DataVXJournal of Materials SciencePaper
journal article·2024-08

A review of recent advances in drug loading, mathematical modeling and applications of hydrogel drug delivery systems

Xiaohan Hu, Chenyun Zhang, Yingshuo Xiong, Songmei Ma, Changmei Sun, Wenlong Xu

Journal of Materials Science· Volume 59· Issue 32
Publisher page
Bibliographic record

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

Polymers

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Drug Delivery Systems · Advancements in Transdermal Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. Mathur S, Hoskins C (2017) Drug development: Lessons from nature. Biomed Rep 6:612–614. https://doi.org/10.3892/br.2017.90910.3892/br.2017.909 ↗
2. Ma X, Qu K, Zhao X, Wang Y, Zhang X, Zhang X et al (2023) Oxidized sodium alginate/polyacrylamide hydrogels adhesive for promoting wheat growth. Int J Biol Macromol 253:127450. https://doi.org/10.1016/j.ijbiomac.2023.12745010.1016/j.ijbiomac.2023.127450 ↗
3. Pushpamalar J, Meganathan P, Tan HL, Dahlan NA, Ooi L-T, Neerooa BNHM et al (2021) Development of a polysaccharide-based hydrogel drug delivery system (DDS): an update. Gels 7:153. https://doi.org/10.3390/gels704015310.3390/gels7040153 ↗
4. Sun Z, Song C, Wang C, Hu Y, Wu J (2020) Hydrogel-based controlled drug delivery for cancer treatment: a review. Mol Pharm 17:373–391. https://doi.org/10.1021/acs.molpharmaceut.9b0102010.1021/acs.molpharmaceut.9b01020 ↗
5. Tang Y, Wang H, Liu S, Pu L, Hu X, Ding J et al (2022) A review of protein hydrogels: Protein assembly mechanisms, properties, and biological applications. Colloids Surf B 220:112973. https://doi.org/10.1016/j.colsurfb.2022.11297310.1016/j.colsurfb.2022.112973 ↗
6. Sun Z, Xie X, Xu W, Chen K, Liu Y, Chu X et al (2021) Chameleon-inspired energy-saving smart window responding to natural weather. ACS Sustain Chem Eng 9:12949–12959. https://doi.org/10.1021/acssuschemeng.1c0441310.1021/acssuschemeng.1c04413 ↗
7. Pu L, Yuan Z, Cai Y, Li X, Xue Z, Niu Y et al (2024) Multiperformance PAM/PVA/CaCO(3) hydrogel for flexible sensing and information encryption. ACS Appl Mater Interfaces 16:32762–32772. https://doi.org/10.1021/acsami.4c0628210.1021/acsami.4c06282 ↗
8. Jiang X, Zhou X, Ding K, Li X, Huang B, Xu W (2024) Anti-swelling gel wearable sensor based on solvent exchange strategy for underwater communication. Adv Func Mater. https://doi.org/10.1002/adfm.20240093610.1002/adfm.202400936 ↗
9. Hameed H, Faheem S, Paiva-Santos AC, Sarwar HS, Jamshaid M (2024) A comprehensive review of hydrogel-based drug delivery systems: classification properties, recent trends, and applications. AAPS PharmSciTech 25:64. https://doi.org/10.1208/s12249-024-02786-x10.1208/s12249-024-02786-x ↗
10. Dreiss CA (2020) Hydrogel design strategies for drug delivery. Curr Opin Colloid Interface Sci 48:1–17. https://doi.org/10.1016/j.cocis.2020.02.00110.1016/j.cocis.2020.02.001 ↗
11. Pu L, Wang H, Zhao Y, Yuan Z, Zhang Y, Ding J et al (2023) Skin-like hydrogels: design strategy and mechanism, properties, and sensing applications. J Mater Chem C 11:8358–8377. https://doi.org/10.1039/d3tc00949a10.1039/d3tc00949a ↗
12. Basso J, Miranda A, Nunes S, Cova T, Sousa J, Vitorino C et al (2018) Hydrogel-based drug delivery nanosystems for the treatment of brain tumors. Gels 4:62. https://doi.org/10.3390/gels403006210.3390/gels4030062 ↗
