Composites of thiol-grafted PEDOT with N-doped graphene or graphitic carbon nitride as an electrochemical sensor for the detection of paracetamol
Source abstract
Abstract
A novel electrochemical sensor with thiol-grafted PEDOT/N-doped graphene (N-Gr/PEDOT-MeSH) and thiol-grafted PEDOT/graphitic carbon nitride (g-C3N4/PEDOT-MeSH) composites was fabricated for the detection of paracetamol (PAR). The formation mechanism of the obtained structure was thoroughly studied. And from the electrochemical results, the synergistic effect between the PEDOT-MeSH and g-C3N4 or N-Gr improved the electron transfer and conductivity of the modified electrodes and enhanced the sensing responses toward the electrochemical oxidation of PAR. The calibration curve of N-Gr/PEDOT-MeSH and g-C3N4/PEDOT-MeSH composites exhibited the wider linear responses for PAR, ranging from 2 to 1680 µM and 0.4 to 1280 µM, and the detection limits (S/N = 3) were 1.42 µM and 1.0 µM, respectively. Furthermore, the obtained composites exhibited the excellent reproducibility, lower detection limit and good stability. And it was capable of detecting PAR in real samples with a satisfying result.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Electrochemical Analysis and Applications · Analytical Chemistry and Sensors
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References (62)
Show source-provided references
1. Pacifici GM, Allegaert K (2015) Clinical pharmacology of paracetamol in neonates: a review. Curr Ther Res 77:24–30. https://doi.org/10.1016/j.curtheres.2014.12.00110.1016/j.curtheres.2014.12.001 ↗
2. Chiumello D, Gotti M, Vergani G (2017) Paracetamol in fever in critically ill patients—an update. J Crit Care 38:245–252. https://doi.org/10.1016/j.jcrc.2016.10.02110.1016/j.jcrc.2016.10.021 ↗
3. Deng C, Deng Y, Wang B, Yang X (2002) Gas chromatography–mass spectrometry method for determination of phenylalanine and tyrosine in neonatal blood spots. J Chromatogr B 780(2):407–41310.1016/S1570-0232(02)00632-3 ↗
4. Castillo-García ML, Aguilar-Caballos MP, Gómez-Hens A (2015) Determination of acetylsalicylic acid and its major metabolites in bovine urine using ultra performance liquid chromatography. J Chromatogr B 985:85–90. https://doi.org/10.1016/j.jchromb.2015.01.02610.1016/j.jchromb.2015.01.026 ↗
5. Behera S (2012) UV–visible spectrophotometric method development and validation of assay of paracetamol tablet formulation. J Anal Bioanal Tech. https://doi.org/10.4172/2155-9872.100015110.4172/2155-9872.1000151 ↗
6. Luo J, Fan C, Wang X, Liu R, Liu X (2013) A novel electrochemical sensor for paracetamol based on molecularly imprinted polymeric micelles. Sens Actuators B Chem 188:909–916. https://doi.org/10.1016/j.snb.2013.07.08810.1016/j.snb.2013.07.088 ↗
7. Si W, Lei W, Han Z, Zhang Y, Hao Q, Xia M (2014) Electrochemical sensing of acetaminophen based on poly(3,4-ethylenedioxythiophene)/graphene oxide composites. Sens Actuators B Chem 193:823–829. https://doi.org/10.1016/j.snb.2013.12.05210.1016/j.snb.2013.12.052 ↗
8. Bhat SA, Rather MA, Pandit SA, Ingole PP, Bhat MA (2016) Sensitive electrochemical sensing of acetaminophen and hydroquinone over single-pot synthesized stabilizer free Ag/Ag-oxide-graphene nanocomposites. J Electroanal Chem 783:280–287. https://doi.org/10.1016/j.jelechem.2016.11.00810.1016/j.jelechem.2016.11.008 ↗
