Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy
Source abstract
Abstract
Chemotherapy in cancer treatment usually leads to serious side effects on patients due to the unselectiveness and high toxicity on normal cells of cancer drugs. Loading cancer drugs into nano-platforms could be an alternative approach to effectively deliver drugs to tumors and reduce toxic exposure on healthy cells. In this work, we synthesized drug delivery nano-systems based on Fe3O4 nanoparticles (obtained from co-precipitation reaction) which could provide targeting of drugs to the tumor sites by an external magnetic field. Also, the magnetic nanoparticles (MNPs) could generate heat to kill cancer cells at a certain temperature range. The systems were designed for loading anticancer agent doxorubicin by using alginate-coated iron oxide MNPs. It was found that the loading was achieved by complex formation of doxorubicin and the alginate layer. Various concentrations of alginate solutions produced different sizes as well as drug loading capacities of the nanoparticles. The highest loading content of 18.96% achieved at the alginate concentration of 4 mg ml−1, corresponding to the mass ratio of alginate to Fe3O4 of around 1:2. The magnetic properties, especially the inductive heating effect of the nanoparticles, along with the impact of the systems on tumor cells were investigated. The results proved that the nanoparticles can serve as a good drug delivery system, in terms of both effective hyperthermia and chemotherapy.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Electrohydrodynamics and Fluid Dynamics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (67)
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1. Nasongkla N, Bey E, Ren J et al (2006) Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett 6:3–610.1021/nl061412u ↗
2. Hong G, Yuan R, Liang B et al (2008) Folate-functionalized polymeric micelle as hepatic carcinoma-targeted, MRI-ultrasensitive delivery system of antitumor drugs. Biomed Microdevice 10:693–70010.1007/s10544-008-9180-9 ↗
3. Yu MK, Jeong YY, Park J, et al (2008) Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo**. Evolution:1–5
4. Ma HL, Xu YF, Qi XR et al (2008) Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers. Int J Pharm 354:217–22610.1016/j.ijpharm.2007.11.036 ↗
5. Sun C, Lee JSH, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252–126510.1016/j.addr.2008.03.018 ↗
6. Lin MM, Kim DK, El Haj AJ, Dobson J (2008) Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applications. IEEE Trans Nanobiosci 7:298–30510.1109/TNB.2008.2011864 ↗
7. Mahmoudi M, Simchi A, Imani M et al (2008) Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging. J Phys Chem B 112:14470–1448110.1021/jp803016n ↗
8. Shete PB, Patil RM, Tiwale BM, Pawar SH (2015) Water dispersible oleic acid-coated Fe3O4 nanoparticles for biomedical applications. J Magn Magn Mater 377:406–41010.1016/j.jmmm.2014.10.137 ↗
9. Jia Y, Yuan M, Yuan H et al (2012) Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery. Int J Nanomed 7:1697–170810.2217/nnm.12.65 ↗
10. Maeng JH, Lee D-H, Jung KH et al (2010) Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer. Biomaterials 31:4995–500610.1016/j.biomaterials.2010.02.068 ↗
11. Unsoy G, Khodadust R, Yalcin S et al (2014) Synthesis of doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery. Eur J Pharm Sci 62:243–25010.1016/j.ejps.2014.05.021 ↗
