Applications of bone regeneration hydrogels in the treatment of bone defects: a review
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OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · 3D Printing in Biomedical Research
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References (100+)
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1. Bartl R, Bartl C (2017) Structure and architecture of bone. In: Bone disorders. Springer, Cham. New York, pp 11–20. https://doi.org/10.1007/978-3-319-29182-6_210.1007/978-3-319-29182-6_2 ↗
2. Osman K, Gabr A, Haddad FS (2019) Bone healing. In: Paschos N, Bentley G (eds) General orthopaedics and basic science. Orthopaedic Study Guide Series. Springer, Cham. New York, pp 111–119. https://doi.org/10.1007/978-3-319-92193-8_1410.1007/978-3-319-92193-8_14 ↗
3. Bartl R, Bartl C (2017) Fracture healing. In: Bone disorders. Springer, Cham. New York, pp 239–242. https://doi.org/10.1007/978-3-319-29182-6_3510.1007/978-3-319-29182-6_35 ↗
4. Li JL, Melissa AK, David LS (2019) Fracture healing. In: Basic and applied bone biology, 2nd ed. Elsevier/Academic Press. London, pp 235–253. https://doi.org/10.1016/B978-0-12-813259-3.00012-910.1016/B978-0-12-813259-3.00012-9 ↗
5. Angshuman B, Ambalangodage C, Jayasuriya (2020) Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration. Mater Sci Eng C 110:110698. https://doi.org/10.1016/j.msec.2020.11069810.1016/j.msec.2020.110698 ↗
6. Zheng TY, Guo LY, Du ZY, Leng HJ, Cai Q, Yang XP (2021) Bioceramic fibrous scaffolds built with calcium silicate/hydroxyapatite nanofibers showing advantages for bone regeneration. CERAM INT 47:18920–18930. https://doi.org/10.1016/j.ceramint.2021.03.23410.1016/j.ceramint.2021.03.234 ↗
7. Li XF, Song T, Chen XN, Wang ML, Yang X, Xiao YM, Zhang XD (2019) Osteoinductivity of porous biphasic calcium phosphate ceramic spheres with nanocrystalline and their efficacy in guiding bone regeneration. ACS Appl Mater Interfaces 11:3722–3736. https://doi.org/10.1021/acsami.8b1852510.1021/acsami.8b18525 ↗
8. He FP, Lu TL, Fang XB, Feng SH, Feng SL, Tian Y, Li YH, Zuo F, Deng X, Ye JD (2020) Novel extrusion-microdrilling approach to fabricate calcium phosphate-based bioceramic scaffolds enabling fast bone regeneration. ACS Appl Mater Interfaces 2020:32340–32351. https://doi.org/10.1021/acsami.0c0730410.1021/acsami.0c07304 ↗
9. Aslankoohi N, Mequanint K (2020) Poly(ester amide)—bioactive glass hybrid biomaterials for bone regeneration and biomolecule delivery. ACS Appl Bio Mater 3:3621–3630. https://doi.org/10.1021/acsabm.0c0025710.1021/acsabm.0c00257 ↗
10. Zheng ZW, Chen YH, Guo B, Wang Y, Liu W, Sun J, Wang XS (2020) Magnesium-organic framework-based stimuli-responsive systems that optimize the bone microenvironment for enhanced bone regeneration. Chem Eng J 396:125241. https://doi.org/10.1016/j.cej.2020.12524110.1016/j.cej.2020.125241 ↗
11. Seong YJ, Song EH, Park C, Lee H, Kang IG, Kim HE, Jeong SH (2020) Porous calcium phosphate—collagen composite microspheres for effective growth factor delivery and bone tissue regeneration. Mater Sci Eng C 109:110480. https://doi.org/10.1016/j.msec.2019.11048010.1016/j.msec.2019.110480 ↗
