A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties
Source abstract
Abstract
The insufficient of H2O2 restricts the efficacy of chemodynamic therapy in tumor microenvironment. Calcium peroxide (CaO2) is expected to solve this problem due to its H2O2-evolving ability. However, it prematurely decomposes in the moist air or water before reaching tumor site. In this study, zeolitic imidazolate framework-67 (ZIF-67) was in-situ grown on the surface of CaO2 to construct a pH-responsive CaO2@ZIF-67 system and then incorporated into poly-L-lactic acid (PLLA) to prepare PLLA/CaO2@ZIF-67 scaffold by selective laser sintering technology. On the one hand, ZIF-67 is used as a chemodynamic therapy agent due to the release of cobalt ions after degradation. On the other hand, ZIF-67 can serve as protective layers to prevent premature decomposition of CaO2 due to its hydrophobic properties, and then CaO2 is exposed and reacts with water to form H2O2 after the pH-responsive degradation of ZIF-67 under tumor acidic microenvironment. Results showed that the PLLA/CaO2@ZIF-67 scaffold could sustainedly produce H2O2 under acidic pH and achieve 84.64% antitumor ratio against MG-63 cells. In addition, the scaffold also promoted proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells due to the release of calcium ions. The prepared PLLA/CaO2@ZIF-67 scaffold with chemodynamic antitumor and osteogenic effects has great potential to treat tumorous bone defect.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Bone Tissue Engineering Materials · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (53)
Show source-provided references
1. Jia CY, Guo YX, Wu FG (2022) Chemodynamic therapy via fenton and fenton-like nanomaterials: strategies and recent advances. Small 18(6):2103868. https://doi.org/10.1002/smll.20210386810.1002/smll.202103868 ↗
2. Wang XW, Zhong XY, Liu Z, Cheng L (2022) Recent progress of chemodynamic therapy-induced combination cancer therapy. Nano Today 35:100946. https://doi.org/10.1016/j.nantod.2020.10094610.1016/j.nantod.2020.100946 ↗
3. Meng XY, Zhang XZ, Liu M, Cai B, He NY, Wang ZF (2020) Fenton reaction-based nanomedicine in cancer chemodynamic and synergistic therapy. Appl Mater Today 21:100864. https://doi.org/10.1016/j.apmt.2020.10086410.1016/j.apmt.2020.100864 ↗
4. Cao W, Jin MY, Yang K, Chen B, Xiong MM, Li X, Cao GD (2021) Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy. J Nanobiotechnol 19(1):1–35. https://doi.org/10.1016/j.apmt.2020.10086410.1016/j.apmt.2020.100864 ↗
5. Li SL, Jiang P, Jiang FL, Liu Y (2021) Recent advances in nanomaterial-based nanoplatforms for chemodynamic cancer therapy. Adv Funct Mater 31(22):2100243. https://doi.org/10.1002/adfm.20210024310.1002/adfm.202100243 ↗
6. Yang ML, Shuai Y, Yang YW, Zeng D, Peng SP, Tian ZJ, Shuai CJ (2022) In situ grown rare earth lanthanum on carbon nanofibre for interfacial reinforcement in Zn implants. VIRTUAL PHYS PROTOTY 17(3):700–717. https://doi.org/10.1080/17452759.2022.205392910.1080/17452759.2022.2053929 ↗
7. Shuai C, Yuan X, Shuai Y, Qian G, Yao J, Xu W, Peng S,Yang W (2022) Nitrogen-doped carbon-ZnO heterojunction derived from ZIF-8: a photocatalytic antibacterial strategy for scaffold. Mater Today Nano 18:100210. https://doi.org/10.1016/j.mtnano.2022.10021010.1016/j.mtnano.2022.100210 ↗
8. Yang YW, Zan J, Shuai Y et al (2022) in situ growth of a metal-organic framework on graphene oxide for the chemo-photothermal therapy of bacterial infection in bone repair. ACS Appl Mater Inter. https://doi.org/10.1021/acsami.2c0484110.1021/acsami.2c04841 ↗
