Oxygen-generating materials and their biomedical applications: a review
Source abstract
Abstract
Oxygen and reactive oxygen species (ROS), as indispensable small molecular substances in the basic metabolism of life, have become the key to the success of implantable medical materials, and their importance cannot be overstated. Either improving the hypoxia environment in vivo to avoid tissue damage or using the ROS to selectively kill cells are the strategies adopted in the actual biomedical applications. Therefore, it is crucial to control the transfer of oxygen and the conversion of ROS. In this review, we summarize the common oxygen sources and divide them into inorganic sources, biological sources and organic oxygen sources. For the carriers that are used for loading of the oxygen sources and controlling the behavior of oxygen generation and active oxygen conversion, we classify and explain the respective mechanisms and functions of inorganic materials, natural and synthetic polymers. Moreover, by analyzing the current biomedical applications, we describe the challenges and prospects of oxygen-generating materials in the last section.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Analytical Chemistry and Sensors · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Carreau A, Hafny-Rahbi BE, Matejuk A, Grillon C, Kieda C (2011) Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med 15(6):1239–1253. https://doi.org/10.1111/j.1582-4934.2011.01258.x10.1111/j.1582-4934.2011.01258.x ↗
2. Oh SH, Ward CL, Atala A, Yoo JJ, Harrison BS (2009) Oxygen generating scaffolds for enhancing engineered tissue survival. Biomaterials 30(5):757–762. https://doi.org/10.1016/j.biomaterials.2008.09.06510.1016/j.biomaterials.2008.09.065 ↗
3. Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): role of cytoplasmic trapping of HIF-2 alpha. Mol Cell Biol 23(14):4959–4971. https://doi.org/10.1128/mcb.23.14.4959-4971.200310.1128/mcb.23.14.4959-4971.2003 ↗
4. Greijer AE, Van Der Groep P, Kemming D, Shvarts A, Semenza GL, Meijer GA, Van De Wiel MA, Belien JAM, van Diest PJ, Van Der Wall E (2005) Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol 206(3):291–304. https://doi.org/10.1002/path.177810.1002/path.1778 ↗
5. Holzwarth C, Vaegler M, Gieseke F, Pfister SM, Handgretinger R, Kers G, Muller I (2010) Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells. Bmc Cell Biol 11(1):1–11. https://doi.org/10.1186/1471-2121-11-1110.1186/1471-2121-11-11 ↗
6. Haque N, Rahman MT, Abu Kasim NH, Alabsi AM (2013) Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy. Sci World J 2013:632972. https://doi.org/10.1155/2013/63297210.1155/2013/632972 ↗
7. Michiels C (2004) Physiological and pathological responses to hypoxia. Am J Pathol 164(6):1875–1882. https://doi.org/10.1016/S0002-9440(10)63747-910.1016/S0002-9440(10)63747-9 ↗
8. Houghton FD (2021) Hypoxic regulation of preimplantation embryos: lessons from human embryonic stem cells. Reproduction 161(1):F41–F51. https://doi.org/10.1530/Rep-20-032210.1530/Rep-20-0322 ↗
9. Ortega JA, Sirois CL, Memi F, Glidden N, Zecevic N (2017) Oxygen levels regulate the development of human cortical radial glia cells. Cereb Cortex 27(7):3736–3751. https://doi.org/10.1093/cercor/bhw19410.1093/cercor/bhw194 ↗