12. Yasutaka M, Fumuki Y, Hideki N, Yuji M, Kousuke I, Toshihiko Y, Sakae T, Kazuhiko I, Yosuke O, Toru M, Taku S (2019) Multi-layered PLLA-nanosheets loaded with FGF-2 induce robust bone regeneration with controlled release in critical-sized mouse femoral defects. Acta Biomater 85:172–179. https://doi.org/10.1016/j.actbio.2018.12.03110.1016/j.actbio.2018.12.031 ↗
13. Chen K, Lin XF, Zhang Q, Ni JF, Li JM, Xiao J, Wang Y, Ye YH, Chen L, Jin KK, Chen L (2015) Decellularized periosteum as a potential biologic scaffold for bone tissue engineering. Acta Biomater 19:46–55. https://doi.org/10.1016/j.actbio.2015.02.02010.1016/j.actbio.2015.02.020 ↗
14. Bai X, Gao MZ, Syed S, Zhuang J, Xu XY, Zhang XQ (2018) Bioactive hydrogels for bone regeneration. Bioact Mater 3:401–417. https://doi.org/10.1016/j.bioactmat.2018.05.00610.1016/j.bioactmat.2018.05.006 ↗
15. Saravanan S, Vimalraj S, Thanikaivelan P, Banudevi S, Manivasagam G (2019) A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration. Int J Biol Macromol 121:38–54. https://doi.org/10.1016/j.ijbiomac.2018.10.01410.1016/j.ijbiomac.2018.10.014 ↗
16. Marco CB, Vinoy T, Gudrun S, Yogesh KV, Chu TG, Michael JK, Gregg MJ (2012) Recent advances in the development of GTR/GBR membranes for periodontal regeneration—a materials perspective. Dent Mater 28:703–721. https://doi.org/10.1016/j.dental.2012.04.02210.1016/j.dental.2012.04.022 ↗
17. Afshar M, Dini G, Vaezifar S, Mehdikhani M, Movahedi B (2020) Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug-loaded chitosan nanoparticles as a drug delivery system. J Drug Deliv Sci Technol 56:101530. https://doi.org/10.1016/j.jddst.2020.10153010.1016/j.jddst.2020.101530 ↗
18. Zhai PS, Peng XX, Li BQ, Liu YP, Sun HC, Li XW (2020) The application of hyaluronic acid in bone regeneration. Int J Biol Macromol 151:1224–1239. https://doi.org/10.1016/j.ijbiomac.2019.10.16910.1016/j.ijbiomac.2019.10.169 ↗
19. Matthew RA, Janet MH, David BB (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35:1003–1012. https://doi.org/10.1016/j.bone.2004.07.01410.1016/j.bone.2004.07.014 ↗
20. Alonzo M, Primo FA, Kumar SA, Muldoff JA, Dominguez E, Fregoso G, Ortiz N, Weiss WM, Joddar B (2021) Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects. Curr opin Biomed Eng 17:100248. https://doi.org/10.1016/j.cobme.2020.10024810.1016/j.cobme.2020.100248 ↗
21. Hussain I, Sayed MS, Liu SL, Oderinde O, Yao F, Fu GD (2018) Glycogen-based self-healing hydrogels with ultra-stretchable, flexible, and enhanced mechanical properties via sacrificial bond interactions. Int J Biol Macromol 117:648–658. https://doi.org/10.1016/j.ijbiomac.2018.04.08810.1016/j.ijbiomac.2018.04.088 ↗
22. Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Suzuki S, Sasaki N, Shibayama M, Chung U (2008) Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers. Macromolecules 41:5379–5384. https://doi.org/10.1021/ma800476x10.1021/ma800476x ↗
23. Gong JP, Katsuyama Y, Kurokawa T, Osada Y (2003) Double-network hydrogels with extremely high mechanical strength. Adv Mater 15:1155–1158. https://doi.org/10.1002/adma.20030490710.1002/adma.200304907 ↗
24. Chen Q, Chen H, Zhu L, Zheng J (2015) Fundamentals of double network hydrogels. J Mat Chem B 3:3654–3676. https://doi.org/10.1039/C5TB00123D10.1039/C5TB00123D ↗
25. Guo F, Huang KQ, Niu JJ, Kuang TR, Zheng YJ, Gu ZP, Zou J (2020) Enhanced osseointegration of double network hydrogels via calcium polyphosphate incorporation for bone regeneration. Int J Biol Macromol 151:1126–1132. https://doi.org/10.1016/j.ijbiomac.2019.10.15510.1016/j.ijbiomac.2019.10.155 ↗
