journal article·2006-04

Investigation of the influence of freeze-thaw processing on the properties of polyvinyl alcohol/polyacrylic acid complexes

M. J. D. Nugent, C. L. Higginbotham

Journal of Materials Science· Volume 41· Issue 8
Publisher page

Abstract

Physically crosslinked poly (vinyl alcohol)/poly (acrylic acid) hydrogels were prepared by freeze thaw processing. The hydrogels were formed in, either, water or a water/DMSO mixture and the chemical, mechanical, and thermal properties were determined by FTIR analysis, rotational rheometry and modulated DSC respectively. The results indicate that the hydrogels containing DMSO are significantly stronger than those containing water alone at temperatures between 20 and 40°C. Materials with different characteristics can be created by varying the solvent and the polymer feed ratios. DSC analysis indicated that thermal transitions are present at temperatures that may make these hydrogels useful in temperature sensitive drug delivery systems.
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research · Microfluidic and Capillary Electrophoresis Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (43)

Show source-provided references
1. A. S. HOFFMAN, J. Adv. Drug Delivery Rev. 43 (2002) 3.10.1016/S0169-409X(01)00239-3 ↗
2. B. JONG and A. GUTOWSKA, Trends Biotechnol. 20 (2002) 305.10.1016/S0167-7799(02)01962-5 ↗
3. A. B. SCRANTON, B. RANGARAJAN and J. KLIER, Bi. J. Adv. Polym. Sci. 122 (1995) 1.10.1007/3540587888_13 ↗
4. C. L. BELL and N. A. PEPPAS, Bi. J. Adv. Polym. Sci. 122 (1995) 126.
5. S. SERSHEN and J. WEST, Adv. Drug Delivery Rev. 54 (2002) 1225.10.1016/S0169-409X(02)00090-X ↗
6. K. D. MAHAVEER and T. M. AMINABHAVI, P. J. Controlled Release 96 (2004) 9.10.1016/j.jconrel.2003.12.025 ↗
7. T. G. PARK, Te. Biomaterials 20 (1999) 517.10.1016/S0142-9612(98)00197-5 ↗
8. J. F. YAUNG and T. K. KWEI, J. applied Polym. Sci. 69 (1998) 921.10.1002/(SICI)1097-4628(19980801)69:5<921::AID-APP11>3.0.CO;2-R ↗
9. A. KISHIDA and Y. IKADA in: “Hydrogels for Biomedical and Pharmaceutical Applications,” edited by S. Dumitriu, 2nd ed. (Polymeric Biomaterials, 2002) p. 133.10.1201/9780203904671.ch6 ↗
10. N. A. PEPPAS, P. BURES, W. LEOBANDUNG and H. ICHIKAWA, J. Pharm. Biopharm. 50 (2000) 27.10.1016/S0939-6411(00)00090-4 ↗
11. S. R STAUFFER and N. A. PEPPAS, P. J. Poly. 33 (1992) 3932.10.1016/0032-3861(92)90385-A ↗
12. P. J. WILLCOX, D. W. HOWIE and K. SCHMIDT ROHR, J. Poly. Sci. 37 (1999) 3438.10.1002/(SICI)1099-0488(19991215)37:24<3438::AID-POLB6>3.0.CO;2-9 ↗
13. C. M. HASSAN and N. A. PEPPAS, J. Adv. Poly. Sci. 153 (2000) 37.10.1007/3-540-46414-X_2 ↗
14. OKA MASANORI, TAKASHI NOGUCHI, PRAVEEN KUMAR, KEN IKEUCHI, TAKAO YAMAMURO, S. H. HYON and YOSHITO IKADA, Development of an artificial articular cartilage Clinical Materials 6 (1990) 361.
15. YOUNG MOO LEE, SU HWI KIM and CHONG SOO CHO, J. Applied Poly. Sci. 62 (1996) 301.10.1002/(SICI)1097-4628(19961010)62:2<301::AID-APP5>3.0.CO;2-0 ↗
