journal article·2023-01

A review: Biomedical applications of phosphorene, antimonene, and germanene-based 2D material/hydrogel complexes

Mayank Garg, Anupma Thakur

Journal of Materials Science· Volume 58· Issue 1
Publisher page

Abstract

Hydrogels have long been developed for a plethora of applications such as soft electronics, energy storage, the development of actuators, sensors, and, most importantly, biomedical applications. The biomedical applications of hydrogels are the most sought after and highly researched because of the various advantages of hydrogels. Having said that, the practical applications of the hydrogels are still restricted and efforts are being made to introduce other materials that add to the advantages of the hydrogels and impart new and exciting properties to the formed composite. In this regard, 2D materials beyond graphene such as phosphorene, antimonene, and germanene have gained significant attention. These are the newest addition to the existing 2D material family. These materials are highly optically active, which is vital while considering biomedical applications. The biomedical applications include antibacterial activity, chemotherapy, photothermal therapy, wound treatment, drug delivery, tissue engineering, and many more. This review intends to give the readers a brief overview of the trends and advancements in using these beyond graphene 2D material/hydrogel composites for biomedical applications.
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Research context

OpenAlex topics: 2D Materials and Applications · MXene and MAX Phase Materials · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (50)

Show source-provided references
1. Rohaizad N, Mayorga-Martinez CC, Fojtů M, Latiff NM, Pumera M (2021) Two-dimensional materials in biomedical, biosensing and sensing applications. Chem Soc Rev 50:619–65710.1039/D0CS00150C ↗
2. Zheng J, Li J, Zhang L, Chen X, Yu Y, Huang H (2020) Post-graphene 2D materials-based antimicrobial agents: focus on fabrication strategies and biosafety assessments. J Mater Sci 55:7226–7246. https://doi.org/10.1007/s10853-020-04507-810.1007/s10853-020-04507-8 ↗
3. Zhao J, Ma D, Wang C, Guo Z, Zhang B, Li J, Nie G, Xie N, Zhang H (2021) Recent advances in anisotropic two-dimensional materials and device applications. Nano Res 14:897–91910.1007/s12274-020-3018-z ↗
4. Shanmugam V, Mensah RA, Babu K, Gawusu S, Chanda A, Tu Y, Neisiany RE, Försth M, Sas G, Das O (2022) A review of the synthesis, properties, and applications of 2D materials. Part Part Syst Charact 39:2200031–220003510.1002/ppsc.202200031 ↗
5. Glavin NR, Rao R, Varshney V, Bianco E, Apte A, Roy A, Ringe E, Ajayan PM (2020) Emerging applications of elemental 2D materials. Adv Mater 32:1904302–190430510.1002/adma.201904302 ↗
6. Mathew M, Shinde PV, Samal R, Rout CS (2021) A review on mechanisms and recent developments in pn heterojunctions of 2D materials for gas sensing applications. J Mater Sci 56:9575–9604. https://doi.org/10.1007/s10853-021-05884-410.1007/s10853-021-05884-4 ↗