10. Shao Y, Zhao FQ (2014) Emerging evidence of the physiological role of hypoxia in mammary development and lactation. J Anim Sci Biotechnol 5(1):1–11. https://doi.org/10.1186/2049-1891-5-910.1186/2049-1891-5-9 ↗
11. Liu JH, Wang ZC (2015) increased oxidative stress as a selective anticancer therapy. Oxid Med Cell Longev 2015:294303. https://doi.org/10.1155/2015/29430310.1155/2015/294303 ↗
12. Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315–424. https://doi.org/10.1152/physrev.00029.200610.1152/physrev.00029.2006 ↗
13. Stadtman ER, Moskovitz J, Levine RL (2003) Oxidation of methionine residues of proteins: biological consequences. Antioxid Redox Signal 5(5):577–582. https://doi.org/10.1089/15230860377031023910.1089/152308603770310239 ↗
14. Halliwell B (2008) The wanderings of a free radical. Free Radical Bio Med 46:531–542. https://doi.org/10.1016/j.freeradbiomed.2008.11.00810.1016/j.freeradbiomed.2008.11.008 ↗
15. Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD (2019) ROS and the DNA damage response in cancer. Redox Biol 25:101084. https://doi.org/10.1016/j.redox.2018.10108410.1016/j.redox.2018.101084 ↗
16. Lewis MC, MacArthur BD, Malda J, Pettet G, Please CP (2005) Heterogeneous proliferation within engineered cartilaginous tissue: the role of oxygen tension. Biotechnol Bioeng 91(5):607–615. https://doi.org/10.1002/bit.2050810.1002/bit.20508 ↗
17. Agarwal T, Kazemi S, Costantini PF, Correia CR, Gaspar V, Montazeri L, De Maria C, Mano JF, Vosough M, Makvandi P, Maiti TK (2021) Oxygen releasing materials: towards addressing the hypoxia-related issues in tissue engineering. Mater Sci Eng C Mater Biol Appl 122:111896. https://doi.org/10.1016/j.msec.2021.11189610.1016/j.msec.2021.111896 ↗
18. Fu L, Zhang LW, Zhang X, Chen LX, Cai Q, Yang XP (2021) Roles of oxygen level and hypoxia-inducible factor signaling pathway in cartilage, bone and osteochondral tissue engineering. Biomed Mater 16(2):022006. https://doi.org/10.1088/1748-605X/abdb7310.1088/1748-605X/abdb73 ↗
19. Zubillaga V, Alonso-Varona A, Fernandes SCM, Salaberria AM, Palomares T (2020) Adipose-derived mesenchymal stem cell chondrospheroids cultured in hypoxia and a 3D porous chitosan/chitin nanocrystal scaffold as a platform for cartilage tissue engineering. Int J Mol Sci 21(3):1004. https://doi.org/10.3390/ijms2103100410.3390/ijms21031004 ↗
20. Taheem DK, Jell G, Gentleman E (2020) Hypoxia inducible factor-1 alpha in osteochondral tissue engineering. Tissue Eng Part B Rev 26(2):105–115. https://doi.org/10.1089/ten.tec.2017.040210.1089/ten.tec.2017.0402 ↗
21. Mohseni-Vadeghani E, Karimi-Soflou R, Khorshidi S, Karkhaneh A (2021) Fabrication of oxygen and calcium releasing microcarriers with different internal structures for bone tissue engineering: Solid filled versus hollow microparticles. Colloids Surf B Biointerfaces 197:111376. https://doi.org/10.1016/j.colsurfb.2020.11137610.1016/j.colsurfb.2020.111376 ↗
22. Fathollahipour S, Patil PS, Leipzig ND (2018) oxygen regulation in development: lessons from embryogenesis towards tissue engineering. Cells Tissues Organs 205(5–6):350–371. https://doi.org/10.1159/00049316210.1159/000493162 ↗
