Metal–organic frameworks based on β-cyclodextrin: design and selective entrapment of non-steroidal anti-inflammatory drugs
Source abstract
Abstract
Metal–organic frameworks based on β-cyclodextrin and potassium cations (K-βCD-MOF) were synthesized and characterized. Influence of nature and amount of anti-solvent, as well as molar ratio of the components and temperature on the K-βCD-MOF synthesis was revealed. The loading of non-steroidal anti-inflammatory drugs (NSAIDs) in K-βCD-MOF was performed by co-crystallization and impregnation methods. It was shown that chemical nature of NSAIDs strongly influences the drug loading. The maximum payload (up to 7 wt%) was reached for ibuprofen as less bulky and more lipophilic compound. The obtained composites were characterized by different experimental techniques. Ibuprofen entrapped in K-βCD-MOF displayed improved aqueous solubility. Solubility rise is caused by formation of the inclusion complexes and clusters stabilized by β-CD.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Crystallography and molecular interactions · X-ray Diffraction in Crystallography
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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