7. Sharma A, Rangra V, Thakur A (2022) Synthesis, properties, and applications of MBenes (two-dimensional metal borides) as emerging 2D materials: a review. J Mater Sci 57:12738–12751. https://doi.org/10.1007/s10853-022-07378-310.1007/s10853-022-07378-3 ↗
8. Xu M, Liang T, Shi M, Chen H (2013) Graphene-like two-dimensional materials. Chem Rev 113:3766–379810.1021/cr300263a ↗
9. Chia X, Pumera M (2018) Characteristics and performance of two-dimensional materials for electrocatalysis. Nature Catal 1:909–92110.1038/s41929-018-0181-7 ↗
10. Bellani S, Bartolotta A, Agresti A, Calogero G, Grancini G, Di Carlo A, Kymakis E, Bonaccorso F (2021) Solution-processed two-dimensional materials for next-generation photovoltaics. Chem Soc Rev 50:11870–11965. https://doi.org/10.1039/D1CS00106J10.1039/D1CS00106J ↗
11. Reserbat-Plantey A, Epstein I, Torre I, Costa AT, Gonçalves P, Mortensen NA, Polini M, Song JC, Peres NM, Koppens FH (2021) Quantum nanophotonics in two-dimensional materials. ACS Photonics 8:85–10110.1021/acsphotonics.0c01224 ↗
12. Wu J, Dong W, Zhang Z, Liu J, Akioma M, Liu J, Liu Y, Pliss A, Zhang X, Luan P (2021) Emerging two-dimensional materials-based diagnosis of neurodegenerative diseases: status and challenges. Nano Today 40:101284–10128610.1016/j.nantod.2021.101284 ↗
13. Aswathy S, Narendrakumar U, Manjubala I (2020) Commercial hydrogels for biomedical applications. Heliyon 6:e03719–e0372210.1016/j.heliyon.2020.e03719 ↗
14. Chai Q, Jiao Y, Yu X (2017) Hydrogels for biomedical applications: their characteristics and the mechanisms behind them. Gels 3:6–910.3390/gels3010006 ↗
15. Billiet T, Vandenhaute M, Schelfhout J, Van Vlierberghe S, Dubruel P (2012) A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. Biomaterials 33:6020–604110.1016/j.biomaterials.2012.04.050 ↗
16. Mei J, He T, Zhang Q, Liao T, Du A, Ayoko GA, Sun Z (2020) Carbon-phosphorus bonds-enriched 3D graphene by self-sacrificing black phosphorus nanosheets for elevating capacitive lithium storage. ACS Appl Mater Interfaces 12:21720–2172910.1021/acsami.0c03583 ↗
17. Mei J, Zhang Y, Liao T, Peng X, Ayoko GA, Sun Z (2019) Black phosphorus nanosheets promoted 2D-TiO2-2D heterostructured anode for high-performance lithium storage. Energy Storage Mater 19:424–43110.1016/j.ensm.2019.03.010 ↗
18. Shen Z, Sun S, Wang W, Liu J, Liu Z, Jimmy CY (2015) A black–red phosphorus heterostructure for efficient visible-light-driven photocatalysis. J Mater Chem A 3:3285–328810.1039/C4TA06871H ↗
19. Bahrani S, Khafri H, Ghaedi M (2021) New materials for water-splitting. In: Interface science and technology. Ghaedi M (ed) Elsevier, Amsterdam, pp 791–87010.1016/B978-0-12-818806-4.00007-3 ↗
20. Liu H, Neal AT, Zhu Z, Luo Z, Xu X, Tománek D, Ye PD (2014) Phosphorene: an unexplored 2D semiconductor with a high hole mobility. ACS Nano 8:4033–404110.1021/nn501226z ↗
21. Choi JR, Yong KW, Choi JY, Nilghaz A, Lin Y, Xu J, Lu X (2018) Black phosphorus and its biomedical applications. Theranostics 8:1005–100910.7150/thno.22573 ↗
22. Brent JR, Savjani N, Lewis EA, Haigh SJ, Lewis DJ, O’Brien P (2014) Production of few-layer phosphorene by liquid exfoliation of black phosphorus. Chem Commun 50:13338–1334110.1039/C4CC05752J ↗