23. Gholipourmalekabadi M, Zhao S, Harrison BS, Mozafari M, Seifalian AM (2016) Oxygen-generating biomaterials: a new, viable paradigm for tissue engineering? Trends Biotechnol 34(12):1010–1021. https://doi.org/10.1016/j.tibtech.2016.05.01210.1016/j.tibtech.2016.05.012 ↗
24. Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. general properties and effect of hyperbaric oxygen. Biochem J 134(3):707–716. https://doi.org/10.1042/bj134070710.1042/bj1340707 ↗
25. Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417:1–13. https://doi.org/10.1042/bj2008138610.1042/bj20081386 ↗
26. Span PN, Bussink J (2015) Biology of hypoxia. Semin Nucl Med 45(2):101–109. https://doi.org/10.1053/j.semnuclmed.2014.10.00210.1053/j.semnuclmed.2014.10.002 ↗
27. LaGory EL, Giaccia AJ (2016) The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol 18(4):356–365. https://doi.org/10.1038/ncb333010.1038/ncb3330 ↗
28. Gilkes DM, Semenza GL, Wirtz D (2014) Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 14(6):430–439. https://doi.org/10.1038/nrc372610.1038/nrc3726 ↗
29. Bhandari V, Hoey C, Liu LY, Lalonde E, Ray J, Livingstone J, Lesurf R, Shiah YJ et al (2019) Molecular landmarks of tumor hypoxia across cancer types. Nat Genet 51(2):308–318. https://doi.org/10.1038/s41588-018-0318-210.1038/s41588-018-0318-2 ↗
30. Liu YY, Jiang YQ, Zhang M, Tang ZM, He MY, Bu WB (2018) Modulating hypoxia via nanomaterials chemistry for efficient treatment of solid tumors. Acc Chem Res 51(10):2502–2511. https://doi.org/10.1021/acs.accounts.8b0021410.1021/acs.accounts.8b00214 ↗
31. Barker HE, Paget JTE, Khan AA, Harrington KJ (2015) The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer 15(7):409–425. https://doi.org/10.1038/nrc395810.1038/nrc3958 ↗
32. Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R, Sethumadhavan S, Philbrook P (2015) Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aaa126010.1126/scitranslmed.aaa1260 ↗
33. Graham K, Unger E (2018) Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment. Int J Nanomed 13:6049–6058. https://doi.org/10.2147/Ijn.S14046210.2147/Ijn.S140462 ↗
34. Baumann M, Krause M, Overgaard J, Debus J, Bentzen SM, Daartz J, Richter C, Zips D, Bortfeld T (2016) Radiation oncology in the era of precision medicine. Nat Rev Cancer 16(4):234–249. https://doi.org/10.1038/nrc.2016.1810.1038/nrc.2016.18 ↗
35. Ashammakhi N, Darabi MA, Kehr NS, Erdem A, Hu SK, Dokmeci MR, Nasr AS, Khademhosseini A (2020) Advances in controlled oxygen generating biomaterials for tissue engineering and regenerative therapy. Biomacromol 21(1):56–72. https://doi.org/10.1021/acs.biomac.9b0054610.1021/acs.biomac.9b00546 ↗
36. Canaparo R, Foglietta F, Limongi T, Serpe L (2020) Biomedical applications of reactive oxygen species generation by metal nanoparticles. Mat 14(1):53. https://doi.org/10.3390/ma1401005310.3390/ma14010053 ↗
37. Suvarnapathaki S, Wu XC, Lantigua D, Nguyen MA, Camci-Unal G (2019) Breathing life into engineered tissues using oxygen-releasing biomaterials. NPG Asia Mat 11(1):65. https://doi.org/10.1038/s41427-019-0166-210.1038/s41427-019-0166-2 ↗
38. Ruan C, Su K, Zhao D, Lu A, Zhong C (2021) Nanomaterials for tumor hypoxia relief to improve the efficacy of ros-generated cancer therapy. Front Chem 9:649158. https://doi.org/10.3389/fchem.2021.64915810.3389/fchem.2021.649158 ↗