26. Kaur G, Valarmathi MT, Potts JD, Jabbari E, Sabo-Attwood T, Qian W (2010) Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Biomaterials 31:1732–1741. https://doi.org/10.1016/j.biomaterials.2009.11.04110.1016/j.biomaterials.2009.11.041 ↗
27. Gaihre B, Liu XF, Li LL, Miller AL, Camilleri ET, Li Y, Waletzki B, Lu LC (2021) Bifunctional hydrogels for potential vascularized bone tissue regeneration. Mater Sci Eng C 124:112075. https://doi.org/10.1016/j.msec.2021.11207510.1016/j.msec.2021.112075 ↗
28. Ou QM, Huang KQ, Fu CQ, Huang CL, Fang YF, Gu ZP, Wu J, Wang Y (2020) Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogels with osteoimmunomodulatory and antibacterial activity for bone Regeneration. Chem Eng J 382:123019. https://doi.org/10.1016/j.cej.2019.12301910.1016/j.cej.2019.123019 ↗
29. Huang KQ, Wu J, Gu ZP (2018) Black phosphorus hydrogels scaffolds enhance bone regeneration via a sustained supply of calcium-free phosphorus. ACS Appl Mater Interfaces 11:2908–2916. https://doi.org/10.1021/acsami.8b2117910.1021/acsami.8b21179 ↗
30. Yi L, Zhong T, Huang YB, Huang SP (2020) Triiodothyronine promotes the osteoblast formation by activating autophagy. Biophys Chem 267:106483. https://doi.org/10.1016/j.bpc.2020.10648310.1016/j.bpc.2020.106483 ↗
31. Radhakrishnan J, Manigandan A, Chinnaswamy P, Subramanian A, Sethuraman S (2018) Gradient nano-engineered in situ forming composite hydrogels for osteochondral regeneration. Biomaterials 162:82–98. https://doi.org/10.1016/j.biomaterials.2018.01.05610.1016/j.biomaterials.2018.01.056 ↗
32. Yaylaci SU, Sen M, Bulut O, Arslan E, Guler MO, Tekinay AB (2016) Chondrogenic differentiation of mesenchymal stem cells on glycosaminoglycan-mimetic peptide nanofibers. ACS Biomater Sci Eng 2:871–878. https://doi.org/10.1021/acsbiomaterials.6b0009910.1021/acsbiomaterials.6b00099 ↗
33. Schuurmans CCL, Mihajlovic M, Hiemstra C, Ito K, Hennink WE, Vermonden T (2021) Hyaluronic acid and chondroitin sulfate (meth)acrylate-based hydrogels for tissue engineering: synthesis, characteristics and pre-clinical evaluation. Biomaterials 268:120602. https://doi.org/10.1016/j.biomaterials.2020.12060210.1016/j.biomaterials.2020.120602 ↗
34. Liu X, Liu S, Yang R, Wang PH, Zhang WJ, Tan XY, Ren YH, Chi B (2021) Gradient chondroitin sulfate/poly (γ-glutamic acid) hydrogels inducing differentiation of stem cells for cartilage tissue engineering. Carbohydr Polym 270:118330. https://doi.org/10.1016/j.carbpol.2021.11833010.1016/j.carbpol.2021.118330 ↗
35. Ma FB, Xia XY, Tang B (2019) Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration. Mater Sci Eng C—Mater Biol Appl 117:111368. https://doi.org/10.1016/j.carbpol.2019.02.06810.1016/j.carbpol.2019.02.068 ↗
36. Zhang W, Zhao FJ, Huang DQ, Fu XL, Li X, Chen XF (2016) Strontium-substituted submicrometer bioactive glasses modulate macrophage responses for improved bone regeneration. ACS Appl Mater Interfaces 8:30747–30758. https://doi.org/10.1021/acsami.6b1037810.1021/acsami.6b10378 ↗
37. Ma FB, Li SJ, Ruiz-Ortega LI, Zhang YJ, Xu L, Wang K, Lin LJ (2020) Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing. Mater Sci Eng C 116:111217. https://doi.org/10.1016/j.msec.2020.11121710.1016/j.msec.2020.111217 ↗