13. Wu C, Li R, Yin Y, Wang J, Zhang L, Zhong W (2017) Redox-responsive supramolecular hydrogel based on 10-hydroxy camptothecin-peptide covalent conjugates with high loading capacity for drug delivery. Mater Sci Eng C 76:196–202. https://doi.org/10.1016/j.msec.2017.03.10310.1016/j.msec.2017.03.103 ↗
14. Kim H-S, Yang J, Kim K, Shin US (2019) Biodegradable and injectable hydrogels as an immunosuppressive drug delivery system. Mater Sci Eng C 98:472–481. https://doi.org/10.1016/j.msec.2018.11.05110.1016/j.msec.2018.11.051 ↗
15. Zhang X, Tang Y, Wang P, Wang Y, Wu T, Li T et al (2022) A review of recent advances in metal ion hydrogels: Mechanism, properties and their biological applications. New J Chem 46:13838–13855. https://doi.org/10.1039/d2nj02843c10.1039/d2nj02843c ↗
16. Liu J, Qi C, Tao K, Zhang J, Zhang J, Xu L et al (2016) Sericin/Dextran injectable hydrogel as an optically trackable drug delivery system for malignant melanoma treatment. ACS Appl Mater Interfaces 8:6411–6422. https://doi.org/10.1021/acsami.6b0095910.1021/acsami.6b00959 ↗
17. Wang W, Shi D, Zhang Y, Li W, Li F, Feng H et al (2023) An injectable hydrogel based on hyaluronic acid prepared by Schiff base for long-term controlled drug release. Int J Biol Macromol 245:125341. https://doi.org/10.1016/j.ijbiomac.2023.12534110.1016/j.ijbiomac.2023.125341 ↗
18. Liang Y, Zhao X, Ma PX, Guo B, Du Y, Han X (2019) pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery. J Colloid Interface Sci 536:224–234. https://doi.org/10.1016/j.jcis.2018.10.05610.1016/j.jcis.2018.10.056 ↗
19. Tang Y, Ding J, Zhou X, Ma X, Zhao Y, Mu Q et al (2023) Injectable hydrogels of enzyme-catalyzed cross-linked tyramine-modified gelatin for drug delivery. Aust J Chem 76:88–99. https://doi.org/10.1071/ch2218810.1071/ch22188 ↗
20. Dai G, Sun L, Xu J, Zhao G, Tan Z, Wang C et al (2021) Catechol–metal coordination-mediated nanocomposite hydrogels for on-demand drug delivery and efficacious combination therapy. Acta Biomater 129:84–95. https://doi.org/10.1016/j.actbio.2021.05.00610.1016/j.actbio.2021.05.006 ↗
21. Aycan D, Karaca F, Koca A, Alemdar N (2023) Electro-stimulated drug release by methacrylated hyaluronic acid-based conductive hydrogel with enhanced mechanical properties. Int J Biol Macromol 231:123297. https://doi.org/10.1016/j.ijbiomac.2023.12329710.1016/j.ijbiomac.2023.123297 ↗
22. Qu J, Liang Y, Shi M, Guo B, Gao Y, Yin Z (2019) Biocompatible conductive hydrogels based on dextran and aniline trimer as electro-responsive drug delivery system for localized drug release. Int J Biol Macromol 140:255–264. https://doi.org/10.1016/j.ijbiomac.2019.08.12010.1016/j.ijbiomac.2019.08.120 ↗
23. Kong L, Zhao X, Liu S, Wang X, Gu X, Ding J et al (2023) Advances in preparation, design strategy and application of electroactive hydrogels. J Power Sources 581:233485. https://doi.org/10.1016/j.jpowsour.2023.23348510.1016/j.jpowsour.2023.233485 ↗
24. Drews J, Ryser S (1997) Drug development: The role of innovation in drug development. Nat Biotechnol 15:1318–1319. https://doi.org/10.1038/nbt1297-131810.1038/nbt1297-1318 ↗
25. MacDermot H (1927) Four housand years of pharmacy. Can Med Assoc J 17:1103
26. Sinha S, Vohora D (2018) Drug discovery and development. Pharm Med Transl Clin Res. https://doi.org/10.1016/b978-0-12-802103-3.00002-x10.1016/b978-0-12-802103-3.00002-x ↗
