Synthesis and physico-chemical properties of poly(N-vinyl pyrrolidone)-based hydrogels with titania nanoparticles
Source abstract
Abstract
Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized by the sol-gel method for the first time and were characterized in different states (native, freeze-dried, air-dried to constant weight and ground to powder, or swollen to constant weight in H2O or D2O) by various methods such as wide-angle and small-angle X-ray and neutron scattering, neutron spin-echo (NSE) spectroscopy, and scanning electron microscopy. The static (static polymer-polymer correlation length (mesh size), associates of cross-links and PVP microchains) and dynamic (polymer chain relaxation rate, hydrodynamic polymer-polymer correlation length) structural elements were determined. The incorporation of titania nanoparticles into PVP hydrogel slightly increases the size of structural inhomogeneities (an increase in the static and dynamic polymer-polymer correlation length, the formation of associates of cross-links and PVP chains). Titania nanoparticles have an impact on the microstructure of the composite hydrogel and form associates with sizes from 0.5 to 2 µm attached to PVP hydrogel pore walls. The PVP and TN/PVP hydrogels show a high degree of water swelling. Moreover, the presence of titania nanoparticles in TN/PVP increases the number of water adsorption cycles compared to PVP hydrogel. The high swelling degree, bacteria-resistant and antimicrobial properties against Staphylococcus aureus allow considering NT/PVP hydrogels for medical applications as wound coatings.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Sensor and Energy Harvesting Materials · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Sen M, Guven O (1998) Prediction of swelling behavior of hydrogels containing diprotic acid moieties. Polymer 39:1165–117210.1016/S0032-3861(97)00391-1 ↗
2. Nicodemus GD, Bryant SJ (2008) Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue EngPart B Rev 14:149–16510.1089/ten.teb.2007.0332 ↗
3. Hoffman AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev 54:3–1210.1016/S0169-409X(01)00239-3 ↗
4. Kamata H, Akagi Y, Kayasuga-Kariya Y, Chung U, Sakai T (2014) “Nonswellable” hydrogel without mechanical hysteresis. Science 343:873–87510.1126/science.1247811 ↗
5. Gaharwar AK, Peppas NA, Khademhosseini A (2014) Nanocomposite hydrogels for biomedical applications. Biotechnol Bioeng 111:441–45310.1002/bit.25160 ↗
6. Gupta B, Agarwal R, Alam MS (2011) 9-Hydrogels for wound healing applications, Biomed Hydrogels, p 184–227. https://doi.org/10.1533/9780857091383.2.18410.1533/9780857091383.2.184 ↗
7. Rosiak JM, Rucinska R, Pekala W. U.S. Patent No. 4871490
8. Rogero SO, Malmonge SM, Lugao AB, Ikeda TI, Miyamaru L, Cruz AS (2003) Biocompatibility study of polymeric biomaterials. Artif Organs 27:424–42710.1046/j.1525-1594.2003.07249.x ↗
9. Maher SA, Doty SB, Torzilli PA, Thornton S, Lowman AM, Thomas JD, Warren R, Wright TM (2007) Myers E (2007) Nondegradable hydrogels for the treatment of focal cartilage defects. J Biomed Mater Res 83:145–15510.1002/jbm.a.31255 ↗
10. Zheng Y, Huang X, Wang Y, Xu H, Chen X (2009) Performance and characterization of irradiated poly(vinyl alcohol)/polyvinylpyrrolidone composite hydrogels used as cartilages replacement. J Appl Polym Sci 113:736–74110.1002/app.29326 ↗
11. Kirsh YuE (1998) Water soluble poly-N-vinylamides. synthesis and physicochemical properties. Wiley, Chichester
12. Jiao YP, Liu ZH, Ding S, Li LH, Zhou CR (2006) Preparation of biodegradable crosslinking agents and application in PVP hydrogel. J Appl Polym Sci 101:1515–152110.1002/app.22291 ↗