38. Mierzwa AGH, Campos JF, Jesus MF, Nader HB, Lazaretti-Castro M (2017) Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats. Osteoarthr Cartil 25:1179–1188. https://doi.org/10.1016/j.joca.2017.02.79310.1016/j.joca.2017.02.793 ↗
39. Edward ON, Guleid A, Leila D, Obum U, Kevin WHL (2018) The roles of ions on bone regeneration. Drug Discov Today 23:879–890. https://doi.org/10.1016/j.drudis.2018.01.04910.1016/j.drudis.2018.01.049 ↗
40. Xu L, Ma FB, Leung FKL, Qin CH, Lu WW, Tang B (2021) Chitosan-strontium chondroitin sulfate scaffolds for reconstruction of bone defects in aged rats. Carbohydr Polym 273:118532. https://doi.org/10.1016/j.carbpol.2021.11853210.1016/j.carbpol.2021.118532 ↗
41. Lam J, Truong NF, Segura T (2014) Design of cell-matrix interactions in hyaluronic acid hydrogels scaffolds. Acta Biomater 10:1571–158010.1016/j.actbio.2013.07.025 ↗
42. An SW, Choi SJ, Min SJ, Cho SW (2021) Hyaluronic acid-based biomimetic hydrogels for tissue engineering and medical applications. Biotechnol Bioprocess Eng 26:503–516. https://doi.org/10.1007/s12257-020-0343-810.1007/s12257-020-0343-8 ↗
43. Abdul-Monem MM, Kamoun EA, Ahmed DM, El-Fakharany EM, Al-Abbassy FH, Aly HM (2021) Light-cured hyaluronic acid composite hydrogels using riboflavin as a photoinitiator for bone regeneration applications. J Taibah Univ Med Soc 16:529–539. https://doi.org/10.1016/j.jtumed.2020.12.02110.1016/j.jtumed.2020.12.021 ↗
44. Taz M, Makkar P, Imran KM, Jang DW, Kim YS, Lee BT (2019) Bone regeneration of multichannel biphasic calcium phosphate granules supplemented with hyaluronic acid. Mater Sci Eng C 99:1058–1066. https://doi.org/10.1016/j.msec.2019.02.05110.1016/j.msec.2019.02.051 ↗
45. Kaczmarek B, Sionkowska A, Kozlowska J, Osyczka A (2018) New composite materials prepared by calcium phosphate precipitation in chitosan/collagen/hyaluronic acid sponge cross-linked by EDC/NHS. Int J Biol Macromol 107:247–253. https://doi.org/10.1016/j.ijbiomac.2017.08.17310.1016/j.ijbiomac.2017.08.173 ↗
46. Lee SJ, Nah H, Heo DN, Kim KH, Seok JM, Heo M, Moon HJ, Lee D, Lee JS, An SY, Hwang YS, Ko WK, Kim SJ, Sohn S, Park SA, Park SY, Kwon IK (2020) Induction of osteogenic differentiation in a rat calvarial bone defect model using an in situ forming graphene oxide incorporated glycol chitosan/oxidized hyaluronic acid injectable hydrogels. Carbon 168:264–277. https://doi.org/10.1016/j.carbon.2020.05.02210.1016/j.carbon.2020.05.022 ↗
47. Yue K, Trujillo-de Santiago G, Alvarez MM, Tamayol A, Annabi N, Khademhosseini A (2015) Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials 73:254–271. https://doi.org/10.1016/j.biomaterials.2015.08.04510.1016/j.biomaterials.2015.08.045 ↗
48. Nichol JW, Koshy ST, Bae H, Hwang CM, Yamanlar S, Khademhosseini A (2010) Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31:5536–5544. https://doi.org/10.1016/j.biomaterials.2010.03.06410.1016/j.biomaterials.2010.03.064 ↗
49. Neffe AT, Zaupa A, Pierce BJ, Hofmann D, Lendlein A (2010) Knowledge-based tailoring of gelatin-based materials by functionalization with tyrosine-derived groups. Macromol Rapid Commun 31:1534–1539. https://doi.org/10.1002/marc.20100027410.1002/marc.201000274 ↗