27. Colombo M, Peretto I (2008) Chemistry strategies in early drug discovery: an overview of recent trends. Drug Discov Today 13:677–684. https://doi.org/10.1016/j.drudis.2008.03.00710.1016/j.drudis.2008.03.007 ↗
28. Park BK, Boobis A, Clarke S, Goldring CEP, Jones D, Kenna JG et al (2011) Managing the challenge of chemically reactive metabolites in drug development. Nat Rev Drug Discov 10:292–306. https://doi.org/10.1038/nrd340810.1038/nrd3408 ↗
29. Qiu Y, Park K (2001) Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 53:321–339. https://doi.org/10.1016/S0169-409X(01)00203-410.1016/S0169-409X(01)00203-4 ↗
30. Jones AW (2011) Early drug discovery and the rise of pharmaceutical chemistry. Drug Test Anal 3:337–344. https://doi.org/10.1002/dta.30110.1002/dta.301 ↗
31. MacCoss M, Baillie TA (2004) Organic chemistry in drug discovery. Science 303:1810–1813. https://doi.org/10.1126/science.109680010.1126/science.1096800 ↗
32. Strebhardt K, Ullrich A (2008) Paul Ehrlich’s magic bullet concept: 100 years of progress. Nat Rev Cancer 8:473–480. https://doi.org/10.1038/nrc239410.1038/nrc2394 ↗
33. Lesko LJ, Schmidt S (2012) Individualization of drug therapy: History, present state, and opportunities for the future. Clin Pharmacol Ther 92:458–466. https://doi.org/10.1038/clpt.2012.11310.1038/clpt.2012.113 ↗
34. Wright PM, Seiple IB, Myers AG (2014) The evolving role of chemical synthesis in antibacterial drug discovery. Angew Chem Int Ed Engl 53:8840–8869. https://doi.org/10.1002/anie.20131084310.1002/anie.201310843 ↗
35. Bruni J, Wilder BJ (1979) Valproic acid: review of a new antiepileptic drug. Arch Neurol 36:393–398. https://doi.org/10.1001/archneur.1979.0050043002300210.1001/archneur.1979.00500430023002 ↗
36. Taher MA, Nyeem MAB, Billah MM, Ahammed MM (2017) Vinca alkaloid-the second most used alkaloid for cancer treatment-A review, Inter. J. Physiol. Nutr. Phys Educ 2:723–727
37. Kwan P, Brodie MJ (2004) Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia 45:1141–1149. https://doi.org/10.1111/j.0013-9580.2004.12704.x10.1111/j.0013-9580.2004.12704.x ↗
38. Huan Y, Kong Q, Tang Q, Wang Y, Mou H, Ying R et al (2022) Antimicrobial peptides/ciprofloxacin-loaded O-carboxymethyl chitosan/self-assembling peptides hydrogel dressing with sustained-release effect for enhanced anti-bacterial infection and wound healing. Carbohydr Polym 280:119033. https://doi.org/10.1016/j.carbpol.2021.11903310.1016/j.carbpol.2021.119033 ↗
39. Thomas E, Ghany MG, Liang TJ (2012) The application and mechanism of action of ribavirin in therapy of hepatitis C. Antivir Chem Chemother 23:1–12. https://doi.org/10.3851/IMP212510.3851/IMP2125 ↗
40. Zanten SJOVV, Jones MJ, Verlinden M, Talley NJ (2001) Efficacy of cisapride and domperidone in functional (nonulcer) dyspepsia: a meta-analysis. Am J Gastroenterol 96:689–696. https://doi.org/10.1111/j.1572-0241.2001.03521.x10.1111/j.1572-0241.2001.03521.x ↗
41. Tsoucalas G, Karamanou M, Androutsos G (2011) Travelling through time with aspirin, a healing companion. Eur J Inflamm 9:13–16. https://doi.org/10.1177/1721727X110090010210.1177/1721727X1100900102 ↗
42. Nieto C, Vega MA, Rodríguez V, Pérez-Esteban P, Martín del Valle EM (2022) Biodegradable gellan gum hydrogels loaded with paclitaxel for HER2+ breast cancer local therapy. Carbohydr Polym 294:119732. https://doi.org/10.1016/j.carbpol.2022.11973210.1016/j.carbpol.2022.119732 ↗