9. Zheng M, Gao F, Wang Q, Cai X, Jiang S, Huang L, Gao F (2013) Electrocatalytical oxidation and sensitive determination of acetaminophen on glassy carbon electrode modified with graphene–chitosan composite. Mater Sci Eng C 33(3):1514–1520. https://doi.org/10.1016/j.msec.2012.12.05510.1016/j.msec.2012.12.055 ↗
10. Yang H, Liu B, Ding Y, Li L, Ouyang X (2015) Fabrication of cuprous oxide nanoparticles-graphene nanocomposite for determination of acetaminophen. J Electroanal Chem 757:88–93. https://doi.org/10.1016/j.jelechem.2015.09.01410.1016/j.jelechem.2015.09.014 ↗
11. Kokulnathan T, Chen S-M (2019) Rational design for the synthesis of europium vanadate-encapsulated graphene oxide nanocomposite: an excellent and efficient catalyst for the electrochemical detection of clioquinol. ACS Sustain Chem Eng 7(4):4136–4146. https://doi.org/10.1021/acssuschemeng.8b0565010.1021/acssuschemeng.8b05650 ↗
12. Patra S, Roy E, Tiwari A, Madhuri R, Sharma PK (2017) 2-Dimensional graphene as a route for emergence of additional dimension nanomaterials. Biosens Bioelectron 89:8–27. https://doi.org/10.1016/j.bios.2016.02.06710.1016/j.bios.2016.02.067 ↗
13. Matsoso BJ, Mutuma BK, Billing C, Ranganathan K, Lerotholi T, Jones G, Coville NJ (2018) The effect of N-configurations on selective detection of dopamine in the presence of uric and ascorbic acids using surfactant-free N-graphene modified ITO electrodes. Electrochim Acta 286:29–38. https://doi.org/10.1016/j.electacta.2018.08.01710.1016/j.electacta.2018.08.017 ↗
14. Sheng Z-H, Shao L, Chen J-J, Bao W-J, Wang F-B, Xia X-H (2011) Catalyst-free synthesis of nitrogen-doped graphene via thermal annealing graphite oxide with melamine and its excellent electrocatalysis. ACS Nano 5(6):4350–4358. https://doi.org/10.1021/nn103584t10.1021/nn103584t ↗
15. Wang Y, Shao Y, Matson DW, Li J, Lin Y (2010) Nitrogen-doped graphene and its application in electrochemical biosensing. ACS Nano 4(4):1790–1798. https://doi.org/10.1021/nn100315s10.1021/nn100315s ↗
16. Bundaleska N, Henriques J, Abrashev M, Botelho do Rego AM, Ferraria AM, Almeida A, Dias FM, Valcheva E, Arnaudov B, Upadhyay KK, Montemor MF, Tatarova E (2018) Large-scale synthesis of free-standing N-doped graphene using microwave plasma. Sci Rep 8(1):12595. https://doi.org/10.1038/s41598-018-30870-310.1038/s41598-018-30870-3 ↗
17. Gu H, Zhou T, Shi G (2015) Synthesis of graphene supported graphene-like C3N4 metal-free layered nanosheets for enhanced electrochemical performance and their biosensing for biomolecules. Talanta 132:871–876. https://doi.org/10.1016/j.talanta.2014.09.04210.1016/j.talanta.2014.09.042 ↗
18. Wang Y, Zhao S, Zhang Y, Chen W, Yuan S, Zhou Y, Huang Z (2019) Synthesis of graphitic carbon nitride with large specific surface area via copolymerizing with nucleobases for photocatalytic hydrogen generation. Appl Surf Sci 463:1–8. https://doi.org/10.1016/j.apsusc.2018.08.21510.1016/j.apsusc.2018.08.215 ↗