50. Gan DL, Xu T, Xing WS, Wang MH, Fang J, Wang KF, Ge X, Chen CW, Ren FZ, Tan H, Lu X (2019) Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration. J Mater Chem B 7:1716–1725. https://doi.org/10.1039/c8tb01664j10.1039/c8tb01664j ↗
51. Paul A, Manoharan V, Krafft D, Assmann A, Uquillas JA, Shin SR, Hasan A, Hussain MA, Memic A, Gaharwar AK (2016) Nanoengineered biomimetic hydrogels for guiding human stem cell osteogenesis in three dimensional microenvironments. J Mater Chem B 4:3544–3554. https://doi.org/10.1039/C5TB02745D10.1039/C5TB02745D ↗
52. Elomaa L, Keshi E, Sauer IM, Weinhart M (2020) Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography. Mater Sci Eng C 112:110958. https://doi.org/10.1016/j.msec.2020.11095810.1016/j.msec.2020.110958 ↗
53. Cao YY, Cheng P, Sang SB, Xiang C, An Y, Wei XC, Yan YY, Li PC (2021) 3D printed PCL/GelMA biphasic scaffold boosts cartilage regeneration using co-culture of mesenchymal stem cells and chondrocytes: In vivo study. Mater Des 210:110065. https://doi.org/10.1016/j.matdes.2021.11006510.1016/j.matdes.2021.110065 ↗
54. Ribeiro JS, Bordini EAF, Ferreira JA, Mei L, Dubey N, Fenno JC, Piva E, Lund RG, Schwendeman A, Bottino MC (2020) Injectable MMP-responsive nanotube-modified gelatin hydrogels for dental infection ablation. ACS Appl Mater Interfaces 12:16006–16017. https://doi.org/10.1021/acsami.9b2296410.1021/acsami.9b22964 ↗
55. Zargar V, Asghari M, Dashti A (2015) A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications. Chem BioEng Rev 2:204–226. https://doi.org/10.1002/cben.20140002510.1002/cben.201400025 ↗
56. Chen YQ, Udduttula A, Xie XL, Zhou M, Sheng WB, Yu F, Weng J, Wang DL, Teng B, Manivasagam G, Zhang JV, Ren PG, Kang B, Zeng H (2021) A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application. Compos Pt B-Eng 222:109057. https://doi.org/10.1016/j.compositesb.2021.10905710.1016/j.compositesb.2021.109057 ↗
57. Purohit SD, Singh H, Bhaskar R, Yadav I, Bhushan S, Gupta MK, Kumar A, Mishra NC (2020) Fabrication of graphene oxide and nanohydroxyapatite reinforced gelatin-alginate nanocomposite scaffold for bone tissue regeneration. Front Mater 7:250. https://doi.org/10.3389/fmats.2020.0025010.3389/fmats.2020.00250 ↗
58. Bundela H, Bajpai AK (2008) Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: correlation with biocompatibility aspects. Express Polym Lett 2:201–213. https://doi.org/10.3144/expresspolymlett.2008.2510.3144/expresspolymlett.2008.25 ↗
59. Deng LZ, Liu Y, Yang LQ, Yi JZ, Deng FL, Zhang LM (2020) Injectable and bioactive methylcellulose hydrogels carrying bone mesenchymal stem cells as a filler for critical-size defects with enhanced bone regeneration. Coll and Surf B Biointerfaces 194:111159. https://doi.org/10.1016/j.colsurfb.2020.11115910.1016/j.colsurfb.2020.111159 ↗
60. Pan YS, Zhao Y, Kuang R, Liu H, Sun D, Mao TJ, Jiang KX, Yang XT, Watanabe N, Mayo KH, Lin Q, Li J (2020) Injectable hydrogels-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion. Mater Sci Eng C—Mater Biol Appl 116:111158. https://doi.org/10.1016/j.msec.2020.11115810.1016/j.msec.2020.111158 ↗
61. Kim EJ, Choi JS, Kim JS, Choi YC, Cho YW (2016) Injectable and thermosensitive soluble extracellular matrix and methylcellulose hydrogels for stem cell delivery in skin wounds. Biomacromolecules 17:4–11. https://doi.org/10.1021/acs.biomac.5b0156610.1021/acs.biomac.5b01566 ↗