9. Tang ZM, Liu YY, He MY, Bu WB (2019) Chemodynamic therapy: tumour microenvironment-mediated Fenton and Fenton-like reactions. Angew Chem Int Edit 58(4):946–956. https://doi.org/10.1002/anie.20180566410.1002/anie.201805664 ↗
10. Lin LS, Song JB, Song L et al (2018) Simultaneous Fenton-like ion delivery and glutathione depletion by MnO2-based nanoagent to enhance chemodynamic therapy. Angew Chem Int Edit 130(18):4996–5000. https://doi.org/10.1002/anie.20171202710.1002/anie.201712027 ↗
11. Zhang C, Bu W, Ni D et al (2016) Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction. Angew Chem Int Edit 128(6):2141–2146. https://doi.org/10.1002/anie.20151003110.1002/anie.201510031 ↗
12. Huo MF, Wang LY, Chen Y, Shi JL (2017) Tumor-selective catalytic nanomedicine by nanocatalyst delivery. Nat Commun 8(1):1–12. https://doi.org/10.1038/s41467-017-00424-810.1038/s41467-017-00424-8 ↗
13. Gao ST, Jin Y, Ge K et al (2019) Self-supply of O2 and H2O2 by a Nanocatalytic medicine to enhance combined chemo/Chemodynamic therapy. Adv Sci 6(24):1902137. https://doi.org/10.1002/advs.20190213710.1002/advs.201902137 ↗
14. Tang ZM, Liu YY, Ni DL et al (2020) Biodegradable nanoprodrugs:“delivering” ROS to cancer cells for molecular dynamic therapy. Adv Mater 32(4):1904011. https://doi.org/10.1002/adma.20190401110.1002/adma.201904011 ↗
15. Liu B, Bian YL, Liang S et al (2021) One-step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced chemodynamic/ion-interference therapy. ACS Nano 16(1):617–630. https://doi.org/10.1021/acsnano.1c0789310.1021/acsnano.1c07893 ↗
16. Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8(7):579–591. https://doi.org/10.1038/nrd280310.1038/nrd2803 ↗
17. He CC, Zhang XJ, Xiang GY (2020) Nanoparticle facilitated delivery of peroxides for effective cancer treatments. Biomater Sci UK 8(20):5574–5582. https://doi.org/10.1039/d0bm01265c10.1039/d0bm01265c ↗
18. Dong SM, Dong YS, Liu B et al (2022) Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Adv Mater 34(7):2107054. https://doi.org/10.1002/adma.20210705410.1002/adma.202107054 ↗
19. He CC, Zhang XJ, Chen C et al (2021) A solid lipid coated calcium peroxide nanocarrier enables combined cancer chemo/chemodynamic therapy with O2/H2O2 self-sufficiency. Acta Biomater 122:354–364. https://doi.org/10.1016/j.actbio.2020.12.03610.1016/j.actbio.2020.12.036 ↗
20. Liu CH, Cao Y, Cheng YR, Wang DD, Xu TL, Su L, Zhang XJ, Dong HF (2020) An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy. Nat Commun 11(1):1–9. https://doi.org/10.1038/s41467-020-15591-410.1038/s41467-020-15591-4 ↗
21. Chu SL, Shi XL, Tian Y, Gao FX (2022) pH-Responsive polymer nanomaterials for tumor therapy. Front Oncol 12. https://doi.org/10.3389/fonc.2022.85501910.3389/fonc.2022.855019 ↗
22. Deng F, Wu P, Qian GW, Shuai Y, Zhang LM, Peng SP, Shuai CJ, Wang GY (2022) Silver-decorated black phosphorus: a synergistic antibacterial strategy. Nanotechnology 33(24):245708. https://doi.org/10.1088/1361-6528/ac5aee10.1088/1361-6528/ac5aee ↗
23. Qi FW, Gao XW, Shuai Y, Peng SP, Deng YW, Yang S, Yang YW, Shuai CJ (2022). Magnetic-driven wireless electrical stimulation in a scaffold. Compos Part B Eng 237:109864. https://doi.org/10.1016/j.compositesb.2022.10986410.1016/j.compositesb.2022.109864 ↗
24. Qian JF, Sun FA, Qin LZ (2012) Hydrothermal synthesis of zeolitic imidazolate framework-67 (ZIF-67) nanocrystals. MATER LETT 82:220–223. https://doi.org/10.1016/j.matlet.2012.05.07710.1016/j.matlet.2012.05.077 ↗
25. Zhong GH, Liu DX, Zhang JY (2018) The application of ZIF-67 and its derivatives: adsorption, separation, electrochemistry and catalysts. J Mater Chem A 6(5):1887–1899. https://doi.org/10.1039/c7ta08268a10.1039/c7ta08268a ↗
