol-gel derived 58S bioactive glasses. J Biomed Mater Res 61:301–311. https://doi.org/10.1002/jbm.1020710.1002/jbm.10207 ↗
35. Meng J, Boschetto F, Yagi S et al (2022) Melt-electrowritten poly(L-lactic acid)- and bioglass-reinforced biomimetic hydrogel for bone regeneration. Mater Des 219:110781. https://doi.org/10.1016/j.matdes.2022.11078110.1016/j.matdes.2022.110781 ↗
36. Zhang X, Li Y, Ma Z et al (2021) Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing. Bioact Mater 6:3692–3704. https://doi.org/10.1016/j.bioactmat.2021.03.03810.1016/j.bioactmat.2021.03.038 ↗
37. Vukajlovic D, Parker J, Bretcanu O, Novakovic K (2019) Chitosan based polymer/bioglass composites for tissue engineering applications. Mater Sci Eng C 96:955–967. https://doi.org/10.1016/j.msec.2018.12.02610.1016/j.msec.2018.12.026 ↗
38. Lin B, Hu H, Deng Z et al (2020) Novel bioactive glass cross-linked PVA hydrogel with enhanced chondrogenesis properties and application in mice chondrocytes for cartilage repair. J Non Cryst Solids 529:119594. https://doi.org/10.1016/j.jnoncrysol.2019.11959410.1016/j.jnoncrysol.2019.119594 ↗
39. Sánchez-Aguinagalde O, Lejardi A, Meaurio E et al (2021) Novel hydrogels of chitosan and poly(vinyl alcohol) reinforced with inorganic particles of bioactive glass. Polym Basel 13:691. https://doi.org/10.3390/polym1305069110.3390/polym13050691 ↗
40. Zhou L, Fan L, Zhang F-M et al (2021) Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation. Bioact Mater 6:890–904. https://doi.org/10.1016/j.bioactmat.2020.09.01210.1016/j.bioactmat.2020.09.012 ↗
41. Srinivasan S, Jayasree R, Chennazhi KP et al (2012) Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration. Carbohydr Polym 87:274–283. https://doi.org/10.1016/j.carbpol.2011.07.05810.1016/j.carbpol.2011.07.058 ↗
42. Clare A, Jones JR (2012) Bio-glasses: an introduction. Wiley, Hoboken, pp 179–202
43. Moghanian A, Firoozi S, Tahriri M (2017) Synthesis and in vitro studies of sol-gel derived lithium substituted 58S bioactive glass. Ceram Int 43(15):12835–1284310.1016/j.ceramint.2017.06.174 ↗
44. Jones JR (2015) Reprint of: review of bioactive glass: from hench to hybrids. Acta Biomater 23:S53–S82. https://doi.org/10.1016/j.actbio.2015.07.01910.1016/j.actbio.2015.07.019 ↗
45. Schulz A, Katsen-Globa A, Huber EJ et al (2018) Poly(amidoamine)-alginate hydrogels: directing the behavior of mesenchymal stem cells with charged hydrogel surfaces. J Mater Sci Mater Med 29:105. https://doi.org/10.1007/s10856-018-6113-x10.1007/s10856-018-6113-x ↗
46. Farokhi M, Solouk A, Mirzadeh H et al (2023) An injectable enzymatically crosslinked and mechanically tunable silk fibroin/chondroitin sulfate chondro-inductive hydrogel. Macromol Mater Eng 308:2200503. https://doi.org/10.1002/mame.20220050310.1002/mame.202200503 ↗
47. Sani M, Hosseinie R, Latifi M et al (2022) Engineered artificial articular cartilage made of decellularized extracellular matrix by mechanical and IGF-1 stimulation. Biomater Adv 139:213019. https://doi.org/10.1016/j.bioadv.2022.21301910.1016/j.bioadv.2022.213019 ↗
48. Gu P, Li B, Wu B et al (2020) Controlled hydration, transition, and drug release realized by adjusting layer thickness in alginate-Ca2+/poly( N -isopropylacrylamide) Interpenetrating polymeric network hydrogels on cotton fabrics. ACS Biomater Sci Eng 6:5051–5060. https://doi.org/10.1021/acsbiomaterials.0c0075610.1021/acsbiomaterials.0c00756 ↗