23. Yang B, Yin J, Chen Y, Pan S, Yao H, Gao Y, Shi J (2018) 2D-black-phosphorus-reinforced 3d-printed scaffolds: a stepwise countermeasure for osteosarcoma. Adv Mater 30:170561110.1002/adma.201705611 ↗
24. Xu C, Xu Y, Yang M, Chang Y, Nie A, Liu Z, Wang J, Luo Z (2020) Black-phosphorus-incorporated hydrogel as a conductive and biodegradable platform for enhancement of the neural differentiation of mesenchymal stem cells. Adv Func Mater 30:200017710.1002/adfm.202000177 ↗
25. Ismail MM, Vigneshwaran J, Arunbalaji S, Mani D, Arivanandhan M, Jose SP, Jayavel R (2020) Antimonene nanosheets with enhanced electrochemical performance for energy storage applications. Dalton Trans 49:13717–1372510.1039/D0DT01753A ↗
26. Yang X, Wu R, Xu N, Dong N, Ling G, Liu Y, Zhang P (2020) Application and prospect of antimonene: a new two-dimensional nanomaterial in cancer theranostics. J Inorg Biochem 212:111232–11123710.1016/j.jinorgbio.2020.111232 ↗
27. Dávila M, Xian L, Cahangirov S, Rubio A, Le Lay G (2014) Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene. New J Phys 16:095002–09500810.1088/1367-2630/16/9/095002 ↗
28. Liu Y, Xiao Y, Cao Y, Guo Z, Li F, Wang L (2020) Construction of chitosan-based hydrogel incorporated with antimonene nanosheets for rapid capture and elimination of bacteria. Adv Funct Mater 30:2003196–200319910.1002/adfm.202003196 ↗
29. Feng C, Ouyang J, Tang Z, Kong N, Liu Y, Fu L, Ji X, Xie T, Farokhzad OC, Tao W (2020) Germanene-based theranostic materials for surgical adjuvant treatment: inhibiting tumor recurrence and wound infection. Matter 3:127–14410.1016/j.matt.2020.04.022 ↗
30. Wang R, Zhang M, Ge B, Zhang L, Zhou J, Liu S, Jiao T (2020) Facile preparation of black phosphorus-based rGO-BP-Pd composite hydrogels with enhanced catalytic reduction of 4-nitrophenol performances for wastewater treatment. J Mol Liq 310:113083–11308710.1016/j.molliq.2020.113083 ↗
31. Li D, Zhao Q, Zhang S, Wu F, Yu X, Xiong Z, Ma W, Wang D, Zhang X, Xing B (2019) Filtration-based water treatment system embedded with black phosphorus for NIR-triggered disinfection. Environ Sci NANO 6:2977–298510.1039/C9EN00774A ↗
32. Xing C, Chen S, Qiu M, Liang X, Liu Q, Zou Q, Li Z, Xie Z, Wang D, Dong B (2018) Conceptually novel black phosphorus/cellulose hydrogels as promising photothermal agents for effective cancer therapy. Adv Healthcare Mater 7:1701510–170151510.1002/adhm.201701510 ↗
33. Debu DT, Bauman SJ, French D, Churchill HO, Herzog JB (2018) Tuning infrared plasmon resonance of black phosphorene nanoribbon with a dielectric interface. Sci Rep 8:1–1010.1038/s41598-018-21365-2 ↗
34. Lu J, Wu J, Carvalho A, Ziletti A, Liu H, Tan J, Chen Y, Castro Neto A, Ozyilmaz B, Sow CH (2015) Bandgap engineering of phosphorene by laser oxidation toward functional 2D materials. ACS Nano 9:10411–1042110.1021/acsnano.5b04623 ↗
35. Shao J, Ruan C, Xie H, Li Z, Wang H, Chu PK, Yu XF (2018) Black-Phosphorus-Incorporated hydrogel as a sprayable and biodegradable photothermal platform for postsurgical treatment of cancer. Adv Sci 5:170084810.1002/advs.201700848 ↗
36. Qin L, Ling G, Peng F, Zhang F, Jiang S, He H, Yang D, Zhang P (2019) Black phosphorus nanosheets and gemcitabine encapsulated thermo-sensitive hydrogel for synergistic photothermal-chemotherapy. J Colloid Interface Sci 556:232–23810.1016/j.jcis.2019.08.058 ↗