19. Huang J, Meng P, Liu X (2019) Porous nanostructure and enhanced charge transfer in graphitic carbon nitride fabricated by polyoxometalate oxidation etching. J Alloys Compd 805:654–662. https://doi.org/10.1016/j.jallcom.2019.07.06610.1016/j.jallcom.2019.07.066 ↗
20. Zhang J, Zhang G, Chen X, Lin S, Möhlmann L, Dołęga G, Lipner G, Antonietti M, Blechert S, Wang X (2012) Co-monomer control of carbon nitride semiconductors to optimize hydrogen evolution with visible light. Angew Chem Int Ed 51(13):3183–3187. https://doi.org/10.1002/anie.20110665610.1002/anie.201106656 ↗
21. Liu Y-N, Zhou X, Shen C-C, Zhao Z-W, Jiang Y-F, Ma L-B, Fang X-X, Akif Z, Cheag T-Y, Xu A-W (2018) Hydrogen-bonding-assisted charge transfer: significantly enhanced photocatalytic H2 evolution over g-C3N4 anchored with ferrocene-based hole relay. Catal Sci Technol 8(11):2853–2859. https://doi.org/10.1039/c8cy00488a10.1039/c8cy00488a ↗
22. Liu Y-N, Shen C-C, Jiang N, Zhao Z-W, Zhou X, Zhao S-J, Xu A-W (2017) g-C3N4 hydrogen-bonding viologen for significantly enhanced visible-light photocatalytic H2 evolution. ACS Catal 7(12):8228–8234. https://doi.org/10.1021/acscatal.7b0326610.1021/acscatal.7b03266 ↗
23. Han Y, Ding B, Tong H, Zhang X (2011) Capacitance properties of graphite oxide/poly(3,4-ethylene dioxythiophene) composites. J Appl Polym Sci 121(2):892–898. https://doi.org/10.1002/app.3361010.1002/app.33610 ↗
24. Xu Y, Lei W, Su J, Hu J, Yu X, Zhou T, Yang Y, Mandler D, Hao Q (2018) A high-performance electrochemical sensor based on g-C3N4-E-PEDOT for the determination of acetaminophen. Electrochim Acta 259:994–1003. https://doi.org/10.1016/j.electacta.2017.11.03410.1016/j.electacta.2017.11.034 ↗
25. Sharma A, Kumar A, Khan R (2018) A highly sensitive amperometric immunosensor probe based on gold nanoparticle functionalized poly (3, 4-ethylenedioxythiophene) doped with graphene oxide for efficient detection of aflatoxin B 1. Synth Met 235:136–144. https://doi.org/10.1016/j.synthmet.2017.12.00710.1016/j.synthmet.2017.12.007 ↗
26. Goda T, Toya M, Matsumoto A, Miyahara Y (2015) Poly(3,4-ethylenedioxythiophene) bearing phosphorylcholine groups for metal-free, antibody-free, and low-impedance biosensors specific for C-reactive protein. ACS Appl Mater Interfaces 7(49):27440–27448. https://doi.org/10.1021/acsami.5b0932510.1021/acsami.5b09325 ↗
27. Ma L, Jayachandran S, Li Z, Song Z, Wang W, Luo X (2019) Antifouling and conducting PEDOT derivative grafted with polyglycerol for highly sensitive electrochemical protein detection in complex biological media. J Electroanal Chem 840:272–278. https://doi.org/10.1016/j.jelechem.2019.04.00210.1016/j.jelechem.2019.04.002 ↗
28. Li OL, Prabakar K, Kaneko A, Park H, Ishizaki T (2019) Exploration of Lewis basicity and oxygen reduction reaction activity in plasma-tailored nitrogen-doped carbon electrocatalysts. Catal Today 337:102–109. https://doi.org/10.1016/j.cattod.2019.02.05810.1016/j.cattod.2019.02.058 ↗
29. Martin DJ, Qiu K, Shevlin SA, Handoko AD, Chen X, Guo Z, Tang J (2014) Highly efficient photocatalytic H2 evolution from water using visible light and structure-controlled graphitic carbon nitride. Angew Chem 126(35):9394–939910.1002/ange.201403375 ↗