43. Singh B, Sharma V (2017) Crosslinking of poly(vinylpyrrolidone)/acrylic acid with tragacanth gum for hydrogels formation for use in drug delivery applications. Carbohydr Polym 157:185–195. https://doi.org/10.1016/j.carbpol.2016.09.08610.1016/j.carbpol.2016.09.086 ↗
44. Zelikin AN, Ehrhardt C, Healy AM (2016) Materials and methods for delivery of biological drugs. Nat Chem 8:997–1007. https://doi.org/10.1038/nchem.262910.1038/nchem.2629 ↗
45. Dranitsaris G, Amir E, Dorward K (2011) Biosimilars of biological drug therapies. Drugs 71:1527–1536. https://doi.org/10.2165/11593730-000000000-0000010.2165/11593730-000000000-00000 ↗
46. Mohs RC, Greig NH (2017) Drug discovery and development: Role of basic biological research. TRCI 3:651–657. https://doi.org/10.1016/j.trci.2017.10.00510.1016/j.trci.2017.10.005 ↗
47. Badano JL, Katsanis N (2002) Beyond mendel: An evolving view of human genetic disease transmission. Nat Rev Genet 3:779–789. https://doi.org/10.1038/nrg91010.1038/nrg910 ↗
48. Onrust SV, Lamb HM, Balfour JAB (1999) Rituximab. Drugs 58:79–8810.2165/00003495-199958010-00009 ↗
49. Sun L (2013) Peptide-based drug development. Mod Chem Appl 1:1–2. https://doi.org/10.4172/mca.1000e10310.4172/mca.1000e103 ↗
50. Roskoski R Jr (2021) Properties of FDA-approved small molecule protein kinase inhibitors: a 2021 update. Pharmacol Res 165:105463. https://doi.org/10.1016/j.phrs.2021.10546310.1016/j.phrs.2021.105463 ↗
51. Holmes MV, Richardson TG, Ference BA, Davies NM, Davey Smith G (2021) Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development. Nat Rev Cardiol 18:435–453. https://doi.org/10.1038/s41569-020-00493-110.1038/s41569-020-00493-1 ↗
52. Rabbani G, Ahn SN (2021) Review: roles of human serum albumin in prediction, diagnoses and treatment of COVID-19. Int J Biol Macromol 193:948–955. https://doi.org/10.1016/j.ijbiomac.2021.10.09510.1016/j.ijbiomac.2021.10.095 ↗
53. Liu X, Zhang Q, Zhang L, Zhou P, Yang J, Fang Y et al (2019) A newly isolated Chinese virulent genotype GIIb porcine epidemic diarrhea virus strain: Biological characteristics, pathogenicity and immune protective effects as an inactivated vaccine candidate. Virus Res 259:18–27. https://doi.org/10.1016/j.virusres.2018.10.01210.1016/j.virusres.2018.10.012 ↗
54. Green JL, Dos Santos WF, Fontana ACK (2021) Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development. Biochem Pharmacol 193:114786. https://doi.org/10.1016/j.bcp.2021.11478610.1016/j.bcp.2021.114786 ↗
55. Sims EK, Carr ALJ, Oram RA, DiMeglio LA, Evans-Molina C (2021) 100 years of insulin: celebrating the past, present and future of diabetes therapy. Nat Med 27:1154–1164. https://doi.org/10.1038/s41591-021-01418-210.1038/s41591-021-01418-2 ↗
56. Li Y, Xu G, Zhou B, Tang Y, Liu X, Wu Y et al (2022) Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: Physiopathology and therapeutic targets. Eur Arch Oto-Rhino-L 279:2743–2752. https://doi.org/10.1007/s00405-021-07201-w10.1007/s00405-021-07201-w ↗
57. Lv D, Liu L, Chen K, Jiang H, Shi X, Wang J (2022) Effectiveness of coenzyme Q10 nanoliposomes in the treatment of heart failure. Appl Nanosci. https://doi.org/10.1007/s13204-022-02467-w10.1007/s13204-022-02467-w ↗
