A study of a biodegradable braided Mg stent for biliary reconstruction
Source abstract
Abstract
Aiming at deficiencies in non-degradable stents for benign common bile duct obstruction, the magnesium (Mg)-based braided stents were developed with one monofilament as a pilot research in this paper. We designed stents with the different monofilament diameter, braided-pin number and surface treatment systematically to study the mechanical and degradation behaviors. The results suggest the fluorinated Mg stents and them with polycaprolactone (PCL) coating can achieve the compression force of 3.35–11.07 N and 11.09–24.08 N, and even maintain 3.10–10.43 N for 3 days immersion and 3.11–9.37 N for 20 days immersion respectively. PCL coating on monofilament can provide significantly better compression force and corrosion resistance. By comparison with the stent in clinic, these Mg stents are expected to meet the demand of the radial compression force and implantation time. Furthermore, the degradation occurs at the ends preferentially for all stents, but for stents without PCL coating, the intersections of wire-mesh are also the area easily corroded. Additionally, the result of the compression test indicates the radial compression force is improved with the increase of monofilament diameter and pins number, but the recovery capability decreases slightly.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Biliary and Gastrointestinal Fistulas · Gallbladder and Bile Duct Disorders
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. Xu XY, Liu TJ, Liu SH, Zhang K, Shen Z, Li YX, Jing XB (2009) Feasibility of biodegradable PLGA common bile duct stents: an in vitro and in vivo study. J Mater Sci Mater Med 20:1167–1173. https://doi.org/10.1007/s10856-008-3672-210.1007/s10856-008-3672-2 ↗
2. Daldoul S, Moussi A, Zaouche A (2012) T-tube drainage of the common bile duct choleperitoneum: etiology and management. J Visc Surg 149:e172–e178. https://doi.org/10.1016/j.jviscsurg.2012.03.00810.1016/j.jviscsurg.2012.03.008 ↗
3. van Boeckel PG, Vleggaar FP, Siersema PD (2009) Plastic or metal stents for benign extrahepatic biliary strictures: a systematic review. BMC Gastroenterol 9:96. https://doi.org/10.1186/1471-230X-9-9610.1186/1471-230X-9-96 ↗
4. Elwir S, Sharzehi K, Veith J, Moyer MT, Dye C, McGarrity T, Mathew A (2013) Biliary stenting in patients with malignant biliary obstruction: comparison of double layer, plastic and metal stents. Dig Dis Sci 58:2088–2092. https://doi.org/10.1007/s10620-013-2607-z10.1007/s10620-013-2607-z ↗
5. Luigiano C, Ferrara F, Cennamo V, Fabbri C, Bassi M, Ghersi S et al (2012) A comparison of uncovered metal stents for the palliation of patients with malignant biliary obstruction: nitinol vs. stainless steel. Dig Liver Dis 44:128–133. https://doi.org/10.1016/j.dld.2011.08.01510.1016/j.dld.2011.08.015 ↗
6. Almeida GG, Donato P (2020) Biodegradable versus multiple plastic stent implantation in benign biliary strictures: a systematic review and meta-analysis. Eur J Radiol 125:108899. https://doi.org/10.1016/j.ejrad.2020.10889910.1016/j.ejrad.2020.108899 ↗
7. Ginsberg G, Cope C, Shah J, Martin T, Carty A, Habecker P et al (2003) In vivo evaluation of a new bioabsorbable self-expanding biliary stent. Gastrointest Endosc 58:777–784. https://doi.org/10.1016/S0016-5107(03)02016-910.1016/S0016-5107(03)02016-9 ↗