39. Wang J, Zhang B, Sun J, Wang Y, Wang H (2020) Nanomedicine-enabled modulation of tumor hypoxic microenvironment for enhanced cancer therapy. Adv Ther 3(1):1900083. https://doi.org/10.1002/adtp.20190008310.1002/adtp.201900083 ↗
40. Wang H, Li J, Wang Y, Gong X, Xu X, Wang J, Li Y, Sha X, Zhang Z (2020) Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy. J Control Release 319:25–45. https://doi.org/10.1016/j.jconrel.2019.12.02810.1016/j.jconrel.2019.12.028 ↗
41. Farris AL, Rindone AN, Grayson WL (2016) Oxygen delivering biomaterials for tissue engineering. J Mater Chem B 4(20):3422–3432. https://doi.org/10.1039/c5tb02635k10.1039/c5tb02635k ↗
42. Hu J, Guan Z, Chen J (2021) Multifunctional biomaterials that modulate oxygen levels in the tumor microenvironment. Cancer Lett 521(28):39–49. https://doi.org/10.1016/j.canlet.2021.08.01910.1016/j.canlet.2021.08.019 ↗
43. Colton CK (2014) Oxygen supply to encapsulated therapeutic cells. Adv Drug Deliv Rev 67–68:93–110. https://doi.org/10.1016/j.addr.2014.02.00710.1016/j.addr.2014.02.007 ↗
44. Yu Z, Li Q, Wang J, Yu Y, Wang Y, Zhou Q, Li P (2020) Reactive oxygen species-related nanoparticle toxicity in the biomedical field. Nanoscale Res Lett 15(1):115. https://doi.org/10.1186/s11671-020-03344-710.1186/s11671-020-03344-7 ↗
45. Mmjpe S, van Blitterswijk CA, LaPointe VLS (2018) Redox regulation in regenerative medicine and tissue engineering: the paradox of oxygen. J Tissue Eng Regen Med 12(10):2013–2020. https://doi.org/10.1002/term.273010.1002/term.2730 ↗
46. Fan Z, Xu Z, Niu H, Gao N, Guan Y, Li C, Dang Y, Cui X et al (2018) An injectable oxygen release system to augment cell survival and promote cardiac repair following myocardial infarction. Sci Rep 8(1):1–22. https://doi.org/10.1038/s41598-018-19906-w10.1038/s41598-018-19906-w ↗
47. Ochoa M, Rahimi R, Huang TL, Alemdar N, Khademhosseini A, Dokmeci MR, Ziaie B (2014) A paper-based oxygen generating platform with spatially defined catalytic regions. Sens Actuators B Chem 198:472–478. https://doi.org/10.1016/j.snb.2014.02.02110.1016/j.snb.2014.02.021 ↗
48. Abdi SIH, Choi JY, Lau HC, Lim JO (2013) Controlled release of oxygen from PLGA-alginate layered matrix and its in vitro characterization on the viability of muscle cells under hypoxic environment. Tissue Eng Regen Med 10(3):131–138. https://doi.org/10.1007/s13770-013-0391-710.1007/s13770-013-0391-7 ↗
49. Abdi SI, Ng SM, Lim JO (2011) An enzyme-modulated oxygen-producing micro-system for regenerative therapeutics. Int J Pharm 409(1–2):203–205. https://doi.org/10.1016/j.ijpharm.2011.02.04110.1016/j.ijpharm.2011.02.041 ↗
50. Montazeri L, Hojjati-Emami S, Bonakdar S, Tahamtani Y, Hajizadeh-Saffar E, Noori-Keshtkar M, Najar-Asl M, Ashtiani MK, Baharvand H (2016) Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation. Biomaterials 89:157–165. https://doi.org/10.1016/j.biomaterials.2016.02.04310.1016/j.biomaterials.2016.02.043 ↗
51. Mallepally RR, Parrish CC, Mc Hugh MA, Ward KR (2014) Hydrogen peroxide filled poly (methyl methacrylate) microcapsules: potential oxygen delivery materials. Int J Pharm 475(1–2):130–137. https://doi.org/10.1016/j.ijpharm.2014.08.05210.1016/j.ijpharm.2014.08.052 ↗