58. Gadekar V, Borade Y, Kannaujia S, Rajpoot K, Anup N, Tambe V et al (2021) Nanomedicines accessible in the market for clinical interventions. J Control Release 330:372–397. https://doi.org/10.1016/j.jconrel.2020.12.03410.1016/j.jconrel.2020.12.034 ↗
59. Shan X, Gong X, Li J, Wen J, Li Y, Zhang Z (2022) Current approaches of nanomedicines in the market and various stage of clinical translation. Acta Pharm Sin B 12:3028–3048. https://doi.org/10.1016/j.apsb.2022.02.02510.1016/j.apsb.2022.02.025 ↗
60. Williams RM, Jaimes EA, Heller DA (2016) Nanomedicines for kidney diseases. Kidney Int 90:740–745. https://doi.org/10.1016/j.kint.2016.03.04110.1016/j.kint.2016.03.041 ↗
61. Liu Q, Zou J, Chen Z, He W, Wu W (2023) Current research trends of nanomedicines. Acta Pharm Sin B 13:4391–4416. https://doi.org/10.1016/j.apsb.2023.05.01810.1016/j.apsb.2023.05.018 ↗
62. Pei Z, Chen S, Ding L, Liu J, Cui X, Li F et al (2022) Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis. J Control Release 352:211–241. https://doi.org/10.1016/j.jconrel.2022.10.02310.1016/j.jconrel.2022.10.023 ↗
63. Mao L, Wang H, Tan M, Ou L, Kong D, Yang Z (2012) Conjugation of two complementary anti-cancer drugs confers molecular hydrogels as a co-delivery system. Chem Commun 48:395–397. https://doi.org/10.1039/c1cc16250k10.1039/c1cc16250k ↗
64. Li Z, Cui C, Zhang Z, Meng X, Yan Q, Ouyang J et al (2019) The investigation of a multi-functional peptide as gelator, dyes separation agent and metal ions adsorbent. ChemistrySelect 4:7838–7843. https://doi.org/10.1002/slct.20190167110.1002/slct.201901671 ↗
65. Wu Y, Xia T, Ma X, Lei L, Du L, Xu X et al (2023) Autocatalytic strategy for tuning drug release from peptide-drug supramolecular hydrogel. Chin Chem Lett 34:108209. https://doi.org/10.1016/j.cclet.2023.10820910.1016/j.cclet.2023.108209 ↗
66. Wang J, He H, Cooper RC, Gui Q, Yang H (2019) Drug-conjugated dendrimer hydrogel enables sustained drug release via a self-cleaving mechanism. Mol Pharm 16:1874–1880. https://doi.org/10.1021/acs.molpharmaceut.8b0120710.1021/acs.molpharmaceut.8b01207 ↗
67. Ha W, Yu J, Song X-Y, Zhang Z-J, Liu Y-Q, Shi Y-P (2013) Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery. J Mater Chem B 1:5532–5538. https://doi.org/10.1039/c3tb20956c10.1039/c3tb20956c ↗
68. Cho YI, Park S, Jeong SY, Yoo HS (2009) In vivo and in vitro anti-cancer activity of thermo-sensitive and photo-crosslinkable doxorubicin hydrogels composed of chitosan–doxorubicin conjugates. Eur J Pharm Biopharm 73:59–65. https://doi.org/10.1016/j.ejpb.2009.04.01010.1016/j.ejpb.2009.04.010 ↗
69. Capanema NSV, Mansur AAP, Carvalho SM, Carvalho IC, Chagas P, de Oliveira LCA et al (2018) Bioengineered carboxymethyl cellulose-doxorubicin prodrug hydrogels for topical chemotherapy of melanoma skin cancer. Carbohydr Polym 195:401–412. https://doi.org/10.1016/j.carbpol.2018.04.10510.1016/j.carbpol.2018.04.105 ↗
70. Mahkam M, Doostie L, Siadat SOR (2006) Synthesis and characterization of acrylic type hydrogels containing azo derivatives of 5-amino salicylic acid for colon-specific drug delivery. Inflammopharmacology 14:72–75. https://doi.org/10.1007/s10787-006-1428-510.1007/s10787-006-1428-5 ↗
71. Mahkam M (2010) Novel pH-sensitive hydrogels for colon-specific drug delivery. Drug Deliv 17:158–163. https://doi.org/10.3109/1071754100360490810.3109/10717541003604908 ↗