49. Petrova VA, Elokhovskiy VY, Raik SV et al (2019) Alginate gel reinforcement with chitin nanowhiskers modulates rheological properties and drug release profile. Biomolecules 9:291. https://doi.org/10.3390/biom907029110.3390/biom9070291 ↗
50. Naghizadeh Z, Karkhaneh A, Nokhbatolfoghahaei H et al (2021) Cartilage regeneration with dual-drug-releasing injectable hydrogel/microparticle system: in vitro and in vivo study. J Cell Physiol 236:2194–2204. https://doi.org/10.1002/jcp.3000610.1002/jcp.30006 ↗
51. Chen H, Xing X, Tan H et al (2017) Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing. Mater Sci Eng C 70:287–295. https://doi.org/10.1016/j.msec.2016.08.08610.1016/j.msec.2016.08.086 ↗
52. Hafezi Moghaddam R, Dadfarnia S, Shabani AMH et al (2019) Electron beam irradiation synthesis of porous and non-porous pectin based hydrogels for a tetracycline drug delivery system. Mater Sci Eng C 102:391–404. https://doi.org/10.1016/j.msec.2019.04.07110.1016/j.msec.2019.04.071 ↗
53. Kaviani A, Pircheraghi G, Bagheri R, Goharpey F (2023) Polyelectrolyte complexes between chitosan and quince seed gum: a rheological, structural, and multiple dye adsorption study. J Polym Environ 31:852–869. https://doi.org/10.1007/s10924-022-02634-810.1007/s10924-022-02634-8 ↗
54. Costa VC, Costa HS, Vasconcelos WL et al (2007) Preparation of hybrid biomaterials for bone tissue engineering. Mater Res 10:21–26. https://doi.org/10.1590/S1516-1439200700010000610.1590/S1516-14392007000100006 ↗
55. Saqaei M, Fathi M, Edris H, Mortazavi V (2015) Preparation and biocompatibility evaluation of bioactive glass–forsterite nanocomposite powder for oral bone defects treatment applications. Mater Sci Eng C 56:409–416. https://doi.org/10.1016/j.msec.2015.07.00210.1016/j.msec.2015.07.002 ↗
56. Li X, Cho B, Martin R et al (2019) Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction. Sci Transl Med 11:eaau6210. https://doi.org/10.1126/scitranslmed.aau621010.1126/scitranslmed.aau6210 ↗
57. Yacob N, Hashim K (2014) Morphological effect on swelling behavior of hydrogel. 153–15910.1063/1.4866123 ↗
58. de Nunes R, M, Girão VCC, Cunha PLR, et al (2021) Decreased sulfate content and zeta potential distinguish glycosaminoglycans of the extracellular matrix of osteoarthritis cartilage. Front Med 8:612370. https://doi.org/10.3389/fmed.2021.61237010.3389/fmed.2021.612370 ↗
59. Xu HHK, Simon CG (2005) Fast setting calcium phosphate–chitosan scaffold: mechanical properties and biocompatibility. Biomaterials 26:1337–1348. https://doi.org/10.1016/j.biomaterials.2004.04.04310.1016/j.biomaterials.2004.04.043 ↗
60. Gaharwar AK, Rivera C, Wu C-J et al (2013) Photocrosslinked nanocomposite hydrogels from PEG and silica nanospheres: structural, mechanical and cell adhesion characteristics. Mater Sci Eng C 33:1800–1807. https://doi.org/10.1016/j.msec.2012.12.09910.1016/j.msec.2012.12.099 ↗
61. Kumar BYS, Isloor AM, Kumar GCM et al (2019) Nanohydroxyapatite reinforced chitosan composite hydrogel with tunable mechanical and biological properties for cartilage regeneration. Sci Rep 9:15957. https://doi.org/10.1038/s41598-019-52042-710.1038/s41598-019-52042-7 ↗
62. Mortier C, Costa DCS, Oliveira MB et al (2022) Advanced hydrogels based on natural macromolecules: chemical routes to achieve mechanical versatility. Mater Today Chem 26:101222. https://doi.org/10.1016/j.mtchem.2022.10122210.1016/j.mtchem.2022.101222 ↗