26. Feng XH, Carreon MA (2015) Kinetics of transformation on ZIF-67 crystals. J Cryst Growth 418:158–162. https://doi.org/10.1016/j.jcrysgro.2015.02.06410.1016/j.jcrysgro.2015.02.064 ↗
27. Lashgari SM, Yari H, Mahdavian M, Ramezanzadeh, B, Bahlakeh, G, Ramezanzadeh, M (2021) Application of nanoporous cobalt-based ZIF-67 metal-organic framework (MOF) for construction of an epoxy-composite coating with superior anti-corrosion properties. Corros Sci 178:109099. https://doi.org/10.1016/j.corsci.2020.10909910.1016/j.corsci.2020.109099 ↗
28. Guo XL, Xing TT, Lou YB, Chen JX (2016) Controlling ZIF-67 crystals formation through various cobalt sources in aqueous solution. J Solid State Chem 235:107–112. https://doi.org/10.1016/j.jssc.2015.12.02110.1016/j.jssc.2015.12.021 ↗
29. Jiang Y, Lu Y, Lei LL, et al (2021) Near-infrared light-triggered synergistic antitumor therapy based on hollow ZIF-67-derived Co3S4-indocyanine green nanocomplex as a superior reactive oxygen species generator. Mat Sci Eng C Mater 130:112465. https://doi.org/10.1016/j.msec.2021.11246510.1016/j.msec.2021.112465 ↗
30. Ma YS, Xu HH, Sun B, Du SL, Cui S, Zhang L, Ding N, Yang DZ (2021) pH-responsive oxygen and hydrogen peroxide self-supplying nanosystem for photodynamic and chemodynamic therapy of wound infection. Acs Appl Mater Inter 13(50):59720–59730. https://doi.org/10.1021/acsami.1c1968110.1021/acsami.1c19681 ↗
31. Shuai CJ, Yang F, Shuai Y, Peng SP, Chen SJ, Deng YW, Feng P (2022) Silicon dioxide nanoparticles decorated on graphene oxide nanosheets and their application in poly (L-lactic acid) scaffold. J Adv Res. https://doi.org/10.1016/j.jare.2022.08.01710.1016/j.jare.2022.08.017 ↗
32. Gao CD, Zeng ZH, Peng SP, Shuai CJ (2022) Magnetostrictive bulk Fe-Ga alloys prepared by selective laser melting for biodegradable implant applications. Mater Design 220:110861. https://doi.org/10.1016/j.matdes.2022.11086110.1016/j.matdes.2022.110861 ↗
33. Shuai CJ, Wang ZC, Peng SP, Shuai Y, Chen YW, Zeng D, Feng P (2022) Water-responsive shape memory thermoplastic polyurethane scaffolds triggered at body temperature for bone defect repair. Mater Chem Front 6(11):1456–1469. https://doi.org/10.1039/d1qm01635k10.1039/d1qm01635k ↗
34. Shuai CJ, Chen X, He CX, Qian GW, Shuai Y, Peng SP, Deng YW, Yang WJ (2022) Construction of magnetic nanochains to achieve magnetic energy coupling in Scaffold. Biomater Res 26(1). https://doi.org/10.1186/s40824-022-00278-210.1186/s40824-022-00278-2 ↗
35. Oladapo BI, Zahedi SA, Ismail SO, Omigbodun FT, Bowoto OK, Olawumi MA, Muhammad MA (2020) 3D printing of PEEK–cHAp scaffold for medical bone implant. Bio Des Manuf 4(1):44–59. https://doi.org/10.1007/s42242-020-00098-010.1007/s42242-020-00098-0 ↗
36. Silva EPE, Huang BY, Helaehil JV et al (2021) In vivo study of conductive 3D printed PCL/MWCNTs scaffolds with electrical stimulation for bone tissue engineering. Bio Des Manuf 4(2):190–202. https://doi.org/10.1007/s42242-020-00116-110.1007/s42242-020-00116-1 ↗
37. Feng P, Shen SP, Yang LYM, Kong Y, Yang S, Shuai CJ (2022) Vertical and uniform growth of MoS2 nanosheets on GO nanosheets for efficient mechanical reinforcement in polymer scaffold. Virtual Phys Prototy 18(1):e2115384. https://doi.org/10.1080/17452759.2022.211538410.1080/17452759.2022.2115384 ↗
38. Qian YJ, Zhang J, Zhang YL, Chen JB, Zhou XF (2016) Degradation of 2, 4-dichlorophenol by nanoscale calcium peroxide: implication for groundwater remediation. Sep Purif Technol 166:222–229. https://doi.org/10.1016/j.seppur.2016.04.01010.1016/j.seppur.2016.04.010 ↗
39. Yan SL, Kim M, Salley SO, Ng KYS (2009) Oil transesterification over calcium oxides modified with lanthanum. Appl Catal A Gen 360(2):163–170. https://doi.org/10.1016/j.apcata.2009.03.01510.1016/j.apcata.2009.03.015 ↗