30. Dong X-X, Li M-Y, Feng N-N, Sun Y-M, Yang C, Xu Z-L (2015) A nanoporous MgO based nonenzymatic electrochemical sensor for rapid screening of hydrogen peroxide in milk. RSC Advances 5(105):86485–86489. https://doi.org/10.1039/c5ra18560b10.1039/c5ra18560b ↗
31. Dhar S, Majumder T, Chakraborty P, Mondal SP (2018) DMSO modified PEDOT:PSS polymer/ZnO nanorods Schottky junction ultraviolet photodetector: photoresponse, external quantum efficiency, detectivity, and responsivity augmentation using N doped graphene quantum dots. Org Electron 53:101–110. https://doi.org/10.1016/j.orgel.2017.11.02410.1016/j.orgel.2017.11.024 ↗
32. Nie T, Zhang K, Xu J, Lu L, Bai L (2014) A facile one-pot strategy for the electrochemical synthesis of poly(3,4-ethylenedioxythiophene)/Zirconia nanocomposite as an effective sensing platform for vitamins B2, B6 and C. J Electroanal Chem 717–718:1–9. https://doi.org/10.1016/j.jelechem.2014.01.00610.1016/j.jelechem.2014.01.006 ↗
33. Apperloo JJ, Janssen RAJ, Nielsen MM, Bechgaard K (2000) Doping in solution as an order-inducing tool prior to film formation of regio-irregular polyalkylthiophenes. Adv Mater 12(21):1594. https://doi.org/10.1002/1521-4095(200011)12:21%3c1594:aid-adma1594%3e3.0.co;2-710.1002/1521-4095(200011)12:21<1594::aid-adma1594>3.0.co;2-7 ↗
34. Zhang Y, Pan Q, Chai G, Liang M, Dong G, Zhang Q, Qiu J (2013) Synthesis and luminescence mechanism of multicolor-emitting g-C3N4 nanopowders by low temperature thermal condensation of melamine. Sci Rep. https://doi.org/10.1038/srep0194310.1038/srep01943 ↗
35. Wei Y, Xu L, Tao Y, Yao C, Xue H, Kong Y (2016) Electrosorption of lead ions by nitrogen-doped graphene aerogels via one-pot hydrothermal route. Ind Eng Chem Res 55(7):1912–1920. https://doi.org/10.1021/acs.iecr.5b0414210.1021/acs.iecr.5b04142 ↗
36. Li C, Xu J, Wu Y, Zhang Y, Zhang C, Lei W, Hao Q (2018) g-C3N4 nanofibers doped poly(3,4-ethylenedioxythiophene) modified electrode for simultaneous determination of ascorbic acid and acetaminophen. J Electroanal Chem 824:52–59. https://doi.org/10.1016/j.jelechem.2018.07.02510.1016/j.jelechem.2018.07.025 ↗
37. Wang D-G, Tan P, Wang H, Song M, Pan J, Kuang G-C (2018) BODIPY modified g-C3N4 as a highly efficient photocatalyst for degradation of Rhodamine B under visible light irradiation. J Solid State Chem 267:22–27. https://doi.org/10.1016/j.jssc.2018.08.00210.1016/j.jssc.2018.08.002 ↗
38. Si W, Lei W, Zhang Y, Xia M, Wang F, Hao Q (2012) Electrodeposition of graphene oxide doped poly(3,4-ethylenedioxythiophene) film and its electrochemical sensing of catechol and hydroquinone. Electrochim Acta 85:295–301. https://doi.org/10.1016/j.electacta.2012.08.09910.1016/j.electacta.2012.08.099 ↗
39. Jiang J, Ou-yang L, Zhu L, Zheng A, Zou J, Yi X, Tang H (2014) Dependence of electronic structure of g-C3N4 on the layer number of its nanosheets: a study by Raman spectroscopy coupled with first-principles calculations. Carbon 80:213–221. https://doi.org/10.1016/j.carbon.2014.08.05910.1016/j.carbon.2014.08.059 ↗
40. Garreau S, Louarn G, Buisson JP, Froyer G, Lefrant S (1999) In situ spectroelectrochemical Raman studies of poly(3,4-ethylenedioxythiophene) (PEDT). Macromolecules 32(20):6807–6812. https://doi.org/10.1021/ma990567410.1021/ma9905674 ↗
