Facile synthesis of hydrophilic polypyrrole nanoparticles for photothermal cancer therapy
Source abstract
Abstract
PPY nanoparticles, as one of the important organic photothermal agents has been attracted great attention due to their good biocompatibility, high photothermal efficiency, and low cost. In order to further evaluate the size-dependent photothermal effect, PPY nanoparticles with two different sizes have been prepared with a facile method. The near infrared absorption and photothermal effect of the two size PPY nanoparticles were compared. The PPY nanoparticle with small size shows better photothermal effect at the same condition. The photostability, stability, and cytotoxicity in biologic system have also been investigated. In addition, the PPY nanoparticles with small size can kill the cancer cells effectively under the irradiation of 808 nm laser with a low-power density. These findings may provide better information for the application of the PPY nanoparticles on the photothermal ablation of cancer cells.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (16)
Show source-provided references
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–9010.3322/caac.20107 ↗
2. Tian Q, Jiang F, Zou R, Liu Q, Chen Z, Zhu M, Yang S, Wang J, Wang J, Hu J (2011) Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7 % heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 5:9761–977110.1021/nn203293t ↗
3. Chen WR, Adams RL, Carubelli R, Nordquist RE (1997) Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment. Cancer Lett 115:25–3010.1016/S0304-3835(97)04707-1 ↗
4. Skrabalak SE, Chen J, Au L, Lu X, Li X, Xia Y (2007) Gold nanocages for biomedical applications. Adv Mater 19:3177–318410.1002/adma.200701972 ↗
5. Huang X, Tang S, Mu X, Dai Y, Chen G, Zhou Z, Ruan F, Yang Z, Zheng N (2011) Freestanding palladium nanosheets with plasmonic and catalytic properties. Nat Nano 6:28–3210.1038/nnano.2010.235 ↗
6. Xu R, Ma J, Sun X, Chen Z, Jiang X, Guo Z, Huang L, Li Y, Wang M, Wang C, Liu J, Fan X, Gu J, Chen X, Zhang Y, Gu N (2009) Ag nanoparticles sensitize IR-induced killing of cancer cells. Cell Res 19:1031–103410.1038/cr.2009.89 ↗
7. Hessel CM, Pattani VP, Rasch M, Panthani MG, Koo B, Tunnell JW, Korgel BA (2011) Copper selenide nanocrystals for photothermal therapy. Nano Lett 11:2560–256610.1021/nl201400z ↗
8. Robinson JT, Tabakman SM, Liang Y, Wang H, Sanchez Casalongue H, Vinh D, Dai H (2011) Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc 133:6825–683110.1021/ja2010175 ↗
9. Yang K, Zhang S, Zhang G, Sun X, Lee S-T, Liu Z (2010) Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett 10:3318–332310.1021/nl100996u ↗
10. Zha Z, Yue X, Ren Q, Dai Z (2013) Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells. Adv Mater 25:777–78210.1002/adma.201202211 ↗
11. Chen M, Fang X, Tang S, Zheng N (2012) Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy. Chem Commun 48:8934–893610.1039/c2cc34463g ↗
12. Yang K, Xu H, Cheng L, Sun C, Wang J, Liu Z (2012) In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv Mater 24:5586–559210.1002/adma.201202625 ↗
13. Kim S, Oh W-K, Jeong YS, Hong J-Y, Cho B-R, Hahn J-S, Jang J (2011) Cytotoxicity of, and innate immune response to, size-controlled polypyrrole nanoparticles in mammalian cells. Biomaterials 32:2342–235010.1016/j.biomaterials.2010.11.080 ↗
14. Roper DK, Ahn W, Hoepfner M (2007) Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles. J Phys Chem C 111:3636–364110.1021/jp064341w ↗
15. Tian Q, Hu J, Zhu Y, Zou R, Chen Z, Yang S, Li R, Su Q, Han Y, Liu X (2013) Sub-10 nm Fe3O4@Cu2–xS core–shell nanoparticles for dual-modal imaging and photothermal therapy. J Am Chem Soc 135:8571–857710.1021/ja4013497 ↗
16. Tian Q, Tang M, Sun Y, Zou R, Chen Z, Zhu M, Yang S, Wang J, Wang J, Hu J (2011) Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv Mater 23:3542–354710.1002/adma.201101295 ↗