12. Insausti M, Salado J, Castellanos I et al (2012) Tailoring biocompatible Fe3O4 nanoparticles for applications to magnetic hyperthermia. Proc SPIE 8232:823210/1–823210/8
13. Kikuchi T, Kasuya R, Endo S, Nakamura A (2010) Preparation of magnetite aqueous dispersion for magnetic fluid hyperthermia. J Magn Magn Mater 323:1216–122210.1016/j.jmmm.2010.11.009 ↗
14. Ang KL, Venkatraman S, Ramanujan RV (2007) Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy. Mater Sci Eng C 27:347–35110.1016/j.msec.2006.05.027 ↗
15. Longhi A, Ferrari S, Bacci G, Specchia S (2007) Long-term follow-up of patients with doxorubicin-induced cardiac toxicity after chemotherapy for osteosarcoma. Anticancer Drugs 18:737–74410.1097/CAD.0b013e32803d36fe ↗
16. Ahn D, Lee J, Park S et al (2014) Doxorubicin-loaded alginate-g-poly(N-isopropylacrylamide) micelles for cancer imaging and therapy. ACS Appl Mater Interfaces 6(24):22069–2207710.1021/am505444c ↗
17. Cheng Y, Yu S, Zhen X et al (2012) Alginic acid nanoparticles prepared through counterion complexation method as a drug delivery system. ACS Appl Mater Interfaces 4:5325–533210.1021/am3012627 ↗
18. Javid A, Ahmadian S, Saboury AA et al (2013) Chitosan-coated superparamagnetic iron oxide nanoparticles for doxorubicin delivery: synthesis and anticancer effect against human ovarian cancer cells. Chem Biol Drug Des 82:296–30610.1111/cbdd.12145 ↗
19. Baghbani F, Moztarzadeh F, Mohandesi JA et al (2016) Formulation design, preparation and characterization of multifunctional alginate stabilized nanodroplets. Int J Biol Macromol 89:550–55810.1016/j.ijbiomac.2016.05.033 ↗
20. Sengupta IS, Shah SH, Shah N (2015) A review on: alginate forming in situ gel for treating peptic ulcers and reflux disorders. J Pharm Sci Biosci Res 5:171–179
21. Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci (Oxford) 37:106–12610.1016/j.progpolymsci.2011.06.003 ↗
22. Nguyen HN, Hoang TMN, Mai TTT et al (2015) Enhanced cellular uptake and cytotoxicity of folate decorated doxorubicin loaded PLA–TPGS nanoparticles. Adv Nat Sci Nanosci Nanotechnol 6:2500510.1088/2043-6262/6/2/025005 ↗
23. Nguyen HN, Thi HHT, Le Quang D et al (2012) Apoptosis induced by paclitaxel-loaded copolymer PLA–TPGS in Hep-G2 cells. Adv Nat Sci Nanosci Nanotechnol 3:4500510.1088/2043-6262/3/4/045005 ↗
24. Phan QT, Le MH, Le TTH et al (2016) Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA–PEG micellar nano systems with various PLA:PEG ratios. Int J Pharm 507:32–4010.1016/j.ijpharm.2016.05.003 ↗
25. Devkota J, Mai TTT, Stojak K et al (2014) Synthesis, inductive heating, and magnetoimpedance-based detection of multifunctional Fe3O4 nanoconjugates. Sensors Actuators B Chem 190:715–72210.1016/j.snb.2013.09.033 ↗
26. Huong LTT, Nam NH, Doan DH et al (2016) Folate attached, curcumin loaded Fe3O4 nanoparticles: a novel multifunctional drug delivery system for cancer treatment. Mater Chem Phys 172:98–10410.1016/j.matchemphys.2015.12.065 ↗
27. Thu HP, Huong LTT, Nhung HTM et al (2011) Fe3O4/o-carboxylmethyl chitosan/curcumin-based nanodrug system for chemotherapy and fluorescence imaging in HT29 cancer cell line. Chem Lett 11:1–4
28. Nguyen XP, Tran DL, Ha PT et al (2012) Iron oxide-based conjugates for cancer theragnostics. Adv Nat Sci Nanosci Nanotechnol 3:3300110.1088/2043-6262/3/3/033001 ↗
29. Kallumadil M, Tada M, Nakagawa T et al (2009) Suitability of commercial colloids for magnetic hyperthermia. J Magn Magn Mater 321:1509–151310.1016/j.jmmm.2009.02.075 ↗
