Ion-linked double-network hydrogel with high toughness and stiffness
Source abstract
Abstract
In this paper, a facile one-pot method was developed to fabricate ion cross-linked calcium-alginate/poly(acrylamide) (PAAm) double-network hydrogels with excellent toughness and stiffness. In comparison to the sodium alginate/PAAm hybrid gel, the as-fabricated calcium-alginate/PAAm gel demonstrated superior mechanical properties. After soaking in calcium chloride (CaCl2) solution, the size of the as-synthesized hybrid gel can be well controlled without observable volumetric swelling through manipulating the equilibrium between shrinkable elastic energy from ionic (Ca2+) bonds and swelling osmotic energy. This material design and processing technology are promising to fabricate complicated-shaped cartilage with high geometric fidelity. After soaking in 8 wt% CaCl2 solution for 2 h, compressive strength of calcium-alginate/PAAm gel was significantly improved by 92 % compared to PAAm single network hydrogel, meanwhile the size and shape of calcium-alginate/PAAm gel were nearly changed and deformed, respectively.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Sensor and Energy Harvesting Materials · Osteoarthritis Treatment and Mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (53)
Show source-provided references
1. Arakaki K, Kitamura N, Fujiki H et al (2010) Artificial cartilage made from a novel double-network hydrogel: in vivo effects on the normal cartilage and ex vivo evaluation of the friction property. J Biomed Mater Res A 93:1160–116810.1002/jbm.a.32613 ↗
2. Ateshian GA (2007) Artificial cartilage: weaving in three dimensions. Nat Mater 6:89–9010.1038/nmat1830 ↗
3. Freed LE, Engelmayr GC, Borenstein JT, Moutos FT, Guilak F (2009) Advanced material strategies for tissue engineering scaffolds. Adv Mater 21:3410–341810.1002/adma.200900303 ↗
4. Fukuda A, Kato K, Hasegawa M et al (2005) Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor. Biomaterials 26:4301–430810.1016/j.biomaterials.2004.11.007 ↗
5. Steadman J, Rodkey W, Briggs K, Rodrigo J (1999) The microfracture technic in the management of complete cartilage defects in the knee joint. Der Orthop 28:26–32
6. Ochi M, Sumen Y, Jitsuiki J, Ikuta Y (1995) Allogeneic deep frozen meniscal graft for repair of osteochondral defects in the knee joint. Arch Orthop Trauma Surg 114:260–26610.1007/BF00452083 ↗
7. Shahgaldi B, Amis A, Heatley F, McDowell J, Bentley G (1991) Repair of cartilage lesions using biological implants. A comparative histological and biomechanical study in goats. J Bone Jt Surg Br 73:57–6410.1302/0301-620X.73B1.1991776 ↗
8. Sun J-Y, Zhao X, Illeperuma WR et al (2012) Highly stretchable and tough hydrogels. Nature 489:133–13610.1038/nature11409 ↗
9. Chen Q, Zhu L, Zhao C, Wang Q, Zheng J (2013) A robust, one-pot synthesis of highly mechanical and recoverable double network hydrogels using thermoreversible sol-gel polysaccharide. Adv Mater 25:4171–417610.1002/adma.201300817 ↗
10. Wang J, Qiu J, Wang S (2013) 3D Core-shell simulation of hydrogel swelling behavior for controlled drug delivery. In: ASME 2013 International Mechanical Engineering Congress and Exposition. doi: 10.1115/IMECE2013-6507010.1115/IMECE2013-65070 ↗
11. Meid J, Dierkes F, Cui J et al (2012) Mechanical properties of temperature sensitive microgel/polyacrylamide composite hydrogels—from soft to hard fillers. Soft Matter 8:4254–426310.1039/c2sm06868k ↗
12. Charati MB, Lee I, Hribar KC, Burdick JA (2010) Light-sensitive polypeptide hydrogel and nanorod composites. Small 6:1608–161110.1002/smll.201000162 ↗
13. Bai H, Li C, Wang X, Shi G (2010) A pH-sensitive graphene oxide composite hydrogel. Chem Commun 46:2376–237810.1039/c000051e ↗