13. Benamer S, Mahlous M, Boukrif A, Mansouri B, Larbi YS (2006) Synthesis and characterisation of hydrogels based on poly(vinyl pyrrolidone). Nucl Instr Methods Phys Res B 248:284–29010.1016/j.nimb.2006.04.072 ↗
14. Ajji Z, Othman I, Rosiak JM (2005) Production of hydrogel wound dressings using gamma radiation. Nucl Instrum Methods Phys Res B 229:375–38010.1016/j.nimb.2004.12.135 ↗
15. Wang D, Hill DJT, Rasoul F, Whittaker AK (2011) A study of the swelling and model protein release behaviours of radiationformed poly(n-vinyl-2-pyrrolidone-co-acrylic acid) hydrogels. Radiat Phys Chem 80:207–21210.1016/j.radphyschem.2010.07.034 ↗
16. Nho Y, Lim Y, An S, Kim Y (2008) Therapeutic hydrogel for atopic dermatitis and preparation method thereof. EP 1 889 608 B1
17. Darwis D, Hilmy N, Hardiningsih L, Erlinda T (1993) Poly(N-vinylpyrrolidone) hydrogels: 1. Radiation polymerization and crosslinking of N-vinylpyrrolidone. Radiat Phys Chem 42:907–91010.1016/0969-806X(93)90399-F ↗
18. Himly N, Darwis D, Hardiningsih L (1993) Poly(n-vinylpyrrolidone) hydrogels: 2. hydrogel composites as wound dressing for tropical environment. Radiat Phys Chem 4:911–91410.1016/0969-806X(93)90400-O ↗
19. Erdem A, Metzler D, Cha D, Huang CP (2015) Inhibition of bacteria by photocatalytic nano-TiO2 particles in the absence of light. Int J Environ Sci Technol 12:2987–299610.1007/s13762-014-0729-2 ↗
20. Huppman T, Yatsenko S, Leonhardt S, Krampe E, Radovanovic I, Bastian M, Wintermantel E (2014) Antimicrobial polymers—The antibacterial effect of photoactivated nano titanium dioxide polymer composites. AIP Conf Proc 1593:440–44310.1063/1.4873817 ↗
21. Bodaghi H, Mostofi Y, Oromiehie A, Zamani Z, Ghanbarzadeh B, Costa C, Conte A, Del Nobile MA (2013) Evaluation of the photocatalytic antimicrobial effects of a TiO2 nanocomposite food packaging film by in vitro and in vivo tests. LWT Food Sci Technol 50:702–70610.1016/j.lwt.2012.07.027 ↗
22. Cao L, Wu X, Wang Q, Wang J (2018) Biocompatible nanocomposite of TiO2 incorporated bi-polymer for articular cartilage tissue regeneration: a facile material. J Photoch Photobio B 178:440–44610.1016/j.jphotobiol.2017.10.026 ↗
23. Archana D, Singh BK, Dutta J, Dutta PK (2013) In vivo evaluation of chitosan–PVP–titanium dioxide nanocomposite as wound dressing material. Carbohydr Polym 95:530–53910.1016/j.carbpol.2013.03.034 ↗
24. Kuz’micheva GM, Podbel’sky VV, Stepanov AN, Gaynanova AA (2017) Program for processing of diffraction patterns of nanosized and amorphous substances and calculation of the substructure. No. 2017610699
25. Korneev VN, Shlektarev VA, Zabelin AV, Aul’chenko VM, Tolochko BP, Ariskin NI, Lanina LF, Vazina AA (2012) X-ray stations based on cylindrical zoom lenses for nanostructural investigations using synchrotron radiation. J Surf Invest X-ray Synchrotron Neutron Tech 6:849–86410.1134/S1027451012100084 ↗
26. Huang TC, Toraya H, Blanton TN, Wu Y (1993) X-ray powder diffraction analysis of silver behenate, a possible low-angle diffraction standard. J Appl Cryst 26:180–18410.1107/S0021889892009762 ↗
27. Hammersley AP (1997) FIT2D: an introduction and overview. ESRF97HA02T, France
28. Konarev PV, Volkov VV, Sokolova AV, Koch MHJ, Svergun DI (2003) PRIMUS: a Windows PC-based system for small-angle scattering data analysis. J Appl Cryst 36:1277–128210.1107/S0021889803012779 ↗
29. Konarev PV, Petoukhov MV, Volkov VV, Svergun DI (2006) ATSAS 2.1, a program package for small-angle scattering data analysis. J Appl Cryst 39:277–28610.1107/S0021889806004699 ↗