16. C. M. HASSAN, J. E. STEWART and N. A. E.PEPPAS, Euro. J. Pharm. Biophar. 49 (2000) 161.10.1016/S0939-6411(99)00056-9 ↗
17. T. SHIGA, H. YOSHIHARU, A. OKADA and K. TOSHIO J. Applied Poly. Sci. 44 (1992) 249.10.1002/app.1992.070440209 ↗
18. J. RUIZ, A. MANTECON and V. CADIZ, J. Applied Poly. Sci. 81 (2001) 1444.10.1002/app.1570 ↗
19. S. Y. KIM, S. S HEUNG, M. L. YOUNG and C. N. JEONG, J. Applied Poly. Sci. 73 (1999) 1656.
20. M. WATASE and K. NISHINAR, J. Poly. Sci. 23 (1985) 1803.
21. Idem., Poly. J. 21 (1989) 567.10.1295/polymj.21.567 ↗
22. T. TANIGAMI, K. MURASE, K. YAMAURA and J. MATSUZAWA, Poly. 35 (1994) 2573.10.1016/0032-3861(94)90381-6 ↗
23. N. TAKAHASHI, T. KANAYA, K. NISHIDA and K. KAJI, Poly. 44 (2003) 4075.10.1016/S0032-3861(03)00390-2 ↗
24. T. KANAYA, H. TAKESHITA, M. NISHIKOJI, M. OHKURA, K. NISHIDA and K. KAJI, Supramol. Sci. 5 (1998) 215.10.1016/S0968-5677(98)00009-1 ↗
25. M. OHKURA, T. KANAYA and K. KAJI, Poly. 33 (1992) 3686.10.1016/0032-3861(92)90656-H ↗
26. K. NIJENHUIS, J. Adv. Poly. Sci. 130 (1997) 3.
27. T. K. L. MEYVIS, B. G. STUBBE, M. J. VAN STEENBERGEN, W. E. HENNINK, S. C. DE SMEDT and J. DEMEESTER, International J. Pharm. 244 (2002) 163.10.1016/S0378-5173(02)00328-9 ↗
28. T. K. L. MEYVIS, S. C. DE SMEDT and J. DEMEESTER J. Rheol. 43 (1999) 933.10.1122/1.551012 ↗
29. A. D. WOODSON, R. K. MALCOLM, K. CAMPBELL, D. S. JONES and J. A. RUSSELL, J. Contr. Rel. 67 (2000) 395.10.1016/S0168-3659(00)00230-3 ↗
30. G. P. ANDREWS, S. P. GORMAN and D. S. JONES, Biomater. 26 (2004) 571.10.1016/j.biomaterials.2004.02.062 ↗
31. D. S. JONES, International J. Pharm. 179 (1999) 167.10.1016/S0378-5173(98)00337-8 ↗
32. DEVINE D. M. and C. L. HIGGINBOTHAM, Poly. 44 (2003) 7851.10.1016/j.polymer.2003.10.017 ↗
33. R. RICCIARDI, C. GAILLET, G. DUCOURET, F. LAFUMA and F. LAUPRETRE, J. Poly. 44 (2003) 3375.
34. M. KOBAYASHI, I. ANDO, T. ISHII and S. AMIYA, J. Molecul. Struc. 440 (1998) 155.10.1016/S0022-2860(97)00238-X ↗
35. Y. MACHIDA, S. KUROKI, M. KANEKIYO, M. KOBAYASHI, I. ANDO and S. AMIYA, J. Molecul. Struc. 554 (2000) 81.
36. E. VERDONCK, K. SCHAAP and L. C. THOMAS, International J. Pharm. 192 (1999) 3.10.1016/S0378-5173(99)00267-7 ↗
37. J. S. PARK, J. W. PARK and E. RUCKENSTEIN, Poly. 42 (2001) 4271.10.1016/S0032-3861(00)00768-0 ↗
38. P. MOLYNEUX, Prop. Ert. Behav. 1 (1983) 77.
39. T. TANIGAMI, K. MURASE, K. YAMAURA and J. MATSUZAWA, Poly. 35 (1994) 2573.10.1016/0032-3861(94)90381-6 ↗
40. L. S. SONG and C. K. BYOUNG, Poly. 45 (2004) 2381.10.1016/j.polymer.2004.01.057 ↗
41. N. A. PEPPAS and S. L. WRIGHT, Europe. J. Pharm. Biopharm. 46 (1998) 15.10.1016/S0939-6411(97)00113-6 ↗
42. I. M. WARD and D. W. HADLEY, “An Introduction to the Mechanical Properties of Solid Polymers” (1993).
43. H. JIANG, W. SU, P.T. MATHER and T.J. BUNNING, Rheol. Highl. Swollen Chitosan/Polyacryl. Hydrogel. Poly. 40 (1999) 4593.10.1016/S0032-3861(99)00070-1 ↗