Enhanced mechanical and osteogenic differentiation performance of hydroxyapatite/zein composite for bone tissue engineering
Source abstract
Abstract
Herein, a series of hydroxyapatite (HAp)/zein biocomposite membranes, with different inorganic/organic weight ratios, are fabricated by solvent casting method by using ultra-long hydroxyapatite nanowires as the reinforcement. The FTIR spectra and XRD analysis of HAp/zein composite membrane confirm the structure of HAp nanowires and zein in composite membranes. When the HAp nanowires content increased from 50 to 90 wt%, the morphology of HAp/zein composite membrane transformed from the rough plane into the fibrous and porous structure, both Young’s modulus and tensile strength exhibited about 40% of the increase, and the water absorption showed about 80% of improvement. Moreover, higher content of HAp nanowires improved the adhesion, proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells according to the examination of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, alkaline phosphatase activity, calcium deposition and gene expression. The prepared HAp/zein 9/1 composite membrane is shown as a promising candidate for the bone repair and regeneration applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Periodontal Regeneration and Treatments · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
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