14. Garg T, Singh S, Goyal AK (2013) Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug 30:369–40910.1615/CritRevTherDrugCarrierSyst.2013007259 ↗
15. Altunbas A, Lee SJ, Rajasekaran SA, Schneider JP, Pochan DJ (2011) Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. Biomaterials 32:5906–591410.1016/j.biomaterials.2011.04.069 ↗
16. Bao Y, Ma J, Li N (2011) Synthesis and swelling behaviors of sodium carboxymethyl cellulose-g-poly (AA-co-AM-co-AMPS)/MMT superabsorbent hydrogel. Carbohydr Polym 84:76–8210.1016/j.carbpol.2010.10.061 ↗
17. Huey DJ, Hu JC, Athanasiou KA (2012) Unlike bone, cartilage regeneration remains elusive. Science 338:917–92110.1126/science.1222454 ↗
18. Chen T, Buckley M, Cohen I, Bonassar L, Awad HA (2012) Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels. Biomech Model Mechanobiol 11:689–70210.1007/s10237-011-0343-x ↗
19. Lee H, Xia CG, Fang NX (2010) First jump of microgel; actuation speed enhancement by elastic instability. Soft Matter 6:4342–434510.1039/c0sm00092b ↗
20. Keplinger C, Sun JY, Foo CC, Rothemund P, Whitesides GM, Suo ZG (2013) Stretchable, transparent, ionic conductors. Science 341:984–98710.1126/science.1240228 ↗
21. Shepherd RF, Ilievski F, Choi W et al (2011) Multigait soft robot. Proc Natl Acad Sci USA 108:20400–2040310.1073/pnas.1116564108 ↗
22. Kobayashi M, Oka M (2004) Composite device for attachment of polyvinyl alcohol-hydrogel to underlying bone. Artif Organs 28:734–73810.1111/j.1525-1594.2004.00079.x ↗
23. Kobayashi M, Oka M (2004) Characterization of a polyvinyl alcohol-hydrogel artificial articular cartilage prepared by injection molding. J Biomater Sci Polym Ed 15:741–75110.1163/156856204774196135 ↗
24. Fan J, Shi Z, Lian M, Li H, Yin J (2013) Mechanically strong graphene oxide/sodium alginate/polyacrylamide nanocomposite hydrogel with improved dye adsorption capacity. J Mater Chem A 1:7433–744310.1039/c3ta10639j ↗
25. Servant A, Methven L, Williams RP, Kostarelos K (2013) Electroresponsive polymer–carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo. Adv Healthc Mater 2:806–81110.1002/adhm.201200193 ↗
26. Shin SR, Jung SM, Zalabany M et al (2013) Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators. ACS Nano 7:2369–238010.1021/nn305559j ↗
27. Yi J-Z, Zhang L-M (2008) Removal of methylene blue dye from aqueous solution by adsorption onto sodium humate/polyacrylamide/clay hybrid hydrogels. Bioresour Technol 99:2182–218610.1016/j.biortech.2007.05.028 ↗
28. Cong HP, Wang P, Yu SH (2014) Highly elastic and superstretchable graphene oxide/polyacrylamide hydrogels. Small 10:448–45310.1002/smll.201301591 ↗
29. Yu S, Li N, Higgins D et al (2014) Self-assembled reduced graphene oxide/polyacrylamide conductive composite films. ACS Appl Mater 6:19783–1979010.1021/am504941p ↗
30. Song W, Wang X, Wang Q, Shao D, Wang X (2015) Plasma-induced grafting of polyacrylamide on graphene oxide nanosheets for simultaneous removal of radionuclides. Phys Chem Chem Phys 17:398–40610.1039/C4CP04289A ↗
31. Wang Q, Cai J, Zhang L et al (2013) A bioplastic with high strength constructed from a cellulose hydrogel by changing the aggregated structure. J Mater Chem A 1:6678–668610.1039/c3ta11130j ↗
32. Wang JL, Wei JH, Su SH, Qiu JJ (2015) Novel fluorescence resonance energy transfer optical sensors for vitamin B-12 detection using thermally reduced carbon dots. New J Chem 39:501–50710.1039/C4NJ00538D ↗
33. Wang J, Zhou Z, Huang X et al (2013) Effect of alcohol pretreatment in conjunction with atmospheric pressure plasmas on hydrophobizing ramie fiber surfaces. J Adhes Sci Technol 27:1278–128810.1080/01694243.2012.738323 ↗