62. Dhivya S, Saravanan S, Sastry TP, Selvamurugan N (2015) Nanohydroxyapatite reinforced chitosan composite hydrogels for bone tissue repair in vitro and in vivo. J Nanobiotechnol 13:40. https://doi.org/10.1186/s12951-015-0099-z10.1186/s12951-015-0099-z ↗
63. Rocha JHG, Lemos AF, Kannan S, Agathopoulos S, Ferreira JMF (2005) Hydroxyapatite scaffolds hydrothermally grown from aragonitic cuttlefish bones. J Mater Chem 15:5007–5011. https://doi.org/10.1039/B510122K10.1039/B510122K ↗
64. Haberko K, Bućko MM, Brzezińska-Miecznik J, Haberko M, Mozgawa W, Panz T, Pyda A, Zarębski J (2006) Natural hydroxyl apatite its behaviour during heat treatment. J Eur Ceram Soc 26:537–542. https://doi.org/10.1016/j.jeurceramsoc.2005.07.03310.1016/j.jeurceramsoc.2005.07.033 ↗
65. Idris A, Ibiyeye TH, Abubakar MB, Haruna S, Hindatu Y, Mohammed NJ, Sulaiman M (2014) From garbage to biomaterials: an overview on egg shell based hydroxyapatite. J Mater 2014:1–6. https://doi.org/10.1155/2014/80246710.1155/2014/802467 ↗
66. Arjama M, Mehnath S, Rajan M, Jeyaraj M (2021) Injectable cuttlefish HAP and macromolecular fibroin protein hydrogels for natural bone mimicking matrix for enhancement of osteoinduction progression. React Funct Pol 160:104841. https://doi.org/10.1016/j.reactfunctpolym.2021.10484110.1016/j.reactfunctpolym.2021.104841 ↗
67. Davoudi S, Chin CY, Cooke MJ, Tam RY, Shoichet MS, Gilbert PM (2018) Muscle stem cell intramuscular delivery within hyaluronan methylcellulose improves engraftment efficiency and dispersion. Biomaterials 173:34–4610.1016/j.biomaterials.2018.04.048 ↗
68. Choi WI, Hwang Y, Sahu A, Min K, Sung D, Tae G, Chang JH (2018) An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation. Biomater Sci 6:2627–2638. https://doi.org/10.1039/c8bm00524a10.1039/c8bm00524a ↗
69. Liu TT, Jin MQ, Zhang YZ, Weng WX, Wang TL, Yang HZ, Zhou L (2021) K+/Sr2+/Na+ triple-doped hydroxyapatites/GelMA composite hydrogels scaffold for the repair of bone defects. Ceram Int 47:30929–30937. https://doi.org/10.1016/j.ceramint.2021.07.27710.1016/j.ceramint.2021.07.277 ↗
70. Chandra VS, Baskar G, Suganthi RV, Elayaraja K, Joshy A, Beaula SW, Mythili R, Venkatraman G, Kalkura NS (2012) Blood compatibility of iron-doped nanosize hydroxyapatite and its drug release. ACS Appl Mater Interfaces 4:1200–1210. https://doi.org/10.1021/am300140q10.1021/am300140q ↗
71. Ullah I, Gloria A, Zhang WC, Ullah MW, Wu B, Li WC, Domingos M, Zhang XL (2020) Synthesis and characterization of sintered Sr/Fe-modified hydroxyapatite bioceramics for bone tissue engineering applications. ACS Biomater Sci Eng 6:375–388. https://doi.org/10.1021/acsbiomaterials.9b0166610.1021/acsbiomaterials.9b01666 ↗
72. Roohani-Esfahani S, Wong KY, Lu ZF, Chen YJ, Li JJ, Gronthos S, Menicanin D, Shi J, Dunstan C, Zreiqat H (2014) Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. J Mater Chem B 2:1866–1878. https://doi.org/10.1039/C3TB21504K10.1039/C3TB21504K ↗
73. Kumar A, Kargozar S, Baino F, Han SS (2019) Additive manufacturing methods for producing hydroxyapatite and hydroxyapatite-based composite scaffolds: a review. Front Mater 6:313. https://doi.org/10.3389/fmats.2019.0031310.3389/fmats.2019.00313 ↗