30. Svergun DI (1992) Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J Appl Cryst 25:495–50310.1107/S0021889892001663 ↗
31. Svergun DI, Shtykova EV, Volkov VV, Feigin LA (2011) Small-angle X-ray scattering, synchrotron radiation, and the structure of bio- and nanosystems. Crystallogr Rep 56:725–75010.1134/S1063774511050221 ↗
32. https://dx.doi.org/10.5291/ILL-DATA.9-12-510
33. Richard D, Ferrand M, Kearley GJ (1996) Analysis and visualisation of neutron-scattering data. J Neutron Res 4:33–3910.1080/10238169608200065 ↗
34. Brebler I, Kohlbrecher J, Thunemann AF (2015) SASfit: a tool for small-angle scattering data analysis using a library of analytical expressions. J Appl Cryst 48:1587–159810.1107/S1600576715016544 ↗
35. Mezei F, Pappas C, Gutberlet T (2003) Neutron spin echo spectroscopy—basics, trends and applications. Springer, Heidelberg10.1007/3-540-45823-9 ↗
36. Kim SH, Chu CC (2000) Pore structure analysis of swollen dextran-methacrylate hydrogels by SEM and mercury intrusion porosimetry. J Biomed Mater Res (Appl Biomater) 53:258–26610.1002/(SICI)1097-4636(2000)53:3<258::AID-JBM11>3.0.CO;2-O ↗
37. Teng J, Bates S, Engers D, Leach K, Schields P, Jang Y (2010) Effect of water vapor sorption on local structure of poly(vinylpyrrolidone). J Pharm Sci 99:3815–382510.1002/jps.22204 ↗
38. Busselez R, Arbe A, Cerveny S, Capponi S, Colmenero J, Frick B (2012) Component dynamics in polyvinylpyrrolidone concentrated aqueous solutions. J Chem Phys 137:08490210.1063/1.4746020 ↗
39. Naohara R, Narita K, Ikeda-Fukazawa T (2017) Change in hydrogen bonding structures of a hydrogel with dehydration. Chem Phys Lett 670:84–8810.1016/j.cplett.2017.01.006 ↗
40. Omidian H, Park K (2010) Introduction to hydrogels. In: Ottenbrite RM (ed) Biomedical applications of hydrogels handbook. Springer, London, pp 1–16
41. Zheng MP, Jin YP, Jin GL, My Gu (2000) Characterization of TiO2-PVP nanocomposites prepared by the sol–gel method. J Mater Sci 19:433–436. https://dx.doi.org/10.1023/A:100670322437910.1023/A:1006703224379 ↗
42. Hammouda B, Ho DL, Kline S (2004) Insight into clustering in poly (ethylene oxide) solutions. Macromolecules 37:6932–693710.1021/ma049623d ↗
43. Teodorescu M, Morariu S, Bercea M, Sacarescu L (2016) Viscoelastic and structural properties of poly(vinyl alcohol)/poly(vinylpyrrolidone) hydrogels. RSC Adv 6:39718–3972710.1039/C6RA04319D ↗
44. Gennes PG (1979) Scaling Concepts in Polymer Physics. Cornell University Press, Ithaca
45. Campanella A, Holderer O, Raftopoulos KN, Papadakis CM, Staropoli MP, Appavou MS, Muller-Buschbaum P, Frielinghaus H (2016) Multi-stage freezing of HEUR polymer networks with magnetite nanoparticles. Soft Matter 12:3214–322510.1039/C6SM00074F ↗
46. Berke B, Czakkel O, Porcar L, Geissler E, Laszlo K (2016) Static and dynamic behaviour of responsive graphene oxide–poly(N-isopropyl acrylamide) composite gels. Soft Matter 12:7166–717310.1039/C6SM00666C ↗
47. Hellweg T, Kratz K, Pouget S, Eimer W (2002) Internal dynamics in colloidal pNIPAM microgel particles immobilised in a mesoscopic crystal. Coll Surf A 202:223–23210.1016/S0927-7757(01)01077-9 ↗
48. Robinson GW, Zhu SB, Singh S, Evans MW (1996) Water in biology, chemistry, and physics: experimental overviews and computational methodologies. World Scientific, Singapore10.1142/2923 ↗
49. Adnadjevic B, Jovanovic J (2008) Novel approach in investigation of the poly(acrylic acid) hydrogel swelling kinetics in water. J Appl Polym Sci 107:3579–358710.1002/app.27451 ↗
50. Datsenko B, Biryukova SV, Tamm TI (1989) Methodical recommendations for experimental (preclinical) study of drugs for topical treatment of purulent wounds. USSR, Moscow