52. Ng SM, Choi JY, Han HS, Huh JS, Lim JO (2010) Novel microencapsulation of potential drugs with low molecular weight and high hydrophilicity: hydrogen peroxide as a candidate compound. Int J Pharm 384(1–2):120–127. https://doi.org/10.1016/j.ijpharm.2009.10.00510.1016/j.ijpharm.2009.10.005 ↗
53. Li Z, Guo X, Guan J (2012) An oxygen release system to augment cardiac progenitor cell survival and differentiation under hypoxic condition. Biomaterials 33(25):5914–5923. https://doi.org/10.1016/j.biomaterials.2012.05.01210.1016/j.biomaterials.2012.05.012 ↗
54. Min JS, Hong JY, Lim YG, Ahn JW, Park K (2021) Oxygen-generating glycol chitosan-manganese dioxide nanoparticles enhance the photodynamic effects of chlorin e6 on activated macrophages in hypoxic conditions. Int J Biol Macromo 184:20–28. https://doi.org/10.1016/j.ijbiomac.2021.06.03610.1016/j.ijbiomac.2021.06.036 ↗
55. Zhang L, Yang Z, He WS, Ren JH, Wong CY (2021) One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy. J Colloid Interface Sci 599:543–555. https://doi.org/10.1016/j.jcis.2021.03.17310.1016/j.jcis.2021.03.173 ↗
56. Zehra M, Zubairi W, Hasan A, Butt H, Ramzan A, Azam M, Mehmood A, Falahati M et al (2020) oxygen generating polymeric nano fibers that stimulate angiogenesis and show efficient wound healing in a diabetic wound model. Int J Nanomed 15:3511–3522. https://doi.org/10.2147/IJN.S24891110.2147/IJN.S248911 ↗
57. Asakura A, Ward CL, Corona BT, Yoo JJ, Harrison BS, Christ GJ (2013) Oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions. PLoS ONE 8(8):e72485. https://doi.org/10.1371/journal.pone.007248510.1371/journal.pone.0072485 ↗
58. Chandra PK, Ross CL, Smith LC, Jeong SS, Kim J, Yoo JJ, Harrison BS (2015) Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds. Wound Repair Regen 23(6):830–841. https://doi.org/10.1111/wrr.1232410.1111/wrr.12324 ↗
59. Suvarnapathaki S, Nguyen MA, Goulopoulos AA, Lantigua D, Camci-Unal G (2021) Engineering calcium peroxide based oxygen generating scaffolds for tissue survival. Biomater Sci 9(7):2519–2532. https://doi.org/10.1039/d0bm02048f10.1039/d0bm02048f ↗
60. Wong CC, Lu CX, Cho EC, Lee PW, Chi NW, Lin PY, Jheng PR, Chen HL, Mansel BW, Chen YM, Chen CH, Chuang EY (2022) Calcium peroxide aids tyramine-alginate gel to crosslink with tyrosinase for efficient cartilage repair. Int J Biol Macromol 208(31):299–313. https://doi.org/10.1016/j.ijbiomac.2022.03.04410.1016/j.ijbiomac.2022.03.044 ↗
61. Zhao B, He JY, Wang F, Xing RX, Sun B, Zhou YM (2021) Polyacrylamide-sodium alginate hydrogel releasing oxygen and vitamin C promotes bone regeneration in rat skull defects. Front Mater 8:758599. https://doi.org/10.3389/fmats.2021.75859910.3389/fmats.2021.758599 ↗
62. Hassan S, Cecen B, Pena-Garcia R, Marciano FR, Miri AK, Fattahi A, Karavasili C, Sebastian S, Zaidi H, Lobo AO (2021) Survival and proliferation under severely hypoxic microenvironments using cell-laden oxygenating hydrogels. J Funct Biomater 12(2):30. https://doi.org/10.3390/jfb1202003010.3390/jfb12020030 ↗
63. Cheng FY, Chan CH, Wang B, Yeh YL, Wang YJ, Chiu HW (2021) The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer. Cancers 13(4):606. https://doi.org/10.3390/cancers1304060610.3390/cancers13040606 ↗