72. Li X, Li J, Gao Y, Kuang Y, Shi J, Xu B (2010) Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent. J Am Chem Soc 132(50):17707–17709. https://doi.org/10.1021/ja109269v10.1021/ja109269v ↗
73. Xiong Y, Wang L, Xu W, Li L, Tang Y, Shi C et al (2022) Electrostatic induced peptide hydrogel containing PHMB for sustained antibacterial activity. J Drug Deliv Sci Technol 75:103717. https://doi.org/10.1016/j.jddst.2022.10371710.1016/j.jddst.2022.103717 ↗
74. Ding H, Li B, Jiang Y, Liu G, Pu S, Feng Y et al (2021) pH-responsive UV crosslinkable chitosan hydrogel via “thiol-ene” click chemistry for active modulating opposite drug release behaviors. Carbohydr Polym 251:117101. https://doi.org/10.1016/j.carbpol.2020.11710110.1016/j.carbpol.2020.117101 ↗
75. Zhou C, Wu T, Xie X, Song G, Ma X, Mu Q et al (2022) Advances and challenges in conductive hydrogels: from properties to applications. Eur Polym J 177:111454. https://doi.org/10.1016/j.eurpolymj.2022.11145410.1016/j.eurpolymj.2022.111454 ↗
76. Liu Y, Fan Q, Huo Y, Liu C, Li B, Li Y (2020) Construction of a mesoporous polydopamine@GO/cellulose nanofibril composite hydrogel with an encapsulation structure for controllable drug release and toxicity shielding. ACS Appl Mater Interfaces 12:57410–57420. https://doi.org/10.1021/acsami.0c1546510.1021/acsami.0c15465 ↗
77. Wang X, Wang C, Wang X, Wang Y, Zhang Q, Cheng Y (2017) A polydopamine nanoparticle-knotted poly(ethylene glycol) hydrogel for on-demand drug delivery and chemo-photothermal therapy. Chem Mater 29:1370–1376. https://doi.org/10.1021/acs.chemmater.6b0519210.1021/acs.chemmater.6b05192 ↗
78. Li X, Liu H, Yu A, Lin D, Bao Z, Wang Y et al (2021) Bioinspired self-assembly supramolecular hydrogel for ocular drug delivery. Chin Chem Lett 32:3936–3939. https://doi.org/10.1016/j.cclet.2021.03.03710.1016/j.cclet.2021.03.037 ↗
79. Zhang W, Jin X, Li H, Zhang R-R, Wu C-W (2018) Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release. Carbohydr Polym 186:82–90. https://doi.org/10.1016/j.carbpol.2018.01.00810.1016/j.carbpol.2018.01.008 ↗
80. Lai TC, Yu J, Tsai WB (2016) Gelatin methacrylate/carboxybetaine methacrylate hydrogels with tunable crosslinking for controlled drug release. J Mater Chem B 4:2304–2313. https://doi.org/10.1039/c5tb02518d10.1039/c5tb02518d ↗
81. Figueroa-Pizano MD, Vélaz I, Peñas FJ, Zavala-Rivera P, Rosas-Durazo AJ, Maldonado-Arce AD et al (2018) Effect of freeze-thawing conditions for preparation of chitosan-poly (vinyl alcohol) hydrogels and drug release studies. Carbohydr Polym 195:476–485. https://doi.org/10.1016/j.carbpol.2018.05.00410.1016/j.carbpol.2018.05.004 ↗
82. Song F, Gong J, Tao Y, Cheng Y, Lu J, Wang H (2021) A robust regenerated cellulose-based dual stimuli-responsive hydrogel as an intelligent switch for controlled drug delivery. Int J Biol Macromol 176:448–458. https://doi.org/10.1016/j.ijbiomac.2021.02.10410.1016/j.ijbiomac.2021.02.104 ↗
83. Park D, Kim JW, Shin K, Kim JW (2021) Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release. Carbohydr Polym 272:118459. https://doi.org/10.1016/j.carbpol.2021.11845910.1016/j.carbpol.2021.118459 ↗