40. Zeglinski J, Piotrowski GP, Piękos R (2006) A study of interaction between hydrogen peroxide and silica gel by FTIR spectroscopy and quantum chemistry. J Mol Struct 794(1–3):83–91. https://doi.org/10.1016/j.molstruc.2006.01.04310.1016/j.molstruc.2006.01.043 ↗
41. Wu JR, Zhang ZJ, Qiao CX, Yi CF, Xu ZS, Chen TY, Dai XF (2021) Synthesis of monodisperse ZIF-67@CuSe@PVP nanoparticles for pH-responsive drug release and photothermal therapy. Acs Biomater Sci Eng 8(1):284–292. https://doi.org/10.1021/acsbiomaterials.1c0112410.1021/acsbiomaterials.1c01124 ↗
42. Ni M, Ratner BD (2008) Differentiating calcium carbonate polymorphs by surface analysis techniques—an XPS and TOF-SIMS study. Surf Interface Anal 40(10):1356–1361. https://doi.org/10.1002/sia.290410.1002/sia.2904 ↗
43. Wang ZP, Zhang YG, Tan ZC, Li QH (2018) A wet process for oxidation-absorption of nitric oxide by persulfate/calcium peroxide. Chem Eng J 350:767–775. https://doi.org/10.1016/j.cej.2018.05.14510.1016/j.cej.2018.05.145 ↗
44. Qin JN, Wang SB, Wang XC (2017) Visible-light reduction CO2 with dodecahedral zeolitic imidazolate framework ZIF-67 as an efficient co-catalyst. Appl Catal B Environ 209:476–482. https://doi.org/10.1016/j.apcatb.2017.03.01810.1016/j.apcatb.2017.03.018 ↗
45. Niu YQ, Galluzzi M, Deng FM, et al (2022) A biomimetic hyaluronic acid‐silk fibroin nanofiber scaffold promoting regeneration of transected urothelium. Bioeng Transl Med 7(2):e10268. https://doi.org/10.1002/btm2.1026810.1002/btm2.10268 ↗
46. Zhang YB, Liu XC, Zeng LD, Zhang J, Zuo JL, Zou J, Ding JX, Chen XS (2019) Polymer fiber scaffolds for bone and cartilage tissue engineering. Adv Funct Mater 29(36):1903279. https://doi.org/10.1002/adfm.20190327910.1002/adfm.201903279 ↗
47. Li YC, Lin ZY, Wang XY, et al (2021) High-hydrophobic ZIF-8@ PLA composite aerogel and application for oil-water separation. Sep Purif Technol 270:118794. https://doi.org/10.1016/j.seppur.2021.11879410.1016/j.seppur.2021.118794 ↗
48. Torii S, Kurihara A, Li XY, Yasumoto KI, Sogawa K (2011) Inhibitory effect of extracellular histidine on cobalt-induced HIF-1α expression. J Biochem 149(2):171–176. https://doi.org/10.1093/jb/mvq12910.1093/jb/mvq129 ↗
49. Qian GW, Wen TC, Shuai Y, Wu XT, Zeng ZK, Peng SP, Shuai CJ (2022) Photothermal and photodynamic effects of g-C3N4 nanosheet/Bi2S3 nanorod composites with antibacterial activity for tracheal injury repair. Acs Appl Nano Mater. https://doi.org/10.1021/acsanm.2c0356910.1021/acsanm.2c03569 ↗
50. Qi FW, Wang ZH, Shuai Y, Peng SP, Shuai CJ (2022) Sr2+ sustained release system augments bioactivity of polymer scaffold. Acs Appl Polym Mater 4(4):2691–2702. https://doi.org/10.1021/acsapm.2c0002410.1021/acsapm.2c00024 ↗
51. Nakamura S, Matsumoto T, Sasaki JI, Egusa H, LEE KY, Nakano T, Sohmura T, Nakahira A, (2010) Effect of calcium ion concentrations on osteogenic differentiation and hematopoietic stem cell niche-related protein expression in osteoblasts. Tissue Eng Pt A 16(8):2467–2473. https://doi.org/10.1089/ten.tea.2009.033710.1089/ten.tea.2009.0337 ↗
52. Seol YJ, Park JY, Jung JW, Jang J, Girdhari R, Kim SW, Cho DW (2014) Improvement of bone regeneration capability of ceramic scaffolds by accelerated release of their calcium ions. Tissue Eng Pt A 20(21–22):2840–2849. https://doi.org/10.1089/ten.tea.2012.072610.1089/ten.tea.2012.0726 ↗
53. Fazeli N, Arefian E, Irani S, Ardeshirylajimi A, Seyedjafari E (2021) 3D-printed PCL scaffolds coated with nanobioceramics enhance osteogenic differentiation of stem cells. ACS Omega 6(51):35284–35296. https://doi.org/10.1021/acsomega.1c0401510.1021/acsomega.1c04015 ↗