74. Sarin N, Kurakula M, Singh KJ, Kumar A, Singh D, Arora S (2021) Strontium and selenium doped bioceramics incorporated polyacrylamide-carboxymethylcellulose hydrogels scaffolds: mimicking key features of bone regeneration. J Asian Ceram Soc 9:531–548. https://doi.org/10.1080/21870764.2021.189816810.1080/21870764.2021.1898168 ↗
75. Kumar A, Han SS (2021) Enhanced mechanical, biomineralization, and cellular response of nanocomposite hydrogels by bioactive glass and halloysite nanotubes for bone tissue regeneration. Mater Sci Eng C—Mater Biol Appl 128:112236. https://doi.org/10.1016/j.msec.2021.11223610.1016/j.msec.2021.112236 ↗
76. Lin BC, Hu HX, Deng ZW, Pang LB, Jiang HZ, Wang DP, Li JS, Liu ZT, Wang H, Zeng XQ (2020) Novel bioactive glass cross-linked PVA hydrogels with enhanced chondrogenesis properties and application in mice chondrocytes for cartilage repair. J Non-Cryst Solids 529:119594. https://doi.org/10.1016/j.jnoncrysol.2019.11959410.1016/j.jnoncrysol.2019.119594 ↗
77. Kumar A, Rao KM, Han SS (2017) Synthesis of mechanically stiff and bioactive hybrid hydrogels for bone tissue engineering applications. Chem Eng J 317:119–131. https://doi.org/10.1016/j.cej.2017.02.06510.1016/j.cej.2017.02.065 ↗
78. Kumar A, Rao KM, Han SS (2018) Mechanically viscoelastic nanoreinforced hybrid hydrogels composed of polyacrylamide, sodium carboxymethylcellulose, graphene oxide, and cellulose nanocrystals. Carbohydr Polym 193:228–238. https://doi.org/10.1016/j.carbpol.2018.04.00410.1016/j.carbpol.2018.04.004 ↗
79. Zhang LM, Xia JG, Zhao QH, Liu LW, Zhang ZJ (2010) Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small 6:537–544. https://doi.org/10.1002/smll.20090168010.1002/smll.200901680 ↗
80. Nayak TR, Anderson H, Makam VS, Khaw C, Bae S, Xu XF, Ee PLR, Ahn JH, Hong BH, Pastorin G, Özyilmaz B (2011) Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano 5:4670–4678. https://doi.org/10.1021/nn200500h10.1021/nn200500h ↗
81. Jiao DL, Zheng A, Liu Y, Zhang XK, Wang X, Wu JN, She WJ, Lv KG, Cao LY, Jiang XQ (2021) Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration. Bioact Mater 6:2011–2028. https://doi.org/10.1016/j.bioactmat.2020.12.00310.1016/j.bioactmat.2020.12.003 ↗
82. Neffe AT, Zaupa A, Pierce BF, Hoffman D, Lendlein A (2010) Knowledge-based tailoring of gelatin-based materials by functionalization with tyrosine-derived groups. Macromol Macromol Rapid Commun 31:1534–1539. https://doi.org/10.1002/marc.20100027410.1002/marc.201000274 ↗
83. Purohit SD, Bhaskar R, Singh H, Yadav I, Gupta MK, Mishra NC (2019) Development of a nanocomposite scaffold of gelatin–alginate–graphene oxide for bone tissue engineering. Int J Biol Macromol 133:592–602. https://doi.org/10.1016/j.ijbiomac.2019.04.11310.1016/j.ijbiomac.2019.04.113 ↗
84. Jiang LB, Ding SL, Ding W, Su DH, Zhang FX, Zhang TW, Yin XF, Xiao L, Li YL, Yuan FL, Dong J (2021) Injectable Sericin Based Nanocomposite hydrogels for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration. Chem Eng J 418:129323. https://doi.org/10.1016/j.cej.2021.12932310.1016/j.cej.2021.129323 ↗
85. Lee WC, Lim CHYX, Shi H, Tang LAL, Wang Y, Lim CT, Loh KP (2011) Origin of enhanced 43 stem cell growth and differentiation on graphene and graphene oxide. ACS Nano 5:7334–7341. https://doi.org/10.1021/nn202190c10.1021/nn202190c ↗
86. Lambert H, Frassetto L, Moore JB, Torgerson D, Gannon R, Burckhardt P, Lanham-New S (2015) The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Osteoporos Int 26:1311–1318. https://doi.org/10.1007/s00198-014-3006-910.1007/s00198-014-3006-9 ↗