41. Chiu WW, Travaš-Sejdić J, Cooney RP, Bowmaker GA (2006) Studies of dopant effects in poly(3,4-ethylenedi-oxythiophene) using Raman spectroscopy. J Raman Spectrosc 37(12):1354–1361. https://doi.org/10.1002/jrs.154510.1002/jrs.1545 ↗
42. Nabilah Azman NH, Lim HN, Sulaiman Y (2016) Effect of electropolymerization potential on the preparation of PEDOT/graphene oxide hybrid material for supercapacitor application. Electrochim Acta 188:785–792. https://doi.org/10.1016/j.electacta.2015.12.01910.1016/j.electacta.2015.12.019 ↗
43. Zhang J, Zhao XS (2012) Conducting polymers directly coated on reduced graphene oxide sheets as high-performance supercapacitor electrodes. J Phys Chem C 116(9):5420–5426. https://doi.org/10.1021/jp211474e10.1021/jp211474e ↗
44. Shao Y, Zhang S, Engelhard MH, Li G, Shao G, Wang Y, Liu J, Aksay IA, Lin Y (2010) Nitrogen-doped graphene and its electrochemical applications. J Mater Chem 20(35):7491. https://doi.org/10.1039/c0jm00782j10.1039/c0jm00782j ↗
45. Wang L, Yin F, Yao C (2014) N-doped graphene as a bifunctional electrocatalyst for oxygen reduction and oxygen evolution reactions in an alkaline electrolyte. Int J Hydrogen Energy 39(28):15913–15919. https://doi.org/10.1016/j.ijhydene.2014.04.07110.1016/j.ijhydene.2014.04.071 ↗
46. She X, Liu L, Ji H, Mo Z, Li Y, Huang L, Du D, Xu H, Li H (2016) Template-free synthesis of 2D porous ultrathin nonmetal-doped g-C3N4 nanosheets with highly efficient photocatalytic H2 evolution from water under visible light. Appl Catal B 187:144–153. https://doi.org/10.1016/j.apcatb.2015.12.04610.1016/j.apcatb.2015.12.046 ↗
47. Bose S, Kuila T, Uddin ME, Kim NH, Lau AKT, Lee JH (2010) In-situ synthesis and characterization of electrically conductive polypyrrole/graphene nanocomposites. Polymer 51(25):5921–5928. https://doi.org/10.1016/j.polymer.2010.10.01410.1016/j.polymer.2010.10.014 ↗
48. Liu Z, Xu J, Yue R, Yang T, Gao L (2016) Facile one-pot synthesis of Au–PEDOT/rGO nanocomposite for highly sensitive detection of caffeic acid in red wine sample. Electrochim Acta 196:1–12. https://doi.org/10.1016/j.electacta.2016.02.17810.1016/j.electacta.2016.02.178 ↗
49. Oh W-D, Lok L-W, Veksha A, Giannis A, Lim T-T (2018) Enhanced photocatalytic degradation of bisphenol A with Ag-decorated S-doped g-C3N4 under solar irradiation: Performance and mechanistic studies. Chem Eng J 333:739–749. https://doi.org/10.1016/j.cej.2017.09.18210.1016/j.cej.2017.09.182 ↗
50. Sahu V, Grover S, Tulachan B, Sharma M, Srivastava G, Roy M, Saxena M, Sethy N, Bhargava K, Philip D, Kim H, Singh G, Singh SK, Das M, Sharma RK (2015) Heavily nitrogen doped, graphene supercapacitor from silk cocoon. Electrochim Acta 160:244–253. https://doi.org/10.1016/j.electacta.2015.02.01910.1016/j.electacta.2015.02.019 ↗
51. Yan J, Wei T, Shao B, Fan Z, Qian W, Zhang M, Wei F (2010) Preparation of a graphene nanosheet/polyaniline composite with high specific capacitance. Carbon 48(2):487–493. https://doi.org/10.1016/j.carbon.2009.09.06610.1016/j.carbon.2009.09.066 ↗
52. Choi KS, Liu F, Choi JS, Seo TS (2010) Fabrication of free-standing multilayered graphene and poly(3,4-ethylenedioxythiophene) composite films with enhanced conductive and mechanical properties. Langmuir 26(15):12902–12908. https://doi.org/10.1021/la101698j10.1021/la101698j ↗