64. Liang JP, Accolla RP, Soundirarajan M, Emerson A, Coronel MM, Stabler CL (2021) Engineering a macroporous oxygen-generating scaffold for enhancing islet cell transplantation within an extrahepatic site. Acta Biomater 130:268–280. https://doi.org/10.1016/j.actbio.2021.05.02810.1016/j.actbio.2021.05.028 ↗
65. Wang CQ, Xu HX, Liu C, Peng ZY, Min RX, Zhang ZM, Li JJ, Jin YL, Wang YH, Li ZH, Guo JS, Zhu LX (2021) CaO2/gelatin oxygen slow-releasing microspheres facilitate tissue engineering efficiency for the osteonecrosis of femoral head by enhancing the angiogenesis and survival of grafted bone marrow mesenchymal stem cells. Biomater Sci 9(8):3005–3018. https://doi.org/10.1039/d0bm02071k10.1039/d0bm02071k ↗
66. Khorshidi S, Karkhaneh A, Bonakdar S (2020) Oxygen-releasing nanofibers for breathable bone tissue engineering application. J Biomater Appl 35(1):72–82. https://doi.org/10.1177/088532822091305110.1177/0885328220913051 ↗
67. Jiang Y, Xie Y, Chen Z, Li K, Zheng X (2020) Preparation and characteristics of a novel oxygen-releasing coating for improved cell responses in hypoxic environment. J Biomed Mater Res A 109(2):248–261. https://doi.org/10.1002/jbm.a.3702010.1002/jbm.a.37020 ↗
68. Zhang M, Kiratiwongwan T, Shen W (2020) Oxygen-releasing polycaprolactone/calcium peroxide composite microspheres. J Biomed Mater Res B Appl Biomater 108(3):1097–1106. https://doi.org/10.1002/jbm.b.3446110.1002/jbm.b.34461 ↗
69. Steg H, Buizer AT, Woudstra W, Veldhuizen AG, Bulstra SK, Grijpma DW, Dirk W, Kuijer R (2017) Oxygen-releasing poly(trimethylene carbonate) microspheres for tissue engineering applications. Polym Adv Technol 28(10):1252–1257. https://doi.org/10.1002/pat.391910.1002/pat.3919 ↗
70. Newland B, Baeger M, Eigel D, Newland H, Werner C (2017) Oxygen-producing gellan gum hydrogels for dual delivery of either oxygen or peroxide with doxorubicin. ACS Biomater Sci Eng 3(5):787–792. https://doi.org/10.1021/acsbiomaterials.7b0007810.1021/acsbiomaterials.7b00078 ↗
71. Wu Y, Song Z, Wang H, Han H (2019) Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections. Nat Commun 10(1):1–10. https://doi.org/10.1038/s41467-019-12233-210.1038/s41467-019-12233-2 ↗
72. Gao S, Jin Y, Ge K, Li Z, Liu H, Dai X, Zhang Y, Chen S et al (2019) Self-supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy. Adv Sci 6:1902137. https://doi.org/10.1002/advs.20190213710.1002/advs.201902137 ↗
73. Pedraza E, Coronel MM, Fraker CA, Ricordi C, Stabler CL (2012) Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials. Proc Natl Acad Sci USA 109(11):4245–4250. https://doi.org/10.1073/pnas.111356010910.1073/pnas.1113560109 ↗
74. Forget A, Staehly C, Ninan N, Harding FJ, Vasilev K, Voelcker NH, Blencowe A (2017) Oxygen-releasing coatings for improved tissue preservation. ACS Biomater Sci Eng 3(10):2384–2390. https://doi.org/10.1021/acsbiomaterials.7b0029710.1021/acsbiomaterials.7b00297 ↗
75. Touri M, Moztarzadeh F, Osman NAA, Dehghan MM, Mozafari M (2018) 3D-printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival. Mater Sci Eng C Mater Biol Appl 84:236–242. https://doi.org/10.1016/j.msec.2017.11.03710.1016/j.msec.2017.11.037 ↗
76. Coronel MM, Liang JP, Li Y, Stabler CL (2019) Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device. Biomaterials 210:1–11. https://doi.org/10.1016/j.biomaterials.2019.04.01710.1016/j.biomaterials.2019.04.017 ↗