63. Nezhad-Mokhtari P, Ghorbani M, Roshangar L, Soleimani Rad J (2019) A review on the construction of hydrogel scaffolds by various chemically techniques for tissue engineering. Eur Polym J 117:64–76. https://doi.org/10.1016/j.eurpolymj.2019.05.00410.1016/j.eurpolymj.2019.05.004 ↗
64. Iviglia G, Cassinelli C, Torre E et al (2016) Novel bioceramic-reinforced hydrogel for alveolar bone regeneration. Acta Biomater 44:97–109. https://doi.org/10.1016/j.actbio.2016.08.01210.1016/j.actbio.2016.08.012 ↗
65. Faghihi S, Gheysour M, Karimi A, Salarian R (2014) Fabrication and mechanical characterization of graphene oxide-reinforced poly (acrylic acid)/gelatin composite hydrogels. J Appl Phys 115:083513. https://doi.org/10.1063/1.486415310.1063/1.4864153 ↗
66. Abedini AA, Pircheraghi G, Kaviani A (2023) The role of calcium crosslinking and glycerol plasticizing on the physical and mechanical properties of superabsorbent. J Polym Res 30:20. https://doi.org/10.1007/s10965-022-03397-510.1007/s10965-022-03397-5 ↗
67. Jang J, Seol Y-J, Kim HJ et al (2014) Effects of alginate hydrogel cross-linking density on mechanical and biological behaviors for tissue engineering. J Mech Behav Biomed Mater 37:69–77. https://doi.org/10.1016/j.jmbbm.2014.05.00410.1016/j.jmbbm.2014.05.004 ↗
68. Jiang Y-Y, Zhu Y-J, Li H et al (2017) Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate. J Colloid Interface Sci 497:266–275. https://doi.org/10.1016/j.jcis.2017.03.03210.1016/j.jcis.2017.03.032 ↗
69. Jeon O, Bouhadir KH, Mansour JM, Alsberg E (2009) Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties. Biomaterials 30:2724–2734. https://doi.org/10.1016/j.biomaterials.2009.01.03410.1016/j.biomaterials.2009.01.034 ↗
70. Di S, Liu X, Liu D et al (2016) A multifunctional porous scaffold with capacities of minimally invasive implantation, self-fitting and drug delivery. Mater Today Chem 1:52–62. https://doi.org/10.1016/j.mtchem.2016.11.00410.1016/j.mtchem.2016.11.004 ↗
71. Cheng Y, Lu J, Liu S et al (2014) The preparation, characterization and evaluation of regenerated cellulose/collagen composite hydrogel films. Carbohydr Polym 107:57–64. https://doi.org/10.1016/j.carbpol.2014.02.03410.1016/j.carbpol.2014.02.034 ↗
72. Mikael PE, Kim HS, Nukavarapu SP (2018) Hybrid extracellular matrix design for cartilage-mediated bone regeneration. J Biomed Mater Res Part B Appl Biomater 106:300–309. https://doi.org/10.1002/jbm.b.3384210.1002/jbm.b.33842 ↗
73. He X, Zeng L, Cheng X et al (2021) Shape memory composite hydrogel based on sodium alginate dual crosslinked network with carboxymethyl cellulose. Eur Polym J 156:110592. https://doi.org/10.1016/j.eurpolymj.2021.11059210.1016/j.eurpolymj.2021.110592 ↗
74. Mansoorianfar M, Shahin K, Mirström MM, Li D (2021) Cellulose-reinforced bioglass composite as flexible bioactive bandage to enhance bone healing. Ceram Int 47:416–423. https://doi.org/10.1016/j.ceramint.2020.08.14810.1016/j.ceramint.2020.08.148 ↗
75. Zhang H, Xiong Y, Dong L et al (2021) Microstructural, mechanical properties and strengthening mechanism of DLP produced β-tricalcium phosphate scaffolds by incorporation of MgO/ZnO/58S bioglass. Ceram Int 47:25863–25874. https://doi.org/10.1016/j.ceramint.2021.05.31710.1016/j.ceramint.2021.05.317 ↗
76. Farag MM (2023) Recent trends on biomaterials for tissue regeneration applications: review. J Mater Sci 58:527–558. https://doi.org/10.1007/s10853-022-08102-x10.1007/s10853-022-08102-x ↗