30. Salas G, Veintemillas-Verdaguer S, Morales MDP (2013) Relationship between physico-chemical properties of magnetic fluids and their heating capacity. Int J Hyperth Off J Eur Soc Hyperth Oncol N Am Hyperth Group 29:768–77610.3109/02656736.2013.826824 ↗
31. Tran LD, Hoang NMT, Mai TT et al (2010) Nanosized magnetofluorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting. Colloids Surf A 371:104–11210.1016/j.colsurfa.2010.09.011 ↗
32. Wang G, Su X, Yang S et al (2012) The double-effect mechanism between Fe3O4 nanoparticles and MSA-capped CdTe QDs. J Lumin 132:2505–251110.1016/j.jlumin.2012.04.036 ↗
33. Liao S-H, Liu C-H, Bishnu Prasad B et al (2015) Functionalized magnetic iron oxide/alginate core–shell nanoparticles for targeting hyperthermia. Int J Nanomed 10:3315–332810.2217/nnm.15.148 ↗
34. Araújo-Neto RP, Silva-Freitas EL, Carvalho JF et al (2014) Monodisperse sodium oleate coated magnetite high susceptibility nanoparticles for hyperthermia applications. J Magn Magn Mater 364:72–7910.1016/j.jmmm.2014.04.001 ↗
35. Vasconcelos IB, Da Silva TG, Militão GCG et al (2012) Cytotoxicity and slow release of the anti-cancer drug doxorubicin from ZIF-8. RSC Adv 2:9437–944210.1039/c2ra21087h ↗
36. Kayal S, Ramanujan RV (2010) Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery. Mater Sci Eng C 30:484–49010.1016/j.msec.2010.01.006 ↗
37. Nigam S, Barick KC, Bahadur D (2011) Development of citrate-stabilized Fe3O4 nanoparticles: conjugation and release of doxorubicin for therapeutic applications. J Magn Magn Mater 323:237–24310.1016/j.jmmm.2010.09.009 ↗
38. Hervault A, Dunn AE, Lim M et al (2016) Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale 8:21–2410.1039/C5NR07773G ↗
39. Fischer MJE (2010) Amine coupling through EDC/NHS: a practical approach methods. Mol Biol 627:55–73
40. Neuberger T, Schöpf B, Hofmann H et al (2005) Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J Magn Magn Mater 293:483–49610.1016/j.jmmm.2005.01.064 ↗
41. Gupta A, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–402110.1016/j.biomaterials.2004.10.012 ↗
42. Hałupka-Bryl M, Bednarowicz M, Dobosz B et al (2015) Doxorubicin loaded PEG-b-poly(4-vinylbenzylphosphonate) coated magnetic iron oxide nanoparticles for targeted drug delivery. J Magn Magn Mater 384:320–32710.1016/j.jmmm.2015.02.078 ↗
43. Marín T, Montoya P, Arnache O, Calderón J (2016) Influence of surface treatment on magnetic properties of Fe3O4 nanoparticles synthesized by electrochemical method. J Phys Chem B 120:6634–664510.1021/acs.jpcb.6b01796 ↗
44. Khalkhali M, Sadighian S, Rostamizadeh K et al (2015) Synthesis and characterization of dextran coated magnetite nanoparticles for simultaneous diagnostics and therapy. Bioimpacts 5:141–15010.15171/bi.2015.19 ↗
45. Aliahmad M, Nasiri Moghaddam N (2013) Synthesis of maghemite (γ-Fe2O3) nanoparticles by thermal-decomposition of magnetite (Fe3O4) nanoparticles. Mater Sci Pol 31:264–26810.2478/s13536-012-0100-6 ↗
46. Pereira C, Pereira AM, Fernandes C et al (2012) Superparamagnetic MFe2O4 (M = Fe Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a novel one-step coprecipitation route. Chem Mater 24:1496–150410.1021/cm300301c ↗
47. Cao S-W, Zhu Y-J, Chang J (2008) Fe3O4 polyhedral nanoparticles with a high magnetization synthesized in mixed solvent ethylene glycol–water system. New J Chem 32:1526–153010.1039/b719436f ↗
48. Akbarzadeh A, Mikaeili H, Zarghami N et al (2012) Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers. Int J Nanomed 7:511–526