77. Hsieh TE, Lin SJ, Chen LC, Chen CC, Lai PL, Huang CC (2020) Optimizing an injectable composite system for relieving tissue hypoxia. Front Bioeng Biotechnol 8:511. https://doi.org/10.3389/fbioe.2020.0051110.3389/fbioe.2020.00511 ↗
78. Abudula T, Gauthaman K, Hammad AH, Joshi Navare K, Alshahrie AA, Bencherif SA, Tamayol A, Memic A (2020) Oxygen-releasing antibacterial nanofibrous scaffolds for tissue engineering applications. Polymers 12(6):1233. https://doi.org/10.3390/polym1206123310.3390/polym12061233 ↗
79. Shiekh PA, Singh A, Kumar A (2018) Oxygen-releasing antioxidant cryogel scaffolds with sustained oxygen delivery for tissue engineering applications. ACS Appl Mater Interfaces 10(22):18458–18469. https://doi.org/10.1021/acsami.8b0173610.1021/acsami.8b01736 ↗
80. Wang J, Zhu Y, Bawa HK, Ng G, Wu Y, Libera M, Van Der Mei HC, Busscher HJ, Yu X (2010) Oxygen-generating nanofiber cell scaffolds with antimicrobial properties. ACS Appl Mater Interfaces 3(1):67–73. https://doi.org/10.1021/am100862h10.1021/am100862h ↗
81. Wang J, Fang L, Li P, Ma L, Na W, Cheng C, Gu Y, Deng D (2019) Inorganic nanozyme with combined self-oxygenation/degradable capabilities for sensitized cancer immunochemotherapy. Nanomicro Lett 11(1):1–18. https://doi.org/10.1007/s40820-019-0305-x10.1007/s40820-019-0305-x ↗
82. Lu Z, Jiang X, Chen M, Feng L, Kang YJ (2019) An oxygen-releasing device to improve the survival of mesenchymal stem cells in tissue engineering. Biofabrication 11(4):045012. https://doi.org/10.1088/1758-5090/ab332a10.1088/1758-5090/ab332a ↗
83. Lv X, Li Z, Chen S, Xie M, Huang J, Peng X, Yang R, Wang H et al (2016) Structural and functional evaluation of oxygenating keratin/silk fibroin scaffold and initial assessment of their potential for urethral tissue engineering. Biomaterials 84:99–110. https://doi.org/10.1016/j.biomaterials.2016.01.03210.1016/j.biomaterials.2016.01.032 ↗
84. Zhang T, Han Z, Zhang W, Wang J, Xu L (2019) Cyanoacrylate-encapsulated calcium peroxide achieved oxygen-sustained release and promoted wound healing. Int J Polym Mater Polym Biomater 69(11):703–708. https://doi.org/10.1080/00914037.2019.160051810.1080/00914037.2019.1600518 ↗
85. Steg H, Buizer AT, Woudstra W, Veldhuizen AG, Bulstra SK, Grijpma DW, Kuijer R (2015) Control of oxygen release from peroxides using polymers. J Mater Sci Mater Med 26(7):1–4. https://doi.org/10.1007/s10856-015-5542-z10.1007/s10856-015-5542-z ↗
86. Alemdar N, Leijten J, Camci-Unal G, Hjortnaes J, Ribas J, Paul A, Mostafalu P, Gaharwar AK et al (2016) Oxygen-generating photo-cross-linkable hydrogels support cardiac progenitor cell survival by reducing hypoxia-induced necrosis. ACS Biomater Sci Eng 3(9):1964–1971. https://doi.org/10.1021/acsbiomaterials.6b0010910.1021/acsbiomaterials.6b00109 ↗
87. Kang JI, Park KM, Park KD (2019) Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing. J Ind Eng Chem 69:397–404. https://doi.org/10.1016/j.jiec.2018.09.04810.1016/j.jiec.2018.09.048 ↗
88. Razavi M, Primavera R, Kevadiya BD, Wang J, Buchwald P, Thakor AS (2020) A collagen based cryogel bioscaffold that generates oxygen for islet transplantation. Adv Funct Mater 30(15):1902463. https://doi.org/10.1002/adfm.20190246310.1002/adfm.201902463 ↗