84. Li Z, Meng X, Xu W, Zhang S, Ouyang J, Zhang Z et al (2020) Single network double cross-linker (SNDCL) hydrogels with excellent stretchability, self-recovery, adhesion strength, and conductivity for human motion monitoring. Soft Matter 16:7323–7331. https://doi.org/10.1039/d0sm00375a10.1039/d0sm00375a ↗
85. Umesh S, Sarkar S, Bera P, Moitra S (2023) Bhattacharya, A self-healable and injectable hydrogel for pH-responsive doxorubicin drug delivery in vitro and in vivo for colon cancer treatment. Mater Today Chem 30:101554. https://doi.org/10.1016/j.mtchem.2023.10155410.1016/j.mtchem.2023.101554 ↗
86. Tang Y, Lu Y, Li L, Shi C, Zhang X, Li X et al (2022) Electrostatic induced peptide hydrogels for pH-controllable doxorubicin release and antitumor activity. ChemistrySelect 7:e202202284. https://doi.org/10.1002/slct.20220228410.1002/slct.202202284 ↗
87. Gao Y, Hao Y, Zhang W, Wei Y, Shu Y, Wang J (2022) Microwave-triggered ionic liquid-based hydrogel dressing with excellent hyperthermia and transdermal drug delivery performance. Chem Eng J 429:131590. https://doi.org/10.1016/j.cej.2021.13159010.1016/j.cej.2021.131590 ↗
88. Yuan Z, Ding J, Zhang Y, Huang B, Song Z, Meng X et al (2022) Components, mechanisms and applications of stimuli-responsive polymer gels. Eur Polym J 177:111473. https://doi.org/10.1016/j.eurpolymj.2022.11147310.1016/j.eurpolymj.2022.111473 ↗
89. Liechty WB, Kryscio DR, Slaughter BV, Peppas NA (2010) Polymers for drug delivery systems. Annu Rev Chem Biomol Eng 1:149–173. https://doi.org/10.1146/annurev-chembioeng-073009-10084710.1146/annurev-chembioeng-073009-100847 ↗
90. Hoare TR, Kohane DS (2008) Hydrogels in drug delivery: Progress and challenges. Polymer 49:1993–2007. https://doi.org/10.1016/j.polymer.2008.01.02710.1016/j.polymer.2008.01.027 ↗
91. Ashley GW, Henise J, Reid R, Santi DV (2013) Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci U S A 110:2318–2323. https://doi.org/10.1073/pnas.121549811010.1073/pnas.1215498110 ↗
92. Singh A, Sharma PK, Garg VK, Garg G (2010) Hydrogels: A Review. Int J Pharm Sci Rev Res 4:97–105
93. Lin CC, Metters AT (2006) Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliv Rev 58:1379–1408. https://doi.org/10.1016/j.addr.2006.09.00410.1016/j.addr.2006.09.004 ↗
94. Amsden B (1998) Solute diffusion within hydrogels. mechanisms and models. Macromolecules 31:8382–8395. https://doi.org/10.1021/ma980765f10.1021/ma980765f ↗
95. Zarzycki R, Modrzejewska Z, Nawrotek K (2010) Drug release from hydrogel matrices. Ecol Chem Eng S 17:117–136
96. Ganji F, Vasheghani-Farahani E (2009) Hydrogels in controlled drug delivery systems. IRAN POLYM J 18:63–88
97. Lowman AM, Peppas NA (1999) Solute transport analysis in pH-responsive, complexing hydrogels of poly(methacrylic acid-g-ethylene glycol). J Biomater Sci Polym Ed 10:999–1009. https://doi.org/10.1163/156856299x0058610.1163/156856299x00586 ↗
98. Siepmann J, Siepmann F (2008) Mathematical modeling of drug delivery. Int J Pharm 364:328–343. https://doi.org/10.1016/j.ijpharm.2008.09.00410.1016/j.ijpharm.2008.09.004 ↗
99. Arifin DY, Lee LY, Wang CH (2006) Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. Adv Drug Deliv Rev 58:1274–1325. https://doi.org/10.1016/j.addr.2006.09.00710.1016/j.addr.2006.09.007 ↗
100. Bajpai AK, Shukla SK, Bhanu S, Kankane S (2008) Responsive polymers in controlled drug delivery. Prog Polym Sci 33:1088–1118. https://doi.org/10.1016/j.progpolymsci.2008.07.00510.1016/j.progpolymsci.2008.07.005 ↗