53. Li F, Chai J, Yang H, Han D, Niu L (2010) Synthesis of Pt/ionic liquid/graphene nanocomposite and its simultaneous determination of ascorbic acid and dopamine. Talanta 81(3):1063–1068. https://doi.org/10.1016/j.talanta.2010.01.06110.1016/j.talanta.2010.01.061 ↗
54. Li X-B, Rahman MM, Xu G-R, Lee J-J (2015) Highly sensitive and selective detection of dopamine at poly(chromotrope 2B)-modified glassy carbon electrode in the presence of uric acid and ascorbic acid. Electrochim Acta 173:440–447. https://doi.org/10.1016/j.electacta.2015.05.06210.1016/j.electacta.2015.05.062 ↗
55. Tukimin N, Abdullah J, Sulaiman Y (2018) Electrodeposition of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide/manganese dioxide for simultaneous detection of uric acid, dopamine and ascorbic acid. J Electroanal Chem 820:74–81. https://doi.org/10.1016/j.jelechem.2018.04.06510.1016/j.jelechem.2018.04.065 ↗
56. Gholizadeh A, Shahrokhian S, Irajizad A, Mohajerzadeh S, Vosoughi M, Darbari S, Koohsorkhi J, Mehran M (2012) Fabrication of sensitive glutamate biosensor based on vertically aligned CNT nanoelectrode array and investigating the effect of CNTs density on the electrode performance. Anal Chem 84(14):5932–5938. https://doi.org/10.1021/ac300463x10.1021/ac300463x ↗
57. Liu L, Lv H, Wang C, Ao Z, Wang G (2016) Fabrication of the protonated graphitic carbon nitride nanosheets as enhanced electrochemical sensing platforms for hydrogen peroxide and paracetamol detection. Electrochim Acta 206:259–269. https://doi.org/10.1016/j.electacta.2016.04.12310.1016/j.electacta.2016.04.123 ↗
58. Li T, Xu J, Zhao L, Shen S, Yuan M, Liu W, Tu Q, Yu R, Wang J (2016) Au nanoparticles/poly(caffeic acid) composite modified glassy carbon electrode for voltammetric determination of acetaminophen. Talanta 159:356–364. https://doi.org/10.1016/j.talanta.2016.06.04410.1016/j.talanta.2016.06.044 ↗
59. Zhang Y, Liu X, Li L, Guo Z, Xue Z, Lu X (2016) An electrochemical paracetamol sensor based on layer-by-layer covalent attachment of MWCNTs and a G4.0 PAMAM modified GCE. Anal Methods 8(10):2218–2225. https://doi.org/10.1039/c5ay03241e10.1039/c5ay03241e ↗
60. Liu J, Xie Y, Wang K, Zeng Q, Liu R, Liu X (2017) A nanocomposite consisting of carbon nanotubes and gold nanoparticles in an amphiphilic copolymer for voltammetric determination of dopamine, paracetamol and uric acid. Microchim Acta 184(6):1739–1745. https://doi.org/10.1007/s00604-017-2185-410.1007/s00604-017-2185-4 ↗
61. Liu R, Zeng X, Liu J, Luo J, Zheng Y, Liu X (2016) A glassy carbon electrode modified with an amphiphilic, electroactive and photosensitive polymer and with multi-walled carbon nanotubes for simultaneous determination of dopamine and paracetamol. Microchim Acta 183(5):1543–1551. https://doi.org/10.1007/s00604-016-1763-110.1007/s00604-016-1763-1 ↗
62. Li M, Wang W, Chen Z, Song Z, Luo X (2018) Electrochemical determination of paracetamol based on Au@graphene core-shell nanoparticles doped conducting polymer PEDOT nanocomposite. Sens Actuators B Chem 260:778–785. https://doi.org/10.1016/j.snb.2018.01.09310.1016/j.snb.2018.01.093 ↗