34. Zhou Z, Liu XC, Hu BT et al (2011) Hydrophobic surface modification of ramie fibers with ethanol pretreatment and atmospheric pressure plasma treatment. Surf Coat Technol 205:4205–421010.1016/j.surfcoat.2011.03.022 ↗
35. Wang J, Su S, Wei J et al (2015) Ratio-metric sensor to detect riboflavin via fluorescence resonance energy transfer with ultrahigh sensitivity. Phys E 72:17–2410.1016/j.physe.2015.04.006 ↗
36. Wang J, Qiu J (2015) Luminescent graphene quantum dots: as emerging fluorescent materials for biological application. Sci Adv Mater. doi: 10.1166/sam.2014.203510.1166/sam.2014.2035 ↗
37. Murayama H, Imran AB, Nagano S et al (2008) Chromic slide-ring gel based on reflection from photonic bandgap. Macromolecules 41:1808–181410.1021/ma0715627 ↗
38. Bin Imran A, Esaki K, Gotoh H et al (2014) Extremely stretchable thermosensitive hydrogels by introducing slide-ring polyrotaxane cross-linkers and ionic groups into the polymer network. Nat Commun 5:5124–513210.1038/ncomms6124 ↗
39. Matsunaga T, Sakai T, Akagi Y, U-i C, Shibayama M (2009) Structure characterization of tetra-PEG gel by small-angle neutron scattering. Macromolecules 42:1344–135110.1021/ma802280n ↗
40. Kamata H, Akagi Y, Kayasuga-Kariya Y, Chung U, Sakai T (2014) “Nonswellable” hydrogel without mechanical hysteresis. Science 343:873–87510.1126/science.1247811 ↗
41. Stile RA, Healy KE (2001) Thermo-responsive peptide-modified hydrogels for tissue regeneration. Biomacromolecules 2:185–19410.1021/bm0000945 ↗
42. Appel EA, Tibbitt MW, Webber MJ, Mattix BA, Veiseh O, Langer R (2015) Self-assembled hydrogels utilizing polymer-nanoparticle interactions. Nat Commun 6:6295. doi: 10.1038/ncomms729510.1038/ncomms7295 ↗
43. Zhai D, Zhang H (2013) Investigation on the application of the TDGL equation in macromolecular microsphere composite hydrogel. Soft Matter 9:820–82510.1039/C2SM26997J ↗
44. Zhao J, Jiao K, Yang J, He C, Wang H (2013) Mechanically strong and thermosensitive macromolecular microsphere composite poly (N-isopropylacrylamide) hydrogels. Polymer 54:1596–160210.1016/j.polymer.2013.01.025 ↗
45. Jiang FZ, Huang T, He CC, Brown HR, Wang HL (2013) Interactions affecting the mechanical properties of macromolecular microsphere composite hydrogels. J Phys Chem B 117:13679–1368710.1021/jp4069587 ↗
46. Yang CH, Wang MX, Haider H et al (2013) Strengthening alginate/polyacrylamide hydrogels using various multivalent cations. ACS Appl Mater 5:10418–1042210.1021/am403966x ↗
47. Darnell MC, Sun JY, Mehta M et al (2013) Performance and biocompatibility of extremely tough alginate/polyacrylamide hydrogels. Biomaterials 34:8042–804810.1016/j.biomaterials.2013.06.061 ↗
48. Naficy S, Razal JM, Whitten PG, Wallace GG, Spinks GM (2012) A pH-sensitive, strong double-network hydrogel: poly (ethylene glycol) methyl ether methacrylates–poly (acrylic acid). J Polym Sci Polym Phys 50:423–43010.1002/polb.23016 ↗
49. Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K (2014) Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells. BMC Musculoskelet Disord 15:222–22810.1186/1471-2474-15-222 ↗
50. Jang SS, Goddard WA, Kalani MYS (2007) Mechanical and transport properties of the poly (ethylene oxide)-poly (acrylic acid) double network hydrogel from molecular dynamic simulations. J Phys Chem B 111:1729–173710.1021/jp0656330 ↗
51. Yasuda K, Ping Gong J, Katsuyama Y et al (2005) Biomechanical properties of high-toughness double network hydrogels. Biomaterials 26:4468–447510.1016/j.biomaterials.2004.11.021 ↗
52. Li ZS, Ramay HR, Hauch KD, Xiao DM, Zhang MQ (2005) Chitosan–alginate hybrid scaffolds for bone tissue engineering. Biomaterials 26:3919–392810.1016/j.biomaterials.2004.09.062 ↗
53. Li JY, Illeperuma WBK, Suo ZG, Vlassak JJ (2014) Hybrid hydrogels with extremely high stiffness and toughness. ACS Macro Lett 3:520–52310.1021/mz5002355 ↗