77. Keshavarz M, Alizadeh P (2021) On the role of alginate coating on the mechanical and biological properties of 58S bioactive glass scaffolds. Int J Biol Macromol 167:947–961. https://doi.org/10.1016/j.ijbiomac.2020.11.05110.1016/j.ijbiomac.2020.11.051 ↗
78. Liu H, Yazici H, Ergun C et al (2008) An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration. Acta Biomater 4:1472–1479. https://doi.org/10.1016/j.actbio.2008.02.02510.1016/j.actbio.2008.02.025 ↗
79. Rocton N, Oudadesse H, Lefeuvre B et al (2020) Fine analysis of interaction mechanism of bioactive glass surface after soaking in SBF solution: AFM and ICP-OES investigations. Appl Surf Sci 505:144076. https://doi.org/10.1016/j.apsusc.2019.14407610.1016/j.apsusc.2019.144076 ↗
80. Montalbano G, Molino G, Fiorilli S, Vitale-Brovarone C (2020) Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: a hybrid formulation for 3D printing of bone scaffolds. J Eur Ceram Soc 40:3689–3697. https://doi.org/10.1016/j.jeurceramsoc.2020.02.01810.1016/j.jeurceramsoc.2020.02.018 ↗
81. Juhasz JA, Best SM (2012) Bioactive ceramics: processing, structures and properties. J Mater Sci 47:610–624. https://doi.org/10.1007/s10853-011-6063-x10.1007/s10853-011-6063-x ↗
82. Abou-Okeil A, Aly AA, Amr A, Soliman AAF (2019) Biocompatible hydrogel for cartilage repair with adjustable properties. Polym Adv Technol 30:2026–2033. https://doi.org/10.1002/pat.463510.1002/pat.4635 ↗
83. Abedi-Gaballu F, Dehghan G, Ghaffari M et al (2018) PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. Appl Mater Today 12:177–190. https://doi.org/10.1016/j.apmt.2018.05.00210.1016/j.apmt.2018.05.002 ↗
84. Kheraldine H, Rachid O, Habib AM et al (2021) Emerging innate biological properties of nano-drug delivery systems: a focus on PAMAM dendrimers and their clinical potential. Adv Drug Deliv Rev 178:113908. https://doi.org/10.1016/j.addr.2021.11390810.1016/j.addr.2021.113908 ↗
85. Fana M, Gallien J, Srinageshwar B et al (2020) PAMAM dendrimer nanomolecules utilized as drug delivery systems for potential treatment of glioblastoma: a systematic review. Int J Nanomed 15:2789–2808. https://doi.org/10.2147/IJN.S24315510.2147/IJN.S243155 ↗
86. Najafi F, Pashaei-Sarnaghi R, Salami-Kalajahi M, Roghani-Mamaqani H (2021) Application of poly(amidoamine) dendrimer as transfer agent to synthesize poly(amidoamine)-b-poly(methyl acrylate) amphiphilc block copolymers: self-assembly in aqueous media and drug delivery. J Drug Deliv Sci Technol 64:102626. https://doi.org/10.1016/j.jddst.2021.10262610.1016/j.jddst.2021.102626 ↗
87. Goodarzi K, Jonidi Shariatzadeh F, Solouk A et al (2020) Injectable drug loaded gelatin based scaffolds as minimally invasive approach for drug delivery system: CNC/PAMAM nanoparticles. Eur Polym J 139:109992. https://doi.org/10.1016/j.eurpolymj.2020.10999210.1016/j.eurpolymj.2020.109992 ↗
88. Xu Q, Huang W, Jiang L et al (2013) KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release. Carbohydr Polym 97:565–570. https://doi.org/10.1016/j.carbpol.2013.05.00710.1016/j.carbpol.2013.05.007 ↗
89. Li J, Mooney DJ (2016) Designing hydrogels for controlled drug delivery. Nat Rev Mater 1:16071. https://doi.org/10.1038/natrevmats.2016.7110.1038/natrevmats.2016.71 ↗
90. Bruschi M (2015) Strategies to modify the drug release from pharmaceutical systems. Woodhead, Sawston, pp 37–89