89. Touri M, Moztarzadeh F, Osman NAA, Dehghan MM, Mozafari M (2019) Optimisation and biological activities of bioceramic robocast scaffolds provided with an oxygen-releasing coating for bone tissue engineering applications. Ceram Int 45(1):805–816. https://doi.org/10.1016/j.ceramint.2018.09.24710.1016/j.ceramint.2018.09.247 ↗
90. Zhou TJ, Xing L, Fan YT, Cui PF, Jiang HL (2019) Inhibition of breast cancer proliferation and metastasis by strengthening host immunity with a prolonged oxygen-generating phototherapy hydrogel. J Control Release 309:82–93. https://doi.org/10.1016/j.jconrel.2019.07.02810.1016/j.jconrel.2019.07.028 ↗
91. Montesdeoca CYC, Afewerki S, Stocco TD, Corat MAF, De Paula MMM, Marciano FR, Lobo AO (2020) Oxygen-generating smart hydrogels supporting chondrocytes survival in oxygen-free environments. Colloids Surf B Biointerfaces 194:111192. https://doi.org/10.1016/j.colsurfb.2020.11119210.1016/j.colsurfb.2020.111192 ↗
92. Yu Q, Huang T, Liu C, Zhao M, Xie M, Li G, Liu S, Huang W et al (2019) Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic. Chem Sci 10(39):9091–9098. https://doi.org/10.1039/c9sc03161h10.1039/c9sc03161h ↗
93. McQuilling JP, Sittadjody S, Pendergraft S, Farney AC, Opara EC (2017) Applications of particulate oxygen-generating substances (POGS) in the bioartificial pancreas. Biomater Sci 5(12):2437–2447. https://doi.org/10.1039/c7bm00790f10.1039/c7bm00790f ↗
94. He C, Zhang X, Yan R, Zhao P, Chen Y, Li M, Chen C, Fan T et al (2019) Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment. Biomater Sci 7(10):4260–4272. https://doi.org/10.1039/c9bm00797k10.1039/c9bm00797k ↗
95. Shiekh PA, Mohammed SA, Gupta S, Das A, Meghwani H, Maulik SK, Banerjee SK, Kumar A (2022) Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction. Chem Eng J 428:132490. https://doi.org/10.1016/j.cej.2021.13249010.1016/j.cej.2021.132490 ↗
96. Zou T, Jiang S, Zhang Y, Liu J, YiQiDissanayakaZhang BYWLC (2021) In situ oxygen generation enhances the scap survival in hydrogel constructs. J Dent Res 100(10):1127–1135. https://doi.org/10.1177/0022034521102715510.1177/00220345211027155 ↗
97. Zhang XJ, He CC, Sun Y, Liu XG, Chen Y, Chen C, Yan RC, Fan T, Yang T, Lu Y, Luo J, Ma X, Xiang GY (2021) A smart O-2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving. Acta Pharm Sin 11(11):3608–3621. https://doi.org/10.1016/j.apsb.2021.04.02110.1016/j.apsb.2021.04.021 ↗
98. Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M (2021) Calcium peroxide-containing polydimethylsiloxane-based microwells for inhibiting cell death in spheroids through improved oxygen supply. Biol Pharm Bull 44(10):1458–1464. https://doi.org/10.1248/bpb.b21-0026910.1248/bpb.b21-00269 ↗
99. Tripathi S, Singh BN, Divakar S, Kumar G, Mallick SP, Srivastava P (2021) Design and evaluation of ciprofloxacin loaded collagen chitosan oxygenating scaffold for skin tissue engineering. Biomed Mater 16(2):025021. https://doi.org/10.1088/1748-605X/abd1b810.1088/1748-605X/abd1b8 ↗
100. Peng ZY, Wang CQ, Liu C, Xu HX, Wang YH, Liu Y, Hu YT, Li JJ, Jin YL, Jiang C, Liu LL, Guo JS, Zhu LX (2021) 3D printed polycaprolactone/beta-tricalcium phosphate/magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing the large bone defect. J Mate Chem B 9(28):5698–5710. https://doi.org/10.1039/d1tb00178g10.1039/d1tb00178g ↗