8. Girard E, Chagnon G, Broisat A, Dejean S, Soubies A, Gil H et al (2020) From in vitro evaluation to human postmortem pre-validation of a radiopaque and resorbable internal biliary stent for liver transplantation applications. Acta Biomater 106:70–81. https://doi.org/10.1016/j.actbio.2020.01.04310.1016/j.actbio.2020.01.043 ↗
9. Mauri G, Michelozzi C, Melchiorre F, Poretti D, Tramarin M, Pedicini V et al (2013) Biodegradable biliary stent implantation in the treatment of benign bilioplastic-refractory biliary strictures: preliminary experience. Eur Radiol 23:3304–3310. https://doi.org/10.1007/s00330-013-2947-210.1007/s00330-013-2947-2 ↗
10. Zheng YF, Gu XN, Witte F (2014) Biodegradable metals. Mater Sci Eng Res 77:1–34. https://doi.org/10.1016/j.mser.2014.01.00110.1016/j.mser.2014.01.001 ↗
11. Liu Y, Zheng SM, Li N, Guo HH, Zheng YF, Peng JR (2017) In vivo response of AZ31 alloy as biliary stents: a 6 months evaluation in rabbits. Sci Rep 7:40184. https://doi.org/10.1038/srep4018410.1038/srep40184 ↗
12. Rebelo R, Vila N, Fangueiro R, Carvalho S, Rana S (2015) Influence of design parameters on the mechanical behavior and porosity of braided fibrous stents. Mater Des 86:237–247. https://doi.org/10.1016/j.matdes.2015.07.05110.1016/j.matdes.2015.07.051 ↗
13. Chen YG, Yan J, Wang XH, Yu S, Wang ZG, Zhang XN et al (2014) In vivo and in vitro evaluation of effects of Mg–6Zn alloy on apoptosis of common bile duct epithelial cell. Biometals 27:1217–1230. https://doi.org/10.1007/s10534-014-9784-x10.1007/s10534-014-9784-x ↗
14. Chen YG, Yan J, Wang ZG, Yu S, Wang XH, Yuan ZM et al (2014) In vitro and in vivo corrosion measurements of Mg–6Zn alloys in the bile. J Mater Sci Mater Med 42:116–123. https://doi.org/10.1016/j.msec.2014.05.01410.1016/j.msec.2014.05.014 ↗
15. Ding PF, Liu YC, He XH, Liu DB, Chen MF (2019) In vitro and in vivo biocompatibility of Mg–Zn–Ca alloy operative clip. Bioact Mater 4:236–244. https://doi.org/10.1016/j.bioactmat.2019.07.00210.1016/j.bioactmat.2019.07.002 ↗
16. Gu XN, Zheng YF, Cheng Y, Zhong SP, Xi TF (2009) In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials 30:484–498. https://doi.org/10.1016/j.biomaterials.2008.10.02110.1016/j.biomaterials.2008.10.021 ↗
17. Min Y, Debao L, Runfang Z, Minfang C (2018) Microstructure and properties of Mg–3Zn–0.2Ca alloy for biomedical application. Rare Met Mater Eng 47:0093–0098. https://doi.org/10.1016/S1875-5372(18)30078-X10.1016/S1875-5372(18)30078-X ↗
18. Liu H, Sun C, Wang C, Li YH, Bai J, Xue F et al (2020) Improving toughness of a Mg–Ca-containing Mg–Al–Ca–Mn alloy via refinement and uniform dispersion of Mg2Ca particles. J Mater Sci Technol 59:61–71. https://doi.org/10.1016/j.jmst.2020.02.09210.1016/j.jmst.2020.02.092 ↗
19. Sun LX, Bai J, Xue F, Tao L, Chu CC, Meng J (2017) Exceptional texture evolution induced by multi-pass cold drawing of magnesium alloy. Mater Des 135:267–274. https://doi.org/10.1016/j.matdes.2017.09.02710.1016/j.matdes.2017.09.027 ↗
20. Cai H, Zhang Y, Meng J, Li X, Xue F, Chu CL, Tao L, Bai J (2018) Enhanced fully-biodegradable Mg/PLA composite rod: effect of surface modification of Mg–2Zn wire on the interfacial bonding. Surf Coat Technol 350:722–731. https://doi.org/10.1016/j.surfcoat.2018.07.04510.1016/j.surfcoat.2018.07.045 ↗
21. Cai H, Meng J, Li X, Xue F, Chu CL, Guo C, Bai J (2019) In vitro degradation behavior of Mg wire/poly(lactic acid) composite rods prepared by hot pressing and hot drawing. Acta Biomater 98:125–141. https://doi.org/10.1016/j.actbio.2019.05.05910.1016/j.actbio.2019.05.059 ↗