49. Chen F-H, Zhang L-M, Chen Q-T et al (2010) Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell. Chem Commun (Camb) 46:8633–863510.1039/c0cc02577a ↗
50. Lima E, De Biasi E, Mansilla MV et al (2013) Heat generation in agglomerated ferrite nanoparticles in an alternating magnetic field. J Phys D Appl Phys 46:04500210.1088/0022-3727/46/4/045002 ↗
51. Chin SF, Iyer KS, Saunders M et al (2009) Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs. Chem Eur J 15:5661–566510.1002/chem.200802747 ↗
52. Jordan A, Scholz R, Wust P et al (1999) Magnetic fluid hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J Magn Magn Mater 201:413–41910.1016/S0304-8853(99)00088-8 ↗
53. Johannsen M, Gneveckow U, Thiesen B et al (2007) Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution. Eur Urol 52:1653–166110.1016/j.eururo.2006.11.023 ↗
54. Van Landeghem FKH, Maier-hauff K, Jordan A et al (2009) Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles. Biomaterials 30:52–5710.1016/j.biomaterials.2008.09.044 ↗
55. Maier-hauff K, Ulrich F, Nestler D et al (2011) Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol 103:317–32410.1007/s11060-010-0389-0 ↗
56. Liu XL, Fan HM, Yi JB et al (2012) Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents. J Mater Chem 22:8235–824410.1039/c2jm30472d ↗
57. De La Presa P, Luengo Y, Multigner M et al (2012) Study of heating efficiency as a function of concentration, size, and applied field in g-Fe2O3 nanoparticles. J Phys Chem C 116:25602–2561010.1021/jp310771p ↗
58. Serantes D, Simeonidis K, Angelakeris M et al (2014) Multiplying magnetic hyperthermia response by nanoparticle assembling. J Phys Chem C 118:5927–593410.1021/jp410717m ↗
59. Nemati Z, Alonso J, Rodrigo I et al (2018) Improving the heating efficiency of iron oxide nanoparticles by tuning their shape and size. J Phys Chem C 122:2367–238110.1021/acs.jpcc.7b10528 ↗
60. Piñeiro-Redondo Y, Bañobre-López M, Pardiñas-Blanco I et al (2011) The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles. Nanoscale Res Lett 6:38310.1186/1556-276X-6-383 ↗
61. Engineer C, Parikh J, Raval A (2011) Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system. Trends Biomater Artif Organs 25:79–85
62. Yang F, Zhang X, Song L et al (2015) Controlled drug release and hydrolysis mechanism of polymer-magnetic nanoparticle composite. ACS Appl Mater Interfaces 7:9410–941910.1021/acsami.5b02210 ↗
63. Margaritis A, Manocha B (2010) Controlled release of doxorubicin from doxorubicin/polyglutamic acid ionic complex. J Nanomater 2010:78017110.1155/2010/780171 ↗
64. Estrella V, Chen T, Lloyd M et al (2013) Acidity generated by the tumor microenvironment drives local invasion. Can Res 73:1524–153510.1158/0008-5472.CAN-12-2796 ↗
65. Javid A, Ahmadian S, Saboury A, Rezaei-zarchi S (2011) Anticancer effect of doxorubicin loaded heparin based super-paramagnetic iron oxide nanoparticles against the human ovarian cancer cells. Int J Biomed Biol Eng 5:141–145
66. Prabha G, Raj V (2017) Sodium alginate–polyvinyl alcohol–bovin serum albumin coated Fe3O4nanoparticles as anticancer drug delivery vehicle: doxorubicin loading and in vitro release study and cytotoxicity to HepG2 and L02 cells. Mater Sci Eng C 79:410–42210.1016/j.msec.2017.04.075 ↗
67. Ghanbari M, Asadi A (2016) Study of the cytotoxicity effect of doxorubicin-loaded/folic acid-targeted super paramagnetic iron oxide nanoparticles on AGS cancer cell line. J Nanomed Nanotechnol 7:36810.4172/2157-7439.1000368 ↗