In vitro biomineralization behaviors and mechanism as well as cell responses of calcium silicate ceramics
Source abstract
Abstract
Calcium silicate ceramics have excellent bioactivity and biomineralization performance. In this work, we investigated the effect of different mineralization environments of one time and five times simulated body fluids (× 1 and × 5 SBF) on the apatite mineralization behavior of CaSiO3 ceramic and explored the mineralization mechanism by soaking them in the × 1 SBF. The CaSiO3 ceramics were found to release Ca2+ and SiO32− ions firstly. The process of ions exchange resulted in the pH increased and the ≡Si–OH groups formed. H+ ions released from the ≡Si–OH groups due to the pH variation, which thereby caused that the surface was negatively charged to recombine with the Ca2+. Meanwhile, the calcium silicate surface layer reformed above the original CaSiO3 ceramic surface. The calcium phosphate layer with different mineral morphologies was induced to be deposited on the reformed calcium silicate surface layer. Importantly, the cytological response results also indicated that a thicker calcium phosphate minerals layer with lamellar-like morphology covered on the CaSiO3 ceramic surface played a more prominent role in up-regulating the expressions of osteogenesis-related genes.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (22)
Show source-provided references
1. Jiang J, Zheng Q, Hou D, Yan Y, Chen H, She W, Wu S, Guo D, Sun W (2018) Calcite crystallization in the cement system: morphological diversity, growth mechanism and shape evolution. PCCP 20(20):14174–1418110.1039/C8CP01979G ↗
2. Xue WC, Liu XY, Zheng XB, Ding CX (2005) In vivo evaluation of plasma-sprayed wollastonite coating. Biomaterials 26(17):3455–346010.1016/j.biomaterials.2004.09.027 ↗
3. Liu XY, Ding CX, Chu PK (2004) Mechanism of apatite formation on wollastonite coatings in simulated body fluids. Biomaterials 25(10):1755–176110.1016/j.biomaterials.2003.08.024 ↗
4. Liu XY, Ding CX (2002) Reactivity of plasma-sprayed wollastonite coating in simulated body fluid. J Biomed Mater Res 59(2):259–26410.1002/jbm.1240 ↗
5. Hench LL (1998) Bioceramics. J Am Ceram Soc 81(7):1705–172810.1111/j.1151-2916.1998.tb02540.x ↗
6. Hench LL (1994) Bioactive ceramics: theory and clinical applications. In: Andersson ÖH, Happonen R-P, Yli-Urpo A (eds) Bioceramics. Pergamon, Oxford, pp 3–1410.1016/B978-0-08-042144-5.50005-4 ↗
7. Ohtsuki C, Kokubo T, Yamamuro T (1992) Mechanism of apatite formation on CaOSiO2P2O5 glasses in a simulated body fluid. J Non-Cryst Solids 143:84–9210.1016/S0022-3093(05)80556-3 ↗
8. Takadama H, Kim HM, Kokubo T, Nakamura T (2001) Mechanism of biomineralization of apatite on a sodium silicate glass: TEM-EDX study in vitro. Chem Mater 13(3):1108–111310.1021/cm0008718 ↗
9. Zhang N, Molenda JA, Fournelle JH, Murphy WL, Sahai N (2010) Effects of pseudowollastonite (CaSiO3) bioceramic on in vitro activity of human mesenchymal stem cells. Biomaterials 31(30):7653–766510.1016/j.biomaterials.2010.06.043 ↗
10. Lin KL, Zhai WY, Ni SY, Chang J, Zeng Y, Qian WJ (2005) Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics. Ceram Int 31(2):323–32610.1016/j.ceramint.2004.05.023 ↗
11. Kolos EC, Ruys AJ, Rohanizadeh R, Muir MM, Roger G (2006) Calcium phosphate fibres synthesized from a simulated body fluid. J Mater Sci Mater Med 17(11):1179–118910.1007/s10856-006-0546-3 ↗
12. Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27(15):2907–291510.1016/j.biomaterials.2006.01.017 ↗
13. Eanes ED (1998) Amorphous calcium phosphate: thermodynamic and kinetic considerations. In: Amjad Z (ed) Calcium Phosphates in Biological and Industrial Systems. Springer, US, Boston, MA, pp 21–3910.1007/978-1-4615-5517-9_2 ↗
14. Paluszkiewicz C, Blazewicz M, Podporska J, Gumula T (2008) Nucleation of hydroxyapatite layer on wollastonite material surface: FTIR studies. Vib Spectrosc 48(2):263–26810.1016/j.vibspec.2008.02.020 ↗
15. Ślósarczyk A, Paszkiewicz Z, Paluszkiewicz C (2005) FTIR and XRD evaluation of carbonated hydroxyapatite powders synthesized by wet methods. J Mol Struct 744–747:657–66110.1016/j.molstruc.2004.11.078 ↗
16. Fleet ME, Liu X (2007) Coupled substitution of type A and B carbonate in sodium-bearing apatite. Biomaterials 28(6):916–92610.1016/j.biomaterials.2006.11.003 ↗
17. Hayakawa S, Osaka A (2000) Biomimetic deposition of calcium phosphates on oxides soaked in a simulated body fluid. J Non-Cryst Solids 263(1–4):409–41510.1016/S0022-3093(99)00649-3 ↗
18. Silbernagel KG, Thomee R, Eriksson BI, Karlsson J (2007) Continued sports activity, using a pain-monitoring model, during rehabilitation in patients with Achilles tendinopathy—a randomized controlled study. Am J Sports Med 35(6):897–90610.1177/0363546506298279 ↗
19. Wang J, Wang ML, Chen FY, Wei YH, Chen XN, Zhou Y, Yang X, Zhu XD, Tu CQ, Zhang XD (2019) Nano-Hydroxyapatite coating promotes porous calcium phosphate ceramic-induced osteogenesis via BMP/Smad signaling pathway. Int J Nanomed 14:7987–800010.2147/IJN.S216182 ↗
20. Wang C, Xue Y, Lin K, Lu J, Chang J, Sun J (2012) The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using beta-CaSiO3/beta-Ca-3(PO4)(2) composite bioceramics. Acta Biomater 8(1):350–36010.1016/j.actbio.2011.08.019 ↗
21. Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C (2008) Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 29(17):2588–259610.1016/j.biomaterials.2008.03.013 ↗
22. Liu J, Li J, Ye J, He F (2016) Setting behavior, mechanical property and biocompatibility of anti-washout wollastonite/calcium phosphate composite cement. Ceram Int 42(12):13670–1368110.1016/j.ceramint.2016.05.165 ↗