22. Pitt HA, Nakeeb A, Espat NJ (2012) In: Jarnagin WR, Blumgart LH (eds) Blumgart’s surgery of the liver, pancreas and biliary tract, 5th edn. Elsevier, Philadelphia, pp 113–12210.1016/B978-1-4377-1454-8.00007-2 ↗
23. Lu J, Wu DH, Rohani S (2014) Influence of Ca2+ on cholesterol crystallization from supersaturated model biles. Fluid Phase Equilib 367:51–56. https://doi.org/10.1016/j.fluid.2014.01.03110.1016/j.fluid.2014.01.031 ↗
24. William H, Admirand SDM (1968) The physicochemical basis of cholesterol formation in man. J Clin Invest 47:1043–1052. https://doi.org/10.1172/JCI10579410.1172/JCI105794 ↗
25. Zhu YQ, Yang K, Cheng RY, Xiang Y, Yuan TW, Cheng YS, Sarment OB, Cui WG (2017) The current status of biodegradable stent to treat benign luminal disease. Mater Today 20:516–529. https://doi.org/10.1016/j.mattod.2017.05.00210.1016/j.mattod.2017.05.002 ↗
26. Liu YH, Zhang PH (2016) Characterization of compression behaviors of fully covered biodegradable polydioxanone biliary stent for human body: a numerical approach by finite element model. J Mech Behav Biomed 62:128–138. https://doi.org/10.1016/j.jmbbm.2016.04.02910.1016/j.jmbbm.2016.04.029 ↗
27. Zou QH, Xue W, Lin J, Fu YJ, Guan GP, Wang FJ, Wang L (2016) Mechanical characteristics of novel polyester/NiTi wires braided composite stent for the medical application. Results Phys 6:440–446. https://doi.org/10.1016/j.rinp.2016.07.00710.1016/j.rinp.2016.07.007 ↗
28. Nicolas F, Renick DL, Ryo T, Juan LG, Alessio M (2014) Impact of stent strut design in metallic stents and biodegradable scaffolds. Int J Cardiol 177:800–808. https://doi.org/10.1016/j.ijcard.2014.09.14310.1016/j.ijcard.2014.09.143 ↗
29. Sanchez AHM, Luthringer BJC, Feyerabend F, Willumeit R (2015) Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review. Acta Biomater 13:16–31. https://doi.org/10.1016/j.actbio.2014.11.04810.1016/j.actbio.2014.11.048 ↗
30. Meng B, Wang J, Zhu N, Meng QY, Cui FZ, Xu YX (2006) Study of biodegradable and self-expandable PLLA helical biliary stent in vivo and in vitro. J Mater Sci Mater Med 17:611–617. https://doi.org/10.1007/s10856-006-9223-910.1007/s10856-006-9223-9 ↗
31. Zhao SJ, Liu XY, Gu LX (2012) The impact of wire stent fabrication technique on the performance of stent placement. J Med Devices 1:007–011. https://doi.org/10.1115/1.400578810.1115/1.4005788 ↗
32. Yan TT, Tan LL, Xiong DS, Liu XJ, Zhang BC, Yang K (2010) Fluoride treatment and in vitro corrosion behavior of an AZ31B magnesium alloy. Mater Sci Eng C Mater 30:740–748. https://doi.org/10.1016/j.msec.2010.03.00710.1016/j.msec.2010.03.007 ↗
33. Preeti M, Jin KH, Andrew RP, Ihho P, Byoung-Gi M, Taek LB (2018) Development and properties of duplex MgF2/PCL coatings on biodegradable magnesium alloy for biomedical applications. PLoS ONE 13:e193927. https://doi.org/10.1371/journal.pone.019392710.1371/journal.pone.0193927 ↗
34. Zeng RC, Cui LY, Jiang K, Liu R, Zhao BD, Zheng YF (2016) In vitro corrosion and cytocompatibility of a microarc oxidation coating and poly(l-lactic acid) composite coating on Mg–1Li–1Ca alloy for orthopedic implants. ACS Appl Mater Interfaces 8:10014–10028. https://doi.org/10.1021/acsami.6b0052710.1021/acsami.6b00527 ↗
35. Chen LX, Sheng YY, Zhou HY, Li ZB, Wang XJ, Li W (2019) Influence of a MAO + PLGA coating on biocorrosion and stress corrosion cracking behavior of a magnesium alloy in a physiological environment. Corros Sci 148:134–143. https://doi.org/10.1016/j.corsci.2018.12.00510.1016/j.corsci.2018.12.005 ↗