87. Bigi A, Boanini E, Gazzano M (2016) Ion substitution in biological and synthetic apatites. In: Biomineralization and biomaterials, Elsevier/Academic Press, pp 235–26610.1016/B978-1-78242-338-6.00008-9 ↗
88. Wang YC, Newman MR, Benoit DSW (2018) Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: a review. Eur J Pharm Biopharm 127:223–236. https://doi.org/10.1016/j.ejpb.2018.02.02310.1016/j.ejpb.2018.02.023 ↗
89. Liu S, Chen XY, Zhang Q, Wu W, Xin JY, Li JS (2014) Multifunctional hydrogels based on β-cyclodextrin with both biomineralization and anti-inflammatory properties. Carbohydr Polym 102:869–876. https://doi.org/10.1016/j.carbpol.2013.10.07610.1016/j.carbpol.2013.10.076 ↗
90. Hedges AR (1998) Industrial applications of cyclodextrins. Chem Rev 98:2035–2044. https://doi.org/10.1021/cr970014w10.1021/cr970014w ↗
91. Huang L, Xin JY, Guo YC, Li JS (2010) A novel insulin oral delivery system assisted by cationic β-cyclodextrin polymers. J Appl Polym Sci 115:1371–1379. https://doi.org/10.1002/app.3077510.1002/app.30775 ↗
92. Roth JA, Kim BG, Lin WL, Cho MI (1999) Melatonin promotes osteoblast differentiation and bone formation. J Biol Chem 274:22041–22047. https://doi.org/10.1074/jbc.274.31.2204110.1074/jbc.274.31.22041 ↗
93. Terauchi M, Tamura A, Yamaguchi S, Yui N (2018) Enhanced cellular uptake and osteogenic differentiation efficiency of melatonin by inclusion complexation with 2-hydroxypropyl β-cyclodextrin. Int J Pharm 547:53–60. https://doi.org/10.1016/j.ijpharm.2018.05.06310.1016/j.ijpharm.2018.05.063 ↗
94. Zhang JX, Ma PX (2013) Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective. Adv Drug Deliv Rev 65:1215–1233. https://doi.org/10.1016/j.addr.2013.05.00110.1016/j.addr.2013.05.001 ↗
95. Rosario CD, Rodríguez-Évora M, Reyes R, Simões S, Concheiro A, Évora C, Alvarez-Lorenzo C, Delgado A (2015) Bone critical defect repair with poloxamine–cyclodextrin supramolecular gels. Int J Pharm 495:463–473. https://doi.org/10.1016/j.ijpharm.2015.09.00310.1016/j.ijpharm.2015.09.003 ↗
96. Liao J, Wu S, Li K, Fan YB, Dunne N, Li XM (2019) Peptide-modified bone repair materials: Factors influencing osteogenic activity. J Biomed Mater Res Part A 107:1491–1512. https://doi.org/10.1002/jbm.a.3666310.1002/jbm.a.36663 ↗
97. Erak M, Bellmann-Sickert K, Els-Heindl S, Beck-Sickinger AG (2018) Peptide chemistry toolbox—transforming natural peptides into peptide therapeutics. Bioorg Med Chem 26:2759–2765. https://doi.org/10.1016/j.bmc.2018.01.01210.1016/j.bmc.2018.01.012 ↗
98. Jabbari E (2013) Osteogenic peptides in bone regeneration. Curr Pharm Des 19:3391–3402. https://doi.org/10.2174/138161281131919000610.2174/1381612811319190006 ↗
99. Saito A, Suzuki Y, Ogata SI, Ohtsuki C, Tanihana M (2005) Accelerated bone repair with the use of a synthetic BMP-2-derived peptide and bone-marrow stromal cells. J Biomed Mater Res Part A 72A:77–82. https://doi.org/10.1002/jbm.a.3020810.1002/jbm.a.30208 ↗
100. Li RX, Sun Y, Cai ZW, Li Y, Sun J, Bi W, Yang F, Zhou QR, Ye TJ, Yu YC (2021) Highly bioactive peptide-HA photo-crosslinking hydrogels for sustained promoting bone regeneration. Chem Eng J 415:129015. https://doi.org/10.1016/j.cej.2021.12901510.1016/j.cej.2021.129015 ↗