37. Moreno-Camacho CA, Montoya-Torres JR, Jaegler A, Gondran N (2019) Sustainability metrics for real case applications of the supply chain network design problem: a systematic literature review. J Clean Prod 231:600–61810.1016/j.jclepro.2019.05.278 ↗
38. Wu R-S, Lin J, Xing Y-M, Dai Z-L, Wang L-W, Zhang X-P (2019) pH-sensitive black phosphorous-incorporated hydrogel as novel implant for cancer treatment. J Pharm Sci 108:2542–255110.1016/j.xphs.2019.03.003 ↗
39. Shou X, Liu Y, Wu D, Zhang H, Zhao Y, Sun W, Shen X (2021) Black phosphorus quantum dots doped multifunctional hydrogel particles for cancer immunotherapy. Chem Eng J 408:12734910.1016/j.cej.2020.127349 ↗
40. Li R, Shan L, Yao Y, Peng F, Jiang S, Yang D, Ling G, Zhang P (2021) Black phosphorus nanosheets and docetaxel micelles co-incorporated thermoreversible hydrogel for combination chemo-photodynamic therapy. Drug Deliv Transl Res 11:1133–114310.1007/s13346-020-00836-y ↗
41. Sang S, Jiang Z, Xie N, Rao H, Liao K, Hu Q, Zhang Z, Guo R, Fan T, Deng K (2021) Black phosphorus nanosheets and paclitaxel encapsulated hydrogel for synergistic photothermal-chemotherapy. Nanophotonics 10:2625–263710.1515/nanoph-2021-0089 ↗
42. He J, Chen G, Zhao P, Ou C (2021) Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy. Nano Res 14:3988–399810.1007/s12274-021-3325-z ↗
43. Pan W, Dai C, Li Y, Yin Y, Gong L, Machuki JOA, Yang Y, Qiu S, Guo K, Gao F (2020) PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis. Biomaterials 239:119851–11985510.1016/j.biomaterials.2020.119851 ↗
44. Huang K, Wu J, Gu Z (2018) Black phosphorus hydrogel scaffolds enhance bone regeneration via a sustained supply of calcium-free phosphorus. ACS Appl Mater Interfaces 11:2908–291610.1021/acsami.8b21179 ↗
45. Shao J, Ruan C, Xie H, Chu PK, Yu XF (2020) Photochemical activity of black phosphorus for near-infrared light controlled in situ biomineralization. Adv Sci 7:2000439–200044010.1002/advs.202000439 ↗
46. Liu X, George MN, Li L, Gamble D, Miller AL II, Gaihre B, Waletzki BE, Lu L (2020) Injectable electrical conductive and phosphate releasing gel with two-dimensional black phosphorus and carbon nanotubes for bone tissue engineering. ACS Biomater Sci Eng 6:4653–466510.1021/acsbiomaterials.0c00612 ↗
47. Yang G, Wan X, Gu Z, Zeng X, Tang J (2018) Near infrared photothermal-responsive poly (vinyl alcohol)/black phosphorus composite hydrogels with excellent on-demand drug release capacity. J Mater Chem B 6:1622–163210.1039/C7TB03090H ↗
48. Qiu M, Wang D, Liang W, Liu L, Zhang Y, Chen X, Sang DK, Xing C, Li Z, Dong B (2018) Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy. Proc Natl Acad Sci 115:501–50610.1073/pnas.1714421115 ↗
49. Ji J, Song X, Liu J, Yan Z, Huo C, Zhang S, Su M, Liao L, Wang W, Ni Z (2016) Two-dimensional antimonene single crystals grown by van der Waals epitaxy. Nat Commun 7:1–910.1038/ncomms13352 ↗
50. Liu N, Bo G, Liu Y, Xu X, Du Y, Dou SX (2019) Recent progress on germanene and functionalized germanene: Preparation, characterizations, applications, and challenges. Small 15:1805147–180515010.1002/smll.201805147 ↗